| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T A Ignatowski, W C Covey, P R Knight, C M Severin, T J Nickola, R N Spengle. Brain-derived TNFalpha mediates neuropathic pain. Brain research. vol 841. issue 1-2. 1999-11-17. PMID:10546989. |
bioactive tnf levels are elevated in the hippocampus. |
1999-11-17 |
2023-08-12 |
rat |
| T A Ignatowski, W C Covey, P R Knight, C M Severin, T J Nickola, R N Spengle. Brain-derived TNFalpha mediates neuropathic pain. Brain research. vol 841. issue 1-2. 1999-11-17. PMID:10546989. |
during the period of injury, hippocampal noradrenergic neurotransmission demonstrates a decrease in stimulated norepinephrine (ne) release, concomitant with elevated hippocampal tnf levels. |
1999-11-17 |
2023-08-12 |
rat |
| S F Tzeng, M Kahn, S Liva, J De Velli. Tumor necrosis factor-alpha regulation of the Id gene family in astrocytes and microglia during CNS inflammatory injury. Glia. vol 26. issue 2. 1999-09-03. PMID:10384879. |
tnf alpha also increased id2 mrna expression in the caudate putamen and hippocampus at the injection site. |
1999-09-03 |
2023-08-12 |
rat |
| S E Ilyin, D Gayle, I González-Gómez, M E Miele, C R Plata-Salamá. Brain tumor development in rats is associated with changes in central nervous system cytokine and neuropeptide systems. Brain research bulletin. vol 48. issue 4. 1999-07-23. PMID:10357067. |
brain tumor formation was associated with significant increased levels of interleukin (il)-1beta, il-1 receptor antagonist, il-1 receptor type i, tumor necrosis factor (tnf)-alpha, and transforming growth factor (tgf)-beta1 mrnas in the cerebellum, hippocampus, and hypothalamus. |
1999-07-23 |
2023-08-12 |
rat |
| S M Knoblach, L Fan, A I Fade. Early neuronal expression of tumor necrosis factor-alpha after experimental brain injury contributes to neurological impairment. Journal of neuroimmunology. vol 95. issue 1-2. 1999-05-17. PMID:10229121. |
macrophages that were present in a hemorrhagic zone along the external capsule, corpus callosum and alveus hippocampus at 4 h after tbi did not express tnf alpha. |
1999-05-17 |
2023-08-12 |
rat |
| M Tamatani, Y H Che, H Matsuzaki, S Ogawa, H Okado, S Miyake, T Mizuno, M Tohyam. Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons. The Journal of biological chemistry. vol 274. issue 13. 1999-04-29. PMID:10085086. |
here we examined the mechanism of tnf in preventing neuronal death in primary hippocampal neurons. |
1999-04-29 |
2023-08-12 |
Not clear |
| S E Ilyin, D Gayle, M C Flynn, C R Plata-Salamá. Interleukin-1beta system (ligand, receptor type I, receptor accessory protein and receptor antagonist), TNF-alpha, TGF-beta1 and neuropeptide Y mRNAs in specific brain regions during bacterial LPS-induced anorexia. Brain research bulletin. vol 45. issue 5. 1998-06-09. PMID:9570721. |
administration of lps on mrna levels of interleukin-1beta (il-1beta) system components, tumor necrosis factor (tnf)-alpha, transforming growth factor (tgf)-beta1, and neuropeptide y (npy) in the cerebellum, hippocampus, and hypothalamus. |
1998-06-09 |
2023-08-12 |
rat |
| S Di Loreto, M Balestrino, P Pellegrini, A M Berghella, T Del Beato, F Di Marco, D Adorn. Blockade of N-methyl-D-aspartate receptor prevents hypoxic neuronal death and cytokine release. Neuroimmunomodulation. vol 4. issue 4. 1998-05-27. PMID:9524964. |
neuronal mortality, interleukin-1 beta (il1 beta) and tumor necrosis factor-alpha (tnf alpha) release were measured in hypoxic hippocampal neuronal cultures. |
1998-05-27 |
2023-08-12 |
Not clear |
| K Furukawa, M P Mattso. The transcription factor NF-kappaB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor-alpha in hippocampal neurons. Journal of neurochemistry. vol 70. issue 5. 1998-05-18. PMID:9572271. |
whole-cell perforated patch clamp recordings in cultured rat hippocampal neurons showed that long-term treatment (24-48 h) with tnf alpha increases ca2+ current density; pharmacological analysis indicated a major increase in current through l-type voltage-dependent calcium channels. |
1998-05-18 |
2023-08-12 |
rat |
| G Farkas, J Márton, Z Nagy, Y Mándi, T Takács, M A Deli, C S Abrahá. Experimental acute pancreatitis results in increased blood-brain barrier permeability in the rat: a potential role for tumor necrosis factor and interleukin 6. Neuroscience letters. vol 242. issue 3. 1998-05-14. PMID:9530927. |
cytokine concentrations were measured in bioassays with specific cell lines (wehi-164 for tnf and b-9 for il-6), while the bbb permeability was determined for a small (sodium fluorescein, molecular weight (mw) 376 da), and a large (evans' blue-albumin, mw 67000 da) tracer by spectrophotometry in the parietal cortex, hippocampus, striatum, cerebellum and medulla of rats. |
1998-05-14 |
2023-08-12 |
rat |
