| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Goujon, P Parnet, S Layé, C Combe, R Dantze. Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide. Brain research. Molecular brain research. vol 36. issue 1. 1997-02-06. PMID:9011765. |
lps induced the expression of pro-inflammatory cytokines at the mrna level in all tissues under investigation, except for tnf alpha in the hippocampus. |
1997-02-06 |
2023-08-12 |
mouse |
| J L Tchélingérian, F Le Saux, C Jacqu. Identification and topography of neuronal cell populations expressing TNF alpha and IL-1 alpha in response to hippocampal lesion. Journal of neuroscience research. vol 43. issue 1. 1996-12-16. PMID:8838580. |
in previous studies, we have shown that a traumatic lesion to the hippocampus of adult mice induces the transitory expression of tnf alpha and il-1 alpha by neurons of different brain areas and also by glial cells at the site of injury. |
1996-12-16 |
2023-08-12 |
mouse |
| J L Tchélingérian, F Le Saux, C Jacqu. Identification and topography of neuronal cell populations expressing TNF alpha and IL-1 alpha in response to hippocampal lesion. Journal of neuroscience research. vol 43. issue 1. 1996-12-16. PMID:8838580. |
identification and topography of neuronal cell populations expressing tnf alpha and il-1 alpha in response to hippocampal lesion. |
1996-12-16 |
2023-08-12 |
mouse |
| T A Ignatowski, R C Chou, R N Spengle. Changes in noradrenergic sensitivity to tumor necrosis factor-alpha in brains of rats administered clonidine. Journal of neuroimmunology. vol 70. issue 1. 1996-11-19. PMID:8862135. |
the fractional release of [3h]-ne during field stimulation of control hippocampal slices was decreased by the addition of tnf alpha in a concentration-dependent manner, an effect which was potentiated by the alpha 2-adrenergic antagonist idazoxan; whereas, tnf alpha attenuated the concentration-dependent potentiating effect of idazoxan. |
1996-11-19 |
2023-08-12 |
rat |
| T A Ignatowski, R C Chou, R N Spengle. Changes in noradrenergic sensitivity to tumor necrosis factor-alpha in brains of rats administered clonidine. Journal of neuroimmunology. vol 70. issue 1. 1996-11-19. PMID:8862135. |
tnf alpha enhanced, rather than inhibited, [3h]-ne release after 1 day of clonidine administration, while a suppressed sensitivity to tnf alpha was observed in the hippocampus after 14 days of clonidine administration. |
1996-11-19 |
2023-08-12 |
rat |
| H Hardin-Pouzet, P Giraudon, A Bernard, E Derrington, M F Belin, M Didier-Baze. Cytokines are increased in the rat hippocampus after serotonergic neuron degeneration and upregulate the expression of GDH, an enzyme involved in glutamate detoxification. Journal of neuroimmunology. vol 69. issue 1-2. 1996-11-05. PMID:8823382. |
the level of gdh mrna was increased in primary cultures of hippocampal astrocytes treated with tnf alpha and il-1 alpha suggesting that these cytokines act on the gdh metabolism. |
1996-11-05 |
2023-08-12 |
rat |
| M P Mattson, B Cheng, S A Baldwin, V L Smith-Swintosky, J Keller, J W Geddes, S W Scheff, S Christako. Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response. Journal of neuroscience research. vol 42. issue 3. 1996-03-20. PMID:8583504. |
tumor necrosis factors (tnf alpha and tnf beta), cytokines that are expressed in response to brain injury, induced the expression of calbindin in cultured rat hippocampal and neocortical astrocytes. |
1996-03-20 |
2023-08-12 |
rat |
| C Betancur, J Borrell, C Guaz. Cytokine regulation of corticosteroid receptors in the rat hippocampus: effects of interleukin-1, interleukin-6, tumor necrosis factor and lipopolysaccharide. Neuroendocrinology. vol 62. issue 1. 1995-11-22. PMID:7566438. |
in contrast, hippocampal type ii receptors were dramatically decreased after the injection of tnf. |
1995-11-22 |
2023-08-12 |
rat |
| C Betancur, J Borrell, C Guaz. Cytokine regulation of corticosteroid receptors in the rat hippocampus: effects of interleukin-1, interleukin-6, tumor necrosis factor and lipopolysaccharide. Neuroendocrinology. vol 62. issue 1. 1995-11-22. PMID:7566438. |
the effects of interleukin-1 beta (il-1), interleukin-6 (il-6), tumor necrosis factor alpha (tnf) and lipopolysaccharide (lps) on hippocampal corticosteroid receptors were studied in the rat. |
1995-11-22 |
2023-08-12 |
rat |
| C Betancur, J Borrell, C Guaz. Cytokine regulation of corticosteroid receptors in the rat hippocampus: effects of interleukin-1, interleukin-6, tumor necrosis factor and lipopolysaccharide. Neuroendocrinology. vol 62. issue 1. 1995-11-22. PMID:7566438. |
