| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Reilly T Enos, Kandy T Velázquez, E Angela Murph. Insight into the impact of dietary saturated fat on tissue-specific cellular processes underlying obesity-related diseases. The Journal of nutritional biochemistry. vol 25. issue 6. 2014-12-23. PMID:24742471. |
specifically, we examined ectopic lipid accumulation, oxidative capacity [peroxisome proliferator-activated receptor gamma coactivator 1-alpha (pgc-1α) mrna and protein; mtdna; cox iv and cytochrome c protein; citrate synthase activity; and gene expression of fission 1, mitofusin (mfn) 1 and mfn2], oxidative stress (4-hydroxy-2-nonenal), endoplasmic reticulum (er) stress (binding immunoglobulin protein, activating transcription factor 6-p50, p-eukaryotic initiation factor 2 alpha and x-box binding protein 1 spliced protein), inflammatory [p-c-jun n-terminal kinase (jnk), p-nuclear factor kappa-b, p-p38 mitogen-activated protein kinase) and insulin signaling (p-akt), and inflammation [tumor necrosis factor-alpha, monocyte chemotactic protein-1, interleukin-6, f4/80, toll-like receptor (tlr)2 and tlr4 gene expression] in various tissues, including the adipose tissue, liver, skeletal muscle and heart. |
2014-12-23 |
2023-08-13 |
mouse |
| Jiang Lin, Liangjia Bi, Xiaoqian Yu, Toshihisa Kawai, Martin A Taubman, Baozhong Shen, Xiaozhe Ha. Porphyromonas gingivalis exacerbates ligature-induced, RANKL-dependent alveolar bone resorption via differential regulation of Toll-like receptor 2 (TLR2) and TLR4. Infection and immunity. vol 82. issue 10. 2014-11-12. PMID:25047844. |
gingival interleukin-1β (il-1β) and tumor necrosis factor alpha (tnf-α) expression was increased, whereas il-10 expression was decreased in wt and tlr2(-/-) mice but not in tlr4(-/-) mice. |
2014-11-12 |
2023-08-13 |
mouse |
| Rémi Planès, Lbachir BenMohamed, Kaoutar Leghmari, Pierre Delobel, Jacques Izopet, Elmostafa Bahraou. HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms. Journal of virology. vol 88. issue 12. 2014-09-30. PMID:24696476. |
the induction of pd-l1 on modcs by hiv-1 tat (i) occurred in dose- and time-dependent manners, (ii) was mediated by the n-terminal 1-45 fragment of tat, (iii) did not require direct cell-cell contact but appeared rather to be mediated by soluble factor(s), (iv) was abrogated following neutralization of tumor necrosis factor alpha (tnf-α) or blocking of toll-like receptor 4 (tlr4), (v) was absent in tlr4-knockoout (ko) mice but could be restored following incubation with tat-conditioned medium from wild-type dcs, (vi) impaired the capacity of modcs to functionally stimulate t cells, and (vii) was not reversed functionally following pd-1/pd-l1 pathway blockade, suggesting the implication of other tat-mediated coinhibitory pathways. |
2014-09-30 |
2023-08-13 |
mouse |
| Chunlan Xu, Rui Sun, Xiangjin Qiao, Cuicui Xu, Xiaoya Shang, Weining Niu, Yu Cha. Effect of vitamin e supplementation on intestinal barrier function in rats exposed to high altitude hypoxia environment. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 18. issue 4. 2014-09-01. PMID:25177163. |
administration of vitamin e significantly increased the s-iga (p<0.001) in ileum and significantly improved the expression levels of occludin and iκbα, and decreased the expression levels of hypoxia-inducible factor 1 alpha and 2 alpha (hif-1α and hif-2α), toll-like receptors (tlr4), p-iκbα and nuclear factor-κb p65(nf-κb p65) in ileum compared to the hh group. |
2014-09-01 |
2023-08-13 |
rat |
| Pleunie van den Borne, Antonius J N M Bastiaansen, Margreet R de Vries, Paul H A Quax, Imo E Hoefer, Gerard Pasterkam. Toll-like receptor 4 inhibitor TAK-242 treatment does not influence perfusion recovery in tissue ischemia. Journal of cardiovascular pharmacology. vol 63. issue 1. 2014-08-27. PMID:24084220. |
after stimulation, cellular tlr4 activation was measured using fluorescence-activated cell sorting and tumor necrosis factor alpha release was measured using enzyme-linked immunosorbent assay. |
2014-08-27 |
2023-08-12 |
mouse |
| Pleunie van den Borne, Antonius J N M Bastiaansen, Margreet R de Vries, Paul H A Quax, Imo E Hoefer, Gerard Pasterkam. Toll-like receptor 4 inhibitor TAK-242 treatment does not influence perfusion recovery in tissue ischemia. Journal of cardiovascular pharmacology. vol 63. issue 1. 2014-08-27. PMID:24084220. |
