| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ning Zhang, Wei Zhao, Zhen-Jie Hu, Sheng-Mei Ge, Yan Huo, Li-Xia Liu, Bu-Lang Ga. Protective effects and mechanisms of high-dose vitamin C on sepsis-associated cognitive impairment in rats. Scientific reports. vol 11. issue 1. 2021-11-17. PMID:34267240. |
in the clp+ saline group, the pyramidal neurons were reduced and distributed sparsely and disorderly, the levels of inflammatory cytokines of tumor necrosis factor (tnf)-α, interleukin (il)-6, and il-10 in the serum and hippocampus were significantly increased (p = 0.000), the blood brain barrier (bbb) permeability in the hippocampus was significantly (p = 0.000) increased, the activities of sod in the serum and hippocampus were significantly (p = 0.000 and p = 0.03, respectively) diminished while the levels of mda in the serum and hippocampus were significantly (p = 0.007) increased. |
2021-11-17 |
2023-08-13 |
rat |
| Ning Zhang, Wei Zhao, Zhen-Jie Hu, Sheng-Mei Ge, Yan Huo, Li-Xia Liu, Bu-Lang Ga. Protective effects and mechanisms of high-dose vitamin C on sepsis-associated cognitive impairment in rats. Scientific reports. vol 11. issue 1. 2021-11-17. PMID:34267240. |
high-dose vitamin c significantly (p < 0.05) decreased the levels of tumor necrosis factor- (tnf)-α, interleukin-6 (il-6), mda in the serum and hippocampus, and the activity of mmp-9 in the hippocampus, but significantly (p < 0.05) increased the levels of sod, the anti-inflammatory cytokine (il-10) in the serum and hippocampus, and nuclear and total nrf2, and ho-1 in the hippocampus. |
2021-11-17 |
2023-08-13 |
rat |
| Maryam Zeraati, Nazila Najdi, Belal Mosaferi, Ali-Akbar Salar. Environmental enrichment alters neurobehavioral development following maternal immune activation in mice offspring with epilepsy. Behavioural brain research. vol 399. 2021-11-15. PMID:33197458. |
tumor-necrosis-factor (tnf)-α and interleukin (il) 10 were measured in the hippocampus of offspring. |
2021-11-15 |
2023-08-13 |
mouse |
| Saeed Naghibi, Mohammad Shariatzadeh Joneydi, Ali Barzegari, Azam Davoodabadi, Amirhossein Ebrahimi, Elham Eghdami, Narges Fahimpour, Mahmood Ghorbani, Ehsan Mohammadikia, Mozhgan Rostami, Ali-Akbar Salar. Treadmill exercise sex-dependently alters susceptibility to depression-like behaviour, cytokines and BDNF in the hippocampus and prefrontal cortex of rats with sporadic Alzheimer-like disease. Physiology & behavior. vol 241. 2021-10-27. PMID:34536437. |
we measured brain-derived-neurotrophic factor (bdnf), tumour-necrosis factor (tnf)-α, and interleukin (il)-10 levels in the hippocampus and prefrontal cortex of animals. |
2021-10-27 |
2023-08-13 |
rat |
| Amin Mokhtari-Zaer, Mahmoud Hosseini, Nama Mohammadian Roshan, Mohammad Hossein Boskabad. Treadmill exercise ameliorates memory deficits and hippocampal inflammation in ovalbumin-sensitized juvenile rats. Brain research bulletin. vol 165. 2021-10-26. PMID:32998022. |
passive avoidance (pa) memory, levels of interleukin (il)-10 and tumor necrosis factor (tnf)-α in the hippocampus, total and differential white blood cell (wbc) count in the blood as well as pathological changes of the lung were then evaluated. |
2021-10-26 |
2023-08-13 |
rat |
| Fatma Nihan Cankara, Caner Günaydın, Zülfinaz Betül Çelik, Yasemin Şahin, Şakir Pekgöz, Yalçın Erzurumlu, Kanat Güll. Agomelatine confers neuroprotection against cisplatin-induced hippocampal neurotoxicity. Metabolic brain disease. vol 36. issue 2. 2021-10-05. PMID:33165734. |
for the evaluation of the effect of agomelatine on oxidative stress and inflammation, gsh, mda, tnf, and il-6 levels were analyzed in ht-22 cells and hippocampal tissues. |
2021-10-05 |
2023-08-13 |
mouse |
| Raheleh Rafaiee, Hosein Khastar, Behzad Garmabi, Malihe Taleb, Pirasteh Norouzi, Mehdi Khaksar. Hydrogen sulfide protects hippocampal CA1 neurons against lead mediated neuronal damage via reduction oxidative stress in male rats. Journal of chemical neuroanatomy. vol 112. 2021-09-30. PMID:33444772. |
h2s was able to significantly improve pb-related spatial learning and memory deficit, and neuronal cell death in the ca1 region of hippocampus in the male rats at least partly by reducing oxidative stress and tnf. |