these results emphasize the important role played by tnf in the modulation of the hypothalamic-pituitary-adrenal axis during immune/inflammatory processes and extend the central sites of action of this cytokine to the corticosteroid receptors of the hippocampus. |
1995-11-22 |
2023-08-12 |
rat |
| W E Maier, H W Brown, H A Tilson, M I Luster, G J Harr. Trimethyltin increases interleukin (IL)-1 alpha, IL-6 and tumor necrosis factor alpha mRNA levels in rat hippocampus. Journal of neuroimmunology. vol 59. issue 1-2. 1995-08-03. PMID:7797621. |
il-1 alpha, il-6 and tnf alpha mrna levels in the hippocampus increased within 6 h and remained elevated for 8 days. |
1995-08-03 |
2023-08-12 |
rat |
| W E Maier, H W Brown, H A Tilson, M I Luster, G J Harr. Trimethyltin increases interleukin (IL)-1 alpha, IL-6 and tumor necrosis factor alpha mRNA levels in rat hippocampus. Journal of neuroimmunology. vol 59. issue 1-2. 1995-08-03. PMID:7797621. |
mrna levels for interleukin (il)-1 alpha, il-1 beta, il-6 and tumor necrosis factor (tnf) alpha were measured in the hippocampus of adult male long-evans hooded rats following an acute injection of trimethyltin hydroxide (8 mg tmt/kg body weight). |
1995-08-03 |
2023-08-12 |
rat |
| W E Maier, H W Brown, H A Tilson, M I Luster, G J Harr. Trimethyltin increases interleukin (IL)-1 alpha, IL-6 and tumor necrosis factor alpha mRNA levels in rat hippocampus. Journal of neuroimmunology. vol 59. issue 1-2. 1995-08-03. PMID:7797621. |
quantitative analysis of mrna transcripts revealed a two-fold increase in both il-6 and tnf alpha within 6 h and a continued elevation of tnf alpha to 9-fold by 12 h. within 96 h, glial fibrillary acidic protein (gfap) mrna levels were elevated in the hippocampus. |
1995-08-03 |
2023-08-12 |
rat |
| C Jacque, J L Tchélingéria. [New concepts on the role of cytokines in the central nervous system]. Revue neurologique. vol 150. issue 11. 1995-08-02. PMID:7597367. |
for example, a lesion to the hippocampus induces neuronal synthesis of il-1 alpha and tnf alpha. |
1995-08-02 |
2023-08-12 |
Not clear |
| T A Ignatowski, R N Spengle. Tumor necrosis factor-alpha: presynaptic sensitivity is modified after antidepressant drug administration. Brain research. vol 665. issue 2. 1995-04-25. PMID:7895065. |
one day of desipramine administration resulted in increased locus coeruleus tnf mrna accumulation and, simultaneously, hippocampal tnf levels escalated. |
1995-04-25 |
2023-08-12 |
rat |
| T A Ignatowski, R N Spengle. Tumor necrosis factor-alpha: presynaptic sensitivity is modified after antidepressant drug administration. Brain research. vol 665. issue 2. 1995-04-25. PMID:7895065. |
while no change in sensitivity to tnf was observed in the hippocampus after one day of desipramine administration, tnf enhanced, rather than inhibited [3h]norepinephrine release after 14 days. |
1995-04-25 |
2023-08-12 |
rat |
| T A Ignatowski, R N Spengle. Tumor necrosis factor-alpha: presynaptic sensitivity is modified after antidepressant drug administration. Brain research. vol 665. issue 2. 1995-04-25. PMID:7895065. |
the fractional release of [3h]norepinephrine during field stimulation of control hippocampal slices was decreased by the addition of tnf in a concentration-dependent manner, an effect which was potentiated by the alpha 2-adrenergic antagonist idazoxan. |
1995-04-25 |
2023-08-12 |
rat |
| T A Ignatowski, R N Spengle. Tumor necrosis factor-alpha: presynaptic sensitivity is modified after antidepressant drug administration. Brain research. vol 665. issue 2. 1995-04-25. PMID:7895065. |
antidepressant administration of desipramine to rats twice-daily for 2 weeks increased hippocampal tnf levels and transformed the presynaptic tnf response. |
1995-04-25 |
2023-08-12 |
rat |
| S Layé, P Parnet, E Goujon, R Dantze. Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice. Brain research. Molecular brain research. vol 27. issue 1. 1995-04-06. PMID:7877446. |
the reverse transcription polymerase chain reaction (rt-pcr) was used to assess the induction of mrna of the proinflammatory cytokines il-1 beta, il-6 and tnf alpha in the spleen, pituitary, hypothalamus and hippocampus of mice after an intraperitoneal injection of lipopolysaccharide (lps, 10 micrograms/mouse). |
1995-04-06 |
2023-08-12 |
mouse |
| J L Tchelingerian, L Vignais, C Jacqu. TNF alpha gene expression is induced in neurones after a hippocampal lesion. Neuroreport. vol 5. issue 5. 1994-08-08. PMID:8025249. |
however, an immunoreactivity for tnf alpha has been observed recently in adult mouse brain after a lesion to the hippocampus. |
1994-08-08 |
2023-08-12 |
mouse |