| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ozlem Equils, Alan Shapiro, Zeynep Madak, Chunren Liu, Daning L. Human immunodeficiency virus type 1 protease inhibitors block toll-like receptor 2 (TLR2)- and TLR4-Induced NF-kappaB activation. Antimicrobial agents and chemotherapy. vol 48. issue 10. 2004-11-29. PMID:15388451. |
human microvessel endothelial cells were transiently transfected with either endothelial cell-leukocyte adhesion molecule nf-kappab luciferase or interleukin 6 (il-6) promoter luciferase constructs by using fugene 6, and they were treated with pi (nelfinavir, ritonavir, or saquinavir) prior to stimulation with the toll-like receptor 4 (tlr4) and tlr2 ligands, with lipopolysaccharide (lps), soluble mycobacterium tuberculosis factor, or staphylococcus epidermidis phenol-soluble modulin, respectively, or with tumor necrosis factor alpha (tnf-alpha). |
2004-11-29 |
2023-08-12 |
human |
| Matthew P Hardy, Anne F McGGettrick, Luke A J O'Neil. Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene. The Biochemical journal. vol 380. issue Pt 1. 2004-10-26. PMID:14960149. |
trif expression can be induced by multiple stimuli, such as the ligands for tlr2, tlr3 and tlr4, and by the pro-inflammatory cytokines tumour necrosis factor alpha and interleukin-1alpha. |
2004-10-26 |
2023-08-12 |
human |
| Lisa C Parker, Moira K B Whyte, Stefanie N Vogel, Steven K Dower, Ian Sabro. Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 8. 2004-07-27. PMID:15067079. |
tlr2 activation caused slower induction of the nf-kappa b and mitogen-activated protein kinase signaling pathways and yet a much enhanced and prolonged macrophage-inflammatory protein 1 alpha (cc chemokine ligand 3) protein production, when compared with tlr4 stimulation. |
2004-07-27 |
2023-08-12 |
human |
| F Y Tanga, V Raghavendra, J A DeLe. Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. Neurochemistry international. vol 45. issue 2-3. 2004-07-26. PMID:15145554. |
spinal lumbar mrna levels of glial fibrillary acidic protein (gfap), integrin alpha m (itgam), toll-like receptor 4 (tlr4) and cluster determinant 14 (cd14) were assayed using real-time reverse transcription polymerase chain reaction (rt-pcr) at 4 h, 1, 4, 7, 14 and 28 days post surgery. |
2004-07-26 |
2023-08-12 |
rat |
| Eric D Boehmer, Joanna Goral, Douglas E Faunce, Elizabeth J Kovac. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. Journal of leukocyte biology. vol 75. issue 2. 2004-03-26. PMID:14634059. |
macrophages produce proinflammatory cytokines, tumor necrosis factor alpha (tnf-alpha) and interleukin (il)-6, when stimulated with lipopolysaccharide (lps), which signals through toll-like receptor-4 (tlr4) and requires activation of mitogen-activated protein kinases (mapks). |
2004-03-26 |
2023-08-12 |
mouse |
| Martha M Monick, Timur O Yarovinsky, Linda S Powers, Noah S Butler, A Brent Carter, Gunnar Gudmundsson, Gary W Hunninghak. Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. The Journal of biological chemistry. vol 278. issue 52. 2004-02-10. PMID:14565959. |
the increased tlr4 results in an lps-induced inflammatory response as demonstrated by increased mitogen-activated protein (map) kinase activity, il-8 production, and tumor necrosis factor alpha production. |
2004-02-10 |
2023-08-12 |
Not clear |
| Martha M Monick, Timur O Yarovinsky, Linda S Powers, Noah S Butler, A Brent Carter, Gunnar Gudmundsson, Gary W Hunninghak. Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. The Journal of biological chemistry. vol 278. issue 52. 2004-02-10. PMID:14565959. |
rsv infection also allowed for tumor necrosis factor alpha production subsequent to tlr4 cross-linking with an immobilized antibody. |
2004-02-10 |
2023-08-12 |
Not clear |
| Mohammad Reza Mirlashari, Torstein Lyber. Expression and involvement of Toll-like receptors (TLR)2, TLR4, and CD14 in monocyte TNF-alpha production induced by lipopolysaccharides from Neisseria meningitidis. Medical science monitor : international medical journal of experimental and clinical research. vol 9. issue 8. 2004-02-09. PMID:12942028. |
the present study was undertaken to examine the ability of lipopolysaccharide-containing outer membrane vesicles (omv-lps) and purified lps (p-lps) from the same meningococcal strain to induce the expression of toll-like receptors (tlr2 and tlr4) and tnf-alpha production in leukocytes, and further to study the involvement of tlrs, and cd14 in monocyte tnf- alpha production in an ex vivo human whole blood system. |
2004-02-09 |
2023-08-12 |
human |
| Marco A Campos, Gracia M S Rosinha, Igor C Almeida, Xirlene S Salgueiro, Bruce W Jarvis, Gary A Splitter, Nilofer Qureshi, Oscar Bruna-Romero, Ricardo T Gazzinelli, Sergio C Oliveir. Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice. Infection and immunity. vol 72. issue 1. 2004-02-02. PMID:14688095. |
consistently, macrophages from c3h/hepas mice exposed to r and s strains and their lps produced higher levels of tumor necrosis factor alpha (tnf-alpha) and interleukin-12 compared to c3h/hej, a tlr4 mutant mouse. |
2004-02-02 |
2023-08-12 |
mouse |
| Qian Li, Bobby J Cherayi. Role of Toll-like receptor 4 in macrophage activation and tolerance during Salmonella enterica serovar Typhimurium infection. Infection and immunity. vol 71. issue 9. 2003-09-29. PMID:12933828. |
we found that macrophages from the c3h/hej mouse strain, which carries a functionally inactive tlr4 gene, exhibit marked impairment of tumor necrosis factor alpha (tnf-alpha) secretion in response to s. enterica serovar typhimurium infection. |
2003-09-29 |
2023-08-12 |
mouse |
| P'ng Loke, James P Alliso. PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 9. 2003-06-11. PMID:12697896. |
pd-l1 up-regulation depends on tlr4 and stat1, whereas pd-l2 expression depends on il-4r alpha and stat6. |
2003-06-11 |
2023-08-12 |
Not clear |