2021-09-30 |
2023-08-13 |
rat |
| Yang Zhang, Hailin Liu, Zixuan Chen, Min Yu, Jiaxin Li, Hongquan Dong, Nana Li, Xiahao Ding, Yahe Ge, Cunming Liu, Tengfei Ma, Bo Gu. TLR4-mediated hippocampal MMP/TIMP imbalance contributes to the aggravation of perioperative neurocognitive disorder in db/db mice. Neurochemistry international. vol 140. 2021-09-02. PMID:32758588. |
the surgery also increased protein levels of tlr4, tumor necrosis factor (tnf)-α, interleukin (il)-1β, albumin, matrix metalloproteinase (mmp)-2, and mmp-9, and decreased protein levels of claudin-5, occludin, tissue inhibitor of matrix metalloproteinase (timp)-1, and timp-2 in the hippocampus of db/db and db/m mice. |
2021-09-02 |
2023-08-13 |
mouse |
| Jin-Ho Kim, Dong-Kyun Lim, Yoo-Hun Suh, Keun-A Chan. Long-Term Treatment of Cuban Policosanol Attenuates Abnormal Oxidative Stress and Inflammatory Response via Amyloid Plaques Reduction in 5xFAD Mice. Antioxidants (Basel, Switzerland). vol 10. issue 8. 2021-08-30. PMID:34439569. |
long-term pco treatment in 5xfad mice resulted in the reduction of gliosis and abnormal inflammatory cytokines level (interleukin [il]-1β, il-6, and tumor necrosis factor [tnf]-α) in the cortex and hippocampus. |
2021-08-30 |
2023-08-13 |
mouse |
| Changliang Zhu, Hong Tao, Shikuo Rong, Lifei Xiao, Xinxiao Li, Shucai Jiang, Baorui Guo, Lei Wang, Jiangwei Ding, Caibing Gao, Haigang Chang, Tao Sun, Feng Wan. Glucagon-Like Peptide-1 Analog Exendin-4 Ameliorates Cocaine-Mediated Behavior by Inhibiting Toll-Like Receptor 4 Signaling in Mice. Frontiers in pharmacology. vol 12. 2021-08-06. PMID:34349653. |
to elucidate the molecular mechanism underlying the potential effects of ex4 on maladaptive behaviors of cocaine, the tlr4-related inflammation within the hippocampus was observed by immunofluorescence staining, and the expression levels of toll-like receptor 4 (tlr4), tumor necrosis factor (tnf)-α, and interleukin (il)-1β were detected by western blotting. |
2021-08-06 |
2023-08-13 |
mouse |
| Yanan Shen, Lihai Chen, Yuan Zhang, Jiayue Du, Jing Hu, Hongguang Bao, Yan Xing, Yanna S. Phosphatase and Tensin Homolog Deleted on Chromosome Ten Knockdown Attenuates Cognitive Deficits by Inhibiting Neuroinflammation in a Mouse Model of Perioperative Neurocognitive Disorder. Neuroscience. vol 468. 2021-07-21. PMID:34166762. |
mice were then sacrificed to examine the expression of pten, amp-activated protein kinase (ampk), ionized calcium binding adaptor molecule (iba)-1, b-cell lymphoma (bcl)-2, bcl2-associated x protein (bax), interleukin (il)-1β, and tumor necrosis factor (tnf)-α in the hippocampus. |
2021-07-21 |
2023-08-13 |
mouse |
| Wenjie Su, Min Xie, Yao Li, Xinran Gong, Jiacen L. Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway. Neuromolecular medicine. vol 22. issue 2. 2021-07-19. PMID:31758388. |
our results revealed that treatment of pocd rats with tpm could suppress neuronal apoptosis in the hippocampus tissues, and the neuroprotective effects of tpm may relate with the regulation of tumor necrosis factor (tnf) signaling pathway. |
2021-07-19 |
2023-08-13 |
rat |
| Anna A Karan, Yulia S Spivak, Konstantin A Gerasimov, Elena M Suleymanova, Maria N Volobueva, Alexey A Kvichansky, Lyudmila V Vinogradova, Alexey P Bolshako. CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex. Molecular neurobiology. vol 58. issue 8. 2021-07-15. PMID:33907944. |
using quantitative pcr, we analyzed expression of interleukin-1b, ccl2, interleukin-6, tumor necrosis factor (tnf), transforming growth factor beta 1 (tgfb1), fractalkine, and cannabinoid receptor type 2 in the neocortex, dorsal and ventral hippocampus, cortical leptomeninges, dura mater, and spleen in 3 and 6 h after induction of gtcs by a high dose of pentylenetetrazole (ptz, 70 mg/kg) and absence-like activity by a low dose of ptz (30 mg/kg). |
2021-07-15 |
2023-08-13 |
Not clear |
| Dmitrii Pavlov, Anna Gorlova, Lucien Bettendorff, Allan A Kalueff, Aleksei Umriukhin, Andrey Proshin, Alexander Lysko, Rainer Landgraf, Daniel C Anthony, Tatyana Strekalov. Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes - Effects that are susceptible to antidepressants. Neurobiology of learning and memory. vol 172. 2021-07-14. PMID:32325189. |
