| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| She Chen, Zhu-Jun Yin, Chen Jiang, Zhan-Qiang Ma, Qiang Fu, Rong Qu, Shi-Ping M. Asiaticoside attenuates memory impairment induced by transient cerebral ischemia-reperfusion in mice through anti-inflammatory mechanism. Pharmacology, biochemistry, and behavior. vol 122. 2015-01-26. PMID:24631487. |
meanwhile the microglial activation and the gene expression of inflammatory cytokines including interleukin (il)-1β, interleukin (il)-6 and tumor necrosis factor (tnf)-α were increased in the hippocampus of the mice with cerebral ischemia and reperfusion. |
2015-01-26 |
2023-08-12 |
mouse |
| Doo Suk Lee, Jinyong Choi, Seon-Hee Kim, Sunyoung Ki. Ameliorating effects of HX106N, a water-soluble botanical formulation, on Aβ25-35-induced memory impairment and oxidative stress in mice. Biological & pharmaceutical bulletin. vol 37. issue 6. 2015-01-20. PMID:24694662. |
quantitative reverse transcription polymerase chain reaction (rt-pcr) demonstrated that hx106 treatment increased levels of heme oxygenase-1 (ho-1) in the hippocampus of aβ25-35-injected mice, while having little effect on the expression of tumor necrosis factor (tnf)-α and interleukin (il)-1β. |
2015-01-20 |
2023-08-13 |
mouse |
| Min Chul Lee, Randeep Rakwal, Junko Shibato, Koshiro Inoue, Hyukki Chang, Hideaki Soy. DNA microarray-based analysis of voluntary resistance wheel running reveals novel transcriptome leading robust hippocampal plasticity. Physiological reports. vol 2. issue 11. 2014-11-21. PMID:25413326. |
interestingly, rwr down-regulated multiple inflammatory cytokines (il1b, il2ra, and tnf) and chemokines (cxcl1, cxcl10, ccl2, and ccr4) with the sycp3, prl genes, which are potentially involved in regulating hippocampal neuroplastic changes. |
2014-11-21 |
2023-08-13 |
rat |
| C A McPherson, B A Merrick, G J Harr. In vivo molecular markers for pro-inflammatory cytokine M1 stage and resident microglia in trimethyltin-induced hippocampal injury. Neurotoxicity research. vol 25. issue 1. 2014-08-28. PMID:24002884. |
we characterized the initial m1 state in a hippocampal injury model dependent upon tumor necrosis factor (tnf) receptor signaling for dentate granule cell death. |
2014-08-28 |
2023-08-12 |
mouse |
| T A Bedrosian, Z M Weil, R J Nelso. Chronic dim light at night provokes reversible depression-like phenotype: possible role for TNF. Molecular psychiatry. vol 18. issue 8. 2014-04-09. PMID:22824811. |
using reverse transcription-quantitative pcr, we identified a reversible increase in hippocampal tumor necrosis factor (tnf), but not interleukin-1β, mrna expression in hamsters exposed to lan. |
2014-04-09 |
2023-08-12 |
Not clear |
| T A Bedrosian, Z M Weil, R J Nelso. Chronic dim light at night provokes reversible depression-like phenotype: possible role for TNF. Molecular psychiatry. vol 18. issue 8. 2014-04-09. PMID:22824811. |
direct intracerebroventricular infusion of a dominant-negative inhibitor of soluble tnf, xpro1595, prevented the development of depression-like behavior under lan, but had no effect on dendritic spine density in the hippocampus. |
2014-04-09 |
2023-08-12 |
Not clear |
| Bingfang Liu, Bojana Zupan, Emma Laird, Shifra Klein, Georgia Gleason, Marjan Bozinoski, Judit Gal Toth, Miklos Tot. Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory. Nature neuroscience. vol 17. issue 1. 2014-02-24. PMID:24292233. |
maternal hematopoietic tnf, via milk chemokines, programs hippocampal development and memory. |
2014-02-24 |
2023-08-12 |
mouse |
| Bingfang Liu, Bojana Zupan, Emma Laird, Shifra Klein, Georgia Gleason, Marjan Bozinoski, Judit Gal Toth, Miklos Tot. Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory. Nature neuroscience. vol 17. issue 1. 2014-02-24. PMID:24292233. |
