| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fernando Lopes, Fernando A Vicentini, Nina L Cluny, Alexander J Mathews, Benjamin H Lee, Wagdi A Almishri, Lateece Griffin, William Gonçalves, Vanessa Pinho, Derek M McKay, Simon A Hirota, Mark G Swain, Quentin J Pittman, Keith A Sharke. Brain TNF drives post-inflammation depression-like behavior and persistent pain in experimental arthritis. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32592863. |
these changes are associated with elevated levels of tnf in the hippocampus and are dependent upon brain tnf. |
2021-04-27 |
2023-08-13 |
mouse |
| Yuchen Song, Haixia Yuan, Tianyi Chen, Manqi Lu, Shuang Lei, Xinmin Ha. An Shen Ding Zhi Ling Alleviates Symptoms of Attention Deficit Hyperactivity Disorder via Anti-Inflammatory Effects in Spontaneous Hypertensive Rats. Frontiers in pharmacology. vol 11. 2021-02-06. PMID:33536923. |
asdzl reduced the pro-inflammatory factors interleukin (il)-1β, il-4, il-6, tumor necrosis factor (tnf)-α and monocyte chemoattractant protein (mcp)-1 and increased anti-inflammatory factor il-10 in shrs, and decreased the activation of microglia, astrocytes and mast cells in the prefrontal cortex (pfc) and hippocampus. |
2021-02-06 |
2023-08-13 |
rat |
| Leila Mohammadzadeh, Khalil Abnous, Bibi Marjan Razavi, Hossein Hosseinzade. Crocin-protected malathion-induced spatial memory deficits by inhibiting TAU protein hyperphosphorylation and antiapoptotic effects. Nutritional neuroscience. vol 23. issue 3. 2020-12-11. PMID:30789100. |
additionally, the elevation of malondialdehyde (mda), tnf α and il-6 levels, amelioration of reduced glutathione (gsh) in the hippocampus and reduction of plasma acetylcholinesterase activity were observed upon administration of the malathion. |
2020-12-11 |
2023-08-13 |
rat |
| Xiao-Li Zhang, Lin Wang, Li Xiong, Feng-Hua Huang, Han Xu. Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:29042992. |
serum and hippocampal cytokines, namely tumor necrosis factor (tnf)-α, interleukin (il)-1β, il-6 and il-10, were quantified using elisas and protein levels of hippocampal brain-derived neurotrophic factor (bdnf), glucagon synthase kinase (gsk)-3β, glutamate receptor subunit 1 (glur1), postsynaptic density protein 95 (psd95) and synapsin i were quantified using western blot analysis. |
2020-10-01 |
2023-08-13 |
mouse |
| Jing Yang, Rongjun Liu, Fan Lu, Fang Xu, Jinwei Zheng, Zhao Li, Wei Cui, Chuang Wang, Junfang Zhang, Shujun Xu, Wenhua Zhou, Qinwen Wang, Junping Chen, Xiaowei Che. Fast Green FCF Attenuates Lipopolysaccharide-Induced Depressive-Like Behavior and Downregulates TLR4/Myd88/NF-κB Signal Pathway in the Mouse Hippocampus. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31139084. |
fast green fcf also downregulated hippocampal tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6, but did not alter the level of the brain-derived neurotrophic factor (bdnf) in the hippocampus of lps-treated mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Christa Løth Myhre, Camilla Thygesen, Birgitte Villadsen, Jeanette Vollerup, Laura Ilkjær, Katrine Tækker Krohn, Manuela Grebing, Shuainan Zhao, Asif Manzoor Khan, Lasse Dissing-Olesen, Morten Skovgaard Jensen, Alicia A Babcock, Bente Finse. Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31417357. |
here, we investigated the expression of igf-1 mrna and igf-1 along with the expression of tumor necrosis factor (tnf) mrna, and the amyloid-β (aβ) plaque load in the hippocampus of 3- to 24-month-old app |
2020-09-30 |
2023-08-13 |
Not clear |
| Paula M Q Bellozi, Renan Pelição, Matheus C Santos, Isabel V A Lima, Soraya W Saliba, Érica L M Vieira, Alline C Campos, Antônio L Teixeira, Antônio C P de Oliveira, Ester M Nakamura-Palacios, Lívia C M Rodrigue. URB597 ameliorates the deleterious effects induced by binge alcohol consumption in adolescent rats. Neuroscience letters. vol 711. 2020-09-28. PMID:31374324. |
