| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marygorret Obonyo, Mojgan Sabet, Sheri P Cole, Joerg Ebmeyer, Satoshi Uematsu, Shizuo Akira, Donald G Guine. Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori. Infection and immunity. vol 75. issue 5. 2007-06-14. PMID:17353291. |
to investigate the contribution of the innate immune system to h. pylori infection, bone marrow-derived macrophages from mice deficient in tlr2, tlr4, tlr9, and myd88 were infected with h. pylori ss1 and sd4 for 24 or 48 h. we demonstrate that myd88 was essential for h. pylori induction of all cytokines investigated except alpha interferon (ifn-alpha). |
2007-06-14 |
2023-08-12 |
mouse |
| Ronan Kapetanovic, Marie-Anne Nahori, Viviane Balloy, Catherine Fitting, Dana J Philpott, Jean-Marc Cavaillon, Minou Adib-Conqu. Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages. Infection and immunity. vol 75. issue 2. 2007-03-08. PMID:17118979. |
using knockout mice, we confirmed that the tlr4 and tlr2 contribution was predominant in the induction of tumor necrosis factor alpha and interleukin-10 by gram-negative bacteria. |
2007-03-08 |
2023-08-12 |
mouse |
| Xiaoyi Yan, Fangming Xiu, Huazhang An, Xiaojian Wang, Jianli Wang, Xuetao Ca. Fever range temperature promotes TLR4 expression and signaling in dendritic cells. Life sciences. vol 80. issue 4. 2007-02-08. PMID:17084417. |
in this study, we found that pretreatment of dcs with 39.5 degrees c temperature can up-regulate tlr4 expression in dcs and enhances lps-induced dc production of interleukins (il) il-6, il-10 and il-12 but not tumor necrosis factor alpha (tnf-alpha). |
2007-02-08 |
2023-08-12 |
Not clear |
| Mohammad K Mohammad, Michael Morran, Brandon Slotterbeck, Douglas W Leaman, Yaping Sun, Hermann von Grafenstein, Soon-Cheol Hong, Marcia F McInerne. Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse. International immunology. vol 18. issue 7. 2006-08-18. PMID:16728431. |
dysregulation of tlr4 expression in the diabetic state correlated with increased nuclear factor kappa b (nf-kappab) activation in response to the tlr4 ligand lps and higher expression of il-12p40, tumor necrosis factor alpha (tnfalpha), il-6 and inducible nitric oxide synthase but lowered expression of il-10. |
2006-08-18 |
2023-08-12 |
mouse |
| Gisela Soboll, Mardi A Crane-Godreau, Magdalena A Lyimo, Charles R Wir. Effect of oestradiol on PAMP-mediated CCL20/MIP-3 alpha production by mouse uterine epithelial cells in culture. Immunology. vol 118. issue 2. 2006-08-04. PMID:16771853. |
when epithelial cells were treated with the toll-like receptor (tlr) agonists pam3cys (tlr2/1), peptidoglycan (tlr2/6) or lipopolysaccharide (lps; tlr4), ccl20/mip-3 alpha increased rapidly (4 hr) in both apical and basolateral secretions. |
2006-08-04 |
2023-08-12 |
mouse |
| Stefanie N Vogel, Agnes A Awomoyi, Prasad Rallabhandi, Andrei E Medvede. Mutations in TLR4 signaling that lead to increased susceptibility to infection in humans: an overview. Journal of endotoxin research. vol 11. issue 6. 2006-01-17. PMID:16303088. |
to date, mutations in the extracellular domain of tlr4 itself, irak-4, nemo (ikk gamma), and i kappa b alpha have been identified and profoundly affect the host response to infection. |
2006-01-17 |
2023-08-12 |
Not clear |
| Bernd Raffeiner, Christian Dejaco, Christina Duftner, Werner Kullich, Christian Goldberger, Sandra C Vega, Michael Keller, Beatrix Grubeck-Loebenstein, Michael Schirme. Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis. Arthritis research & therapy. vol 7. issue 6. 2006-01-10. PMID:16277694. |
incubation of peripheral blood mononuclear cells with tumour necrosis factor alpha led to an upregulation of tlr4 and tlr2 on cd4+cd28null t cells in vitro, and treatment of patients with antibodies specifically directed against tumour necrosis factor alpha resulted in decreased expression of tlr4 and tlr2 on cd4+cd28null t cells in vivo. |
