| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lee-Wei Chen, Wei-Jung Chang, Pei-Hsuan Chen, Wen-Chung Liu, Ching-Mei Hs. TLR ligand decreases mesenteric ischemia and reperfusion injury-induced gut damage through TNF-alpha signaling. Shock (Augusta, Ga.). vol 30. issue 5. 2009-04-20. PMID:18317407. |
we hypothesize that lps, a ligand for tlr4, decreases mesenteric i/r injury-induced gut damage through tumor necrosis factor alpha (tnf-alpha) signaling. |
2009-04-20 |
2023-08-12 |
mouse |
| Jesús M Pradillo, David Fernández-López, Isaac García-Yébenes, Mónica Sobrado, Olivia Hurtado, María A Moro, Ignacio Lizasoai. Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning. Journal of neurochemistry. vol 109. issue 1. 2009-04-13. PMID:19200341. |
western blot analysis of tumor necrosis factor alpha (tnf-alpha), inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2) showed an up-regulation in the expression of these proteins in both substrains of mice measured 18, 24 and 48 h after ipc, being higher in mice with tlr4. |
2009-04-13 |
2023-08-12 |
mouse |
| Sherene Shalhub, Tam N Pham, Nicole S Gibran, Grant E O'keef. Tumor necrosis factor gene variation and the risk of mortality after burn injury: a cohort study. Journal of burn care & research : official publication of the American Burn Association. vol 30. issue 1. 2009-03-06. PMID:19060757. |
we genotyped single nucleotide polymorphism (snps) in toll-like receptor 4 (tlr4) a896g, tumor necrosis factor alpha (tnf-alpha) g-308a, interleukin-6 (il-6) g-174c, interleukin-1beta (il-1beta) t-31c, and cluster of differentiation marker 14 (cd14) c-159t. |
2009-03-06 |
2023-08-12 |
human |
| Wlodzimierz Ptak, Monika Majewska, Krzysztof Bryniarski, Maria Ptak, Francis M Lobo, Katarzyna Zajac, Philip W Askenase, Marian Szczepani. Epicutaneous immunization with protein antigen in the presence of TLR4 ligand induces TCR alpha beta+CD4+ T contrasuppressor cells that reverse skin-induced suppression of Th1-mediated contact sensitivity. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 2. 2009-02-19. PMID:19124727. |
epicutaneous immunization with protein antigen in the presence of tlr4 ligand induces tcr alpha beta+cd4+ t contrasuppressor cells that reverse skin-induced suppression of th1-mediated contact sensitivity. |
2009-02-19 |
2023-08-12 |
mouse |
| S C Soares, K Abé-Sandes, V B Nascimento Filho, F M F Nunes, W A Silv. Genetic polymorphisms in TLR4, CR1 and Duffy genes are not associated with malaria resistance in patients from Baixo Amazonas region, Brazil. Genetics and molecular research : GMR. vol 7. issue 4. 2009-02-06. PMID:19048480. |
according to the results obtained and statistical analysis considering a significance level or alpha = 0.01, we conclude that the low heterozygote frequency (2.27%) for the asp299gly mutation, detected in the tlr4 gene, is not related to the pv and pf infections in the patients analyzed. |
2009-02-06 |
2023-08-12 |
human |
| Sandra Ribes, Sandra Ebert, Dirk Czesnik, Tommy Regen, Andre Zeug, Stephanie Bukowski, Alexander Mildner, Helmut Eiffert, Uwe-Karsten Hanisch, Sven Hammerschmidt, Roland Na. Toll-like receptor prestimulation increases phagocytosis of Escherichia coli DH5alpha and Escherichia coli K1 strains by murine microglial cells. Infection and immunity. vol 77. issue 1. 2009-01-23. PMID:18981243. |
here, murine microglial cultures were stimulated with the tlr agonists pam(3)csk(4) (tlr1/tlr2), lipopolysaccharide (tlr4), and cpg oligodeoxynucleotide (tlr9) for 24 h. upon stimulation, levels of tumor necrosis factor alpha and the neutrophil chemoattractant cxcl1 were increased, indicating microglial activation. |
