| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Dempsie, M R MacLea. Pulmonary hypertension: therapeutic targets within the serotonin system. British journal of pharmacology. vol 155. issue 4. 2008-11-25. PMID:18536742. |
serotonin is synthesized, through tph1, in the endothelial cells of the pulmonary artery and can then act on underlying pulmonary arterial smooth muscle cells and pulmonary arterial fibroblasts in a paracrine fashion causing constriction and remodelling. |
2008-11-25 |
2023-08-12 |
Not clear |
| Nashat Abumaria, Adema Ribic, Christoph Anacker, Eberhard Fuchs, Gabriele Flügg. Stress upregulates TPH1 but not TPH2 mRNA in the rat dorsal raphe nucleus: identification of two TPH2 mRNA splice variants. Cellular and molecular neurobiology. vol 28. issue 3. 2008-08-11. PMID:18197473. |
two isoforms of the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase, tph1 and tph2, are known. |
2008-08-11 |
2023-08-12 |
rat |
| Nashat Abumaria, Adema Ribic, Christoph Anacker, Eberhard Fuchs, Gabriele Flügg. Stress upregulates TPH1 but not TPH2 mRNA in the rat dorsal raphe nucleus: identification of two TPH2 mRNA splice variants. Cellular and molecular neurobiology. vol 28. issue 3. 2008-08-11. PMID:18197473. |
we show here that in the rat dorsal raphe nucleus (drn), the nucleus that contains the highest number of 5-ht neurons in the brain, tph1 mrna reveals a low level of expression but is detectable both by quantitative real-time pcr and in situ hybridization whereas in the pineal gland (pig), tph1 mrna is strongly expressed. |
2008-08-11 |
2023-08-12 |
rat |
| Antonio Nocito, Felix Dahm, Wolfram Jochum, Jae Hwi Jang, Panco Georgiev, Michael Bader, Rolf Graf, Pierre-Alain Clavie. Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts. Cancer research. vol 68. issue 13. 2008-08-05. PMID:18593914. |
using a genetic model of serotonin deficiency (tph1(-/-)) in mice, we show serotonin to be crucial for the growth of s.c. colon cancer allografts in vivo. |
2008-08-05 |
2023-08-12 |
mouse |
| Antonio Nocito, Felix Dahm, Wolfram Jochum, Jae Hwi Jang, Panco Georgiev, Michael Bader, Rolf Graf, Pierre-Alain Clavie. Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts. Cancer research. vol 68. issue 13. 2008-08-05. PMID:18593914. |
the biological relevance of these effects is underscored by the reconstitution of serotonin synthesis in tph1(-/-) mice, which restores allograft phenotype in all aspects. |
2008-08-05 |
2023-08-12 |
mouse |
| Yvonne Dempsie, Ian Morecroft, David J Welsh, Neil A MacRitchie, Nigel Herold, Lynn Loughlin, Margaret Nilsen, Andrew J Peacock, Anthony Harmar, Michael Bader, Margaret R MacLea. Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice. Circulation. vol 117. issue 22. 2008-07-23. PMID:18506000. |
here, we used novel transgenic mice lacking peripheral serotonin (deficient in tryptophan hydroxylase-1; tph1(-/-) mice) or overexpressing the gene for the human serotonin transporter (sert; sert(+) mice) to investigate this further. |
2008-07-23 |
2023-08-12 |
mouse |
| Basudha Basu, Radha Desai, J Balaji, Raghothama Chaerkady, V Sriram, Sudipta Maiti, Mitradas M Panicke. Serotonin in pre-implantation mouse embryos is localized to the mitochondria and can modulate mitochondrial potential. Reproduction (Cambridge, England). vol 135. issue 5. 2008-06-11. PMID:18304982. |
pre-implantation mouse embryos were also examined at various developmental stages for the presence of transcripts of the peripheral and neuronal forms of tryptophan hydroxylase (tph1 and tph2 respectively) and the classical serotonin transporter (slc6a4). |
2008-06-11 |
2023-08-12 |
mouse |
| Qingyun Liu, Qi Yang, Weimei Sun, Pete Vogel, William Heydorn, Xiang-Qing Yu, Zhixiang Hu, Wangsheng Yu, Brandie Jonas, Randy Pineda, Valerie Calderon-Gay, Michael Germann, Emily O'Neill, Robert Brommage, Emily Cullinan, Ken Platt, Alan Wilson, Dave Powell, Arthur Sands, Brian Zambrowicz, Zhi-Cai Sh. Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract. The Journal of pharmacology and experimental therapeutics. vol 325. issue 1. 2008-04-22. PMID:18192499. |
mice lacking tph1 contain little to no 5-ht in the blood and gi tract while maintaining normal levels in the brain. |
2008-04-22 |
2023-08-12 |
mouse |
| Qingyun Liu, Qi Yang, Weimei Sun, Pete Vogel, William Heydorn, Xiang-Qing Yu, Zhixiang Hu, Wangsheng Yu, Brandie Jonas, Randy Pineda, Valerie Calderon-Gay, Michael Germann, Emily O'Neill, Robert Brommage, Emily Cullinan, Ken Platt, Alan Wilson, Dave Powell, Arthur Sands, Brian Zambrowicz, Zhi-Cai Sh. Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract. The Journal of pharmacology and experimental therapeutics. vol 325. issue 1. 2008-04-22. PMID:18192499. |