tlr4 responses measured by tumor necrosis factor alpha levels were inhibited by tak-242 in human and mouse blood after long-term stimulation. |
2014-08-27 |
2023-08-12 |
mouse |
| Wei Shen, Yang Gao, Boyu Lu, Qingjiong Zhang, Yang Hu, Ying Che. Negatively regulating TLR4/NF-κB signaling via PPARα in endotoxin-induced uveitis. Biochimica et biophysica acta. vol 1842. issue 7. 2014-07-24. PMID:24717912. |
in the present study, we showed that lipopolysaccharide (lps), a tlr4 ligand, functions as an antagonist of peroxisome proliferator-activated receptor alpha (pparα), a nuclear transcription factor. |
2014-07-24 |
2023-08-13 |
human |
| Se-Ra Park, Dong-Jae Kim, Seung-Hyun Han, Min-Jung Kang, Jun-Young Lee, Yu-Jin Jeong, Sang-Jin Lee, Tae-Hyoun Kim, Sang-Gun Ahn, Jung-Hoon Yoon, Jong-Hwan Par. Diverse Toll-like receptors mediate cytokine production by Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans in macrophages. Infection and immunity. vol 82. issue 5. 2014-06-05. PMID:24566622. |
tlr2 and tlr4 are redundant in the production of cytokines (interleukin-6 [il-6] and tumor necrosis factor alpha [tnf-α]) in f. nucleatum- and a. actinomycetemcomitans-infected macrophages. |
2014-06-05 |
2023-08-12 |
Not clear |
| Laura Brudecki, Donald A Ferguson, Charles E McCall, Mohamed El Gazza. MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes. Immunology and cell biology. vol 91. issue 8. 2014-03-31. PMID:23897118. |
our and other studies have established that gene-specific reprogramming following tlr4 responses independently represses transcription and translation of proinflammatory genes such as tumor necrosis factor alpha (tnfα). |
2014-03-31 |
2023-08-12 |
human |
| Sigifredo Pedraza-Sánchez, Amy G Hise, Lakshmi Ramachandra, Fabian Arechavaleta-Velasco, Christopher L Kin. Reduced frequency of a CD14+ CD16+ monocyte subset with high Toll-like receptor 4 expression in cord blood compared to adult blood contributes to lipopolysaccharide hyporesponsiveness in newborns. Clinical and vaccine immunology : CVI. vol 20. issue 7. 2014-01-21. PMID:23595503. |
to better understand the mechanistic basis for this age-related difference in innate immunity, we compared tumor necrosis factor alpha (tnf-α) production by monocytes from cord blood (cb) and adult blood (ab) in response to lam (lipoarabinomannan from mycobacterium tuberculosis, a tlr2 ligand) and lps (lipopolysaccharide from escherichia coli, a tlr4 ligand). |
2014-01-21 |
2023-08-12 |
human |
| Quang-Tam Nguyen, Thu-Ha T Nguyen, Seong-A Ju, Yea-Sol Lee, Seung Hyun Han, Sang-Chul Lee, Byoung S Kwon, Rina Yu, Gyu Yeol Kim, Byung Ju Lee, Byung-Sam Ki. CD137 expressed on neutrophils plays dual roles in antibacterial responses against Gram-positive and Gram-negative bacterial infections. Infection and immunity. vol 81. issue 6. 2013-08-08. PMID:23545301. |
furthermore, we found that combined signaling of cd137 and toll-like receptor 2 (tlr2) induced synergistic production of tumor necrosis factor alpha (tnf-α) and interleukin-6 (il-6) by neutrophils, but combined signaling of cd137 and tlr4 did not. |
2013-08-08 |
2023-08-12 |
mouse |
| Fu Yunhe, Liu Bo, Feng Xiaosheng, Li Fengyang, Liang Dejie, Liu Zhicheng, Li Depeng, Cao Yongguo, Zhang Xichen, Zhang Naisheng, Yang Zhengta. The effect of magnolol on the Toll-like receptor 4/nuclear factor κB signaling pathway in lipopolysaccharide-induced acute lung injury in mice. European journal of pharmacology. vol 689. issue 1-3. 2013-05-23. PMID:22683864. |
the extent of phosphorylation of nuclear factor of inhibitory kappa b alpha (iκb-α), nuclear factor kappa-b (nf-κb) p65 and the expression of toll-like receptor-4 (tlr4) were detected by western blot. |
2013-05-23 |
2023-08-12 |
mouse |
| L I Garay, M C González Deniselle, M E Brocca, A Lima, P Roig, A F De Nicol. Progesterone down-regulates spinal cord inflammatory mediators and increases myelination in experimental autoimmune encephalomyelitis. Neuroscience. vol 226. 2013-04-22. PMID:23000619. |
real time pcr technology demonstrated that progesterone blocked the eae-induced increase of the proinflammatory mediators tumor necrosis factor alpha (tnfα) and its receptor tnfr1, the microglial marker cd11b and toll-like receptor 4 (tlr4) mrnas, and increased mrna expression of plp and mbp, the myelin transcription factors nkx2.2 and olig1 and enhanced cc1+oligodendrocyte density respect of untreated eae mice. |
