| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giovanni Cianchetta, Terry Stouch, Wangsheng Yu, Zhi-Cai Shi, Leslie W Tari, Ronald V Swanson, Michael J Hunter, Isaac D Hoffman, Qingyun Li. Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Current chemical genomics. vol 4. 2011-07-14. PMID:20556201. |
trytophan hydroxylase type i (tph1), most abundantly expressed in the gastrointestinal tract, initiates the synthesis of serotonin by catalyzing hydroxylation of tryptophan in the presence of biopterin and oxygen. |
2011-07-14 |
2023-08-12 |
Not clear |
| Giovanni Cianchetta, Terry Stouch, Wangsheng Yu, Zhi-Cai Shi, Leslie W Tari, Ronald V Swanson, Michael J Hunter, Isaac D Hoffman, Qingyun Li. Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Current chemical genomics. vol 4. 2011-07-14. PMID:20556201. |
we have previously described three series of novel, periphery-specific tph1 inhibitors that selectively deplete serotonin in the gastrointestinal tract. |
2011-07-14 |
2023-08-12 |
Not clear |
| S Jun, R Kohen, K C Cain, M E Jarrett, M M Heitkempe. Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 3. 2011-05-31. PMID:21073637. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms: tph1 and tph2. |
2011-05-31 |
2023-08-12 |
Not clear |
| M Camiller. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 3. 2011-05-31. PMID:21159063. |
lx-1031 appears promising for chronic diarrhea associated with increased 5-ht expression including ibs-d. optimal doses, efficacy and safety in ibs clinical trials need to be fully elucidated; low systemic exposure, selectivity for tph1 over tph2, and lack of effect on brain 5-ht in several species suggest that lx-1031 is unlikely to cause affective disorders. |
2011-05-31 |
2023-08-12 |
human |
| Nan Li, Jean-Eric Ghia, Huaqing Wang, Jessica McClemens, Francine Cote, Youko Suehiro, Jacques Mallet, Waliul I Kha. Serotonin activates dendritic cell function in the context of gut inflammation. The American journal of pathology. vol 178. issue 2. 2011-05-23. PMID:21281798. |
dcs isolated from tryptophan hydroxylase-1-deficient (tph1(-/-)) mice, which have reduced serotonin in the gut, and wild-type (tph1(+/+)) mice with or without dextran sulfate sodium (dss)-induced colitis were stimulated with lipopolysaccharide to assess interleukin-12 (il-12) production. |
2011-05-23 |
2023-08-12 |
mouse |
| Nan Li, Jean-Eric Ghia, Huaqing Wang, Jessica McClemens, Francine Cote, Youko Suehiro, Jacques Mallet, Waliul I Kha. Serotonin activates dendritic cell function in the context of gut inflammation. The American journal of pathology. vol 178. issue 2. 2011-05-23. PMID:21281798. |
isolated dcs from tph1(+/+) and tph1(-/-) mice were also cocultured with cd4(+) t cells of naive tph1(+/+) mice to assess the role of serotonin in priming t cells. |
2011-05-23 |
2023-08-12 |
mouse |
| Nan Li, Jean-Eric Ghia, Huaqing Wang, Jessica McClemens, Francine Cote, Youko Suehiro, Jacques Mallet, Waliul I Kha. Serotonin activates dendritic cell function in the context of gut inflammation. The American journal of pathology. vol 178. issue 2. 2011-05-23. PMID:21281798. |
in vitro serotonin stimulation restored the cytokine production from tph1(-/-) dcs and adoptive transfer of serotonin-pulsed dcs into tph1(-/-) up-regulated colitis. |
2011-05-23 |
2023-08-12 |
mouse |
| Hsuan-Chi Wang, Tzung Lieh Yeh, Hui Hua Chang, Po Wu Gean, Mei Hung Chi, Yen Kuang Yang, Ru-Band Lu, Po See Che. TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients. Psychopharmacology. vol 213. issue 4. 2011-05-13. PMID:20945066. |
