| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Barbara Pelosi, Marta Pratelli, Sara Migliarini, Giulia Pacini, Massimo Pasqualett. Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin. PloS one. vol 10. issue 8. 2016-05-13. PMID:26291320. |
as we could not detect tph1 expression in the raphe, we made the hypothesis that the tph2Δ3Δ4 isoform can be at the origin of the residual, sub-threshold amount of serotonin detected in the brain of tph2null/null mice. |
2016-05-13 |
2023-08-13 |
mouse |
| Jingyao Zhang, Qing Pang, Sidong Song, Ruiyao Zhang, Sushun Liu, Zichao Huang, Qifei Wu, Yang Liu, Chang Li. Role of Serotonin in MODS: Deficiency of Serotonin Protects Against Zymosan-Induced Multiple Organ Failure in Mice. Shock (Augusta, Ga.). vol 43. issue 3. 2016-04-22. PMID:25394250. |
tryptophan hydroxylase 1-knockout mice (tph1, leading to the absence of 5-ht), tph1 + 5-hydroxytryptophan (precursor of 5-ht) treatment mice, wild-type (tph1) mice, and wild-type plus p-chlorophenylalanine (pcpa, tph1 inhibitor) treatment mice received zymosan intraperitoneally at a dose of 500 mg/kg. |
2016-04-22 |
2023-08-13 |
mouse |
| Jingyao Zhang, Qing Pang, Sidong Song, Ruiyao Zhang, Sushun Liu, Zichao Huang, Qifei Wu, Yang Liu, Chang Li. Role of Serotonin in MODS: Deficiency of Serotonin Protects Against Zymosan-Induced Multiple Organ Failure in Mice. Shock (Augusta, Ga.). vol 43. issue 3. 2016-04-22. PMID:25394250. |
in conclusion, the lack of 5-ht by genetic knockout or by pharmacologic inhibition of the tph1 enzyme significantly attenuated zymosan-induced mods. |
2016-04-22 |
2023-08-13 |
mouse |
| Hitoshi Iida, Takeshi Ogihara, Mun-kyeong Min, Akemi Hara, Yeong Gi Kim, Kyoko Fujimaki, Motoyuki Tamaki, Yoshio Fujitani, Hail Kim, Hirotaka Watad. Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy. Journal of molecular endocrinology. vol 55. issue 1. 2016-03-30. PMID:26136513. |
increased expression of tryptophan hydroxylase 1 (tph1), a rate-limiting enzyme for serotonin synthesis by lactogenic hormones, is involved in this phenomenon. |
2016-03-30 |
2023-08-13 |
mouse |
| Marta Costa, Alessio Squassina, Ignazio Stefano Piras, Claudia Pisanu, Donatella Congiu, Paola Niola, Andrea Angius, Caterina Chillotti, Raffaella Ardau, Giovanni Severino, Erminia Stochino, Arianna Deidda, Antonio M Persico, Martin Alda, Maria Del Zomp. Preliminary Transcriptome Analysis in Lymphoblasts from Cluster Headache and Bipolar Disorder Patients Implicates Dysregulation of Circadian and Serotonergic Genes. Journal of molecular neuroscience : MN. vol 56. issue 3. 2016-03-24. PMID:25912293. |
these genes encode for elements involved in circadian rhythm regulation (rbm3 and nr1d1) and in serotonin synthesis (tph1), processes previously involved in both disorders, and in the mechanism of action of lithium. |
2016-03-24 |
2023-08-13 |
Not clear |
| Chang-Myung Oh, Jun Namkung, Younghoon Go, Ko Eun Shong, Kyuho Kim, Hyeongseok Kim, Bo-Yoon Park, Ho Won Lee, Yong Hyun Jeon, Junghan Song, Minho Shong, Vijay K Yadav, Gerard Karsenty, Shingo Kajimura, In-Kyu Lee, Sangkyu Park, Hail Ki. Regulation of systemic energy homeostasis by serotonin in adipose tissues. Nature communications. vol 6. 2016-01-08. PMID:25864946. |
mice with inducible tph1 ko in adipose tissues exhibit a similar phenotype as mice in which 5-ht synthesis is inhibited pharmacologically, suggesting 5-ht has localized effects on adipose tissues. |
2016-01-08 |
2023-08-13 |
mouse |
| Jimena Laporta, Kimberly P Keil, Chad M Vezina, Laura L Hernande. Peripheral serotonin regulates maternal calcium trafficking in mammary epithelial cells during lactation in mice. PloS one. vol 9. issue 10. 2015-12-28. PMID:25299122. |
