| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eveline Boudin, Karen Jennes, Fenna de Freitas, David Tegay, Geert Mortier, Wim Van Hu. No mutations in the serotonin related TPH1 and HTR1B genes in patients with monogenic sclerosing bone disorders. Bone. vol 55. issue 1. 2013-11-25. PMID:23563356. |
furthermore mice lacking either tph1 or htr1b, the receptor for serotonin on the osteoblasts, were reported to have an increased bone mass due to increased bone formation. |
2013-11-25 |
2023-08-12 |
mouse |
| Of Khabour, Bh Amarneh, Ea Bani Hani, Im Lataife. Associations Between Variations in TPH1 , TPH2 and SLC6A4 Genes and Postpartum Depression: A Study in the Jordanian Population. Balkan journal of medical genetics : BJMG. vol 16. issue 1. 2013-11-22. PMID:24265583. |
in this study, we investigated the association between tryptophan hydroxylase-1 (tph1 ) (218a>c), tryptophan hydroxylase-2 ( tph2 ) (1463g>a) and serotonin carrier family 6, member 4 (slc6a4) [long (l) vs. short (s)] gene polymorphisms with post-partum depression (ppd) in women from jordan. |
2013-11-22 |
2023-08-12 |
Not clear |
| Georgette L Suidan, Daniel Duerschmied, Gregory M Dillon, Veronique Vanderhorst, Thomas G Hampton, Siu Ling Wong, Jaymie R Voorhees, Denisa D Wagne. Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities. PloS one. vol 8. issue 3. 2013-11-01. PMID:23516593. |
tryptophan hydroxylase-1 (tph1) is expressed by non-neuronal cells including enterochromaffin cells of the gut, mast cells and the pineal gland and is the rate-limiting enzyme involved in the biosynthesis of peripheral serotonin. |
2013-11-01 |
2023-08-12 |
mouse |
| Michael D Gersho. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Transactions of the American Clinical and Climatological Association. vol 123. 2013-07-01. PMID:23303993. |
surprisingly, deletion of tryptophan hydroxylase-1 (tph1), upon which 5-ht biosynthesis in ec cells depends, does not alter constitutive gi motility, whereas deletion of tph2, upon which biosynthesis of neuronal 5-ht depends, slows intestinal transit and accelerates gastric emptying. |
2013-07-01 |
2023-08-12 |
mouse |
| Michael D Gersho. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Transactions of the American Clinical and Climatological Association. vol 123. 2013-07-01. PMID:23303993. |
tph1 deletion, however, protects mice from experimental inflammation; 5-ht potentiation and tph2 deletion each make inflammation more severe. |
2013-07-01 |
2023-08-12 |
mouse |
| Francisco Jiménez-Trejo, Miguel Tapia-Rodríguez, Marco Cerbón, Donald M Kuhn, Gabriel Manjarrez-Gutiérrez, C Adriana Mendoza-Rodríguez, Ofir Picaz. Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility. Reproduction (Cambridge, England). vol 144. issue 6. 2013-04-26. PMID:23028123. |
we used both immunocytochemistry and western blot to detect serotoninergic markers such as 5-ht, tph1, mao(a), 5-ht(1b), 5-ht(3), and 5ht(t); hplc for tph enzymatic activity; computer assisted semen analysis assays to measure sperm motility parameters and pharmacological approaches to show the effect of 5-ht in sperm motility and tyrosine phosphorylation was assessed by western blot. |
2013-04-26 |
2023-08-12 |
human |
| Francisco Jiménez-Trejo, Miguel Tapia-Rodríguez, Marco Cerbón, Donald M Kuhn, Gabriel Manjarrez-Gutiérrez, C Adriana Mendoza-Rodríguez, Ofir Picaz. Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility. Reproduction (Cambridge, England). vol 144. issue 6. 2013-04-26. PMID:23028123. |
