| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie M Schindler, Matthew G Frank, Jessica L Annis, Steven F Maier, Andis Klegeri. Pattern recognition receptors mediate pro-inflammatory effects of extracellular mitochondrial transcription factor A (TFAM). Molecular and cellular neurosciences. vol 89. 2019-01-10. PMID:29678518. |
here, we demonstrate that tfam injected into the cisterna magna of male sprague-dawley rats upregulates (i) the expression of monocyte chemotactic protein (mcp)-1, interleukin (il)-1β, il-6, tumor necrosis factor (tnf)-α and nuclear factor-kappa b inhibitor alpha (nf-κbia) in the hippocampus; (ii) the expression of mcp-1, il-1β and tnf-α in the frontal cortex; and (iii) il-1β protein concentration in both these brain regions. |
2019-01-10 |
2023-08-13 |
human |
| Mohsen Khalili, Mitra Alavi, Elham Esmaeil-Jamaat, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Trigonelline mitigates lipopolysaccharide-induced learning and memory impairment in the rat due to its anti-oxidative and anti-inflammatory effect. International immunopharmacology. vol 61. 2018-11-08. PMID:29935483. |
furthermore, trigonelline depressed hippocampal nuclear factor-kappab (nf-κb), toll-like receptor 4 (tlr4), and tumor necrosis factor α (tnf α) in lps-challenged rats. |
2018-11-08 |
2023-08-13 |
rat |
| Xiaofeng Ou, Yusi Hua, Xuelian Liao, Cansheng Gong, Yan Kan. Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats. Molecular medicine reports. vol 18. issue 3. 2018-11-08. PMID:30066867. |
survival rates, performance of behavioral tests (automated rotarod and fear conditioning tests), blood brain barrier (bbb) permeability, and the expression levels of tumor necrosis factor (tnf)‑α and interleukin (il)‑1β in hippocampal tissues were also determined. |
2018-11-08 |
2023-08-13 |
rat |
| Inssaf Berkiks, S Boulbaroud, L M Garcia-Segura, A Mesfioui, A Ouichou, S Mouden, H Benmhammed, A El Hasnaoui, R Nakache, Y Bahbiti, A El Hessn. Thymelaea lythroides extract attenuates microglial activation and depressive-like behavior in LPS-induced inflammation in adult male rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 99. 2018-09-17. PMID:29710462. |
both treatments attenuate the overactivated microglial cells in the ca1 and ca3 of hippocampus (hp) and significantly reduced the oxidative-nitrosative stress markers and cytokine (tnf ?) |
2018-09-17 |
2023-08-13 |
rat |
| Lei Shi, Zaizong Wang, Xianjin Liu, Mao Li, Shangfei Zhang, Xiaobin Son. Bax inhibitor-1 is required for resisting the Early Brain Injury induced by subarachnoid hemorrhage through regulating IRE1-JNK pathway. Neurological research. vol 40. issue 3. 2018-08-20. PMID:29334839. |
results we found that bi-1 knockdown increased histological injury and the percentages of tunel-positive neuron in hippocampal, promoted the expressions of endoplasmic reticulum (er) stress proteins inositol-requiring enzyme 1α (ire1α) and tnf receptor-associated factor 2 (traf2), and increased the activation levels of apoptosis signal-regulating kinase 1 (ask1) and c-jun n-terminal kinase (jnk) in the hippocampus of sah rats compared with rats in sah + vehicle group. |
2018-08-20 |
2023-08-13 |
rat |
| Peng Guo, Si-Ping H. Thalidomide alleviates postoperative pain and spatial memory deficit in aged rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-19. PMID:28869897. |
single administration of thalidomide significantly reduced production of cytokines (tumor necrosis factor (tnf)-α and interleukin (il)-1β) in serum but not in the brain, and attenuated upregulation of nmda receptor (nr) 2a/b subunits in the hippocampus at pod 14. |
2018-06-19 |
2023-08-13 |
rat |
| Qi Wang, Xiaomei Dong, Yan Wang, Mengxi Liu, Anji Sun, Nannan Li, Yiwei Lin, Zhongli Geng, Ye Jin, Xiaobai L. Adolescent escitalopram prevents the effects of maternal separation on depression- and anxiety-like behaviours and regulates the levels of inflammatory cytokines in adult male mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 62. 2018-05-15. PMID:28778811. |