| T Kita, L Liu, N Tanaka, Y Kinoshit. The expression of tumor necrosis factor-alpha in the rat brain after fluid percussive injury. International journal of legal medicine. vol 110. issue 6. 1998-01-22. PMID:9387012. |
tnf alpha levels in cerebrospinal fluid (csf) gradually increased during the first 1 h, rose to a maximal elevation at 3 h and 6 h and returned to basal values by 24 h. horseradish peroxidase tracer experiments revealed that primary microvascular damage appeared as early as 15 min after impact, but rapidly recovered and 1 h after impact secondary microvascular damage occurred in the hippocampus and parasagittal cortex. |
1998-01-22 |
2023-08-12 |
rat |
| T Kita, L Liu, N Tanaka, Y Kinoshit. The expression of tumor necrosis factor-alpha in the rat brain after fluid percussive injury. International journal of legal medicine. vol 110. issue 6. 1998-01-22. PMID:9387012. |
by immunoelectron microscopy, tnf alpha reactions were detected in the lysosomes of microglia accumulated at the impact site of the cortex 30 min after impact, and 1 h after impact these reactions were mainly detected at the glial cells (such as microglia and astrocytes) in the hippocampus and parasagittal cortex. |
1998-01-22 |
2023-08-12 |
rat |
| M G De Simoni, L Terreni, R Chiesa, F Mangiarotti, G L Forlon. Interferon-gamma potentiates interleukin (IL)-6 and tumor necrosis factor-alpha but not IL-1beta induced by endotoxin in the brain. Endocrinology. vol 138. issue 12. 1997-12-29. PMID:9389504. |
cerebrospinal fluid (csf) and serum levels of interleukin (il)-1beta, il-6, and tumor necrosis factor-alpha (tnf alpha), their messenger rna expression in brain areas (hypothalamus, hippocampus, and striatum) and in spleen were evaluated 2 and 8 h after endotoxin [lipopolysaccharide (lps), 25 microg/rat i.c.v. |
1997-12-29 |
2023-08-12 |
rat |
| T A Ignatowski, B K Noble, J R Wright, J L Gorfien, R R Heffner, R N Spengle. Neuronal-associated tumor necrosis factor (TNF alpha): its role in noradrenergic functioning and modification of its expression following antidepressant drug administration. Journal of neuroimmunology. vol 79. issue 1. 1997-12-16. PMID:9357451. |
presently, we demonstrate that similar to alpha 2-adrenergic activation, tnf alpha regulation of ne release in a region of the brain rich in noradrenergic nerve terminals, is dependent upon the frequency of electrical stimulation applied to the hippocampal slice. |
1997-12-16 |
2023-08-12 |
rat |
| T A Ignatowski, B K Noble, J R Wright, J L Gorfien, R R Heffner, R N Spengle. Neuronal-associated tumor necrosis factor (TNF alpha): its role in noradrenergic functioning and modification of its expression following antidepressant drug administration. Journal of neuroimmunology. vol 79. issue 1. 1997-12-16. PMID:9357451. |
after administration of the tricyclic antidepressant desipramine, tissue sections obtained from the rat hippocampus and locus coeruleus are devoid of neuronal-associated tnf alpha immunoreactivity. |
1997-12-16 |
2023-08-12 |
rat |
| J L Tchélingérian, F Le Saux, B Pouzet, C Jacqu. Widespread neuronal expression of c-Fos throughout the brain and local expression in glia following a hippocampal injury. Neuroscience letters. vol 226. issue 3. 1997-07-22. PMID:9175595. |
we have previously shown that a mechanical lesion to the hippocampus of adult mice induces a neuronal expression of the cytokines interleukin-1alpha (il-1alpha) and tumor necrosis factor-alpha (tnf alpha) whereas a lesion to the striatum does not. |
1997-07-22 |
2023-08-12 |
mouse |
| R A Floyd, J M Kruege. Diurnal variation of TNF alpha in the rat brain. Neuroreport. vol 8. issue 4. 1997-07-14. PMID:9141064. |
tnf alpha was highest at light onset in the hypothalamus, hippocampus and cerebral cortex. |
1997-07-14 |
2023-08-12 |
rat |
| F de Bock, J Dornand, G Rondoui. Release of TNF alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage. Neuroreport. vol 7. issue 6. 1997-03-13. PMID:8817515. |
release of tnf alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage. |
1997-03-13 |
2023-08-12 |
rat |
| F de Bock, J Dornand, G Rondoui. Release of TNF alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage. Neuroreport. vol 7. issue 6. 1997-03-13. PMID:8817515. |
since se-induced neuronal damage is probably due to excitotoxicity, we investigated the effects of agonists of glutamate receptors on tnf alpha release in organotypic hippocampal cultures. |
1997-03-13 |
2023-08-12 |
rat |
| F de Bock, J Dornand, G Rondoui. Release of TNF alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage. Neuroreport. vol 7. issue 6. 1997-03-13. PMID:8817515. |
at day 2 the release of both cytokines by hippocampal slices prepared from epileptic animals was increased compared to controls, whereas at day 7 only tnf alpha secretion was enhanced. |
1997-03-13 |
2023-08-12 |
rat |