| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
thus, tph1 gene expression in the mouse brain is too low to significantly affect 5-ht synthesis in normal conditions and during inflammation. |
2023-03-31 |
2023-08-14 |
mouse |
| Wei Du, Zhi Fei Zhang, Jia Ying Xiao, Ying Wang, Weng Yi Liu, Hui Ling Zhen. 5-hydroxytryptophan inhibits β-casein biosynthesis and promotes goat mammary epithelial cell apoptosis through the JAK2/STAT5a axis and the HTR7. Journal of animal science. 2023-03-25. PMID:36964762. |
tryptophan hydroxylase 1 (tph1) catalyzes the conversion of 5-hydroxytryptophan (5-htp) into l-tryptophan, which is then converted into 5-ht by monoamine-oxidase (mao-a). |
2023-03-25 |
2023-08-14 |
Not clear |
| Shalinda J A Fernando, Qian Wang, Debbie L Hay, Ross Bathgate, Peter R Shepherd, Kate L Le. Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin. Bioscience reports. 2023-03-22. PMID:36947541. |
this was paralleled by a reduction in expression of mrna for tph1, the enzyme controlling the rate limiting step in the production of serotonin. overexpression of rxfp4 also attenuated the camp-induced release of serotonin from colo320 cells. together this demonstrates that serotonin producing enterochromaffin cells are the major site of rxfp4 expression in the gut and that rxfp4 can have inhibitory functional impacts on camp production as well as tph1 expression and serotonin release. |
2023-03-22 |
2023-08-14 |
mouse |
| Sergey A Sinenko, Andrey A Kuzmin, Elena V Skvortsova, Sergey V Ponomartsev, Evgeniya V Efimova, Michael Bader, Natalia Alenina, Alexey N Tomili. Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902295. |
as serotonin is synthesized from tryptophan by the rate limiting enzymes tryptophan hydroxylase-1 and -2 (tph1 and tph2), we have assessed the reprogramming of tph1- and/or tph2-deficient mouse embryonic fibroblasts (mefs) to induced pluripotent stem cells (ipscs). |
2023-03-11 |
2023-08-14 |
mouse |
| Katsunori Nonogaki, Takao Kaj. Ingestion of whey protein and β-conglycinin exerts opposite effects on intestinal FGF15 and serotonin secretion in mice. Frontiers in endocrinology. vol 14. 2023-02-13. PMID:36777350. |
moreover, ingestion of whey protein isolate significantly decreased the expression of tgr5, glucagon-like peptide 1 (glp-1), and tryptophan hydroxylase1 (tph1) in the small intestine, leading to decreases in plasma 5-ht and insulin levels. |
2023-02-13 |
2023-08-14 |
mouse |
| Katsunori Nonogaki, Takao Kaj. Ingestion of whey protein and β-conglycinin exerts opposite effects on intestinal FGF15 and serotonin secretion in mice. Frontiers in endocrinology. vol 14. 2023-02-13. PMID:36777350. |
moreover, ingestion of β-conglycinin significantly increased the expression of intestinal tgr5, glp-1, and tph1, leading to increases in plasma 5-ht and insulin levels. |
2023-02-13 |
2023-08-14 |
mouse |
| Lijuan Yu, Chunhua Huang, Wei Yang, Zhenxing Ren, Lifeng Li, Huiyuan Cheng, Chengyuan Lin, Lixiang Zhai, Ziwan Ning, Hoileong Xavier Wong, Quanbin Han, Wei Jia, Zhaoxiang Bian, Ling Zha. Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats. Frontiers in pharmacology. vol 13. 2023-01-26. PMID:36699075. |
both, gene and protein levels of the colonic 5-ht synthetase, tryptophan hydroxylase 1 (tph1), were also decreased in ce-treated ibs rats. |
2023-01-26 |
2023-08-14 |
rat |
