| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Regina T Martuscello, Robert N Spengler, Adela C Bonoiu, Bruce A Davidson, Jadwiga Helinski, Hong Ding, Supriya Mahajan, Rajiv Kumar, Earl J Bergey, Paul R Knight, Paras N Prasad, Tracey A Ignatowsk. Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms. Pain. vol 153. issue 9. 2013-01-08. PMID:22770843. |
in the present study, tnf gene expression was induced exclusively in the hippocampus, eliciting increased local bioactive tnf levels, and animals were assessed for pain behaviors. |
2013-01-08 |
2023-08-12 |
rat |
| Regina T Martuscello, Robert N Spengler, Adela C Bonoiu, Bruce A Davidson, Jadwiga Helinski, Hong Ding, Supriya Mahajan, Rajiv Kumar, Earl J Bergey, Paul R Knight, Paras N Prasad, Tracey A Ignatowsk. Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms. Pain. vol 153. issue 9. 2013-01-08. PMID:22770843. |
animals receiving hippocampal microinjection of tnf nanoplasmidexes developed thermal hyperalgesia bilaterally. |
2013-01-08 |
2023-08-12 |
rat |
| Regina T Martuscello, Robert N Spengler, Adela C Bonoiu, Bruce A Davidson, Jadwiga Helinski, Hong Ding, Supriya Mahajan, Rajiv Kumar, Earl J Bergey, Paul R Knight, Paras N Prasad, Tracey A Ignatowsk. Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms. Pain. vol 153. issue 9. 2013-01-08. PMID:22770843. |
in support of these behavioral findings, immunoreactive staining for tnf, bioactive levels of tnf, and levels of tnf mrna per polymerase chain reaction analysis were assessed in several brain regions and found to be increased only in the hippocampus. |
2013-01-08 |
2023-08-12 |
rat |
| Regina T Martuscello, Robert N Spengler, Adela C Bonoiu, Bruce A Davidson, Jadwiga Helinski, Hong Ding, Supriya Mahajan, Rajiv Kumar, Earl J Bergey, Paul R Knight, Paras N Prasad, Tracey A Ignatowsk. Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms. Pain. vol 153. issue 9. 2013-01-08. PMID:22770843. |
these findings indicate that the specific elevation of tnf in the hippocampus is not a consequence of pain, but in fact induces these behaviors/symptoms. |
2013-01-08 |
2023-08-12 |
rat |
| Diana M Sama, Hafiz Mohmmad Abdul, Jennifer L Furman, Irina A Artiushin, David E Szymkowski, Stephen W Scheff, Christopher M Norri. Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats. PloS one. vol 7. issue 5. 2012-10-29. PMID:22666474. |
here, we show that protein levels for tnf receptor 1 (tnfr1) are significantly elevated in the hippocampus relative to tnf receptor 2 (tnfr2) in aged (22 months) but not young adult (6 months) fischer 344 rats. |
2012-10-29 |
2023-08-12 |
rat |
| Noha N Nassar, Rania M Abdelsalam, Abdel A Abdel-Rahman, Dalaal M Abdalla. Possible involvement of oxidative stress and inflammatory mediators in the protective effects of the early preconditioning window against transient global ischemia in rats. Neurochemical research. vol 37. issue 3. 2012-06-29. PMID:22113727. |
ir produced cerebral infarction accompanied by an imbalance in the hippocampal redox status, neutrophil infiltration, elevation in tumor necrosis factor (tnf)-α and prostaglandin (pg)e₂, besides reduction in interleukin (il)-10 and nitric oxide (no) levels. |
2012-06-29 |
2023-08-12 |
human |
| Muhammad Y Al-Shorbagy, Bahia M El Sayeh, Dalaal M Abdalla. Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats. Canadian journal of physiology and pharmacology. vol 90. issue 1. 2012-05-07. PMID:22171792. |
li-pil induced seizures that were associated with neuronal cell loss in the ca3 region, and increased prostaglandin (pg)e(2), tumor necrosis factor (tnf)-α, interleukin (il)-10, nitric oxide, and neutrophil infiltration in the hippocampus. |
