| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hsueh-Fang Wang, Chien-Yu Tseng, Mu-Hsin Chang, James A Lin, Fu-Jen Tsai, Chang-Hai Tsai, Ying-Chen Lu, Chao-Hung Lai, Chih-Yang Huang, Cheng-Chih Tsa. Anti-inflammatory effects of probiotic Lactobacillus paracasi on ventricles of BALB/C mice treated with ovalbumin. The Chinese journal of physiology. vol 55. issue 1. 2012-04-19. PMID:22242953. |
the inflammatory pathway, including toll-like receptor 4 (tlr4), phospholate-jun-n-terminal kinase (p-jnk), jnk1/2 and tumor necrosis factor- alpha (tnf-α) and the mitochondria-dependent apoptosis phospholate-p38 (p-p38), bcl-2 associated agonist of cell death (bad), bcl-2 associated x (bax) and activated caspase 3, were found to be significant- ly increased in the hearts of allergy mice. |
2012-04-19 |
2023-08-12 |
mouse |
| Duangjit Kanistanon, Daniel A Powell, Adeline M Hajjar, Mark R Pelletier, Ilana E Cohen, Sing Sing Way, Shawn J Skerrett, Xiaoyuan Wang, Christian R H Raetz, Robert K Erns. Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses. Infection and immunity. vol 80. issue 3. 2012-04-09. PMID:22215738. |
to determine the mechanism(s) by which the host controlled primary infection by the lpxf-null mutant, the role of innate immune components, including toll-like receptor 2 (tlr2), tlr4, caspase-1, myd88, alpha interferon (ifn-α), and gamma interferon(ifn-γ), was examined using knockout mice. |
2012-04-09 |
2023-08-12 |
mouse |
| Kelli K Ryckman, Scott M Williams, Marijane A Krohn, Hyagriv N Simha. Interaction between interleukin-1 receptor 2 and Toll-like receptor 4, and cervical cytokines. Journal of reproductive immunology. vol 90. issue 2. 2011-11-14. PMID:21704385. |
the objective was to assess the impact of genetic variation on cervical cytokine concentrations of interleukin (il)-1α, il-1β, il-6, il-8 and tumor necrosis factor alpha (tnf-α), and first, to determine if these variants interact with polymorphisms in toll-like receptor 4 (tlr4) that were previously shown to associate with pro-inflammatory cervical cytokine concentrations, and second, to determine if findings are affected by bacterial vaginosis (bv). |
2011-11-14 |
2023-08-12 |
Not clear |
| Anne-Marie Chaussé, Olivier Grépinet, Elisabeth Bottreau, Yves Le Vern, Pierrette Menanteau, Jérome Trotereau, Vincent Robert, Zhiguang Wu, Dominique Kerboeuf, Catherine Beaumont, Philippe Velg. Expression of Toll-like receptor 4 and downstream effectors in selected cecal cell subpopulations of chicks resistant or susceptible to Salmonella carrier state. Infection and immunity. vol 79. issue 8. 2011-09-13. PMID:21628520. |
we analyzed the mrna expression of tlr4, interleukin-1β (il-1β), il-8, il-12, and lipopolysaccharide-induced tumor necrosis factor alpha factor (litaf) in cecal subpopulations of chicks from inbred lines resistant or susceptible to the carrier state infected with salmonella enterica serovar enteritidis. |
2011-09-13 |
2023-08-12 |
mouse |
| Carolina Gallego, Douglas Golenbock, Maria Adelaida Gomez, Nancy Gore Saravi. Toll-like receptors participate in macrophage activation and intracellular control of Leishmania (Viannia) panamensis. Infection and immunity. vol 79. issue 7. 2011-09-02. PMID:21518783. |
l. panamensis infection resulted in upregulation of tlr1, tlr2, tlr3, and tlr4 expression and induced tumor necrosis factor alpha (tnf-α) secretion by human primary macrophages at comparable levels and kinetics to those of specific tlr ligands. |
2011-09-02 |
2023-08-12 |
mouse |
| Jin-Bin Wu, Hin-Ru Chuang, Li-Chan Yang, Wen-Chuan Li. A standardized aqueous extract of Anoectochilus formosanus ameliorated thioacetamide-induced liver fibrosis in mice: the role of Kupffer cells. Bioscience, biotechnology, and biochemistry. vol 74. issue 4. 2010-08-10. PMID:20378990. |
an in vitro study showed that the inhibitive effect of kinsenoside, a major component of saeaf, on tumor necrosis factor alpha (tnf-alpha) secretion from kupffer cells might be derived at least partly from downregulation of lps-receptor toll-like receptor 4 (tlr4) signaling. |