we found the presence of serotoninergic markers (5-ht, tph1, mao(a), 5-ht(1b), 5-ht(2a), 5-ht(3), 5-ht(t), and tph enzymatic activity) in human sperm. |
2013-04-26 |
2023-08-12 |
human |
| Daniel Duerschmied, Georgette L Suidan, Melanie Demers, Nadine Herr, Carla Carbo, Alexander Brill, Stephen M Cifuni, Maximilian Mauler, Sanja Cicko, Michael Bader, Marco Idzko, Christoph Bode, Denisa D Wagne. Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice. Blood. vol 121. issue 6. 2013-04-05. PMID:23243271. |
stimulation of endothelium with histamine, a secretagogue of wpbs, or injection of serotonin normalized the rolling in tph1(-/-) mice. |
2013-04-05 |
2023-08-12 |
mouse |
| Daniel Duerschmied, Georgette L Suidan, Melanie Demers, Nadine Herr, Carla Carbo, Alexander Brill, Stephen M Cifuni, Maximilian Mauler, Sanja Cicko, Michael Bader, Marco Idzko, Christoph Bode, Denisa D Wagne. Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice. Blood. vol 121. issue 6. 2013-04-05. PMID:23243271. |
four hours after inflammatory stimulation, neutrophil extravasation into lung, peritoneum, and skin wounds was reduced in tph1(-/-) mice, whereas in vitro neutrophil chemotaxis was independent of serotonin. |
2013-04-05 |
2023-08-12 |
mouse |
| Gabriel Manjarrez-Gutiérrez, Karina Martínez-Radilla, Alfonso Boyzo-Montes de Oca, Sandra Orozco-Suárez, Jorge Hernández-Rodrígue. Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 6. 2013-02-05. PMID:22819790. |
it was confirmed that ium produces an increase in 5-ht in the brainstem and also showed increased expression of tph1 at birth, with decreased expression of tph2. |
2013-02-05 |
2023-08-12 |
Not clear |
| Gabriel Manjarrez-Gutiérrez, Karina Martínez-Radilla, Alfonso Boyzo-Montes de Oca, Sandra Orozco-Suárez, Jorge Hernández-Rodrígue. Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 6. 2013-02-05. PMID:22819790. |
these findings together allow us to propose that chronic elevation of synthesis of 5-ht observed in the brain of the offspring with ium is probably due to a change in the expression and activity of tph1 induced from fetal life. |
2013-02-05 |
2023-08-12 |
Not clear |
| Armen K Goenjian, Julia N Bailey, David P Walling, Alan M Steinberg, Devon Schmidt, Uma Dandekar, Ernest P Nobl. Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms. Journal of affective disorders. vol 140. issue 3. 2013-01-31. PMID:22483952. |
to examine the potential contribution of the serotonin hydroxylase (tph1 and tph2) genes, and the serotonin transporter promoter polymorphism (5httlpr) to the unique and pleiotropic risk of ptsd symptoms and depressive symptoms. |
2013-01-31 |
2023-08-12 |
Not clear |
| Ian Morecroft, Katie White, Paola Caruso, Margaret Nilsen, Lynn Loughlin, Raul Alba, Paul N Reynolds, Sergei M Danilov, Andrew H Baker, Margaret R Maclea. Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. Molecular therapy : the journal of the American Society of Gene Therapy. vol 20. issue 8. 2013-01-11. PMID:22525513. |
serotonin is produced by pulmonary arterial endothelial cells (paec) via tryptophan hydroxylase-1 (tph1). |
2013-01-11 |
2023-08-12 |
human |
| Salina Gairhe, Natalie N Bauer, Sarah A Gebb, Ivan F McMurtr. Serotonin passes through myoendothelial gap junctions to promote pulmonary arterial smooth muscle cell differentiation. American journal of physiology. Lung cellular and molecular physiology. vol 303. issue 9. 2013-01-03. PMID:22923644. |