2013-04-22 |
2023-08-12 |
mouse |
| Ping Fan, Jian-Jun Zhang, Bo Wang, Han-Qing Wu, Si-Xing Zhou, Chun-You Wang, Jing-Hui Zhang, Yuan Tian, He-Shui W. Hypoxia-inducible factor-1 up-regulates the expression of Toll-like receptor 4 in pancreatic cancer cells under hypoxic conditions. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. vol 12. issue 2. 2012-11-20. PMID:22487528. |
in this study, the correlation between the expression of tlr4 and the change of the protein level of hypoxia-inducible factor-1 alpha (hif-1α) was studied. |
2012-11-20 |
2023-08-12 |
Not clear |
| Prasad Rallabhandi, Rachel L Phillips, Marina S Boukhvalova, Lioubov M Pletneva, Kari Ann Shirey, Theresa L Gioannini, Jerrold P Weiss, Jesse C Chow, Lynn D Hawkins, Stefanie N Vogel, Jorge C G Blanc. Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2. mBio. vol 3. issue 4. 2012-10-22. PMID:22872782. |
both rhodobacter sphaeroides lps and synthetic e5564 (eritoran), lps antagonists that inhibit tlr4 signaling by binding a hydrophobic pocket in md-2, significantly reduced rsv f-protein-mediated tlr4 activity in hek293t-tlr4-cd14-md-2 transfectants in a dose-dependent manner, while tlr4-independent nf-κb activation by tumor necrosis factor alpha (tnf-α) was unaffected. |
2012-10-22 |
2023-08-12 |
Not clear |
| Mark Asquith, Kristen Haberthur, Monica Brown, Flora Engelmann, Ashleigh Murphy, Zainab Al-Mahdi, Ilhem Messaoud. Age-dependent changes in innate immune phenotype and function in rhesus macaques (Macaca mulatta). Pathobiology of aging & age related diseases. vol 2. 2012-09-06. PMID:22953039. |
we also found that tlr4, tlr5, and innate negative regulator, sterile alpha and tir motif containing protein (sarm), were all expressed at lower levels in young animals. |
2012-09-06 |
2023-08-12 |
monkey |
| Long Peng, Yan-Ting Luo, Jin-Lai Li. [The effects of atorvastatin on C-reactive protein induced Toll-like receptor 4 expression on CD14+ monocyte]. Zhonghua xin xue guan bing za zhi. vol 39. issue 7. 2012-06-25. PMID:22088250. |
to investigate the effects of atorvastatin on c-reactive protein (crp) induced toll-like receptor 4 (tlr4)expression on cd14+ monocyte, and the production of proinflammatory cytokines tumor necrosis factor alpha (tnfalpha), interleukin-6 (il-6), matrix metalloproteinases-9 (mmp-9), and to study the anti-inflammatory mechanisms of statins. |
2012-06-25 |
2023-08-12 |
Not clear |
| Zhen Yan, Qiao Zhang, Lei Xu, Wei-dong Wu, Wen-jie Ren, Lin-hong Liu, Wu Yao, Yi-ming W. [Involvement of Toll-like receptor in silica-induced tumor necrosis factor alpha release from human macrophage cell line]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 28. issue 6. 2012-06-07. PMID:21033154. |
to characterize the role of toll-like receptor 4 (tlr4) in silica-induced production of tumor necrosis factor alpha (tnfalpha) from macrophage cell line. |
2012-06-07 |
2023-08-12 |
human |
| Patricia G Vallés, Silvia Melechuck, Adriana González, Walter Manucha, Victoria Bocanegra, Roberto Vallé. Toll-like receptor 4 expression on circulating leucocytes in hemolytic uremic syndrome. Pediatric nephrology (Berlin, Germany). vol 27. issue 3. 2012-05-25. PMID:21969092. |
moreover, tlr4 protein expression on neutrophils, determined by flow cytometry, was upregulated, driving dependent proinflammatory cytokine, tumor necrosis factor alpha (tnf-α), and interleukin 8 (il-8) increase, and decreased anti-inflammatory il-10 release at hus onset compared with patients with ehec diarrhea and controls. |
2012-05-25 |
2023-08-12 |
Not clear |
| Xin Kuang, Yan Huang, Hong-Feng Gu, Xu-Yu Zu, Wang-Yuan Zou, Zong-Bin Song, Qu-Lian Gu. Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats. European journal of pharmacology. vol 676. issue 1-3. 2012-05-18. PMID:22173123. |
lumbar spinal cord was sampled and the mrna and protein expressions of tlr4 and high mobility group 1 protein (hmgb1) were detected, the contents of tumor necrosis factor alpha (tnf-α), interleukin-1 beta (il-1β) and interleukin-10 (il-10) were measured by elisa, and immunohistochemistry for nuclear factor kappa b (nf-κb) was also carried out. |
2012-05-18 |
2023-08-12 |
rat |