2006-01-10 |
2023-08-12 |
Not clear |
| Molly A Hughes, Candace S Green, Lisa Lowchyj, Gloria M Lee, Vanessa K Grippe, Michael F Smith, Li-Yun Huang, Eric T Harvill, Tod J Merke. MyD88-dependent signaling contributes to protection following Bacillus anthracis spore challenge of mice: implications for Toll-like receptor signaling. Infection and immunity. vol 73. issue 11. 2005-12-06. PMID:16239556. |
heat-killed bacillus anthracis stimulated tlr2, but not tlr4, signaling in hek293 cells and stimulated tumor necrosis factor alpha (tnf-alpha) production in c3h/hen, c3h/hej, and c57bl/6j bone marrow-derived macrophages. |
2005-12-06 |
2023-08-12 |
mouse |
| Wen-Jye Lin, Wen-Chen Ye. Implication of Toll-like receptor and tumor necrosis factor alpha signaling in septic shock. Shock (Augusta, Ga.). vol 24. issue 3. 2005-11-23. PMID:16135957. |
in recent years, there has been significant progress in understanding the signaling pathways activated by lps and its receptor toll-like receptor 4 (tlr4), as well as by tumor necrosis factor alpha (tnfalpha), a potent inflammatory cytokine induced by lps stimulation. |
2005-11-23 |
2023-08-12 |
Not clear |
| L Vychodilova-Krenkova, J Matiasovic, P Hori. Single nucleotide polymorphisms in four functionally related immune response genes in the horse: CD14,TLR4, Cepsilon, andFcepsilon R1 alpha. International journal of immunogenetics. vol 32. issue 5. 2005-11-03. PMID:16164694. |
single nucleotide polymorphisms in four functionally related immune response genes in the horse: cd14,tlr4, cepsilon, andfcepsilon r1 alpha. |
2005-11-03 |
2023-08-12 |
Not clear |
| L Vychodilova-Krenkova, J Matiasovic, P Hori. Single nucleotide polymorphisms in four functionally related immune response genes in the horse: CD14,TLR4, Cepsilon, andFcepsilon R1 alpha. International journal of immunogenetics. vol 32. issue 5. 2005-11-03. PMID:16164694. |
the genes analysed were: the lipopolysaccharide (lps) receptor gene cd14, the toll-like receptor 4 gene tlr4, the gene cepsilon encoding the ige heavy chain molecule and the gene fcepsilonr1 alpha coding for the alpha subunit of the ige receptor molecule. |
2005-11-03 |
2023-08-12 |
Not clear |
| L Vychodilova-Krenkova, J Matiasovic, P Hori. Single nucleotide polymorphisms in four functionally related immune response genes in the horse: CD14,TLR4, Cepsilon, andFcepsilon R1 alpha. International journal of immunogenetics. vol 32. issue 5. 2005-11-03. PMID:16164694. |
three snps were found in the cd14 gene, four in the tlr4 gene; two snps were identified in the cepsilon gene, and one snp was found in the fcepsilonr1 alpha gene. |
2005-11-03 |
2023-08-12 |
Not clear |
| Yi Jia, John J Ture. Altered NF-kappaB gene expression and collagen formation induced by polyunsaturated fatty acids. The Journal of nutritional biochemistry. vol 16. issue 8. 2005-09-22. PMID:16043032. |
genes in the nf-kappab signaling pathway that had increased expression in epa-treated cells included the toll-like receptor 4 (tlr4), adaptor proteins [tnf receptor-associated factor 6 (traf6), myeloid differentiation primary response gene 88], signal transduction kinases (nf-kappab-inducing kinase, inhibitors of kappa light polypeptide gene enhancer isoforms), inhibitor protein (i-kappab alpha chain), transcription factors (nuclear factor of kappa light chain gene enhancer, (p)105 and nf-kappab subunit p100), dna binding proteins (camp response element binding protein) and response genes known to affect cp [interleukin 6 (il-6), inducible nitric oxide synthase (inos), monocyte chemotactic protein-1]. |
2005-09-22 |
2023-08-12 |
Not clear |
| Huazhang An, Hongmei Xu, Minghui Zhang, Jun Zhou, Tao Feng, Cheng Qian, Runzi Qi, Xuetao Ca. Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism. Blood. vol 105. issue 12. 2005-07-13. PMID:15701712. |