2009-01-23 |
2023-08-12 |
Not clear |
| David A Bergin, Catherine M Greene, Erwin E Sterchi, Cliona Kenna, Patrick Geraghty, Abderrazzaq Belaaouaj, Abderazzaq Belaaouaj, Clifford C Taggart, Shane J O'Neill, Noel G McElvane. Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway. The Journal of biological chemistry. vol 283. issue 46. 2009-01-07. PMID:18772136. |
confocal studies confirmed colocalization of egfr and tlr4 in 16hbe14o- cells stimulated with meprin alpha. |
2009-01-07 |
2023-08-12 |
mouse |
| Shanta M Zimmer, Jin Liu, Jaime L Clayton, David S Stephens, James P Snyde. Paclitaxel binding to human and murine MD-2. The Journal of biological chemistry. vol 283. issue 41. 2008-11-10. PMID:18650420. |
as measured by human tumor necrosis factor alpha production, human thp-1 monocytes expressing tlr4 and md-2 were poorly responsive to the addition of ptx, but murine macrophages expressing tlr4 and md-2 responded in a dose-dependent manner. |
2008-11-10 |
2023-08-12 |
mouse |
| Harjinder Lall, Karen Coughlan, Vadim V Sumbaye. HIF-1alpha protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports Toll-like receptor 4-mediated production of IL-6. Molecular immunology. vol 45. issue 11. 2008-07-29. PMID:18462799. |
recently it was found that tlr4 downstream signalling leads to the accumulation of hypoxia-inducible factor 1 alpha (hif-1alpha), which is important for tlr4-dependent expression of pro-inflammatory cytokines, however, basic biochemical mechanisms of involvement of this protein in tlr4 downstream signalling remains unclear. |
2008-07-29 |
2023-08-12 |
Not clear |
| J Singh, R D Murray, G Mshelia, Z Woldehiwe. The immune status of the bovine uterus during the peripartum period. Veterinary journal (London, England : 1997). vol 175. issue 3. 2008-06-27. PMID:17400489. |
activation of tlr4 triggers the production of tumour necrosis factor alpha and other pro-inflammatory cytokines. |
2008-06-27 |
2023-08-12 |
cattle |
| Kazunori Otsui, Nobutaka Inoue, Seiichi Kobayashi, Rio Shiraki, Tomoyuki Honjo, Motonori Takahashi, Ken-Ichi Hirata, Seinosuke Kawashima, Mitsuhiro Yokoyam. Enhanced expression of TLR4 in smooth muscle cells in human atherosclerotic coronary arteries. Heart and vessels. vol 22. issue 6. 2008-06-03. PMID:18044001. |
stimulation with tumor necrosis factor alpha and angiotensin ii increased the expression of tlr4 mrna in cultured human vascular smooth muscle cells. |
2008-06-03 |
2023-08-12 |
human |
| Simon Rousseau, Matoula Papoutsopoulou, Antony Symons, Dorthe Cook, John M Lucocq, Alan R Prescott, Anne O'Garra, Steven C Ley, Philip Cohe. TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages. Journal of cell science. vol 121. issue Pt 2. 2008-05-21. PMID:18187448. |
here, we demonstrate that, unexpectedly, tpl2-deficient or mkk1-inhibited macrophages produce near normal levels of pre-tnf alpha when tlr2, tlr4 and tlr6 are activated by their respective agonists, but fail to secrete tnfalpha. |
2008-05-21 |
2023-08-12 |
Not clear |
| Maria L D Udan, Deepa Ajit, Nikkilina R Crouse, Michael R Nichol. Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line. Journal of neurochemistry. vol 104. issue 2. 2008-02-05. PMID:17986235. |
using antibody neutralization assays and tumor necrosis factor alpha release in the human monocytic thp-1 cell line, we determined that both tlr2 and tlr4 mediated an inflammatory response to aggregated abeta(1-42). |
2008-02-05 |
