| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Izikki, N Hanoun, E Marcos, L Savale, A M Barlier-Mur, F Saurini, S Eddahibi, M Hamon, S Adno. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 4. 2007-11-27. PMID:17675372. |
these results provide evidence that dysregulation of 5-ht synthesis is closely linked to the hypoxic ph phenotype in mice and that tph1 and tph2 may contribute to ph development. |
2007-11-27 |
2023-08-12 |
mouse |
| Ana M Coutinho, Inês Sousa, Madalena Martins, Catarina Correia, Teresa Morgadinho, Celeste Bento, Carla Marques, Assunção Ataíde, Teresa S Miguel, Jason H Moore, Guiomar Oliveira, Astrid M Vicent. Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Human genetics. vol 121. issue 2. 2007-07-20. PMID:17203304. |
the role in autism etiology of seven candidate genes in the serotonin metabolic and neurotransmission pathways and mapping to autism linkage regions (slc6a4, htr1a, htr1d, htr2a, htr5a, tph1 and itgb3) was analyzed in a sample of 186 nuclear families. |
2007-07-20 |
2023-08-12 |
Not clear |
| Ana M Coutinho, Inês Sousa, Madalena Martins, Catarina Correia, Teresa Morgadinho, Celeste Bento, Carla Marques, Assunção Ataíde, Teresa S Miguel, Jason H Moore, Guiomar Oliveira, Astrid M Vicent. Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Human genetics. vol 121. issue 2. 2007-07-20. PMID:17203304. |
the most significant models contributing to serotonin distribution were found for interactions between tph1 rs4537731 and slc6a4 haplotypes (p = 0.002) and between htr1d rs6300 and slc6a4 haplotypes (p = 0.013). |
2007-07-20 |
2023-08-12 |
Not clear |
| Antonio Di Lieto, Damiana Leo, Floriana Volpicelli, Umberto di Porzio, Luca Colucci-D'Amat. FLUOXETINE modifies the expression of serotonergic markers in a differentiation-dependent fashion in the mesencephalic neural cell line A1 mes c-myc. Brain research. vol 1143. 2007-06-13. PMID:17321503. |
here we show that a mesencephalic neural cell line, mes-c-myc a1 (a1) produces 5-ht and expresses sert and both peripheral (tph1) and cns-specific (tph2) form of tryptophan hydroxylase, the limiting enzyme in 5-ht biosynthesis. |
2007-06-13 |
2023-08-12 |
Not clear |
| Jens-Uwe Peter, Natalia Alenina, Michael Bader, Diego J Walthe. Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase. Molecular and cellular biochemistry. vol 295. issue 1-2. 2007-04-03. PMID:16924415. |
mice deficient in peripheral tryptophan hydroxylase (tph1) and serotonin exhibit a reduced risk of thrombosis and thromboembolism. |
2007-04-03 |
2023-08-12 |
mouse |
| Jens-Uwe Peter, Natalia Alenina, Michael Bader, Diego J Walthe. Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase. Molecular and cellular biochemistry. vol 295. issue 1-2. 2007-04-03. PMID:16924415. |
we also demonstrated that this active trna-miniribozyme chimera is capable of selectively cleaving native tph1 mrna in vivo, with concomitant downregulation of the serotonin biosynthesis. |
2007-04-03 |
2023-08-12 |
mouse |
| Eduard Maron, Innar Tõru, Anne Must, Gunnar Tasa, Egle Toover, Veiko Vasar, Aavo Lang, Jakov Shli. Association study of tryptophan hydroxylase 2 gene polymorphisms in panic disorder. Neuroscience letters. vol 411. issue 3. 2007-03-30. PMID:17123728. |
recently, it has been discovered that the tryptophan hydroxylase gene isoform 2 (tph2), rather than tph1, is preferentially expressed in the neuronal tissue and, therefore, is primarily responsible for the regulation of brain 5-ht synthesis. |
2007-03-30 |
2023-08-12 |
human |
| Byung-Joo Ham, Boung-Chul Lee, Jong-Woo Paik, Rhee-Hun Kang, Myoung-Jin Choi, Ihn-Geun Choi, Min-Soo Le. Association between the tryptophan hydroxylase-1 gene A218C polymorphism and citalopram antidepressant response in a Korean population. Progress in neuro-psychopharmacology & biological psychiatry. vol 31. issue 1. 2007-03-15. PMID:16979275. |
tryptophan hydroxylase-1 (tph1) is the rate-limiting enzyme in serotonin biosynthesis, and selective serotonin reuptake inhibitors (ssris) exert their activity enhancing the general serotonergic tone. |
2007-03-15 |
2023-08-12 |
human |
| Michael D Gershon, Jan Tac. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. vol 132. issue 1. 2007-03-14. PMID:17241888. |
serotonin is synthesized through the actions of 2 different tryptophan hydroxylases, tph1 and tph2, which are found, respectively, in ec cells and neurons. |
2007-03-14 |
2023-08-12 |
Not clear |
| Nicolas Ramoz, Guiqing Cai, Jennifer G Reichert, Thomas E Corwin, Lauren A Kryzak, Christopher J Smith, Jeremy M Silverman, Eric Hollander, Joseph D Buxbau. Family-based association study of TPH1 and TPH2 polymorphisms in autism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 8. 2007-02-13. PMID:16958027. |
the tph1 and tph2 genes encode the rate-limiting enzymes that control serotonin biosynthesis, and serotonin is clearly altered in autism. |
2007-02-13 |
2023-08-12 |
Not clear |