the chronic binge alcohol administration increased the interferon (ifn)-γ and tumor necrosis factor (tnf)-α levels in the pfc and hippocampus and the interleukin (il)-10 and bdnf levels in the pfc, and these effects were prevented by urb597. |
2020-09-28 |
2023-08-13 |
rat |
| Tao Guo, Jia Fang, Zhong Y Tong, Shasha He, Yingying Lu. Transcranial Direct Current Stimulation Ameliorates Cognitive Impairment via Modulating Oxidative Stress, Inflammation, and Autophagy in a Rat Model of Vascular Dementia. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32063834. |
the rats were sacrificed for the measurement of the level of superoxide (sod), glutathione (gsh), reactive oxidative species (ros), malondialdehyd (mda), interleukin (il)-1β, il-6, and tumor necrosis factor (tnf)-α level in the hippocampus. |
2020-09-28 |
2023-08-13 |
rat |
| Shaimaa N Amin, Sherif S Hassan, Ahmed S Khashaba, Magdy F Youakim, Noha S Abdel Latif, Laila A Rashed, Hanan D Yass. Hippocampal and Cerebellar Changes in Acute Restraint Stress and the Impact of Pretreatment with Ceftriaxone. Brain sciences. vol 10. issue 4. 2020-09-28. PMID:32218213. |
the biochemical analyses included measurements of serum cortisol, tumor necrotic factor (tnf), interleukin-6, hippocampal expression of bone morphogenetic protein 9 (bmp9), lysosomal-associated membrane protein 1 (lamp1), glutamate transporter 1 (glt1), heat shock protein 90, cerebellar expression of s100 protein, glutamic acid decarboxylase (gad), and carbon anhydrase. |
2020-09-28 |
2023-08-13 |
mouse |
| Bruk Getachew, Yousef Tizab. Antidepressant effects of moxidectin, an antiparasitic drug, in a rat model of depression. Behavioural brain research. vol 376. 2020-09-22. PMID:31513828. |
we undertook this study to determine whether mox would actually show antidepressant-like properties in an animal model of depression and whether it would affect the hippocampal and frontal cortex levels of brain-derived neurotrophic factor (bdnf) or tumor necrosis factor (tnf)-alpha, peptides that have been implicated in pathogenesis of depression and effectiveness of various antidepressants. |
2020-09-22 |
2023-08-13 |
rat |
| Maryam Zeraati, Mohsen Enayati, Laya Kafami, Seyed Houtan Shahidi, Ali-Akbar Salar. Gut microbiota depletion from early adolescence alters adult immunological and neurobehavioral responses in a mouse model of multiple sclerosis. Neuropharmacology. vol 157. 2020-07-21. PMID:31247271. |
we measured levels of interferon (ifn)-γ, interleukin (il)-17a and il-10 in serum, and bdnf, il-1β and tumor necrosis factor (tnf)-α) in the hippocampus. |
2020-07-21 |
2023-08-13 |
mouse |
| Narumi Hashikawa-Hobara, Ami Otsuka, Risa Ishikawa, Naoya Hashikaw. Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 118. 2020-02-05. PMID:31369988. |
next, we examined the hippocampal mrna levels of two cytokines, tumor necrosis factor (tnf) alpha and interleukin-6 (il-6); a neurotrophic factor, brain derived-neurotrophic factor (bdnf); and nerve growth factor (ngf). |
2020-02-05 |
2023-08-13 |
mouse |
| Narumi Hashikawa-Hobara, Ami Otsuka, Risa Ishikawa, Naoya Hashikaw. Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 118. 2020-02-05. PMID:31369988. |
tnf alpha, il-6 and bdnf mrna levels did not change in the hippocampus of stressed mice. |
2020-02-05 |
2023-08-13 |
mouse |
| María L Leicaj, Laura A Pasquini, Analia Lima, Maria C Gonzalez Deniselle, Juana M Pasquini, Alejandro F De Nicola, Laura I Gara. Changes in neurosteroidogenesis during demyelination and remyelination in cuprizone-treated mice. Journal of neuroendocrinology. vol 30. issue 11. 2019-09-30. PMID:30303567. |