a partial or complete maternal tnf deficit, specifically in hematopoietic cells, resulted in reduced milk levels of the chemokines ip-10, mcp-1, mcp-3, mcp-5 and mip-1β, which in turn augmented offspring postnatal hippocampal proliferation, leading to improved adult spatial memory in mice. |
2014-02-24 |
2023-08-12 |
mouse |
| Tatiana Barichello, Jaqueline S Generoso, Lutiana R Simões, Samuel G Elias, Michael H Tashiro, Diogo Dominguini, Clarissa M Comim, Márcia Carvalho Vilela, Antonio Lucio Teixeira, João Queved. Inhibition of indoleamine 2,3-dioxygenase prevented cognitive impairment in adult Wistar rats subjected to pneumococcal meningitis. Translational research : the journal of laboratory and clinical medicine. vol 162. issue 6. 2014-01-21. PMID:23994082. |
during the first experiment, the animals were killed 24 hours later, and the hippocampus was isolated for the analysis of tumor necrosis factor (tnf)-α, interleukin (il)-4, il-6, il-10, and cytokine-induced neutrophil chemoattractant 1 (cinc-1) levels. |
2014-01-21 |
2023-08-12 |
rat |
| Daniel C Lee, Claudia R Ruiz, Lori Lebson, Maj-Linda B Selenica, Justin Rizer, Jerry B Hunt, Rahil Rojiani, Patrick Reid, Sidharth Kammath, Kevin Nash, Chad A Dickey, Marcia Gordon, Dave Morga. Aging enhances classical activation but mitigates alternative activation in the central nervous system. Neurobiology of aging. vol 34. issue 6. 2013-12-11. PMID:23481567. |
two cocktails containing either tumor necrosis factor (tnf)-α, interleukin (il)-12, and il-1β (referred to as ckt-1) or il-13 and il-4 (referred to ckt-2) were injections into the hippocampus of mice aged 6, 12, or 24 months. |
2013-12-11 |
2023-08-12 |
mouse |
| Jianming Wang, Tetsuhiro Fujiyoshi, Yasuharu Kosaka, Jonathan D Raybuck, K Matthew Lattal, Mizuko Ikeda, Paco S Herson, Ines P Koerne. Inhibition of soluble epoxide hydrolase after cardiac arrest/cardiopulmonary resuscitation induces a neuroprotective phenotype in activated microglia and improves neuronal survival. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 10. 2013-11-22. PMID:23820647. |
we found early activation of microglia and increased expression of inflammatory tumor necrosis factor (tnf)-α and interleukin (il)-1β in the hippocampus after ca/cpr, which was unchanged after 4-pco treatment, while expression of antiinflammatory il-10 increased significantly. |
2013-11-22 |
2023-08-12 |
mouse |
| Anders Jorgensen, Katrine Maigaard, Gitta Wörtwein, Ida Hageman, Trine Henriksen, Allan Weimann, Peter Møller, Steffen Loft, Jann Hau, Henrik Enghusen Poulsen, Martin Balslev Jorgense. Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage. Progress in neuro-psychopharmacology & biological psychiatry. vol 40. 2013-03-26. PMID:22960608. |
we further determined frontal cortex and hippocampal levels of oxidatively generated nuclear dna damage, as measured by oxoguanine dna glycosylase and formamidopyrimidine dna glycosylase sensitive sites detected by the comet assay, as well as the expression of genes involved in dna repair (ogg1 and nudt1) and inflammation (ccl2 and tnf). |
2013-03-26 |
2023-08-12 |
rat |
| V V Kolobov, Z I Storozheva, M A Gruden, V V Sherstne. Regional features of the expression of genes involved in neurogenesis and apoptosis in the brain of adult rats. Bulletin of experimental biology and medicine. vol 153. issue 5. 2013-03-12. PMID:23113275. |
the expression of mrna of genes involved in neurogenesis and apoptosis (apaf1, ascl1, bax, bcl2, casp3, casp8, casp9, dffb, myh10, naip2, napa, notch2, numb, pura, s100a6, tnf) in the prefrontal cortex, hippocampus, and cerebellum was studied in adult rats. |
2013-03-12 |
2023-08-12 |