using maternal separation (ms), a paradigm of early adversity, we investigated the effects of adolescent (pnd 33-54) escitalopram (es; 10mg/kg) exposure on depression- and anxiety-like behaviours and the levels of inflammatory cytokines (interleukin [il]-1β, tumor necrosis factor [tnf]-α, and il-10) in the ventral hippocampus (hpv), prefrontal cortex (pfc), and serum in adult (pnd 61) male offspring mice. |
2018-05-15 |
2023-08-13 |
mouse |
| Sijie Tan, Yan Wang, Ke Chen, Zhifeng Long, Ju Zo. Ketamine Alleviates Depressive-Like Behaviors via Down-Regulating Inflammatory Cytokines Induced by Chronic Restraint Stress in Mice. Biological & pharmaceutical bulletin. vol 40. issue 8. 2018-05-02. PMID:28769008. |
crs exposure caused depressive-like behaviors in mice, which was associated with increased pre-inflammatory cytokines (interleukin (il)-1β, tumor necrosis factor (tnf)-α and il-6) levels, reactive microglia numbers and up-regulated regulatory molecules such as tlr4/p38 and p2x7 receptor in hippocampus. |
2018-05-02 |
2023-08-13 |
mouse |
| Dipan C Patel, Glenna Wallis, E Jill Dahle, Pallavi B McElroy, Kyle E Thomson, Raymond J Tesi, David E Szymkowski, Peter J West, Roy M Smeal, Manisha Patel, Robert S Fujinami, H Steve White, Karen S Wilco. Hippocampal TNFα Signaling Contributes to Seizure Generation in an Infection-Induced Mouse Model of Limbic Epilepsy. eNeuro. vol 4. issue 2. 2018-03-08. PMID:28497109. |
we found a significant increase in both mrna and protein levels of tnfα and the protein expression ratio of tnf receptors (tnfr1:tnfr2) in the hippocampus, a brain region most likely involved in seizure initiation, after tmev infection, which suggests that tnfα signaling, predominantly through tnfr1, may contribute to limbic hyperexcitability. |
2018-03-08 |
2023-08-13 |
mouse |
| Morteza Kosari-Nasab, Ghaffar Shokouhi, Amir Ghorbanihaghjo, Mehran Mesgari Abbasi, Ali-Akbar Salar. Anxiolytic- and antidepressant-like effects of Silymarin compared to diazepam and fluoxetine in a mouse model of mild traumatic brain injury. Toxicology and applied pharmacology. vol 338. 2018-01-12. PMID:29175455. |
the levels of tumor necrosis factor (tnf)-α protein, a marker of inflammation, in the prefrontal cortex and hippocampus was also measured. |
2018-01-12 |
2023-08-13 |
mouse |
| Masahiro Ohgidani, Takahiro A Kato, Noriaki Sagata, Kohei Hayakawa, Norihiro Shimokawa, Mina Sato-Kasai, Shigenobu Kanb. TNF-α from hippocampal microglia induces working memory deficits by acute stress in mice. Brain, behavior, and immunity. vol 55. 2017-12-29. PMID:26551431. |
interestingly, hippocampal tumor necrosis factor (tnf)-α levels were significantly elevated after acute stress, and acute stress-induced tnf-α was produced by hippocampal-ramified microglia. |
2017-12-29 |
2023-08-13 |
mouse |
| Alline C Campos, Natalia P Rocha, Jacques R Nicoli, Leda Q Vieira, Mauro M Teixeira, Antonio L Teixeir. Absence of gut microbiota influences lipopolysaccharide-induced behavioral changes in mice. Behavioural brain research. vol 312. 2017-12-19. PMID:27316342. |
lps-induced changes were followed by up-regulation of the expression of tnf and iba-1 in the hippocampus. |
2017-12-19 |
2023-08-13 |
mouse |
| Weiwei Tao, Yu Dong, Qiang Su, Hanqing Wang, Yanyan Chen, Wenda Xue, Chang Chen, Baomei Xia, Jinao Duan, Gang Che. Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway. Behavioural brain research. vol 308. 2017-11-21. PMID:27113683. |
enzyme-linked immunosorbent assay (elisa) revealed that treatment with liquiritigenin significantly reduced the concentrations of pro-inflammatory cytokines including interleukin (il)-6, il-1β and tumor necrosis factor (tnf)-α in serum and hippocampus. |
2017-11-21 |
2023-08-13 |
mouse |