here, increased time spent floating on day 5, a parameter of enhanced learning of the adverse context, was accompanied by hypercorticosteronemia, increased gene expression of gsk-3α, gsk-3β, c-fos, cyclooxygenase-1 (cox-1) and pro-inflammatory cytokines interleukin-1 beta (il-1β), tumor necrosis factor (tnf), and elevated concentrations of protein carbonyl, a marker of oxidative stress, in the prefrontal cortex and hippocampus. |
2021-07-14 |
2023-08-13 |
mouse |
| Kanishk Luhach, Giriraj T Kulkarni, Vijay P Singh, Bhupesh Sharm. Effect of papaverine on developmental hyperserotonemia induced autism spectrum disorder related behavioural phenotypes by altering markers of neuronal function, inflammation, and oxidative stress in rats. Clinical and experimental pharmacology & physiology. vol 48. issue 4. 2021-07-13. PMID:33480092. |
also, effects on important biochemical markers related with neuronal function (brain-derived neurotrophic factor (bdnf)-neuronal survival and phosphorylated-camp response element binding protein (pcreb)-neuronal transcription factor), brain inflammation (interleukin (il)-6, il-10 and tumour necrosis factor (tnf)-α) and brain oxidative stress (tbars and gsh) were studied in important brain areas (frontal cortex, cerebellum, hippocampus and striatum). |
2021-07-13 |
2023-08-13 |
rat |
| Hamideh Bashiri, Mohsen Enayati, Alireza Bashiri, Ali-Akbar Salar. Swimming exercise improves cognitive and behavioral disorders in male NMRI mice with sporadic Alzheimer-like disease. Physiology & behavior. vol 223. 2021-06-21. PMID:32522682. |
to understand the possible mechanisms, amyloid-β (aβ)-42, brain-derived neurotrophic factor (bdnf), glutamate, malondialdehyde (mda), tumor-necrosis-factor (tnf)-α, and interleukin (il)-6 levels were measured in the hippocampus. |
2021-06-21 |
2023-08-13 |
mouse |
| Semil Selcen Gocmez, Yusufhan Yazir, Gulcin Gacar, Tuğçe Demirtaş Şahin, Sertan Arkan, Ayşe Karson, Tijen Utka. Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats. Physiology & behavior. vol 224. 2021-06-21. PMID:32569601. |
thoracic enos expression, hippocampal bdnf expression and serum and hippocampal tnf levels were also measured. |
2021-06-21 |
2023-08-13 |
rat |
| Semil Selcen Gocmez, Yusufhan Yazir, Gulcin Gacar, Tuğçe Demirtaş Şahin, Sertan Arkan, Ayşe Karson, Tijen Utka. Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats. Physiology & behavior. vol 224. 2021-06-21. PMID:32569601. |
furthermore, aging resulted in endothelial dysfunction, decreased expressions of thoracic enos and hippocampal bdnf, and increased level of tnf in serum and hippocampus. |
2021-06-21 |
2023-08-13 |
rat |
| Wang-Xia Wang, Paresh Prajapati, Hemendra J Vekaria, Malinda Spry, Amber L Cloud, Patrick G Sullivan, Joe E Springe. Temporal changes in inflammatory mitochondria-enriched microRNAs following traumatic brain injury and effects of miR-146a nanoparticle delivery. Neural regeneration research. vol 16. issue 3. 2021-06-04. PMID:32985480. |
moreover, injections of mir-146a containing nanoparticles into the brain immediately following controlled cortical impact injury significantly reduced hippocampal tnf receptor-associated factor 6 and interleukin-1 receptor-associated kinase 1 levels. |
2021-06-04 |
2023-08-13 |
rat |
| Quezya Mendes Camargos, Bruno Costa Silva, Daniele Gonçalves Silva, Eliana Cristina de Brito Toscano, Bruna da Silva Oliveira, Paula Maria Quaglio Bellozi, Bruna Lorrayne de Oliveira Jardim, Érica Leandro Marciano Vieira, Antônio Carlos Pinheiro de Oliveira, Lirlândia Pires Sousa, Antônio Lúcio Teixeira, Aline Silva de Miranda, Milene Alvarenga Rachi. Minocycline treatment prevents depression and anxiety-like behaviors and promotes neuroprotection after experimental ischemic stroke. Brain research bulletin. vol 155. 2021-06-03. PMID:31756420. |
then, the brains were removed and processed to evaluate brain damage by histological and morphometric analysis, hippocampal neurodegeneration using fluoro-jade c histochemistry, microglial activity using iba-1 immunohistochemistry, brain levels of tnf, ifn-γ, il-6, il-10, il-12p70 and ccl2 by cba, cx3cl1 and bdnf by elisa assays. |
2021-06-03 |
2023-08-13 |
mouse |