| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xi-Ting Guan, Wen-Juan Lin, Ming-Ming Tan. Comparison of stress-induced and LPS-induced depressive-like behaviors and the alterations of central proinflammatory cytokines mRNA in rats. PsyCh journal. vol 4. issue 3. 2016-06-13. PMID:26354152. |
the levels of tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6 mrna were examined in the brain regions of the prefrontal cortex, amygdala, and hippocampus using real-time polymerase chain reaction (rt-pcr). |
2016-06-13 |
2023-08-13 |
rat |
| Huiyu Liu, Yuanyuan Deng, Jianmei Gao, Yuangui Liu, Wenxian Li, Jingshan Shi, Qihai Gon. Sodium Hydrosulfide Attenuates Beta-Amyloid-Induced Cognitive Deficits and Neuroinflammation via Modulation of MAPK/NF-κB Pathway in Rats. Current Alzheimer research. vol 12. issue 7. 2016-04-28. PMID:26165866. |
subsequently, nahs significantly suppressed the expression of tumor necrosis factor (tnf)-α, interleukin-1β (il-1β) and cyclooxygenase-2 (cox-2) in rat hippocampus following aβ administration. |
2016-04-28 |
2023-08-13 |
human |
| Samia Habbas, Mirko Santello, Denise Becker, Hiltrud Stubbe, Giovanna Zappia, Nicolas Liaudet, Federica R Klaus, George Kollias, Adriano Fontana, Christopher R Pryce, Tobias Suter, Andrea Volterr. Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling. Cell. vol 163. issue 7. 2016-04-22. PMID:26686654. |
here, we show that local increase of tnfα in the hippocampal dentate gyrus activates astrocyte tnf receptor type 1 (tnfr1), which in turn triggers an astrocyte-neuron signaling cascade that results in persistent functional modification of hippocampal excitatory synapses. |
2016-04-22 |
2023-08-13 |
Not clear |
| Elizabeth Gerard, Robert N Spengler, Adela C Bonoiu, Supriya D Mahajan, Bruce A Davidson, Hong Ding, Rajiv Kumar, Paras N Prasad, Paul R Knight, Tracey A Ignatowsk. Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor. Pain. vol 156. issue 7. 2016-04-11. PMID:25851457. |
the objective of this study was to determine whether specific blockade of tnf in the hippocampus, a site of pain integration, could prove efficacious in reducing sciatic nerve chronic constriction injury (cci)-induced pain behavior. |
2016-04-11 |
2023-08-13 |
rat |
| Elizabeth Gerard, Robert N Spengler, Adela C Bonoiu, Supriya D Mahajan, Bruce A Davidson, Hong Ding, Rajiv Kumar, Paras N Prasad, Paul R Knight, Tracey A Ignatowsk. Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor. Pain. vol 156. issue 7. 2016-04-11. PMID:25851457. |
small inhibitory rna directed against tnf mrna was complexed to gold nanorods (gnr-tnf sirna; tnf nanoplexes) and injected into the contralateral hippocampus of rats 4 days after unilateral cci. |
2016-04-11 |
2023-08-13 |
rat |
| Elizabeth Gerard, Robert N Spengler, Adela C Bonoiu, Supriya D Mahajan, Bruce A Davidson, Hong Ding, Rajiv Kumar, Paras N Prasad, Paul R Knight, Tracey A Ignatowsk. Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor. Pain. vol 156. issue 7. 2016-04-11. PMID:25851457. |
thermal hyperalgesia was dramatically decreased in cci rats receiving hippocampal tnf nanoplexes; and mechanical allodynia was transiently relieved. |
2016-04-11 |
2023-08-13 |
rat |
| Elizabeth Gerard, Robert N Spengler, Adela C Bonoiu, Supriya D Mahajan, Bruce A Davidson, Hong Ding, Rajiv Kumar, Paras N Prasad, Paul R Knight, Tracey A Ignatowsk. Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor. Pain. vol 156. issue 7. 2016-04-11. PMID:25851457. |
tnf levels (bioactive protein, tnf immunoreactivity) in hippocampal tissue were decreased. |
2016-04-11 |
2023-08-13 |