similar to the tph1 knockout results, these tph inhibitors have the ability to selectively reduce 5-ht levels in the murine gi tract without affecting brain 5-ht levels. |
2008-04-22 |
2023-08-12 |
mouse |
| M R MacLea. Pulmonary hypertension and the serotonin hypothesis: where are we now? International journal of clinical practice. Supplement. issue 156. 2008-04-14. PMID:17663674. |
serotonin can be synthesised in the pulmonary endothelium with the rate-limiting step being the activity of tryptophan hydroxylase1 (tph1). |
2008-04-14 |
2023-08-12 |
human |
| M R MacLea. Pulmonary hypertension and the serotonin hypothesis: where are we now? International journal of clinical practice. Supplement. issue 156. 2008-04-14. PMID:17663674. |
in conclusion, the activity of serotonin receptors, the sert and tph1 can all be elevated in clinical and experimental pah and each offers a potentially unique therapeutic target. |
2008-04-14 |
2023-08-12 |
human |
| Ingeborg Winge, Jeffrey A McKinney, Ming Ying, Clive S D'Santos, Rune Kleppe, Per M Knappskog, Jan Haavi. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. The Biochemical journal. vol 410. issue 1. 2008-04-01. PMID:17973628. |
tph (tryptophan hydroxylase) catalyses the rate-limiting step in the synthesis of serotonin, and exists in two isoforms: tph1, mainly found in peripheral tissues and the pineal body, and tph2, a neuronal form. |
2008-04-01 |
2023-08-12 |
human |
| S W Kang, A Thayananuphat, T Bakken, M E El Halawan. Dopamine-melatonin neurons in the avian hypothalamus controlling seasonal reproduction. Neuroscience. vol 150. issue 1. 2008-03-28. PMID:17935892. |
moreover, we found these neurons to express tryptophan hydroxylase 1 (tph1; the first enzyme in mel biosynthesis) and 5-ht n-acetyltransferase (aanat; a key regulatory enzyme in mel synthesis) mrnas but not neuronal tryptophan hydroxylase 2 mrna (tph 2; the rate limiting enzyme in 5-ht pathway). |
2008-03-28 |
2023-08-12 |
Not clear |
| François Dubé, Pascal Amireaul. Local serotonergic signaling in mammalian follicles, oocytes and early embryos. Life sciences. vol 81. issue 25-26. 2008-02-15. PMID:18023821. |
additional serotonergic players, including the 5-ht transporter (sert or slc6a4) expressed in oocytes and embryos, and the 5-ht-producing enzyme tryptophan hydroxylase-1 (tph1) expressed in cumulus cells, now make up a complete and autonomous local serotonergic network. |
2008-02-15 |
2023-08-12 |
mouse |
| François Dubé, Pascal Amireaul. Local serotonergic signaling in mammalian follicles, oocytes and early embryos. Life sciences. vol 81. issue 25-26. 2008-02-15. PMID:18023821. |
recent evidence shows that mouse mothers with knocked-out tph1 have embryos with impaired early development, establishing that maternal 5-ht is required for normal embryonic development. |
2008-02-15 |
2023-08-12 |
mouse |
| Sarah Cross, Soo-Jeong Kim, Lauren A Weiss, Ryan J Delahanty, James S Sutcliffe, Bennett L Leventhal, Edwin H Cook, Jeremy Veenstra-Vanderweel. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17406648. |
haplotypes at slc6a4 and individual genotypes of polymorphisms at slc6a4, htr7, htr2a, itgb3, and tph1 showed no significant association with whole blood 5-ht. |
2008-02-06 |
2023-08-12 |
human |
| Sarah Cross, Soo-Jeong Kim, Lauren A Weiss, Ryan J Delahanty, James S Sutcliffe, Bennett L Leventhal, Edwin H Cook, Jeremy Veenstra-Vanderweel. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17406648. |
haplotype analysis of two polymorphisms in tph1 revealed a nominally significant association with whole blood 5-ht (p=0.046). |
2008-02-06 |
2023-08-12 |
human |
| M Izikki, N Hanoun, E Marcos, L Savale, A M Barlier-Mur, F Saurini, S Eddahibi, M Hamon, S Adno. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 4. 2007-11-27. PMID:17675372. |
serotonin [5-hydroxytryptamine (5-ht)] biosynthesis depends on two rate-limiting tryptophan hydroxylases (tph): tph1, which is expressed in peripheral organs, and tph2, which is expressed in neurons. |
2007-11-27 |
2023-08-12 |
mouse |
| M Izikki, N Hanoun, E Marcos, L Savale, A M Barlier-Mur, F Saurini, S Eddahibi, M Hamon, S Adno. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 4. 2007-11-27. PMID:17675372. |
because 5-ht is involved in pulmonary hypertension (ph), we investigated whether genetic variations in tph1 and/or tph2 affected ph development in mice. |
2007-11-27 |
2023-08-12 |
mouse |
| M Izikki, N Hanoun, E Marcos, L Savale, A M Barlier-Mur, F Saurini, S Eddahibi, M Hamon, S Adno. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 4. 2007-11-27. PMID:17675372. |
to examine the functional impact of peripheral tph1 deficiency on hypoxic ph, we used tph1(-/-) mice characterized by very low 5-ht synthesis rates and contents in the gut and lung and increased 5-ht synthesis in the forebrain. |
2007-11-27 |
2023-08-12 |
mouse |