| Michael D Gersho. The Shaggy Dog Story of Enteric Signaling: Serotonin, a Molecular Megillah. Advances in experimental medicine and biology. vol 1383. 2022-12-31. PMID:36587168. |
the larger of two enteric 5-ht stores is mucosal, biosynthetically dependent upon tryptophan hydroxylase1 (tph1), and located in ec cells. |
2022-12-31 |
2023-08-14 |
dog |
| Yun Han Kwon, Suhrid Banskota, Huaqing Wang, Laura Rossi, Jensine A Grondin, Saad A Syed, Yeganeh Yousefi, Jonathan D Schertzer, Katherine M Morrison, Michael G Wade, Alison C Holloway, Michael G Surette, Gregory R Steinberg, Waliul I Kha. Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice. Nature communications. vol 13. issue 1. 2022-12-20. PMID:36539404. |
importantly, chronic exposure to ar does not influence colitis susceptibility in mice lacking tryptophan hydroxylase 1 (tph1), the rate limiting enzyme for 5-ht biosynthesis. |
2022-12-20 |
2023-08-14 |
mouse |
| Ze Li, Weiwei Wang, Jiali Li, Shaoguo R. New insight on the mechanism of eating disorder in females based on metabolic differences of bisphenol S in female and male zebrafish. Environmental pollution (Barking, Essex : 1987). 2022-12-09. PMID:36493936. |
in addition, the mrna expression levels of tryptophan 5-monooxygenase (tph1) that regulated serotonin synthesis was reduced in gut of females in all bps groups, and tph1 protein has very high affinity with bps molecule. |
2022-12-09 |
2023-08-14 |
zebrafish |
| Ze Li, Weiwei Wang, Jiali Li, Shaoguo R. New insight on the mechanism of eating disorder in females based on metabolic differences of bisphenol S in female and male zebrafish. Environmental pollution (Barking, Essex : 1987). 2022-12-09. PMID:36493936. |
adult females treated with bps exhibited symptoms including overeating, a decrease of serotonin in the gut, hypoglycemia and hyperlipidemia, a similar effect of tph1 protein inhibitor lp533401 on adult females. |
2022-12-09 |
2023-08-14 |
zebrafish |
| Heeyoung Park, Chang-Wook Lee, Jieun Kang, Ali Sadra, Sung-Oh Hu. Glutamine increases stability of TPH1 mRNA via p38 mitogen-activated kinase in mouse mastocytoma cells. Molecular biology reports. 2022-11-04. PMID:36331742. |
expression changes for tryptophan hydroxylase 1 (tph1), the rate-limiting enzyme in serotonin synthesis, by environmental glutamine (gln) were examined in mouse mastocytoma-derived p815-htr cells. |
2022-11-04 |
2023-08-14 |
mouse |
| Danielle S Roberts, Laura G Sherlock, Janelle N Posey, Jamie L Archambault, Eva S Nozik, Cassidy A Delane. Serotonin-deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension. Physiological reports. vol 10. issue 19. 2022-10-06. PMID:36200294. |
in experimental pulmonary hypertension (ph), pulmonary expression of tryptophan hydroxylase-1 (tph1), the rate limiting enzyme in 5-ht synthesis, and plasma 5-ht are increased. |
2022-10-06 |
2023-08-14 |
mouse |
| Chengguo Ge, Jiusong Yan, Xiaoyu Yuan, Guangyong X. A positive feedback loop between tryptophan hydroxylase 1 and β-Catenin/ZBP-89 signaling promotes prostate cancer progression. Frontiers in oncology. vol 12. 2022-09-29. PMID:36172162. |
in this study, we reported that the overexpression of trp hydroxylase 1 (tph1) caused the upregulation of trp hydroxylation and mediated the production of 5-hydroxytryptamine (5-ht), contributing to tumor growth and poor prognosis in patients with prostate cancer. |
2022-09-29 |
2023-08-14 |
mouse |