using immunohistochemistry and a quantitative polymerase chain reaction, we demonstrated a decreased expression of star, p450scc and 5α-r with respect to an increase astrocytic and microglial reaction and elevated levels of tumor necrosis factor (tnf)α during the cuprizone demyelination period in the hippocampus, cortex and corpus callosum. |
2019-09-30 |
2023-08-13 |
mouse |
| Huiling Fu, Li Liu, Yue Tong, Yuanjie Li, Xia Zhang, Xiaojuan Gao, Jingjiao Yong, Jianjun Zhao, Dong Xiao, Kuishen Wen, Hanqing Wan. The antidepressant effects of hesperidin on chronic unpredictable mild stress-induced mice. European journal of pharmacology. vol 853. 2019-09-03. PMID:30928632. |
the serum, hippocampal and cell supernatant concentrations of interleukin (il)-1β, il-6 and tumor necrosis factor (tnf)-α were determined using enzyme-linked immunosorbent assay (elisa) commercial kits. |
2019-09-03 |
2023-08-13 |
mouse |
| Anna N Taylor, Delia L Tio, Afshin Paydar, Richard L Sutto. Sex Differences in Thermal, Stress, and Inflammatory Responses to Minocycline Administration in Rats with Traumatic Brain Injury. Journal of neurotrauma. vol 35. issue 4. 2019-07-08. PMID:29179648. |
the brains were removed and ipsilateral cortical tissue and hippocampus were dissected and subsequently assayed for interleukin (il)-1β, il-6, and tumor necrosis factor (tnf)-α. |
2019-07-08 |
2023-08-13 |
mouse |
| Xiaoli Wu, Benqin Tang, Xian Liao, Ziren Su, Simon Ming-Yuen Lee, Yefeng Cai, Chuwen L. Suppressive effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice. Food & function. vol 10. issue 2. 2019-06-14. PMID:30741293. |
in addition, sec was found to suppress the expression of pro-inflammatory cytokines, including the tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6 in the hippocampal of cums mice. |
2019-06-14 |
2023-08-13 |
mouse |
| Lorenz Fülle, Nina Offermann, Jan Niklas Hansen, Björn Breithausen, Anna Belen Erazo, Oliver Schanz, Luca Radau, Fabian Gondorf, Konrad Knöpper, Judith Alferink, Zeinab Abdullah, Harald Neumann, Heike Weighardt, Christian Henneberger, Annett Halle, Irmgard Förste. CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons. Glia. vol 66. issue 10. 2019-03-18. PMID:30277599. |
lps-mediated induction of ccl17 in the hippocampus was dependent on local tumor necrosis factor (tnf) signaling, whereas upregulation of ccl22 required granulocyte-macrophage colony-stimulating factor (gm-csf). |
2019-03-18 |
2023-08-13 |
mouse |
| Ghazaleh Hajiluian, Mahdieh Abbasalizad Farhangi, Ghazaleh Nameni, Parviz Shahabi, Mehran Megari-Abbas. Oxidative stress-induced cognitive impairment in obesity can be reversed by vitamin D administration in rats. Nutritional neuroscience. vol 21. issue 10. 2019-02-13. PMID:28683595. |
in the current study we aimed to investigate the effects of vitamin d on cognitive function, nuclear factor (nf)-κb, tumor necrosis factor (tnf)-α concentration and markers of oxidative stress in the hippocampus of high-fat diet-induced obese rats. |
2019-02-13 |
2023-08-13 |
rat |
| Luisa Cigliano, Maria Stefania Spagnuolo, Raffaella Crescenzo, Rosa Cancelliere, Lucia Iannotta, Arianna Mazzoli, Giovanna Liverini, Susanna Ioss. Short-Term Fructose Feeding Induces Inflammation and Oxidative Stress in the Hippocampus of Young and Adult Rats. Molecular neurobiology. vol 55. issue 4. 2019-02-11. PMID:28455700. |
after the high-fructose diet, plasma lipopolysaccharide and tumour necrosis factor (tnf)-alpha were found significantly increased in parallel with hippocampus inflammation, evidenced by a significant rise in tnf-alpha and glial fibrillar acidic protein concentrations in both the young and adult groups. |
2019-02-11 |
2023-08-13 |
rat |