rat |
| V V Kolobov, Z I Storozheva, M A Gruden, V V Sherstne. Regional features of the expression of genes involved in neurogenesis and apoptosis in the brain of adult rats. Bulletin of experimental biology and medicine. vol 153. issue 5. 2013-03-12. PMID:23113275. |
in the hippocampus, the expression of apaf1 was significantly lower than in the prefrontal cortex, while the expression of ascl1, pura, s100b, and tnf was higher. |
2013-03-12 |
2023-08-12 |
rat |
| Harris Eyre, Bernhard T Baun. Neuroplastic changes in depression: a role for the immune system. Psychoneuroendocrinology. vol 37. issue 9. 2013-01-14. PMID:22525700. |
in rodent models of depression, il-1, il-6 and tnf are associated with reduced hippocampal neurogenesis; mechanisms which are associated with this include the stress-activated protein kinase (sapk)/janus kinase (jnk) pathway, hypoxia-inducible factors (hif)-1α, jak-signal transducer and activator of transcription (stat) pathway, mitogen-activated protein kinase (mapk)/camp responsive element binding protein (creb) pathway, ras-mapk, pi-3 kinase, ikk/nuclear factor (nf)-κb and tgfβ activated kinase-1 (tak-1). |
2013-01-14 |
2023-08-12 |
Not clear |
| Regina T Martuscello, Robert N Spengler, Adela C Bonoiu, Bruce A Davidson, Jadwiga Helinski, Hong Ding, Supriya Mahajan, Rajiv Kumar, Earl J Bergey, Paul R Knight, Paras N Prasad, Tracey A Ignatowsk. Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms. Pain. vol 153. issue 9. 2013-01-08. PMID:22770843. |
increasing tnf levels solely in the rat hippocampus produces persistent pain-like symptoms. |
2013-01-08 |
2023-08-12 |
rat |
| Regina T Martuscello, Robert N Spengler, Adela C Bonoiu, Bruce A Davidson, Jadwiga Helinski, Hong Ding, Supriya Mahajan, Rajiv Kumar, Earl J Bergey, Paul R Knight, Paras N Prasad, Tracey A Ignatowsk. Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms. Pain. vol 153. issue 9. 2013-01-08. PMID:22770843. |
using an animal model of peripheral neuropathic pain, we have demonstrated that intracerebroventricular infusion of a tnf antibody adjacent to the hippocampus completely alleviated pain. |
2013-01-08 |
2023-08-12 |
rat |
| Regina T Martuscello, Robert N Spengler, Adela C Bonoiu, Bruce A Davidson, Jadwiga Helinski, Hong Ding, Supriya Mahajan, Rajiv Kumar, Earl J Bergey, Paul R Knight, Paras N Prasad, Tracey A Ignatowsk. Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms. Pain. vol 153. issue 9. 2013-01-08. PMID:22770843. |
in the present study, tnf gene expression was induced exclusively in the hippocampus, eliciting increased local bioactive tnf levels, and animals were assessed for pain behaviors. |
2013-01-08 |
2023-08-12 |
rat |
| Regina T Martuscello, Robert N Spengler, Adela C Bonoiu, Bruce A Davidson, Jadwiga Helinski, Hong Ding, Supriya Mahajan, Rajiv Kumar, Earl J Bergey, Paul R Knight, Paras N Prasad, Tracey A Ignatowsk. Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms. Pain. vol 153. issue 9. 2013-01-08. PMID:22770843. |
animals receiving hippocampal microinjection of tnf nanoplasmidexes developed thermal hyperalgesia bilaterally. |
2013-01-08 |
2023-08-12 |
rat |
| Regina T Martuscello, Robert N Spengler, Adela C Bonoiu, Bruce A Davidson, Jadwiga Helinski, Hong Ding, Supriya Mahajan, Rajiv Kumar, Earl J Bergey, Paul R Knight, Paras N Prasad, Tracey A Ignatowsk. Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms. Pain. vol 153. issue 9. 2013-01-08. PMID:22770843. |
in support of these behavioral findings, immunoreactive staining for tnf, bioactive levels of tnf, and levels of tnf mrna per polymerase chain reaction analysis were assessed in several brain regions and found to be increased only in the hippocampus. |
2013-01-08 |
2023-08-12 |
rat |