| Ping-Yuan Ge, Shu-Yue Qu, Sai-Jia Ni, Zeng-Ying Yao, Yi-Yu Qi, Xin Zhao, Rui Guo, Nian-Yun Yang, Qi-Chun Zhang, Hua-Xu Zh. Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism. Phytotherapy research : PTR. 2022-09-11. PMID:36089660. |
moreover, berberine induced retraction of the abnormal neurotransmitters and metabolomics assays revealed that berberine promoted tryptophan biotransformation into serotonin and inhibited the kynurenine metabolism pathway, which was attributed to the potential agonist of tryptophan 5-hydroxylase 1 (tph1) and inhibitor of indoleamine 2,3-dioxygenase 1 (ido1). |
2022-09-11 |
2023-08-14 |
mouse |
| Margaret R MacLean, Barry Fanburg, Nicolas Hill, Howard M Lazarus, Thomas F Pack, Michelle Palacios, Krishna C Penumatsa, Stephen A Wrin. Serotonin and Pulmonary Hypertension; Sex and Drugs and ROCK and Rho. Comprehensive Physiology. vol 12. issue 4. 2022-08-29. PMID:36036567. |
the rate-limiting enzyme in the synthesis of serotonin in the periphery of the body is tryptophan hydroxylase 1 (tph1). |
2022-08-29 |
2023-08-14 |
Not clear |
| Margaret R MacLean, Barry Fanburg, Nicolas Hill, Howard M Lazarus, Thomas F Pack, Michelle Palacios, Krishna C Penumatsa, Stephen A Wrin. Serotonin and Pulmonary Hypertension; Sex and Drugs and ROCK and Rho. Comprehensive Physiology. vol 12. issue 4. 2022-08-29. PMID:36036567. |
tph1 expression and serotonin synthesis are elevated in pulmonary artery endothelial cells in patients with pah. |
2022-08-29 |
2023-08-14 |
Not clear |
| Howard M Lazarus, Jill Denning, Stephen Wring, Michelle Palacios, Sidra Hoffman, Katelyn Crizer, Watiri Kamau-Kelley, William Symonds, Jeremy Feldma. A trial design to maximize knowledge of the effects of rodatristat ethyl in the treatment of pulmonary arterial hypertension (ELEVATE 2). Pulmonary circulation. vol 12. issue 2. 2022-07-07. PMID:35795492. |
tryptophan hydroxylase 1 (tph1) is the rate-limiting enzyme for biosynthesis of serotonin and is upregulated in pah arterial endothelial cells, supporting tph1 inhibition to treat pah. |
2022-07-07 |
2023-08-14 |
human |
| Howard M Lazarus, Jill Denning, Stephen Wring, Michelle Palacios, Sidra Hoffman, Katelyn Crizer, Watiri Kamau-Kelley, William Symonds, Jeremy Feldma. A trial design to maximize knowledge of the effects of rodatristat ethyl in the treatment of pulmonary arterial hypertension (ELEVATE 2). Pulmonary circulation. vol 12. issue 2. 2022-07-07. PMID:35795492. |
rodatristat ethyl, a prodrug for rodatristat, a potent, peripheral inhibitor of tph1, has demonstrated efficacy in monocrotaline and sugen hypoxia nonclinical models of pah and robust dose-dependent reductions of 5-hydroxyindoleacetic acid, the major metabolite of serotonin in plasma and urine of healthy human subjects. |
2022-07-07 |
2023-08-14 |
human |
| Suvarna H Pagire, Haushabhau S Pagire, Kun-Young Park, Eun Jung Bae, Kwang-Eun Kim, Minhee Kim, Jihyeon Yoon, Saravanan Parameswaran, Jun-Ho Choi, Sungmi Park, Jae-Han Jeon, Jin Sook Song, Myung Ae Bae, In-Kyu Lee, Hail Kim, Jae Myoung Suh, Jin Hee Ah. Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease. Molecules (Basel, Switzerland). vol 27. issue 11. 2022-06-10. PMID:35684355. |
because serotonin cannot cross the blood-brain barrier (bbb), we focused on identifying new tryptophan hydroxylase type i (tph1) inhibitors that act only in peripheral tissues for treating obesity and fatty liver disease without affecting the central nervous system. |
2022-06-10 |
2023-08-14 |
Not clear |