2010-08-10 |
2023-08-12 |
mouse |
| M J Zhu, M Du, P W Nathanielsz, S P For. Maternal obesity up-regulates inflammatory signaling pathways and enhances cytokine expression in the mid-gestation sheep placenta. Placenta. vol 31. issue 5. 2010-08-03. PMID:20185176. |
mo increased mrna levels of toll-like receptor (tlr) 2 (p < 0.05) and tlr4 (p = 0.06), macrophage markers cluster of differentiation (cd)11b (p = 0.06), cd14 and cd68 (p < 0.05), and proinflammatory cytokines tumor necrosis factor (tnf)alpha (p < 0.01), interleukin (il)-6 (p < 0.05), il-8(p < 0.01) and il-18 (p = 0.06), in cot tissue. |
2010-08-03 |
2023-08-12 |
Not clear |
| Sindhu Saraswathy, Angeline M Nguyen, Narsing A Ra. The role of TLR4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis. Investigative ophthalmology & visual science. vol 51. issue 7. 2010-08-02. PMID:20207969. |
the role of tlr4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis. |
2010-08-02 |
2023-08-12 |
mouse |
| Souvenir D Tachado, Xin Li, Medhavi Bole, Katharine Swan, Asha Anandaiah, Naimish R Patel, Henry Kozie. MyD88-dependent TLR4 signaling is selectively impaired in alveolar macrophages from asymptomatic HIV+ persons. Blood. vol 115. issue 17. 2010-05-20. PMID:20197549. |
tlr4-mediated tumor necrosis factor alpha (tnfalpha) release is significantly impaired in hiv(+) macrophages, but whether hiv impairs myeloid differentiation factor 88 (myd88)-dependent and/or myd-independent tlr4 signaling pathways in human macrophages is not known. |
2010-05-20 |
2023-08-12 |
human |
| Sally A Nicholas, Vadim V Sumbaye. The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1 alpha prolyl hydroxylation. Immunology and cell biology. vol 88. issue 2. 2010-05-18. PMID:19841637. |
in this study, we report that r848 (specific ligand)-induced activation of endosomal tlrs 7 and 8 (which recognize viral single-stranded rna) and lipopolysaccharide (lps)-induced activation of tlr4 (which specifically recognizes lps as a ligand) leads to downregulation of degradative hif-1 alpha prolyl hydroxylation. |
2010-05-18 |
2023-08-12 |
Not clear |
| Cheng-Ying Wu, Pei-Ling Chi, Hsi-Lung Hsieh, Shue-Fen Luo, Chuen-Mao Yan. TLR4-dependent induction of vascular adhesion molecule-1 in rheumatoid arthritis synovial fibroblasts: Roles of cytosolic phospholipase A(2)alpha/cyclooxygenase-2. Journal of cellular physiology. vol 223. issue 2. 2010-05-06. PMID:20112284. |
treatment of ra synovial fibroblasts (rasfs) with lps, a tlr4 agonist, promoted the vcam-1 expression and thp-1 adherence which were decreased by pretreatment with a selective cytosolic phospholipase a(2) (cpla(2)) inhibitor (aacocf(3)), implying the involvement of cpla(2)alpha in these responses. |
2010-05-06 |
2023-08-12 |
human |
| Geun-Tae Kim, Mi-La Cho, Young-Eun Park, Wan Hee Yoo, Jung-Hee Kim, Hye-Jwa Oh, Dae-Sung Kim, Seung-Hoon Baek, Sun-Hee Lee, Jun-Hee Lee, Ho-Youn Kim, Sung-Il Ki. Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis. Clinical rheumatology. vol 29. issue 3. 2010-04-13. PMID:19953283. |
the aim of this study was to investigate the expressions of toll-like receptor (tlr) 2, tlr4, tlr9, and their correlations with the expression of cytokines that are associated with activation of cd4(+) t cells and inflammation including interferon gamma (ifngamma), interleukin 4 (il4), interleukin 17 (il17), and tumor necrosis factor alpha (tnfalpha) in muscle tissues of patients with dermatomyositis (dm) and polymyositis (pm). |
2010-04-13 |
2023-08-12 |
Not clear |
| Flávio V Loures, Adriana Pina, Maíra Felonato, Eliseu F Araújo, Katia R M Leite, Vera L G Calic. Toll-like receptor 4 signaling leads to severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells. Infection and immunity. vol 78. issue 3. 2010-03-26. PMID:20008536. |
tlr4-competent mice produced elevated levels of il-12 and tumor necrosis factor alpha (tnf-alpha), besides cytokines of the th17 pattern, indicating a proinflammatory role for tlr4 signaling. |
2010-03-26 |
2023-08-12 |
mouse |