tryptophan hydroxylase 1 (tph1), which encodes the rate-limiting enzyme tryptophan hydroxylase in the biosynthesis of serotonin, is a candidate gene in the development and treatment response of major depressive disorder (mdd); however, its actual role is uncertain. |
2011-05-13 |
2023-08-12 |
Not clear |
| Dimitrios Andreou, Peter Saetre, Thomas Werge, Ole A Andreassen, Ingrid Agartz, Göran C Sedvall, Håkan Hall, Lars Terenius, Erik G Jönsso. Tryptophan hydroxylase gene 1 (TPH1) variants associated with cerebrospinal fluid 5-hydroxyindole acetic acid and homovanillic acid concentrations in healthy volunteers. Psychiatry research. vol 180. issue 2-3. 2011-02-08. PMID:20580984. |
we investigated possible relationships between five tph1 gene polymorphisms and cerebrospinal fluid (csf) concentrations of the major serotonin metabolite 5-hydroxyindoleacetic acid (5-hiaa), the major dopamine metabolite homovanillic acid (hva), and the major norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (mhpg) in healthy volunteers (n=132). |
2011-02-08 |
2023-08-12 |
human |
| Dimitrios Andreou, Peter Saetre, Thomas Werge, Ole A Andreassen, Ingrid Agartz, Göran C Sedvall, Håkan Hall, Lars Terenius, Erik G Jönsso. Tryptophan hydroxylase gene 1 (TPH1) variants associated with cerebrospinal fluid 5-hydroxyindole acetic acid and homovanillic acid concentrations in healthy volunteers. Psychiatry research. vol 180. issue 2-3. 2011-02-08. PMID:20580984. |
the results suggest that tph1 gene variation participates in the regulation of serotonin and dopamine turnover rates in the central nervous system of healthy human subjects. |
2011-02-08 |
2023-08-12 |
human |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
raphe neurons of a brain-specific constitutive tph2 ko were completely devoid of tph2-positive neurons and, consequently, 5-ht in the brain, and also displayed no compensatory up-regulation of tph1 expression. |
2010-12-22 |
2023-08-12 |
mouse |
| Peter Saetre, Per Lundmark, August Wang, Thomas Hansen, Henrik B Rasmussen, Srdjan Djurovic, Ingrid Melle, Ole A Andreassen, Thomas Werge, Ingrid Agartz, Håkan Hall, Lars Terenius, Erik G Jönsso. The tryptophan hydroxylase 1 (TPH1) gene, schizophrenia susceptibility, and suicidal behavior: a multi-centre case-control study and meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 2. 2010-12-20. PMID:19526457. |
tryptophan hydroxylase (tryptophan 5-monooxygenase; tph) is the rate-limiting enzyme in the biosynthesis of 5-ht, and sequence variation in intron 6 of the tph1 gene has been associated with schizophrenia. |
2010-12-20 |
2023-08-12 |
Not clear |
| Susann Matthes, Valentina Mosienko, Saleh Bashammakh, Natalia Alenina, Michael Bade. Tryptophan hydroxylase as novel target for the treatment of depressive disorders. Pharmacology. vol 85. issue 2. 2010-10-04. PMID:20130443. |
the peripheral and cerebral biosynthesis of 5-ht is initiated by two distinct tryptophan hydroxylases: tph1 and tph2. |
2010-10-04 |
2023-08-12 |
Not clear |
| Stefan Johansson, Anne Halmøy, Thegna Mavroconstanti, Kaya K Jacobsen, Elisabeth T Landaas, Andreas Reif, Christian Jacob, Andrea Boreatti-Hümmer, Susanne Kreiker, Klaus-Peter Lesch, Cornelis C Kan, J J Sandra Kooij, Lambertus A Kiemeney, Jan K Buitelaar, Barbara Franke, Marta Ribasés, Rosa Bosch, Mònica Bayés, Miguel Casas, Josep Antoni Ramos-Quiroga, Bru Cormand, Per Knappskog, Jan Haavi. Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 5. 2010-09-29. PMID:20213726. |
