| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mandana Shekarchian, Maghsoud Peeri, Mohammad Ali Azarbayjan. Physical activity in a swimming pool attenuates memory impairment by reducing glutamate and inflammatory cytokines and increasing BDNF in the brain of mice with type 2 diabetes. Brain research bulletin. 2023-08-05. PMID:37543294. |
we also measured inflammatory cytokines (interleukin (il)-6, il-1β, and tumor-necrosis-factor (tnf)-α), an anti-inflammatory cytokine (il-10), and brain-derived-neurotrophic-factor (bdnf), and glutamate levels in the hippocampus or prefrontal cortex of mice. |
2023-08-05 |
2023-08-14 |
mouse |
| Ali Barzegari, Hassan Amouzad Mahdirejei, Masoumeh Hanani, Mohammad Hossein Esmaeili, Ali-Akbar Salar. Adolescent swimming exercise following maternal valproic acid treatment improves cognition and reduces stress-related symptoms in offspring mice: Role of sex and brain cytokines. Physiology & behavior. 2023-06-09. PMID:37295664. |
we assessed neurobehavioral performances and inflammatory cytokines (interleukin-(il)6, tumor-necrosis-factor-(tnf)α, interferon-(ifn)γ, and il-17a) in the hippocampus and prefrontal cortex of offspring. |
2023-06-09 |
2023-08-14 |
mouse |
| Zhijing Zhang, Lideng Guo, Fei Yang, Shanpan Peng, Di Wang, Xiawei Lai, Baiqin Su, Haihui Xi. Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats. ACS chemical neuroscience. 2023-05-04. PMID:37141577. |
further experiments indicated that apn could inhibit the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88)/nuclear factor kappa b (nf-κb) p65 pathway to decrease the degree of oxidative damage (malondialdehyde (mda) and superoxide dismutase (sod)), microglia-mediated neuroinflammation (ionized calcium binding adapter molecule 1 (iba1), caspase-1, tumor necrosis factor (tnf)-α, interleukin-1β (il-1β), and interleukin-6 (il-6)), and apoptosis (p53, bcl2, bax, and caspase 3) in hippocampus. |
2023-05-04 |
2023-08-14 |
rat |
| b' Sinan Saral, Atilla Top\\xc3\\xa7u, Mehmet Alkanat, Tolga Mercantepe, Zafer \\xc5\\x9eahin, Kerimali Aky\\xc4\\xb1ld\\xc4\\xb1z, Kader Semra Karata\\xc5\\x9f, Lamiye Y\\xc4\\xb1ld\\xc4\\xb1z, Levent T\\xc3\\xbcmkaya, Zihni A\\xc3\\xa7ar Yaz\\xc4\\xb1c\\xc4\\xb. Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus. Journal of chemical neuroanatomy. 2023-03-31. PMID:37001681.' |
after behavioral tests, rats were euthanized and bdnf, tnf, il-1β, mda and gsh levels were measured in hippocampal homegenates by elisa. |
2023-03-31 |
2023-08-14 |
rat |
| Wenshu Zou, Kai Zhang, Zhengying Qiu, Ruihua Xin, Guibo Wang, Jingyan Zhang, Jianxi L. Asiatic acid and andrographolide reduce hippocampal injury through suppressing neuroinflammation caused by Salmonella typhimurium infection. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-12-29. PMID:36581090. |
the results showed that the neurons in the hippocampus of mice were damaged after s. typhimurium invaded cns in mice, and the inflammation was increased, which was manifested by the increased expression of inflammatory factors interleukin (il)-1β, tumor necrosis factor (tnf)-α, il-6, interferon (ifn)-γ and il-12b and the activation of nod-, lrr- and pyrin domain-containing protein 3 (nlrp3) inflammasomes. |
2022-12-29 |
2023-08-14 |
mouse |
| Hongtao Shen, Tianzhen Zhang, Yao Ji, Yu Zhang, Yongxiang Wang, Yuling Jiang, Xiongjin Chen, Qiuhao Liang, Kefeng Wu, Yunfeng Li, Xingyu Lu, Lili Cui, Bin Zhao, Yan Wan. GRK5 Deficiency in the Hippocampus Leads to Cognitive Impairment via Abnormal Microglial Alterations. Molecular neurobiology. 2022-12-16. PMID:36525154. |
in addition, transcriptional analysis of hippocampal tissues revealed striking changes in neuroactive ligand‒receptor interactions and tnf signaling in grk5-deficient mice. |
2022-12-16 |
2023-08-14 |
mouse |