| Francine Côté, Cécile Fligny, Elisa Bayard, Jean-Marie Launay, Michael D Gershon, Jacques Mallet, Guilan Vodjdan. Maternal serotonin is crucial for murine embryonic development. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 1. 2007-02-07. PMID:17182745. |
this hypothesis was tested by using knockout mice lacking the tph1 gene, which is responsible for the synthesis of peripheral serotonin. |
2007-02-07 |
2023-08-12 |
mouse |
| Rafael Ortíz-Alvarado, Omar Guzmán-Quevedo, Rosalio Mercado-Camargo, Thomas Haertle, Caroline Vignes, Francisco Bolaños-Jiméne. Expression of tryptophan hydroxylase in developing mouse taste papillae. FEBS letters. vol 580. issue 22. 2006-11-09. PMID:16989820. |
here, we show by quantitative real time rt-pcr that both isoforms of tryptophan hydroxylase (tph1 and tph2), the first and rate limiting enzyme of serotonin (5-ht) synthesis, are expressed in developing circumvallate papillae. |
2006-11-09 |
2023-08-12 |
mouse |
| Mamoru Tochigi, Hiroyuki Hibino, Takeshi Otowa, Toshiyuki Ohtani, Takashi Ebisawa, Nobumasa Kato, Tsukasa Sasak. No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population. Neuroscience letters. vol 403. issue 1-2. 2006-09-28. PMID:16682118. |
serotonin 2c receptor (5-ht(2c)), serotonin 6 receptor (5-ht(6)), and tryptophan hydroxylase-1 (tph1) genes could be candidates for personality-related genes considering the role of serotonin in various mental functions and behavior. |
2006-09-28 |
2023-08-12 |
human |
| Mamoru Tochigi, Hiroyuki Hibino, Takeshi Otowa, Toshiyuki Ohtani, Takashi Ebisawa, Nobumasa Kato, Tsukasa Sasak. No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population. Neuroscience letters. vol 403. issue 1-2. 2006-09-28. PMID:16682118. |
in the present study, we investigated the three serotonin-related genes, 5-ht(2c), 5-ht(6), and tph1 genes, in relation to personality traits in the japanese population. |
2006-09-28 |
2023-08-12 |
human |
| Mamoru Tochigi, Hiroyuki Hibino, Takeshi Otowa, Toshiyuki Ohtani, Takashi Ebisawa, Nobumasa Kato, Tsukasa Sasak. No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population. Neuroscience letters. vol 403. issue 1-2. 2006-09-28. PMID:16682118. |
the cys23ser polymorphisms in the 5-ht(2c) gene, the 267t/c polymorphism of the 5-ht(6) gene, and the 779a/c polymorphisms in the tph1 gene were genotyped in 253 healthy japanese subjects. |
2006-09-28 |
2023-08-12 |
human |
| B Bondy, A Buettner, P Zil. Genetics of suicide. Molecular psychiatry. vol 11. issue 4. 2006-07-27. PMID:16462816. |
two genes have so far emerged as being involved in the vulnerability for suicidality: first, the intronic polymorphisms (a218c or a779c) of the tryptophan hydroxylase 1 (tph1) gene, which was suggested as a quantitative risk factor for suicidal behaviour; second, the insertion/deletion polymorphism of the serotonin transporter gene (5-httlpr), which does not seem to be involved in general suicidal behaviour, but in violent and repeated suicide attempts. |
2006-07-27 |
2023-08-12 |
human |
| Eduard Maron, Aavo Lang, Gunnar Tasa, Liivi Liivlaid, Innar Tõru, Anne Must, Veiko Vasar, Jakov Shli. Associations between serotonin-related gene polymorphisms and panic disorder. The international journal of neuropsychopharmacology. vol 8. issue 2. 2006-07-19. PMID:15670397. |
in the present case-control study we investigated possible associations between pd phenotype and five candidate polymorphisms including 5-ht transporter (5-httlpr and vntr), monoamine oxidase a (maoa promoter region), tryptophan hydroxylase 1 (tph1 218a/c) and 5-ht1b receptor (5-ht1br 861g/c) genes. |
2006-07-19 |
2023-08-12 |
human |
| Kazuhiro Nakamura, Yuko Sugawara, Keiko Sawabe, Akiko Ohashi, Hiromichi Tsurui, Yan Xiu, Mareki Ohtsuji, Qing Shun Lin, Hiroyuki Nishimura, Hiroyuki Hasegawa, Sachiko Hiros. Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 2. 2006-03-17. PMID:16407550. |
therefore, contribution of tph1 to brain 5-ht levels is not known, and the mechanisms how tph1 possibly contributes to the pathogenesis of psychiatric disorders are not understood. |
2006-03-17 |
2023-08-12 |
mouse |
| Kazuhiro Nakamura, Yuko Sugawara, Keiko Sawabe, Akiko Ohashi, Hiromichi Tsurui, Yan Xiu, Mareki Ohtsuji, Qing Shun Lin, Hiroyuki Nishimura, Hiroyuki Hasegawa, Sachiko Hiros. Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 2. 2006-03-17. PMID:16407550. |
low 5-ht contents in the raphe nucleus were seen during development in new zealand white (nzw) and swr mice having common functional polymorphisms in the tph1 gene. |
2006-03-17 |
2023-08-12 |
mouse |
| Kazuhiro Nakamura, Yuko Sugawara, Keiko Sawabe, Akiko Ohashi, Hiromichi Tsurui, Yan Xiu, Mareki Ohtsuji, Qing Shun Lin, Hiroyuki Nishimura, Hiroyuki Hasegawa, Sachiko Hiros. Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 2. 2006-03-17. PMID:16407550. |
considering an involvement of developmental brain disturbance in psychiatric disorders, tph1 may act specifically on development of 5-ht neurons, and thereby influence behavior later in life. |
2006-03-17 |
2023-08-12 |
mouse |