| Ye Chen, Yu Lei, Li-Qun Mo, Jun Li, Mao-Hua Wang, Ji-Cheng Wei, Jun Zho. Electroacupuncture pretreatment with different waveforms prevents brain injury in rats subjected to cecal ligation and puncture via inhibiting microglial activation, and attenuating inflammation, oxidative stress and apoptosis. Brain research bulletin. vol 127. 2017-11-13. PMID:27771396. |
ea pretreatment decreased the production of tumor necrosis factor(tnf)-α, interleukin(il)-6, malondialdehyde (mda), and increased the activity of superoxide dismutase (sod) and catalase (cat) in serum and hippocampus at 48h after sham or clp operation. |
2017-11-13 |
2023-08-13 |
rat |
| Susmita Sil, Tusharkanti Ghosh, Rupsa Ghosh, Pritha Gupt. Nitric oxide synthase inhibitor, aminoguanidine reduces intracerebroventricular colchicine induced neurodegeneration, memory impairments and changes of systemic immune responses in rats. Journal of neuroimmunology. vol 303. 2017-08-14. PMID:28065581. |
in the present study the impairments of working and reference memories, neurodegeneration (chromatolysis and plaque formation) and changes of neuroinflammatory markers in the hippocampus (increased tnf α, il 1β, ros and nitrite) along with changes of serum inflammatory markers (tnf α, il 1β, ros and nitrite) and alteration of systemic immune responses (higher phagocytic activity of blood wbc and splenic pmn, higher cytotoxicity and lower leukocyte adhesion inhibition index of splenic mnc) were measured in the intracerebroventricular colchicine injected rats (icir). |
2017-08-14 |
2023-08-13 |
rat |
| D Stacey, R Redlich, A Büschel, N Opel, D Grotegerd, D Zaremba, K Dohm, C Bürger, S L Meinert, K Förster, J Repple, C Kaufmann, H Kugel, W Heindel, V Arolt, U Dannlowski, B T Baun. TNF receptors 1 and 2 exert distinct region-specific effects on striatal and hippocampal grey matter volumes (VBM) in healthy adults. Genes, brain, and behavior. vol 16. issue 3. 2017-06-28. PMID:27528091. |
tnf receptors 1 and 2 exert distinct region-specific effects on striatal and hippocampal grey matter volumes (vbm) in healthy adults. |
2017-06-28 |
2023-08-13 |
human |
| Qiang Su, Weiwei Tao, Huang Huang, Yan Du, Xing Chu, Gang Che. Protective effect of liquiritigenin on depressive-like behavior in mice after lipopolysaccharide administration. Psychiatry research. vol 240. 2017-02-27. PMID:27107388. |
interleukin (il)-6 and tumor necrosis factor (tnf)-α levels in serum and hippocampus were detected by enzyme-linked immunosorbent assay (elisa). |
2017-02-27 |
2023-08-13 |
mouse |
| Marcelo Ananias Teocchi, Lília D'Souza-L. Apoptosis through Death Receptors in Temporal Lobe Epilepsy-Associated Hippocampal Sclerosis. Mediators of inflammation. vol 2016. 2016-12-30. PMID:27006531. |
in addition, we evaluated the hippocampal relative mrna expression of the two tnf receptors, tnfrsf1a and tnfrsf1b, in patients, being both upregulated (n = 14; p < 0.01 and p < 0.04, resp.) |
2016-12-30 |
2023-08-13 |
Not clear |
| Junhua Yang, Fangfang Qi, Huaiyu Gu, Juntao Zou, Yang Yang, Qunfang Yuan, Zhibin Ya. Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life. Brain research bulletin. vol 120. 2016-09-30. PMID:26536170. |
the bcg-injected mice showed better behavioral performances at 4 w. we observed elevated neurogenesis, m2 microglial activation and a neurotrophic profile of neuroimmune molecules [more interferon (ifn)-γ, interleukin (il)-4, transforming growth factor (tgf)-β, brain-derived neurotrophic factor (bdnf) and insulin-like growth factor (igf)-1 and less tumor necrosis factor (tnf)-α and il-1β] in the hippocampus of the 2-w-old bcg-mice. |
2016-09-30 |
2023-08-13 |
mouse |
| Kai Zhang, Jingyan Liu, Xintong You, Ping Kong, Yichen Song, Lu Cao, Song Yang, Wenbing Wang, Qiang Fu, Zhangqiang M. P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice. Neuroscience letters. vol 613. 2016-07-01. PMID:26724370. |
interleukin (il)-6, il-1β and tumor necrosis factor (tnf)-α levels in serum and hippocampus were measured by enzyme-linked immunosorbent assay (elisa). |
2016-07-01 |
2023-08-13 |
mouse |