| Sami Banerjee, Jaroslaw W Zmijewski, Emmanuel Lorne, Gang Liu, Yonggang Sha, Edward Abraha. Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide. The Journal of biological chemistry. vol 285. issue 4. 2010-02-22. PMID:19933270. |
recent studies have indicated that increases in intracellular concentrations of hydrogen peroxide (h(2)o(2)) have anti-inflammatory effects in neutrophils, including inhibition of the degradation of i kappab alpha after tlr4 engagement. |
2010-02-22 |
2023-08-12 |
mouse |
| T Eoin West, Thomas R Hawn, Shawn J Skerret. Toll-like receptor signaling in airborne Burkholderia thailandensis infection. Infection and immunity. vol 77. issue 12. 2009-12-04. PMID:19797072. |
in macrophages, tlr4 and the adaptor molecule myd88, but not tlr2 or tlr5, are required for tumor necrosis factor alpha production induced by b. thailandensis. |
2009-12-04 |
2023-08-12 |
mouse |
| Kristy J Szretter, Melanie A Samuel, Susan Gilfillan, Anja Fuchs, Marco Colonna, Michael S Diamon. The immune adaptor molecule SARM modulates tumor necrosis factor alpha production and microglia activation in the brainstem and restricts West Nile Virus pathogenesis. Journal of virology. vol 83. issue 18. 2009-10-02. PMID:19587044. |
sterile alpha and heat/armadillo motif (sarm) is a highly conserved toll/interleukin-1 receptor (tir)-containing adaptor protein that is believed to negatively regulate signaling of the pathogen recognition receptors toll-like receptor 3 (tlr3) and tlr4. |
2009-10-02 |
2023-08-12 |
mouse |
| Carl F Raetzsch, Natasha L Brooks, J McKee Alderman, Kelli S Moore, Peter A Hosick, Simon Klebanov, Shizuo Akira, James E Bear, Albert S Baldwin, Nigel Mackman, Terry P Comb. Lipopolysaccharide inhibition of glucose production through the Toll-like receptor-4, myeloid differentiation factor 88, and nuclear factor kappa b pathway. Hepatology (Baltimore, Md.). vol 50. issue 2. 2009-08-21. PMID:19492426. |
we set out to determine whether insulin resistance is linked to hypoglycemia through toll-like receptor-4 (tlr4), myeloid differentiation factor 88 (myd88), and nuclear factor kappab (nfkappab), a cell signaling pathway that mediates lps induction of the proinflammatory cytokine tumor necrosis factor alpha (tnfalpha). |
2009-08-21 |
2023-08-12 |
mouse |
| ZhengYu He, YeSen Zhu, Hong Jian. Toll-like receptor 4 mediates lipopolysaccharide-induced collagen secretion by phosphoinositide3-kinase-Akt pathway in fibroblasts during acute lung injury. Journal of receptor and signal transduction research. vol 29. issue 2. 2009-08-21. PMID:19519177. |
we found that overexpression of tlr4, type i procollagen, alpha smooth muscle actin (alpha-sma), and p-akt in primary cultured mouse lung fibroblast stimulated by lps were detected by real-time pcr or western blots, and the contents of c-terminal propeptide of type i procollagen (picp) in cell culture supernatants were increased simultaneously. |
2009-08-21 |
2023-08-12 |
mouse |
| Xu Teng, Ling-Fen Xu, Ping Zhou, Hong-Wei Sun, Mei Su. Effects of trefoil peptide 3 on expression of TNF-alpha, TLR4, and NF-kappaB in trinitrobenzene sulphonic acid induced colitis mice. Inflammation. vol 32. issue 2. 2009-06-17. PMID:19238529. |
the main aims of this study is to evaluate effects of intraperitoneal injection recombinant human tff3 on the expression of tumour necrosis factor alpha (tnf-alpha), toll-like receptor 4(tlr4), and nuclear factor kappab (nf-kappab) in trinitrobenzene sulphonic acid (tnbs) induced colitis mice. |
2009-06-17 |
2023-08-12 |
mouse |
| Vijay A K Rathinam, Daniel M Appledorn, Kathleen A Hoag, Andrea Amalfitano, Linda S Mansfiel. Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes. Infection and immunity. vol 77. issue 6. 2009-06-09. PMID:19332531. |
similarly, c. jejuni-induced secretion of il-12, il-6, and tumor necrosis factor alpha was significantly inhibited in tlr2(-/-), tlr4(-/-), myd88(-/-), and trif(-/-) dcs compared to that in wild-type dcs; however, the magnitude of inhibition was greater in myd88(-/-), trif(-/-), and tlr4(-/-) dcs than in tlr2(-/-) dcs. |
2009-06-09 |
2023-08-12 |
human |