genetic ablation of tryptophan hydroxylase 1 (tph1), which encodes the rate-limiting enzyme in non-neuronal serotonin synthesis, causes a deficiency in circulating serotonin. |
2015-12-28 |
2023-08-13 |
mouse |
| Hai-Juan Li, Rui-Yun Peng, Chang-Zhen Wang, Si-Mo Qiao, Zou Yong, Ya-Bing Gao, Xin-Ping Xu, Shao-Xia Wang, Ji Dong, Hong-Yan Zuo, Zhao Li, Hong-Mei Zhou, Li-Feng Wang, Xiang-Jun H. Alterations of cognitive function and 5-HT system in rats after long term microwave exposure. Physiology & behavior. vol 140. 2015-12-28. PMID:25542888. |
tryptophan hydroxylase 1 (tph1) and monoamine oxidase (mao), two important rate-limiting enzymes in serotonin synthesis and metabolic process respectively, were detected. |
2015-12-28 |
2023-08-13 |
rat |
| Janice J Kim, Huaqing Wang, Joshua D Terc, Brian Zambrowicz, Qi M Yang, Waliul I Kha. Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation. American journal of physiology. Gastrointestinal and liver physiology. vol 309. issue 6. 2015-12-08. PMID:26206858. |
intestinal 5-ht synthesis is catalyzed by tryptophan hydroxylase 1 (tph1) and we have shown that mice deficient in this rate-limiting enzyme have reduced severity of intestinal inflammation in models of chemical-induced experimental colitis. |
2015-12-08 |
2023-08-13 |
mouse |
| Yuho Takano, Takuji Machida, Yusuke Obara, Megumi Hirano, Sae Kudo, Minako Takagi, Naoya Hamaue, Kenji Iizuka, Masahiko Hirafuj. Methotrexate causes a change in intestinal 5-hydroxytryptamine metabolism in rats. European journal of pharmacology. vol 740. 2015-10-30. PMID:24975094. |
methotrexate also caused a significant increase in 5-ht and 5-hydroxyindoleacetic acid (5-hiaa) content and in tph1 mrna expression in the ileal tissues. |
2015-10-30 |
2023-08-13 |
rat |
| Aneta Piesiewicz, Urszula Kedzierska, Elzbieta Turkowska, Iwona Adamska, Pawel M Majewsk. Seasonal postembryonic maturation of the diurnal rhythm of serotonin in the chicken pineal gland. Chronobiology international. vol 32. issue 1. 2015-09-22. PMID:25222180. |
the present study was undertaken with the following objectives: (1) to examine whether the pineal concentration of the 5-ht precursors trp and 5-htp exhibit age- and season-related changes; (2) to look for season-related differences in the transcription of the tph1 and ddc genes encoding enzymes tph and aadc; (3) to identify the step(s) in postembryonic development in which these season-related variations in pineal gland function are most pronounced. |
2015-09-22 |
2023-08-13 |
chicken |
| Aneta Piesiewicz, Urszula Kedzierska, Elzbieta Turkowska, Iwona Adamska, Pawel M Majewsk. Seasonal postembryonic maturation of the diurnal rhythm of serotonin in the chicken pineal gland. Chronobiology international. vol 32. issue 1. 2015-09-22. PMID:25222180. |
at the age of 2 or 9 days, animals were sacrificed every 2 or 4 h over a 24-h period and their pineal glands were isolated under dim red light and processed for the measurement of (i) the pineal content of trp, 5-htp and 5-ht, and (ii) the level of tph1 and ddc mrnas. |
2015-09-22 |
2023-08-13 |
chicken |
| Aneta Piesiewicz, Urszula Kedzierska, Elzbieta Turkowska, Iwona Adamska, Pawel M Majewsk. Seasonal postembryonic maturation of the diurnal rhythm of serotonin in the chicken pineal gland. Chronobiology international. vol 32. issue 1. 2015-09-22. PMID:25222180. |
the pineal levels of trp and 5-ht as well as the tph1 and ddc transcripts changed during postembryonic development in a season-related way. |
2015-09-22 |
2023-08-13 |
chicken |