2012-05-07 |
2023-08-12 |
rat |
| Jin-Feng Hu, Xiu-Yun Song, Shi-Feng Chu, Ji Chen, Hai-Jie Ji, Xiao-Yu Chen, Yu-He Yuan, Ning Han, Jun-Tian Zhang, Nai-Hong Che. Inhibitory effect of ginsenoside Rg1 on lipopolysaccharide-induced microglial activation in mice. Brain research. vol 1374. 2011-12-12. PMID:21126513. |
no and tumor necrosis factor (tnf)-α production in both cerebral cortex and hippocampus decreased at dose-dependent manner by oral administration with rg1. |
2011-12-12 |
2023-08-12 |
mouse |
| Jason A Funk, Julia Gohlke, Andrew D Kraft, Christopher A McPherson, Jennifer B Collins, G Jean Harr. Voluntary exercise protects hippocampal neurons from trimethyltin injury: possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity. Brain, behavior, and immunity. vol 25. issue 6. 2011-12-07. PMID:21435392. |
using a chemical-induced model of hippocampal dentate granule cell death (trimethyltin, tmt 2.4 mg/kg, ip) dependent upon tnf receptor signaling, we demonstrate neuroprotection in mice with 2 weeks access to running wheel. |
2011-12-07 |
2023-08-12 |
mouse |
| Samina Salim, Mohammad Asghar, Manish Taneja, Iiris Hovatta, Gaurav Chugh, Craig Vollert, Anthony V. Potential contribution of oxidative stress and inflammation to anxiety and hypertension. Brain research. vol 1404. 2011-11-21. PMID:21704983. |
here, we report that sub-chronic induction of oxidative stress via pharmacological induction leads to i) reduction in glyoxalase (glo)-1 and glutathione reductase (gsr)-1 expression; ii) calpain mediated reduction of brain derived neurotrophic factor (bdnf) levels; iii) nfκb mediated upregulation of proinflammatory factors interleukin (il)-6 and tumor necrosis factor (tnf)-α and elevated angiotensin (at)-1 receptor levels in hippocampus, amygdala and locus coeruleus regions of the brain. |
2011-11-21 |
2023-08-12 |
rat |
| Qi-Hai Gong, Li-Long Pan, Xin-Hua Liu, Qian Wang, Hui Huang, Yi-Zhun Zh. S-propargyl-cysteine (ZYZ-802), a sulphur-containing amino acid, attenuates beta-amyloid-induced cognitive deficits and pro-inflammatory response: involvement of ERK1/2 and NF-κB pathway in rats. Amino acids. vol 40. issue 2. 2011-05-23. PMID:20640462. |
subsequently, sprc inhibited the expressions of tumor necrosis factor (tnf)-α, cyclooxygenase-2 (cox-2) mrna, and protein in rat hippocampus. |
2011-05-23 |
2023-08-12 |
rat |
| Chad E Beyer, Jason M Dwyer, Michael J Piesla, Brian J Platt, Ru Shen, Zia Rahman, Karen Chan, Melissa T Manners, Tarek A Samad, Jeffrey D Kennedy, Brendan Bingham, Garth T Whitesid. Depression-like phenotype following chronic CB1 receptor antagonism. Neurobiology of disease. vol 39. issue 2. 2010-09-10. PMID:20381618. |
additionally, chronic treatment with rimonabant produced decreases in frontal cortex serotonin levels, marked reductions in hippocampal cell proliferation, survival, and bdnf levels, and elevations in the concentrations of pro-inflammatory cytokines including interferon gamma and tnf alpha. |
2010-09-10 |
2023-08-12 |
rat |
| Yuan-Zhong Xu, Mikael Nygård, Krister Kristensson, Marina Bentivogli. Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge. Brain, behavior, and immunity. vol 24. issue 1. 2010-02-17. PMID:19765643. |
we first analyzed the expression of molecules involved in t-cell infiltration and cytokine signaling regulation in the septum and hippocampus of 2-3 months and 20- to 24-month-old mice at 4h after intracerebroventricular injections of tumor necrosis factor (tnf)-alpha or interferon-gammaversus saline injections. |
2010-02-17 |
2023-08-12 |
mouse |