the tryptophan hydroxylase 1 and 2 (tph1 and tph2) genes encode the rate-limiting enzymes in the serotonin biosynthesis. |
2010-09-29 |
2023-08-12 |
Not clear |
| Hail Kim, Yukiko Toyofuku, Francis C Lynn, Eric Chak, Toyoyoshi Uchida, Hiroki Mizukami, Yoshio Fujitani, Ryuzo Kawamori, Takeshi Miyatsuka, Yasuhiro Kosaka, Katherine Yang, Gerard Honig, Marieke van der Hart, Nina Kishimoto, Juehu Wang, Soroku Yagihashi, Laurence H Tecott, Hirotaka Watada, Michael S Germa. Serotonin regulates pancreatic beta cell mass during pregnancy. Nature medicine. vol 16. issue 7. 2010-07-29. PMID:20581837. |
expression of serotonin synthetic enzyme tryptophan hydroxylase-1 (tph1) and serotonin production rose sharply in beta cells during pregnancy or after treatment with lactogens in vitro. |
2010-07-29 |
2023-08-12 |
mouse |
| Gabriella Juhasz, Darragh Downey, Neal Hinvest, Emma Thomas, Diana Chase, Zoltan G Toth, Kathryn Lloyd-Williams, Krisztina Mekli, Hazel Platt, Antony Payton, Gyorgy Bagdy, Rebecca Elliott, J F William Deakin, Ian M Anderso. Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 5. 2010-06-21. PMID:20043001. |
we tested the hypothesis that variations in serotonergic genes (tph2, tph1, slc6a4, htr1a), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. |
2010-06-21 |
2023-08-12 |
human |
| Kyoichi Shiroiwa, Akitoyo Hishimoto, Kentaro Mouri, Masaaki Fukutake, Irwan Supriyanto, Naoki Nishiguchi, Osamu Shirakaw. Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population. Neuroscience letters. vol 472. issue 3. 2010-06-11. PMID:20144688. |
although a genetic association of tryptophan hydroxylase isoform 1 (tph1), the rate-limiting enzyme in serotonin synthesis, with schizophrenia has been suggested by recent systematic meta-analyses, the newly identified neuronal isoform tph2 is more relevant to the central nervous system and the association of tph2 gene with schizophrenia has been much less explored. |
2010-06-11 |
2023-08-12 |
Not clear |
| Margaret R Maclean, Yvonne Dempsi. The serotonin hypothesis of pulmonary hypertension revisited. Advances in experimental medicine and biology. vol 661. 2010-04-26. PMID:20204739. |
synthesis of serotonin can occur in pulmonary artery endothelial cells by the enzyme tryptophan hydroxylase 1 (tph1). |
2010-04-26 |
2023-08-12 |
Not clear |
| Sirilak Disatian, Carla Lacerda, E Christopher Orto. Tryptophan hydroxylase 1 expression is increased in phenotype-altered canine and human degenerative myxomatous mitral valves. The Journal of heart valve disease. vol 19. issue 1. 2010-04-16. PMID:20329492. |
tryptophan hydroxylase 1 (tph1) is the limiting enzyme for peripheral serotonin synthesis, and its expression by valve interstitial cells (ic) could implicate an autocrine serotonin signaling mechanism in primary degenerative myxomatous mitral valve disease. |
2010-04-16 |
2023-08-12 |
human |
| Hitoshi Doihara, Katsura Nozawa, Ryosuke Kojima, Eri Kawabata-Shoda, Toshihide Yokoyama, Hiroyuki It. QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells. Molecular and cellular biochemistry. vol 331. issue 1-2. 2010-01-18. PMID:19507004. |
in this study, qgp-1 cells, a human pancreatic endocrine cell line, were found to highly express trpa1 and ec cell marker genes, such as tryptophan hydroxylase 1 (tph1), chromogranin a (cga), synaptophysin, atp-dependent vesicular monoamine transporter 1 (vmat1), metabotropic glutamate receptor 4 (mglur4), beta1-adrenergic receptor (adb1), muscarinic 4 acetylcholine receptor (acm4), substance p, serotonin transporter (sert), and guanylin. |
2010-01-18 |
2023-08-12 |
human |