| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Guan, Xin Tong, Yi Zhang, Fan Xu, Yuxin Zhang, Xiurui Liang, Jiaqi Jin, Hongyan Jing, Liuxian Guo, Xinrui Ni, Jihua F. Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules. Chemico-biological interactions. vol 349. 2021-11-08. PMID:34560070. |
in vivo, by he and tunel staining, we found that cisplatin-induced renal lesions and apoptotic regions, which were located in proximal tubular epithelial cells, were also the regions in which tryptophan hydroxylase 1 (tph1), aromatic l-amino acid decarboxylase (aadc), 5-ht |
2021-11-08 |
2023-08-13 |
Not clear |
| Lu Xiao, Junyan Yan, Ting Yang, Jiang Zhu, Tingyu Li, Hong Wei, Jie Che. Fecal Microbiome Transplantation from Children with Autism Spectrum Disorder Modulates Tryptophan and Serotonergic Synapse Metabolism and Induces Altered Behaviors in Germ-Free Mice. mSystems. vol 6. issue 2. 2021-10-28. PMID:33824200. |
western blotting detected the protein expression levels of tryptophan hydroxylase 1 (tph1), serotonin transporter (sert), and serotonin 1a receptor (5-ht1ar) in the colon and tph2, sert, and 5-ht1ar in the prefrontal cortex of mice. |
2021-10-28 |
2023-08-13 |
mouse |
| Ming-Fen Ho, Cheng Zhang, Lingxin Zhang, Lixuan Wei, Ying Zhou, Irene Moon, Jennifer R Geske, Doo-Sup Choi, Joanna Biernacka, Mark Frye, Zhexing Wen, Victor M Karpyak, Hu Li, Richard Weinshilbou. TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response. Molecular psychiatry. vol 26. issue 7. 2021-10-15. PMID:32753686. |
ethanol treatment resulted in decreased 5-ht concentrations in human induced pluripotent stem cell (ipsc)-derived neuron culture media, and the downregulation of gene expression of tspan5, ddc, maoa, maob, tph1, and tph2 in those cells. |
2021-10-15 |
2023-08-13 |
human |
| Akihisa Kamiya, Takuji Machida, Megumi Hirano, Maiko Machida, Saki Shiga, Naoya Hamaue, Masahiko Hirafuji, Kenji Iizuk. Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury. Journal of pharmacological sciences. vol 147. issue 3. 2021-09-14. PMID:34507634. |
cyclophosphamide significantly increased tryptophan hydroxylase 1 (tph1) mrna expression, number of anti-tph antibody-positive cells, and 5-ht content in the intestine. |
2021-09-14 |
2023-08-13 |
rat |
| Tao Li, Bin Fu, Xin Zhang, Yunjiang Zhou, Mengdi Yang, Mengran Cao, Yaxin Chen, Yingying Tan, Rong H. Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation. Cancer immunology research. vol 9. issue 9. 2021-09-02. PMID:34285037. |
in this study, we found that 5-ht levels, as well as the expression of tryptophan hydroxylase 1 (tph1), the 5-ht biosynthesis rate-limiting enzyme, were significantly upregulated in colorectal tumor tissues from patients with colorectal cancer, colorectal cancer mouse models, and colorectal cancer cell lines when compared with normal colorectal tissues or epithelial cell lines. |
2021-09-02 |
2023-08-13 |
mouse |
| Xinmei Wang, Nandini Deb, Carla M R Lacerd. Comparison of Serotonin-Regulated Calcific Processes in Aortic and Mitral Valvular Interstitial Cells. ACS omega. vol 6. issue 30. 2021-08-10. PMID:34368536. |
to evaluate calcification progress, calcium and collagen deposits along with the expression of protein markers, including the rate-limiting enzyme of serotonin synthesis [tryptophan hydroxylase 1 (tph1)], were assessed. |
2021-08-10 |
2023-08-13 |
Not clear |
| Misa Tatsuoka, Yosuke Osaki, Fumina Ohsaka, Takeshi Tsuruta, Yoshihiro Kadota, Takumi Tochio, Shingo Hino, Tatsuya Morita, Kei Sonoyam. Consumption of indigestible saccharides and administration of The British journal of nutrition. 2021-06-18. PMID:33849681. |