| Aneta Piesiewicz, Urszula Kedzierska, Elzbieta Turkowska, Iwona Adamska, Pawel M Majewsk. Seasonal postembryonic maturation of the diurnal rhythm of serotonin in the chicken pineal gland. Chronobiology international. vol 32. issue 1. 2015-09-22. PMID:25222180. |
these findings indicated that the efficiency of season-related mel biosynthesis, reported previously, is limited by 5-ht availability and this limitation depends on the transcription of both the tph1 and ddc genes. |
2015-09-22 |
2023-08-13 |
chicken |
| Fang-Xu Jiang, Yuji Mishina, Akma Baten, Grant Morahan, Leonard C Harriso. Transcriptome of pancreas-specific Bmpr1a-deleted islets links to TPH1-5-HT axis. Biology open. vol 4. issue 8. 2015-08-16. PMID:26187948. |
critically among these, the tryptophan hydroxylase 1 gene (tph1), encoding the rate-limiting enzyme for the production of 5-hydroxytryptamine (5-ht) was the highest over-expressed one. |
2015-08-16 |
2023-08-13 |
mouse |
| Liang Ouyang, Gu He, Wei Huang, Xiangrong Song, Fengbo Wu, Mingli Xian. Combined structure-based pharmacophore and 3D-QSAR studies on phenylalanine series compounds as TPH1 inhibitors. International journal of molecular sciences. vol 13. issue 5. 2015-08-11. PMID:22754301. |
tryptophan hydroxylase-1 (tph1) is a key enzyme in the synthesis of serotonin. |
2015-08-11 |
2023-08-12 |
Not clear |
| Robert Brommage, Jeff Liu, Deon Doree, Wangsheng Yu, David R Powell, Qi Melissa Yan. Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness. BoneKEy reports. vol 4. 2015-08-03. PMID:26229596. |
disruption of serotonin synthesis in neurons and the periphery by knockout (ko) of mouse genes for tryptophan hydroxylases (peripheral tph1 and neuronal tph2) has been claimed to decrease (tph2 ko) and increase (tph1 ko) bone mass. |
2015-08-03 |
2023-08-13 |
mouse |
| Jimena Laporta, Kimberly P Keil, Samantha R Weaver, Callyssa M Cronick, Austin P Prichard, Thomas D Crenshaw, Galen W Heyne, Chad M Vezina, Robert J Lipinski, Laura L Hernande. Serotonin regulates calcium homeostasis in lactation by epigenetic activation of hedgehog signaling. Molecular endocrinology (Baltimore, Md.). vol 28. issue 11. 2015-07-07. PMID:25192038. |
here, using a mouse model, we found that genetic inactivation of tryptophan hydroxylase 1 (tph1), which catalyzes the rate-limiting step in peripheral 5-ht synthesis, reduced circulating and mammary pthrp expression, osteoclast activity, and maternal circulating calcium concentrations during the transition from pregnancy to lactation. |
2015-07-07 |
2023-08-13 |
mouse |
| Christopher S Reigstad, Charles E Salmonson, John F Rainey, Joseph H Szurszewski, David R Linden, Justin L Sonnenburg, Gianrico Farrugia, Purna C Kashya. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 4. 2015-06-22. PMID:25550456. |
microbiota from hm and conventionally raised (cr) mice significantly increased colonic mrnas tph1 [(tryptophan hydroxylase) 1, rate limiting for mucosal 5-ht synthesis; p < 0.01] and chromogranin a (neuroendocrine secretion; p < 0.01), with no effect on monoamine oxidase a (serotonin catabolism), serotonin receptor 5-ht4, or mouse serotonin transporter. |
2015-06-22 |
2023-08-13 |
mouse |
| Christopher S Reigstad, Charles E Salmonson, John F Rainey, Joseph H Szurszewski, David R Linden, Justin L Sonnenburg, Gianrico Farrugia, Purna C Kashya. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 4. 2015-06-22. PMID:25550456. |
hm and cr mice also had increased colonic tph1 protein (p < 0.05) and 5-ht concentrations (gf, 17 ± 3 ng/mg; hm, 25 ± 2 ng/mg; and cr, 35 ± 3 ng/mg; p < 0.05). |
2015-06-22 |
2023-08-13 |
mouse |