| Edward Tobinic. Tumour necrosis factor modulation for treatment of Alzheimer's disease: rationale and current evidence. CNS drugs. vol 23. issue 9. 2009-11-09. PMID:19689163. |
the role of tnf as a gliotransmitter may help explain the profound synaptic effects of tnf that have been demonstrated in the hippocampus, in the spinal cord and in a variety of experimental models. |
2009-11-09 |
2023-08-12 |
Not clear |
| James M Olcese, Chuanhai Cao, Takashi Mori, Malgorzata B Mamcarz, Anne Maxwell, Melissa J Runfeldt, Li Wang, Chi Zhang, Xiaoyang Lin, Guixin Zhang, Gary W Arendas. Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. Journal of pineal research. vol 47. issue 1. 2009-09-03. PMID:19538338. |
inflammatory cytokines such as tumor necrosis factor (tnf)-alpha were decreased in hippocampus (but not plasma) of tg+ melatonin mice. |
2009-09-03 |
2023-08-12 |
mouse |
| Moses Rodriguez, Laurie Zoecklein, Louisa Papke, Jeff Gamez, Aleksandar Denic, Slobodan Macura, Charles How. Tumor necrosis factor alpha is reparative via TNFR2 [corrected] in the hippocampus and via TNFR1 [corrected] in the striatum after virus-induced encephalitis. Brain pathology (Zurich, Switzerland). vol 19. issue 1. 2009-02-19. PMID:18422761. |
however, parenchymal hippocampal and striatal injury persisted in b6/129 tnf(-/-) mice following infection. |
2009-02-19 |
2023-08-12 |
mouse |
| Moses Rodriguez, Laurie Zoecklein, Louisa Papke, Jeff Gamez, Aleksandar Denic, Slobodan Macura, Charles How. Tumor necrosis factor alpha is reparative via TNFR2 [corrected] in the hippocampus and via TNFR1 [corrected] in the striatum after virus-induced encephalitis. Brain pathology (Zurich, Switzerland). vol 19. issue 1. 2009-02-19. PMID:18422761. |
t1 "black holes" appeared on mri during early infection in the hippocampus and striatum in all mice but persisted only in tnf(-/-) mice. |
2009-02-19 |
2023-08-12 |
mouse |
| Tina Markus, Tobias Cronberg, Corrado Cilio, Cornelis Pronk, Tadeusz Wieloch, David Le. Tumor necrosis factor receptor-1 is essential for LPS-induced sensitization and tolerance to oxygen-glucose deprivation in murine neonatal organotypic hippocampal slices. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 29. issue 1. 2009-01-30. PMID:18728678. |
the role of tumor necrosis factor (tnf) receptors 1 and 2 in lipopolysaccharide (lps)-induced sensitization and tolerance to oxygen-glucose deprivation (ogd) was evaluated in neonatal murine hippocampal organotypic slices. |
2009-01-30 |
2023-08-12 |
mouse |
| Melissa K McCoy, Malú G Tanse. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. Journal of neuroinflammation. vol 5. 2009-01-08. PMID:18925972. |
a potential role for tnf in synaptic scaling and hippocampal neurogenesis demonstrated by recent studies suggest additional in-depth mechanistic studies are warranted to delineate the distinct functions of the two tnf ligands in different parts of the brain prior to large-scale development of anti-tnf therapies in the cns. |
2009-01-08 |
2023-08-12 |
Not clear |
| Joana Gonçalves, Tânia Martins, Raquel Ferreira, Nuno Milhazes, Fernanda Borges, Carlos Fontes Ribeiro, João O Malva, Tice R Macedo, Ana P Silv. Methamphetamine-induced early increase of IL-6 and TNF-alpha mRNA expression in the mouse brain. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991854. |
therefore, in the present work we evaluated the effect of an acute administration of meth (30 mg/kg in a single intraperitoneal injection) on the interleukin (il)-1beta, il-6, and tumor necrosis factor (tnf)-alpha mrna expression levels in the hippocampus, frontal cortex, and striatum of mice. |
2008-12-09 |
2023-08-12 |
mouse |