rat |
| Elizabeth Gerard, Robert N Spengler, Adela C Bonoiu, Supriya D Mahajan, Bruce A Davidson, Hong Ding, Rajiv Kumar, Paras N Prasad, Paul R Knight, Tracey A Ignatowsk. Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor. Pain. vol 156. issue 7. 2016-04-11. PMID:25851457. |
the observation that tnf nanoplex injection into the hippocampus alleviated neuropathic pain-like behavior advances our previous findings that hippocampal tnf levels modulate pain perception. |
2016-04-11 |
2023-08-13 |
rat |
| Marie Lou Camara, Frances Corrigan, Emily J Jaehne, M Catharine Jawahar, Helen Anscomb, Bernhard T Baun. Tumor necrosis factor alpha and its receptors in behaviour and neurobiology of adult mice, in the absence of an immune challenge. Behavioural brain research. vol 290. 2016-04-04. PMID:25934492. |
additionally, tnf(-/-) mice expressed significantly lower levels of bdnf than wt mice in the hippocampus while tnf-r1(-/-) mice displayed significantly lower bdnf levels compared to both wt and tnf-r2(-/-) mice. |
2016-04-04 |
2023-08-13 |
mouse |
| Victoria Fasick, Robert N Spengler, Shabnam Samankan, Nader D Nader, Tracey A Ignatowsk. The hippocampus and TNF: Common links between chronic pain and depression. Neuroscience and biobehavioral reviews. vol 53. 2016-03-28. PMID:25857253. |
the hippocampus and tnf: common links between chronic pain and depression. |
2016-03-28 |
2023-08-13 |
Not clear |
| Jinsong Xue, Hongyan Li, Xueyang Deng, Zhanqiang Ma, Qiang Fu, Shiping M. L-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmitters. Pharmacology, biochemistry, and behavior. vol 134. 2016-03-23. PMID:25937574. |
moreover, mtn treatments reversed the ucms-induced alterations in the concentrations of neurotransmitter norepinephrine (ne) and serotonin (5-ht) and inhibited the expression of pro-inflammatory cytokines (pic) interleukin (il)-1β, il-6, and tumor necrosis factor (tnf)-α in the hippocampus of mice. |
2016-03-23 |
2023-08-13 |
mouse |
| S Q Cui, Q Wang, Y Zheng, B Xiao, H W Sun, X L Gu, Y C Zhang, C H Fu, P X Dong, X M Wan. Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 48. issue 6. 2015-12-15. PMID:25831201. |
glutamic acid (glu) and gamma amino butyric acid (gaba) in the cortex and hippocampus were assayed by high-performance liquid chromatography (hplc), and tumor necrosis factor (tnf)-α and interleukin (il)-1β were determined by elisa. |
2015-12-15 |
2023-08-13 |
mouse |
| Túlio Cezar de Souza Bernardino, Antonio Lúcio Teixeira, Aline Silva Miranda, Patrícia Maia Guidine, Gustavo Rezende, Maria Carolina Doretto, Gabriel Perfeito Castro, Luciana Drummond, Márcio Flávio Dutra Moraes, Pedro Augusto Lopes Tito, Antonio Carlos Pinheiro de Oliveira, Helton José Rei. Wistar Audiogenic Rats (WAR) exhibit altered levels of cytokines and brain-derived neurotrophic factor following audiogenic seizures. Neuroscience letters. vol 597. 2015-10-19. PMID:25936592. |
four hours after stimulation, animals were decapitated and the hippocampus, inferior colliculus, striatum and cortex were removed for evaluation of the levels of interleukin (il)-1β, il-6, tumor necrosis factor (tnf)-α and brain derived neurotrophic factor (bdnf). |
2015-10-19 |
2023-08-13 |
rat |
| Andressa Souza, Jairo Alberto Dussan-Sarria, Liciane Fernandes Medeiros, Ana Cláudia Souza, Carla Oliveira, Vanessa Leal Scarabelot, Lauren Naomi Adachi, Elisa Cristiana Winkelmann-Duarte, Bárbara Beatriz Philippi-Martins, Carlos Alexandre Netto, Wolnei Caumo, Iraci L S Torre. Neonatal hypoxic-ischemic encephalopathy reduces c-Fos activation in the rat hippocampus: evidence of a long-lasting effect. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 38. 2015-08-21. PMID:25262910. |