colonic 5-ht content and enterochromaffin (ec) cell numbers were lower in mice supplemented with kes than those without supplementation, while monoamine oxidase a activity and mrna levels of tryptophan hydroxylase 1 (tph1), chromogranin a (chga), slc6a4 and monoamine oxidase a (maoa) genes in the colonic mucosa, serum 5-ht concentration and total 5-ht content in the colonic contents did not differ between groups. |
2021-06-18 |
2023-08-13 |
mouse |
| Yongxin Hou, Lixia Xu, Sirong Song, Weijia Fan, Qiaoli Wu, Xiaoguang Tong, Hua Ya. Oral Administration of Brain Protein Combined With Probiotics Induces Immune Tolerance Through the Tryptophan Pathway. Frontiers in molecular neuroscience. vol 14. 2021-06-15. PMID:34122006. |
a series of experiments further confirmed that indoleamine 2,3 dioxygenase (ido)/kynurenine (kyn)/aryl hydrocarbon receptor (ahr) expression was high in the bp group, while tryptophan hydroxylase 1(tph1)/5-hydroxytryptamine (5-ht) only changed in the combined group. |
2021-06-15 |
2023-08-13 |
rat |
| Junchao Wang, Wenjuan Xu, Rongjuan Wang, Rongrong Cheng, Zhengquan Tang, Min Zhan. The outer membrane protein Amuc_1100 of Food & function. vol 12. issue 8. 2021-05-27. PMID:33900345. |
this study demonstrated that amuc_1100 could promote the expression of the 5-ht synthesis rate-limiting enzyme tph1 in rin-14b cells and reduce the expression of the serotonin reuptake transporter (sert) in caco-2 cells through direct interaction with tlr2, thereby improving 5-ht biosynthesis and extracellular availability. |
2021-05-27 |
2023-08-13 |
mouse |
| Ke Zhang, Xue Li, Xian Wang, Hongyu Zheng, Shusheng Tang, Lin Lu, Xi M. Gut Barrier Proteins Mediate Liver Regulation by the Effects of Serotonin on the Non-Alcoholic Fatty Liver Disease. Current protein & peptide science. vol 21. issue 10. 2021-05-25. PMID:32538722. |
in addition, increasing the expression of serotonin reuptake transporter (sert) and decreasing the expression of tryptophan hydroxylase1 (tph1) can relieve the symptoms of nafld. |
2021-05-25 |
2023-08-13 |
mouse |
| David A Nielsen, Huiqiong Deng, Michelle A Patriquin, Mark J Harding, John Oldham, Ramiro Salas, J Christopher Fowler, B Christopher Frue. Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study. European archives of psychiatry and clinical neuroscience. vol 270. issue 5. 2021-04-05. PMID:30923939. |
association of tph1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study. |
2021-04-05 |
2023-08-13 |
Not clear |
| David A Nielsen, Huiqiong Deng, Michelle A Patriquin, Mark J Harding, John Oldham, Ramiro Salas, J Christopher Fowler, B Christopher Frue. Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study. European archives of psychiatry and clinical neuroscience. vol 270. issue 5. 2021-04-05. PMID:30923939. |
variants in three genes coding for components of the serotonergic system, the tryptophan hydroxylase 1 (tph1) rs1799913, serotonin transporter (slc6a4) 5-httlpr, and serotonin receptor 2a (htr2a) rs6311, were evaluated for association with suicidal ideation (si) and with recovery from si in a psychiatric inpatient population. |
2021-04-05 |
2023-08-13 |
Not clear |
| David A Nielsen, Huiqiong Deng, Michelle A Patriquin, Mark J Harding, John Oldham, Ramiro Salas, J Christopher Fowler, B Christopher Frue. Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study. European archives of psychiatry and clinical neuroscience. vol 270. issue 5. 2021-04-05. PMID:30923939. |
this study provides evidence that variation in the tph1 and serotonin transporter genes play key roles in moderating recovery from si during treatment in an inpatient psychiatric clinic. |