| Fu-Sheng Wei, Mu-Wen Rao, Yuan-Lu Huang, Shi-Biao Chen, Yu-Qian Wu, Lei Yan. miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway. Neurotoxicity research. 2022-10-29. PMID:36308704. |
besides, the morris water maze (mwm) and fear conditioning test were used to evaluate the learning and memory ability of rats; western blot to detect the expression levels of neurotrophic factors (brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf)) as well as nf-κb pathway-related proteins (p65 and p-p65) in rat hippocampal tissues or pc-12 cells; qrt-pcr to assess the expression levels of mir-182-5p and bdnf in rat plasma, plasma exosomes, hippocampal tissues, and pc-12 cells; elisa to evaluate the levels of tumor necrosis factor (tnf)-α, interleukin (il)-6, and il-1β in rat hippocampal tissues; and dual-luciferase reporter assay to verify the targeting relationship between mir-182-5p and bdnf. |
2022-10-29 |
2023-08-14 |
rat |
| Xiaoli Wu, Jingwen Gu, Zhicong Zou, Meng Yu, Chen Zhang, Qinghui Xiao, Xin Chen, Chuwen L. Suppressive Effects of Isofraxidin on Depressive-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice. Brain sciences. vol 12. issue 10. 2022-10-27. PMID:36291310. |
also, isofraxidin suppresses tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6 expression in the hippocampus of cums mice. |
2022-10-27 |
2023-08-14 |
mouse |
| Gina M Kemp, Haider F Altimimi, Yoonmi Nho, Renu Heir, Adam Klyczek, David Stellwage. Sustained TNF signaling is required for the synaptic and anxiety-like behavioral response to acute stress. Molecular psychiatry. 2022-09-14. PMID:36104437. |
here we reveal that tumor necrosis factor α (tnf) is a required downstream mediator of the stress response in mice, necessary for stress-induced synaptic potentiation in the ventral hippocampus and for an increase in anxiety-like behaviour. |
2022-09-14 |
2023-08-14 |
mouse |
| Gina M Kemp, Haider F Altimimi, Yoonmi Nho, Renu Heir, Adam Klyczek, David Stellwage. Sustained TNF signaling is required for the synaptic and anxiety-like behavioral response to acute stress. Molecular psychiatry. 2022-09-14. PMID:36104437. |
critically, on-going tnf signaling specifically in the ventral hippocampus is necessary to sustain both the stress-induced synaptic and behavioral changes, as these could be reversed hours after induction by antagonizing tnf signaling. |
2022-09-14 |
2023-08-14 |
mouse |
| Jianan Li, Haoran B. Integrated Strategy of Network Pharmacology and in vitro Screening to Identify Mechanism of Diazinon-induced Hippocampal Neurotoxicity. Neurotoxicology. 2022-08-07. PMID:35934178. |
dzn-induced hippocampal neurotoxicity was associated with the altered activity of multiple signaling pathways (including pi3k-akt, tnf, and apoptosis signaling). |
2022-08-07 |
2023-08-14 |
mouse |
| Soraya Mansouri, Ali-Akbar Salari, Ali Abedi, Parham Mohammadi, Mohammad Aman. Melatonin treatment improves cognitive deficits by altering inflammatory and neurotrophic factors in the hippocampus of obese mice. Physiology & behavior. 2022-07-20. PMID:35858673. |
we measured inflammatory cytokines including tumor necrosis factor (tnf)-α, interferon (ifn)-γ, interleukin (il)-17a, and brain-derived neurotrophic factor (bdnf) in the hippocampus of obese mice. |
2022-07-20 |
2023-08-14 |
mouse |
| Dong An, Xiuting Qi, Kunpeng Li, Weixing Xu, Yue Wang, Xi Chen, Sha Sha, Chunfeng Wu, Yimei Du, Lei Che. Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus. Cellular and molecular neurobiology. 2022-07-15. PMID:35840809. |
administration of the tlr4 antagonist tak-242 or the nf-κb pathway inhibitor bay 11-7082 led to a noticeable reduction in the hippocampal protein levels of cleaved il-1β, il-6 and tnf, as well as those of cytoplasmic p-p65 and nuclear p65 and p50 in gsk1016790a-injected mice. |
2022-07-15 |
2023-08-14 |
mouse |
