| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura L Hernandez, Bernadette E Grayson, Ekta Yadav, Randy J Seeley, Nelson D Horsema. High fat diet alters lactation outcomes: possible involvement of inflammatory and serotonergic pathways. PloS one. vol 7. issue 3. 2012-07-09. PMID:22403677. |
expression of tryptophan hydroxylase 1 (tph1), the rate-limiting enzyme in serotonin (5-ht) biosynthesis, and the 5-ht(7) receptor (htr7), which regulates mammary gland involution, were significantly increased in mammary glands of hfd animals. |
2012-07-09 |
2023-08-12 |
rat |
| A Chin, B Svejda, B I Gustafsson, A B Granlund, A K Sandvik, A Timberlake, B Sumpio, R Pfragner, I M Modlin, M Kid. The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 3. 2012-04-23. PMID:22038827. |
mechanical stimulation using a rhythmic flex model induced transcription and activation of tph1 (tryptophan hydroxylase) and vmat₁ (vesicular monoamine transporter 1) and the release of 5-ht, which could be inhibited by mrs1754 and amplified by neca. |
2012-04-23 |
2023-08-12 |
human |
| Soo Heon Kwak, Byoung Lae Park, Hail Kim, Michael S German, Min Jin Go, Hye Seung Jung, Bo Kyong Koo, Young Min Cho, Sung Hee Choi, Yoon Shin Cho, Hyoung Doo Shin, Hak C Jang, Kyong Soo Par. Association of variations in TPH1 and HTR2B with gestational weight gain and measures of obesity. Obesity (Silver Spring, Md.). vol 20. issue 1. 2012-04-12. PMID:21836641. |
recently, it has been reported that 5-hydroxytryptamine receptor 2b (htr2b) and tryptophan hydroxylase 1 (tph1) play major role in β-cell proliferation in mouse during pregnancy. |
2012-04-12 |
2023-08-12 |
mouse |
| R Asghari, M S Y Lung, P M Pilowsky, M Conno. Sex differences in the expression of serotonin-synthesizing enzymes in mouse trigeminal ganglia. Neuroscience. vol 199. 2012-04-06. PMID:22056601. |
the trigeminal ganglion (tg) has been proposed as a site for 5-ht synthesis based on the expression of the rate limiting enzyme in peripheral 5-ht synthesis, tryptophan hydroxylase 1 (tph1), in female rodent trigeminal ganglia. |
2012-04-06 |
2023-08-12 |
mouse |
| R Asghari, M S Y Lung, P M Pilowsky, M Conno. Sex differences in the expression of serotonin-synthesizing enzymes in mouse trigeminal ganglia. Neuroscience. vol 199. 2012-04-06. PMID:22056601. |
c57/bl6 mice of both sexes expressed tph1 and aromatic amino acid decarboxylase (aadc), the key enzymes involved in 5-ht synthesis. |
2012-04-06 |
2023-08-12 |
mouse |
| Se Joo Kim, Jee In Kang, Kee Namkoong, Dong-Ho Son. The effects of serotonin transporter promoter and monoamine oxidase A gene polymorphisms on trait emotional intelligence. Neuropsychobiology. vol 64. issue 4. 2012-01-20. PMID:21912191. |
the purpose of this study was to evaluate the influences of major serotonin-related genetic variants of the serotonin transporter-linked promoter region (5-httlpr), tryptophan hydroxylase 1 gene (tph1) and monoamine oxidase a gene (maoa-ecorv) on trait emotional intelligence (ei). |
2012-01-20 |
2023-08-12 |
Not clear |
| Sara Trowbridge, Nicolas Narboux-Nême, Patricia Gaspa. Genetic models of serotonin (5-HT) depletion: what do they tell us about the developmental role of 5-HT? Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 10. 2012-01-17. PMID:20818612. |
serotonin (5-ht) depletion has been obtained via targeting of genes involved in 5-ht synthesis (tph1 and tph2), specification and determination of the 5-ht phenotype during development (gata3, pet1, and lmx1b), and 5-ht storage or clearance (vmat2 and sert). |
2012-01-17 |
2023-08-12 |
Not clear |
| Hiroyuki Inose, Bin Zhou, Vijay K Yadav, X Edward Guo, Gerard Karsenty, Patricia Duc. Efficacy of serotonin inhibition in mouse models of bone loss. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 26. issue 9. 2011-12-14. PMID:21608033. |
in a proof-of-concept study it was shown that decreasing synthesis of gut serotonin through a small molecule inhibitor of tph1 could prevent and treat ovariectomy-induced osteoporosis in young mice and rats. |
2011-12-14 |
2023-08-12 |
mouse |
| b' Pascal Amireault, Sarah Hatia, Elisa Bayard, Florence Bernex, Corinne Collet, Jacques Callebert, Jean-Marie Launay, Olivier Hermine, Elke Schneider, Jacques Mallet, Michel Dy, Francine C\\xc3\\xb4t\\xc3\\xa. Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 32. 2011-10-18. PMID:21788492.' |
availability of 5-ht depends on the expression of the enzyme tryptophan hydroxylase (tph), and the recent discovery of a dual system for 5-ht synthesis in the brain (tph2) and periphery (tph1) has renewed interest in studying the potential functions played by 5-ht in nonnervous tissues. |
2011-10-18 |
2023-08-12 |
mouse |
| b' Pascal Amireault, Sarah Hatia, Elisa Bayard, Florence Bernex, Corinne Collet, Jacques Callebert, Jean-Marie Launay, Olivier Hermine, Elke Schneider, Jacques Mallet, Michel Dy, Francine C\\xc3\\xb4t\\xc3\\xa. Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 32. 2011-10-18. PMID:21788492.' |