2021-04-05 |
2023-08-13 |
Not clear |
| Qing Pang, Hao Jin, Yong Wang, Mengnan Dai, Shuangchi Liu, Yi Tan, Huichun Liu, Zheng L. Depletion of serotonin relieves concanavalin A-induced liver fibrosis in mice by inhibiting inflammation, oxidative stress, and TGF-β1/Smads signaling pathway. Toxicology letters. vol 340. 2021-02-22. PMID:33429011. |
to establish the mouse model of lf, mice of wild-type (wt) and tryptophan hydroxylase 1 (tph1) knockout (serotonin depletion) received con a for 8 successive weeks. |
2021-02-22 |
2023-08-13 |
mouse |
| Konstantina Kyritsi, Lixian Chen, April O'Brien, Heather Francis, Travis W Hein, Julie Venter, Nan Wu, Ludovica Ceci, Tianhao Zhou, David Zawieja, Anatoliy A Gashev, Fanyin Meng, Pietro Invernizzi, Luca Fabris, Chaodong Wu, Nicholas J Skill, Romil Saxena, Suthat Liangpunsakul, Gianfranco Alpini, Shannon S Glase. Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis. Hepatology (Baltimore, Md.). vol 71. issue 3. 2021-02-17. PMID:31344280. |
tryptophan hydroxylase (tph1) and monoamine oxidase (mao-a) are the key enzymes for the synthesis and catabolism of 5ht, respectively. |
2021-02-17 |
2023-08-13 |
mouse |
| Cezary Chojnacki, Tomasz Popławski, Anita Gasiorowska, Jan Chojnacki, Janusz Blasia. Serotonin in the Pathogenesis of Lymphocytic Colitis. Journal of clinical medicine. vol 10. issue 2. 2021-01-26. PMID:33466782. |
in the present work, the level of 5-ht in serum and the number of enteroendocrine cells (eecs) as well as the expression of the 5-ht rate-limiting enzyme tryptophan hydroxylase 1 (tph1) in colonic biopsies and urine 5-hydroxyindoeoacetic acid (5-hiaa) were determined in 36 lc patients that were treated with budesonide and 32 healthy controls. |
2021-01-26 |
2023-08-13 |
Not clear |
| Cezary Chojnacki, Tomasz Popławski, Anita Gasiorowska, Jan Chojnacki, Janusz Blasia. Serotonin in the Pathogenesis of Lymphocytic Colitis. Journal of clinical medicine. vol 10. issue 2. 2021-01-26. PMID:33466782. |
the 5-ht serum and 5-hiaa urine levels were measured using elisa, the eec number was determined immunohistochemically, and the colonic tph1 mrna expression was determined using rt-pcr. |
2021-01-26 |
2023-08-13 |
Not clear |
| Cezary Chojnacki, Tomasz Popławski, Anita Gasiorowska, Jan Chojnacki, Janusz Blasia. Serotonin in the Pathogenesis of Lymphocytic Colitis. Journal of clinical medicine. vol 10. issue 2. 2021-01-26. PMID:33466782. |
the levels of 5-ht and 5-hiaa and the number of eecs were higher in lc patients than in the controls, and positive correlations were observed between the 5-ht and 5-hiaa levels, 5-ht and eec number, tph1 mrna and eec number, as well as the severity of disease symptoms and 5-hiaa. |
2021-01-26 |
2023-08-13 |
Not clear |
| Cezary Chojnacki, Tomasz Popławski, Anita Gasiorowska, Jan Chojnacki, Janusz Blasia. Serotonin in the Pathogenesis of Lymphocytic Colitis. Journal of clinical medicine. vol 10. issue 2. 2021-01-26. PMID:33466782. |
budesonide decreased the levels of 5-ht, 5-hiaa, and tph1 expression and the number of eecs to values that did not differ from those for controls. |
2021-01-26 |
2023-08-13 |
Not clear |
| Yunting Xie, Chong Wang, Di Zhao, Chao Wang, Chunbao L. Dietary Proteins Regulate Serotonin Biosynthesis and Catabolism by Specific Gut Microbes. Journal of agricultural and food chemistry. vol 68. issue 21. 2021-01-07. PMID:32363863. |
the emulsion-type sausage protein and cooked pork protein diets increased the mrna levels of tryptophan hydroxylase 1 (tph1) and monoamine oxidase a (maoa) and serotonin level as well but reduced the number of enterochromaffin cells. |
2021-01-07 |
2023-08-13 |
mouse |