| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
despite increased 5-ht synthesis, there was no change in either tph2 or tph1 mrna levels or in maximal in vitro tph activity in the brainstem of sert -/- mice. |
2006-03-10 |
2023-08-12 |
mouse |
| b' Pascal Amireault, Fran\\xc3\\xa7ois Dub\\xc3\\xa. Serotonin and its antidepressant-sensitive transport in mouse cumulus-oocyte complexes and early embryos. Biology of reproduction. vol 73. issue 2. 2005-11-08. PMID:15858217.' |
to clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-ht itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (tph1); and the 5-ht-specific transporter (slc6a4) required for modulating its cellular effects. |
2005-11-08 |
2023-08-12 |
mouse |
| b' Pascal Amireault, Fran\\xc3\\xa7ois Dub\\xc3\\xa. Serotonin and its antidepressant-sensitive transport in mouse cumulus-oocyte complexes and early embryos. Biology of reproduction. vol 73. issue 2. 2005-11-08. PMID:15858217.' |
using a combination of reverse transcription-polymerase chain reaction analysis and immunofluorescence confocal microscopy, we showed that mouse cumulus cells, oocytes, and embryos contain 5-ht and slc6a4, while only cumulus cells possess the 5-ht-producing enzyme tph1 and may thus be the local source of 5-ht observed in their neighboring cells. |
2005-11-08 |
2023-08-12 |
mouse |
| Jeffrey McKinney, Per M Knappskog, Jan Haavi. Different properties of the central and peripheral forms of human tryptophan hydroxylase. Journal of neurochemistry. vol 92. issue 2. 2005-05-26. PMID:15663479. |
the differences between tph1 and tph2 have important implications for the regulation of serotonin production in the brain and the periphery and may provide an explanation for some of the diverging results reported for tph from different sources in the past. |
2005-05-26 |
2023-08-12 |
human |
| M Reuter, J Henni. Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 134B. issue 1. 2005-05-09. PMID:15635702. |
recent studies from molecular genetics have suggested an association between the tryptophan hydroxylase 1 (tph1) gene and nicotine addiction indicating a dysfunction of the serotonergic (5-ht) system in smoking behavior. |
2005-05-09 |
2023-08-12 |
human |
| H S Sun, H-W Tsai, H-C Ko, F-M Chang, T-L Ye. Association of tryptophan hydroxylase gene polymorphism with depression, anxiety and comorbid depression and anxiety in a population-based sample of postpartum Taiwanese women. Genes, brain, and behavior. vol 3. issue 6. 2005-03-15. PMID:15544576. |
since tryptophan hydroxylase (tph1) is the rate-limiting enzyme in serotonin biosynthesis, its role in the pathophysiology of these psychiatric diseases has been intensively studied. |
2005-03-15 |
2023-08-12 |
human |
| Francine Côté, Cécile Fligny, Jacques Mallet, Guilan Vodjdan. [Abnormal cardiac activity in mice in the absence of peripheral serotonin synthesis]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146950. |
the rate limiting enzyme of 5-ht synthesis, tryptophan hydroxylase (tph), is encoded by two genes: the well characterized tph1 gene and a recently identified tph2 gene. |
2004-07-19 |
2023-08-12 |
mouse |
| Francine Côté, Cécile Fligny, Jacques Mallet, Guilan Vodjdan. [Abnormal cardiac activity in mice in the absence of peripheral serotonin synthesis]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146950. |
this is the first report linking loss of tph1 gene expression, and thus of peripheral 5-ht, to a cardiac dysfunction phenotype. |
2004-07-19 |
2023-08-12 |
mouse |
| Francine Côté, Etienne Thévenot, Cécile Fligny, Yves Fromes, Michèle Darmon, Marie-Anne Ripoche, Elisa Bayard, Naima Hanoun, Francoise Saurini, Philippe Lechat, Luisa Dandolo, Michel Hamon, Jacques Mallet, Guilan Vodjdan. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14597720. |
disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. |
2004-01-05 |
2023-08-12 |
mouse |
| Francine Côté, Etienne Thévenot, Cécile Fligny, Yves Fromes, Michèle Darmon, Marie-Anne Ripoche, Elisa Bayard, Naima Hanoun, Francoise Saurini, Philippe Lechat, Luisa Dandolo, Michel Hamon, Jacques Mallet, Guilan Vodjdan. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14597720. |
the rate-limiting enzyme of 5-ht synthesis, tryptophan hydroxylase (tph), is encoded by two genes, the well characterized tph1 gene and a recently identified tph2 gene. |
2004-01-05 |
2023-08-12 |
mouse |
| Francine Côté, Etienne Thévenot, Cécile Fligny, Yves Fromes, Michèle Darmon, Marie-Anne Ripoche, Elisa Bayard, Naima Hanoun, Francoise Saurini, Philippe Lechat, Luisa Dandolo, Michel Hamon, Jacques Mallet, Guilan Vodjdan. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14597720. |
this report links loss of tph1 gene expression, and thus of peripheral 5-ht, to a cardiac dysfunction phenotype. |
2004-01-05 |
2023-08-12 |
mouse |
| David Sugde. Comparison of circadian expression of tryptophan hydroxylase isoform mRNAs in the rat pineal gland using real-time PCR. Journal of neurochemistry. vol 86. issue 5. 2003-11-12. PMID:12911638. |
as serotonin (5-ht) has an important role as a precursor of the nocturnal synthesis of the pineal gland hormone, melatonin, it was of interest to determine the relative expression of tph1 and 2 mrna in the rat pineal during the light:dark (l:d) cycle using sensitive real-time rt-pcr assays which were developed for each tph isoform. |
2003-11-12 |
2023-08-12 |
rat |