moreover, characterization of the tph1 knockout mouse model (tph1(-/-)) led to the identification of unsuspected roles for peripheral 5-ht, revealing the importance of this monoamine in regulating key physiological functions outside the brain. |
2011-10-18 |
2023-08-12 |
mouse |
| b' Pascal Amireault, Sarah Hatia, Elisa Bayard, Florence Bernex, Corinne Collet, Jacques Callebert, Jean-Marie Launay, Olivier Hermine, Elke Schneider, Jacques Mallet, Michel Dy, Francine C\\xc3\\xb4t\\xc3\\xa. Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 32. 2011-10-18. PMID:21788492.' |
our thorough analysis of tph1(-/-) mice provides a unique model of morphological and functional aberrations of erythropoiesis and identifies 5-ht as a key factor for red blood cell production and survival. |
2011-10-18 |
2023-08-12 |
mouse |
| Zhishan Li, Alcmène Chalazonitis, Yung-Yu Huang, J John Mann, Kara Gross Margolis, Qi Melissa Yang, Dolly O Kim, Francine Côté, Jacques Mallet, Michael D Gersho. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 24. 2011-08-22. PMID:21677183. |
5-ht biosynthesis depends on tryptophan hydroxylase 1 (tph1) in ec cells and on tph2 in neurons; therefore, mice lacking tph1 and/or tph2 distinguish ec-derived from neuronal 5-ht. |
2011-08-22 |
2023-08-12 |
mouse |
| Richard B Rothman, Jean L Cadet, Christina M Dersch, Michael T McCoy, Elin Lehrmann, Kevin G Becker, Michael Bader, Natalia Alenina, Michael H Bauman. Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension. PloS one. vol 6. issue 3. 2011-07-18. PMID:21464983. |
a recent study reported that female mice lacking the gene for tryptophan hydroxylase-1 (tph1(-/-) mice) were protected from pah caused by chronic dexfenfluramine, suggesting a pivotal role for peripheral serotonin (5-ht) in the disease process. |
2011-07-18 |
2023-08-12 |
mouse |
| Richard B Rothman, Jean L Cadet, Christina M Dersch, Michael T McCoy, Elin Lehrmann, Kevin G Becker, Michael Bader, Natalia Alenina, Michael H Bauman. Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension. PloS one. vol 6. issue 3. 2011-07-18. PMID:21464983. |
we postulated that: 1) tph1(-/-) mice express lower levels of pulmonary 5-ht transporter (sert) when compared to wild-type controls, and 2) tph1(-/-) mice display adaptive changes in the expression of non-serotonergic pulmonary genes which are implicated in pah. |
2011-07-18 |
2023-08-12 |
mouse |
| Richard B Rothman, Jean L Cadet, Christina M Dersch, Michael T McCoy, Elin Lehrmann, Kevin G Becker, Michael Bader, Natalia Alenina, Michael H Bauman. Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension. PloS one. vol 6. issue 3. 2011-07-18. PMID:21464983. |
the finding that female tph1(-/-) mice are protected from dexfenfluramine-induced pah could be related to compensatory changes in pulmonary gene expression, in addition to reductions in peripheral 5-ht. |
2011-07-18 |
2023-08-12 |
mouse |
| Clara Dees, Alfiya Akhmetshina, Pawel Zerr, Nicole Reich, Katrin Palumbo, Angelika Horn, Astrid Jüngel, Christian Beyer, Gerhard Krönke, Jochen Zwerina, Rudolf Reiter, Natalia Alenina, Luc Maroteaux, Steffen Gay, Georg Schett, Oliver Distler, Jörg H W Distle. Platelet-derived serotonin links vascular disease and tissue fibrosis. The Journal of experimental medicine. vol 208. issue 5. 2011-07-18. PMID:21518801. |
consistently, mice deficient for tph1, the rate-limiting enzyme for 5-ht production outside the central nervous system, showed reduced experimental skin fibrosis. |
2011-07-18 |
2023-08-12 |
mouse |
| Giovanni Cianchetta, Terry Stouch, Wangsheng Yu, Zhi-Cai Shi, Leslie W Tari, Ronald V Swanson, Michael J Hunter, Isaac D Hoffman, Qingyun Li. Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Current chemical genomics. vol 4. 2011-07-14. PMID:20556201. |
trytophan hydroxylase type i (tph1), most abundantly expressed in the gastrointestinal tract, initiates the synthesis of serotonin by catalyzing hydroxylation of tryptophan in the presence of biopterin and oxygen. |
2011-07-14 |
2023-08-12 |
Not clear |
| Giovanni Cianchetta, Terry Stouch, Wangsheng Yu, Zhi-Cai Shi, Leslie W Tari, Ronald V Swanson, Michael J Hunter, Isaac D Hoffman, Qingyun Li. Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Current chemical genomics. vol 4. 2011-07-14. PMID:20556201. |
we have previously described three series of novel, periphery-specific tph1 inhibitors that selectively deplete serotonin in the gastrointestinal tract. |
2011-07-14 |
2023-08-12 |
Not clear |
| S Jun, R Kohen, K C Cain, M E Jarrett, M M Heitkempe. Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 3. 2011-05-31. PMID:21073637. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms: tph1 and tph2. |
2011-05-31 |
2023-08-12 |
Not clear |
| M Camiller. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 3. 2011-05-31. PMID:21159063. |
lx-1031 appears promising for chronic diarrhea associated with increased 5-ht expression including ibs-d. optimal doses, efficacy and safety in ibs clinical trials need to be fully elucidated; low systemic exposure, selectivity for tph1 over tph2, and lack of effect on brain 5-ht in several species suggest that lx-1031 is unlikely to cause affective disorders. |
2011-05-31 |
2023-08-12 |
human |