neuronal activity (c-fos activation at region ca1 and dentate gyrus of the hippocampus), nociceptive behavior (von frey, tail-flick, and hot-plate tests), neuroplasticity mediators (bdnf, tnf), and a cellular injury marker (lactase dehydrogenase [ldh]) were assessed in blood serum 14, 30, and 60 days after birth. |
2015-08-21 |
2023-08-13 |
rat |
| Juhwan Kim, Miyoung Yang, Yeonghoon Son, Hyosun Jang, Dongwoo Kim, Jong-Choon Kim, Sung-Ho Kim, Man-Jong Kang, Heh-In Im, Taekyun Shin, Changjong Moo. Glial activation with concurrent up-regulation of inflammatory mediators in trimethyltin-induced neurotoxicity in mice. Acta histochemica. vol 116. issue 8. 2015-08-20. PMID:25265880. |
the expression of m1 and m2 microglial markers (inducible nitric oxide synthase [inos] and cd206, respectively) and pro-inflammatory cytokines (interleukin [il]-1β, il-6 and tumor necrosis factor [tnf]-α) were significantly increased in the mouse hippocampus following tmt treatment. |
2015-08-20 |
2023-08-13 |
mouse |
| Takashi Kawano, Akihiro Morikawa, Satoko Imori, Sayaka Waki, Takahiko Tamura, Daiki Yamanaka, Fumimoto Yamazaki, Masataka Yokoyam. Preventive effects of multisensory rehabilitation on development of cognitive dysfunction following systemic inflammation in aged rats. Journal of anesthesia. vol 28. issue 5. 2015-06-15. PMID:24442128. |
these memory deficits were positively correlated with the levels of both tumor necrosis factor (tnf)-α and interleukin (il)-1β in the hippocampus. |
2015-06-15 |
2023-08-12 |
rat |
| Anna Dellarole, Paul Morton, Roberta Brambilla, Winston Walters, Spencer Summers, Danielle Bernardes, Mariagrazia Grilli, John R Bethe. Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24938671. |
here we sought to investigate: (1) the occurrence of depressive-like behavior in chronic neuropathic pain and the associated forms of hippocampal plasticity, and (2) the involvement of tnfr1-mediated tnf signaling as a possible regulator of such events. |
2015-06-09 |
2023-08-13 |
mouse |
| Anna Dellarole, Paul Morton, Roberta Brambilla, Winston Walters, Spencer Summers, Danielle Bernardes, Mariagrazia Grilli, John R Bethe. Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24938671. |
the onset of depressive-like behavior also coincided with increased hippocampal levels of tnf, and decreased expression of tnf receptor 2 (tnfr2), which were all fully restored after mice spontaneously recovered from pain. |
2015-06-09 |
2023-08-13 |
mouse |
| Anna Dellarole, Paul Morton, Roberta Brambilla, Winston Walters, Spencer Summers, Danielle Bernardes, Mariagrazia Grilli, John R Bethe. Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24938671. |
our data show that neuropathic pain induces a cluster of depressive-like symptoms and profound hippocampal plasticity that are dependent on tnf signaling through tnfr1. |
2015-06-09 |
2023-08-13 |
mouse |
| Hiroko Nomaru, Kunihiko Sakumi, Atsuhisa Katogi, Yoshinori N Ohnishi, Kosuke Kajitani, Daisuke Tsuchimoto, Eric J Nestler, Yusaku Nakabepp. Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia. Glia. vol 62. issue 8. 2015-02-04. PMID:24771617. |
furthermore, microglial activation after kainate administration was significantly diminished in fosb-null hippocampus, as shown by significant reductions in cd68 immunoreactivity, morphological change and reduced levels of il6 and tnf mrnas, although no change in the number of iba-1-positive cells was observed. |
2015-02-04 |
2023-08-13 |
mouse |