ship1-specific rna-interfering and ship1 overexpression experiments demonstrate that ship1 inhibits lps-induced tumor necrosis factor alpha (tnf-alpha) and interleukin 6 (il-6) production by negatively regulating the lps-induced combination between tlr4 and myeloid differentiation factor 88 (myd88); activation of ras (p21(ras) protein), pi-3k, extracellular signal-regulated kinase 1/2 (erk1/2), p38, and c-jun nh2-terminal kinase (jnk); and degradation of ikappab-alpha. |
2005-07-13 |
2023-08-12 |
Not clear |
| Qing-Wu Yang, Ling Mou, Feng-Lin Lv, Pei-Fang Zhu, Zheng-Guo Wang, Jian-Xin Jiang, Jing-Zhou Wan. Novel TLR4-antagonizing peptides inhibit LPS-induced release of inflammatory mediators by monocytes. Biochemical and biophysical research communications. vol 329. issue 3. 2005-05-16. PMID:15752733. |
the two peptides were found to significantly inhibit lps-induced nf-kappab activation in hek-293 cells that were transfected with tlr4 cdna, lps-induced ikappabalpha (ikappab alpha) phosphorylation and nf-kappab activation in monocytes, and release of il-1, il-6, and tnf-alpha by monocytes. |
2005-05-16 |
2023-08-12 |
Not clear |
| Eva Lorenz, Diana C Chemotti, Alice L Jiang, Letitia D McDouga. Differential involvement of toll-like receptors 2 and 4 in the host response to acute respiratory infections with wild-type and mutant Haemophilus influenzae strains. Infection and immunity. vol 73. issue 4. 2005-04-14. PMID:15784548. |
in response to h. influenzae htrb infection, tumor necrosis factor alpha (tnf-alpha) secretion remained tlr4 dependent. |
2005-04-14 |
2023-08-12 |
mouse |
| Manoj Muthukuru, Ravi Jotwani, Christopher W Cutle. Oral mucosal endotoxin tolerance induction in chronic periodontitis. Infection and immunity. vol 73. issue 2. 2005-03-11. PMID:15664906. |
in vitro studies with human mc indicate that mc respond to an initial stimulus of lipopolysaccharide (lps) from porphyromonas gingivalis (pglps) or escherichia coli (eclps) by upregulation of tlr2 and tlr4 mrna and protein; moreover, il-1beta mrna is induced and tumor necrosis factor alpha (tnf-alpha), il-10, il-6, and il-8 proteins are secreted. |
2005-03-11 |
2023-08-12 |
human |
| Thomas J Murphy, Hugh M Paterson, Sara Kriynovich, Yan Zang, Evelyn A Kurt-Jones, John A Mannick, James A Ledere. Linking the "two-hit" response following injury to enhanced TLR4 reactivity. Journal of leukocyte biology. vol 77. issue 1. 2005-03-08. PMID:15496450. |
using high-purity escherichia coli lipopolysaccharide (lps) to selectively stimulate toll-like receptor 4 (tlr4), we demonstrate augmented interleukin (il)-1beta, tumor necrosis factor alpha (tnf-alpha), and il-6 production by 1 day but particularly, at 7 days after injury. |
2005-03-08 |
2023-08-12 |
mouse |
| Masahiro Kaneko, Tsunehide Mizunuma, Hiroaki Takimoto, Yoshio Kumazaw. Development of TCR alpha beta CD8 alpha alpha intestinal intraepithelial lymphocytes is promoted by interleukin-15-producing epithelial cells constitutively stimulated by gram-negative bacteria via TLR4. Biological & pharmaceutical bulletin. vol 27. issue 6. 2005-01-25. PMID:15187438. |
development of tcr alpha beta cd8 alpha alpha intestinal intraepithelial lymphocytes is promoted by interleukin-15-producing epithelial cells constitutively stimulated by gram-negative bacteria via tlr4. |
2005-01-25 |
2023-08-12 |
mouse |
| Paul B Mann, Kelly D Elder, Mary J Kennett, Eric T Harvil. Toll-like receptor 4-dependent early elicited tumor necrosis factor alpha expression is critical for innate host defense against Bordetella bronchiseptica. Infection and immunity. vol 72. issue 11. 2004-12-02. PMID:15501798. |
however, early tumor necrosis factor alpha (tnf-alpha) mrna expression is primarily dependent on tlr4 and in vitro and in vivo protein levels substantiate this finding. |
2004-12-02 |
2023-08-12 |
mouse |