2023-08-12 |
human |
| Maria L D Udan, Deepa Ajit, Nikkilina R Crouse, Michael R Nichol. Toll-like receptors 2 and 4 mediate Abeta(1-42) activation of the innate immune response in a human monocytic cell line. Journal of neurochemistry. vol 104. issue 2. 2008-02-05. PMID:17986235. |
these data demonstrate that fibrillar abeta(1-42) can trigger the innate immune response and that both tlr2 and tlr4 mediate abeta-induced tumor necrosis factor alpha production in a human monocytic cell line. |
2008-02-05 |
2023-08-12 |
human |
| Amy Thomas, Carl Laxton, Joanne Rodman, Nisha Myangar, Nigel Horscroft, Tanya Parkinso. Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. Antimicrobial agents and chemotherapy. vol 51. issue 8. 2007-10-19. PMID:17548497. |
tlr4 and tlr8 agonists were found to strongly induce the proinflammatory cytokines interleukin 1beta and tumor necrosis factor alpha at concentrations similar to those inducing antiviral activity. |
2007-10-19 |
2023-08-12 |
human |
| Xinhua Zhang, Yuko Kimura, Chongyun Fang, Lin Zhou, Georgia Sfyroera, John D Lambris, Rick A Wetsel, Takashi Miwa, Wen-Chao Son. Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood. vol 110. issue 1. 2007-09-27. PMID:17363730. |
the tlr ligands lipopolysacharride (tlr4), zymosan (tlr2/6), and cpg oligonucleotide (tlr9) caused, in a complement-dependent manner, strikingly elevated plasma interleukin-6 (il-6), tumor necrosis factor alpha (tnf-alpha), and il-1beta, and/or decreased plasma il-12 levels in mice deficient in the membrane complement inhibitor decay-accelerating factor (daf). |
2007-09-27 |
2023-08-12 |
mouse |
| Zhao-xia Duan, Pei-fang Zhu, Hong Dong, Wei Gu, Ce Yang, Qing Liu, Zheng-guo Wang, Jian-xin Jian. Functional significance of the TLR4/11367 polymorphism identified in Chinese Han population. Shock (Augusta, Ga.). vol 28. issue 2. 2007-09-27. PMID:17529905. |
the tlr4 protein expression on peripheral leukocytes and plasma tumor necrosis factor alpha levels were determined by means of flow cytometry and enzyme-linked immunosorbent assay. |
2007-09-27 |
2023-08-12 |
human |
| Zhao-xia Duan, Pei-fang Zhu, Hong Dong, Wei Gu, Ce Yang, Qing Liu, Zheng-guo Wang, Jian-xin Jian. Functional significance of the TLR4/11367 polymorphism identified in Chinese Han population. Shock (Augusta, Ga.). vol 28. issue 2. 2007-09-27. PMID:17529905. |
in response to ex vivo lps stimulation, the tlr4 expression on the surface of peripheral leukocytes and the plasma tumor necrosis factor alpha levels were significantly lower in carriers of 11367c variant allele than in carriers of 11367g allele. |
2007-09-27 |
2023-08-12 |
human |
| Katie J Loniewski, Sonika Patial, Narayanan Parameswara. Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages. Molecular immunology. vol 44. issue 15. 2007-07-30. PMID:17507094. |
furthermore, although tlr4-mediated ikk-induced p105 phosphorylation is not sensitive to traf6 knockdown, i kappa b alpha phosphorylation (also, ikk-induced) is significantly blocked, suggesting that tlr4 activation results in a traf6-sensitive and -insensitive ikk activation in macrophages. |
2007-07-30 |
2023-08-12 |
mouse |
| Katie J Loniewski, Sonika Patial, Narayanan Parameswara. Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages. Molecular immunology. vol 44. issue 15. 2007-07-30. PMID:17507094. |
in contrast to tlr4 signaling, tlr7 activation of erk, jnk pathways and phosphorylation of p105 and i kappa b alpha are completely inhibited in traf6 knockdown cells. |
2007-07-30 |
2023-08-12 |
mouse |