inhibition of serotonin synthesis pharmacologically or by small interfering rnas to tph1 in paecs inhibited the paec-induced activation of tgf-β signaling and differentiation of pasmcs. |
2013-01-03 |
2023-08-12 |
rat |
| Dante Cicchetti, Fred A Rogosch, Eric L Thibodea. The effects of child maltreatment on early signs of antisocial behavior: genetic moderation by tryptophan hydroxylase, serotonin transporter, and monoamine oxidase A genes. Development and psychopathology. vol 24. issue 3. 2012-12-04. PMID:22781862. |
variants in three genes were examined: tryptophan hydroxylase 1 (tph1), serotonin transporter linked polymorphic region (5-httlpr), and monoamine oxidase a (maoa) upstream variable number tandem repeat. |
2012-12-04 |
2023-08-12 |
Not clear |
| Jae-Hwi Jang, Andreas Rickenbacher, Bostjan Humar, Achim Weber, Dimitri Aristotle Raptis, Kuno Lehmann, Bruno Stieger, Wolfgang Moritz, Christopher Soll, Panco Georgiev, David Fischer, Endre Laczko, Rolf Graf, Pierre-Alain Clavie. Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation. Hepatology (Baltimore, Md.). vol 56. issue 1. 2012-10-17. PMID:22290718. |
we induced cholestasis by ligation of the bile duct (bdl) in either wild-type (wt) mice or mice lacking peripheral serotonin (tph1(-/-) and immune thrombocytopenic [itp] mice). |
2012-10-17 |
2023-08-12 |
mouse |
| Jae-Hwi Jang, Andreas Rickenbacher, Bostjan Humar, Achim Weber, Dimitri Aristotle Raptis, Kuno Lehmann, Bruno Stieger, Wolfgang Moritz, Christopher Soll, Panco Georgiev, David Fischer, Endre Laczko, Rolf Graf, Pierre-Alain Clavie. Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation. Hepatology (Baltimore, Md.). vol 56. issue 1. 2012-10-17. PMID:22290718. |
serotonin reloading of tph1(-/-) mice reversed this phenotype, resulting in a reduction of circulating bile salts and liver injury. |
2012-10-17 |
2023-08-12 |
mouse |
| Carla M R Lacerda, Holly B Maclea, John D Kisiday, E Christopher Orto. Static and cyclic tensile strain induce myxomatous effector proteins and serotonin in canine mitral valves. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. vol 14. issue 1. 2012-09-25. PMID:22364693. |
we also explored whether tensile strain could induce the serotonin synthetic enzyme tryptophan hydroxylase 1 (tph1), serotonin synthesis, and markers of chondrogenesis. |
2012-09-25 |
2023-08-12 |
Not clear |
| Carla M R Lacerda, John Kisiday, Brennan Johnson, E Christopher Orto. Local serotonin mediates cyclic strain-induced phenotype transformation, matrix degradation, and glycosaminoglycan synthesis in cultured sheep mitral valves. American journal of physiology. Heart and circulatory physiology. vol 302. issue 10. 2012-07-26. PMID:22345569. |
expression of the serotonin synthetic enzyme tryptophan hydroxylase 1 (tph1) increased in strained mitral valves. |
2012-07-26 |
2023-08-12 |
Not clear |
| Carla M R Lacerda, John Kisiday, Brennan Johnson, E Christopher Orto. Local serotonin mediates cyclic strain-induced phenotype transformation, matrix degradation, and glycosaminoglycan synthesis in cultured sheep mitral valves. American journal of physiology. Heart and circulatory physiology. vol 302. issue 10. 2012-07-26. PMID:22345569. |
pharmacologic inhibition of the serotonin 2b/2c receptor or tph1 diminished expression of phenotype markers (α-sma and smemb) and matrix catabolic enzyme (mmp1, mmp13, and cathepsin k) expression in 10- and 30%-strained mitral valves. |
2012-07-26 |
2023-08-12 |
Not clear |