| Katelyn Larson, Melissa Damon, Rajasa Randhi, Nancy Nixon-Lee, Kirsty J Dixo. Selective inhibition of soluble TNF using XPro1595 improves hippocampal pathology to promote improved neurological recovery following traumatic brain injury in mice. CNS & neurological disorders drug targets. 2022-06-13. PMID:35692164. |
selective inhibition of soluble tnf using xpro1595 improves hippocampal pathology to promote improved neurological recovery following traumatic brain injury in mice. |
2022-06-13 |
2023-08-14 |
mouse |
| Kelley T Patten, Anthony E Valenzuela, Christopher Wallis, Danielle J Harvey, Keith J Bein, Anthony S Wexler, Fredric A Gorin, Pamela J Lei. Hippocampal but Not Serum Cytokine Levels Are Altered by Traffic-Related Air Pollution in TgF344-AD and Wildtype Fischer 344 Rats in a Sex- and Age-Dependent Manner. Frontiers in cellular neuroscience. vol 16. 2022-05-09. PMID:35530180. |
however, in the hippocampus, in 3-month-old tgf344-ad and wt animals, trap increased il-1ß in females while increasing tnf ɑin males. |
2022-05-09 |
2023-08-13 |
rat |
| Marcela Pereira, Isadora P Siba, Alexandra Acco, Diego Correia, Fernanda R Lapa, Adair Rs Santos, Ana P Ruani, Moacir G Pizzolatti, Roberto Andreatin. Myricitrin exhibits antidepressant-like effects and reduces IL-6 hippocampal levels in the chronic mild stress model. Behavioural brain research. 2022-05-01. PMID:35490774. |
interleukin (il)-6 and tumor necrosis factor (tnf)-alpha levels were measured in the hippocampus. |
2022-05-01 |
2023-08-13 |
mouse |
| Soosan Pourmohammadi, Mehrdad Roghani, Zahra Kiasalari, Mohsen Khalil. Paeonol Ameliorates Cuprizone-Induced Hippocampal Demyelination and Cognitive Deficits through Inhibition of Oxidative and Inflammatory Events. Journal of molecular neuroscience : MN. 2022-01-10. PMID:35001353. |
in addition, paeonol treatment at the higher dose was also associated with partial restoration of hippocampal level of oxidative stress and inflammatory markers including mda, ros, gsh, sod, catalase, nf-kb, and tnf. |
2022-01-10 |
2023-08-13 |
mouse |
| Matthew G Frank, Kathy H Nguyen, Jayson B Ball, Shelby Hopkins, Tel Kelley, Michael V Baratta, Monika Fleshner, Steven F Maie. SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: evidence of PAMP-like properties. Brain, behavior, and immunity. 2021-12-16. PMID:34915155. |
s1 increased and/or modulated neuroimmune gene expression (iba1, cd11b, mhciiα, cd200r1, gfap, tlr2, tlr4, nlrp3, il1b, hmgb1) and protein levels (ifnγ, il-1β, tnf, cxcl1, il-2, il-10), which varied across brain regions (hypothalamus, hippocampus, and frontal cortex) and time (24h and 7d) post-s1 treatment. |
2021-12-16 |
2023-08-13 |
human |
| Yan Yang, Yue Liu, Jixiang Zhu, Shiyu Song, Yulin Huang, Wei Zhang, Yu'e Sun, Jing Hao, Xuli Yang, Qian Gao, Zhengliang Ma, Juan Zhang, Xiaoping G. Neuroinflammation-mediated mitochondrial dysregulation involved in postoperative cognitive dysfunction. Free radical biology & medicine. vol 178. 2021-12-11. PMID:34875338. |
we found an increase in drp1 activation as well as mitochondrial fragmentation both in the hippocampus of mice after surgery and primary neurons after tnf exposure. |
2021-12-11 |
2023-08-13 |
mouse |
| Francesca Romana Rizzo, Livia Guadalupi, Krizia Sanna, Valentina Vanni, Diego Fresegna, Francesca De Vito, Alessandra Musella, Silvia Caioli, Sara Balletta, Silvia Bullitta, Antonio Bruno, Ettore Dolcetti, Mario Stampanoni Bassi, Fabio Buttari, Luana Gilio, Georgia Mandolesi, Diego Centonze, Antonietta Gentil. Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34391817. |
indeed, exercise significantly reduced microgliosis in the ca1 area, the expression of tumour necrosis factor (tnf) in microglia and, to a lesser extent, the hippocampal level of interleukin 1 beta (il-1β), previously shown to contribute to aberrant synaptic plasticity in the eae hippocampus. |
2021-12-09 |
2023-08-13 |
mouse |