| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad Gharaibeh, Monica Hagedorn, Stefanie Lilla, Matthias Hauptmann, Holger Heine, Bernhard Fleischer, Christian Kelle. Toll-Like Receptor 2 Recognizes Orientia tsutsugamushi and Increases Susceptibility to Murine Experimental Scrub Typhus. Infection and immunity. vol 84. issue 12. 2017-05-18. PMID:27620720. |
by overexpression of tlr2 or tlr4 in hek293 cells, we demonstrated that tlr2, but not tlr4, recognizes heat-stable compounds of o. tsutsugamushi that were sensitive to treatment with sodium hydroxide, hydrogen peroxide, and proteinase k. tlr2 was required for the secretion of tumor necrosis factor alpha (tnf-α) and interleukin-6 (il-6) by dendritic cells. |
2017-05-18 |
2023-08-13 |
mouse |
| Xiaojie Cao, Lili Zhang, Chunhai Chen, Qingsong Wang, Lu Guo, Qinlong Ma, Ping Deng, Gang Zhu, Binghu Li, Yan Pi, Chunyan Long, Lei Zhang, Zhengping Yu, Zhou Zhou, Jingcheng L. The critical role of ABCG1 and PPARγ/LXRα signaling in TLR4 mediates inflammatory responses and lipid accumulation in vascular smooth muscle cells. Cell and tissue research. vol 368. issue 1. 2017-05-15. PMID:27807703. |
the expression of peroxisome proliferator-activated receptor gamma (pparγ), liver x receptor alpha (lxrα) and abcg1 was inhibited by tlr4 activation. |
2017-05-15 |
2023-08-13 |
mouse |
| Rémi Planès, Nawal Ben Haij, Kaoutar Leghmari, Manutea Serrero, Lbachir BenMohamed, Elmostafa Bahraou. HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes. Journal of virology. vol 90. issue 13. 2017-05-10. PMID:27053552. |
the pretreatment of human monocytes with tat protein for 10 to 30 min suffices to irreversibly engage the activation of the tlr4 pathway, leading to the production of tumor necrosis factor alpha (tnf-α) and interleukin-10 (il-10), two cytokines strongly implicated in the chronic activation and dysregulation of the immune system during hiv-1 infection. |
2017-05-10 |
2023-08-13 |
mouse |
| Wu Wu, Qing Chen, Feng Geng, Li Tong, Rui Yang, Jinju Yang, Hongwei Zhang, Zongchao Jia, Qun We. Calcineurin B stimulates cytokine production through a CD14-independent Toll-like receptor 4 pathway. Immunology and cell biology. vol 94. issue 3. 2016-12-13. PMID:26471241. |
in this study, we demonstrate that extracellular cnb was effectively internalized through a cd14-independent toll-like receptor 4 (tlr4) pathway, which led to the phosphorylation of nuclear factor (nf)-kappa-b inhibitor alpha (iκb-α) and upregulation of pro-inflammatory cytokines in human monocytes. |
2016-12-13 |
2023-08-13 |
human |
| Mohammad Jafari, Mohammad Reza Nasiri, Roozbeh Sanaei, Saber Anoosheh, Parisa Farnia, Adel Sepanjnia, Nader Taji. The NRAMP1, VDR, TNF-α, ICAM1, TLR2 and TLR4 gene polymorphisms in Iranian patients with pulmonary tuberculosis: A case-control study. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. vol 39. 2016-12-13. PMID:26774366. |
since human genetic variation is an important determinant in the outcome of infection with m. tuberculosis, we typed polymorphisms in the innate immune molecules, such as natural-resistance-associated macrophage protein 1 (nramp1), vitamin d receptor (vdr), tumor necrosis factor alpha (tnf-α), intercellular adhesion molecule1 (icam-1), toll-like receptor 2 (tlr2) and toll-like receptor 4 (tlr4) in a case-control study of pulmonary tuberculosis in iranian population. |
2016-12-13 |
2023-08-13 |
human |
| Mardi M Algandaby, Ali M El-Halawany, Hossam M Abdallah, Abdulrahman M Alahdal, Ayman A Nagy, Osama M Ashour, Ashraf B Abdel-Nai. Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators. Naunyn-Schmiedeberg's archives of pharmacology. vol 389. issue 4. 2016-12-13. PMID:26809353. |
the observed antifibrotic activities involved decreased production of nuclear factor κb (nf-κb), tumor necrosis factor alpha (tnf-α), expression of toll-like receptor 4 (tlr4), intercellular adhesion molecule (icam), and vascular cell adhesion molecule (vcam). |
2016-12-13 |
2023-08-13 |
rat |
| Parisa Davoodi, P A Mahesh, Amrutha D Holla, Nallur B Ramachandr. A preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (IL4), IL13, IL4 receptor alpha (IL4Rα) & Toll-like receptor 4 (TLR4) genes with asthma in Indian adults. The Indian journal of medical research. vol 142. issue 6. 2016-10-31. PMID:26831416. |
a preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (il4), il13, il4 receptor alpha (il4rα) & toll-like receptor 4 (tlr4) genes with asthma in indian adults. |
2016-10-31 |
2023-08-13 |
Not clear |
| Kai-Hei Tse, Kevin B S Chow, Helen Wis. PGE2 released by primary sensory neurons modulates Toll-like receptor 4 activities through an EP4 receptor-dependent process. Journal of neuroimmunology. vol 293. 2016-08-17. PMID:27049555. |
we show here that endogenously-produced nanomolar concentrations of pge2, such as that generated in response to toll-like receptor 4 (tlr4) stimulation, inhibits both cyclooxygenase-2 (cox-2) and tumour necrosis factor alpha (tnfα) mrna expression in drg cells in an ep4 receptor-dependent manner. |
2016-08-17 |
2023-08-13 |
Not clear |
| Chao Cui, Peng Wang, Ningshan Cui, Shuliang Song, Hao Liang, Aiguo J. Sulfated polysaccharide isolated from the sea cucumber Stichopus japonicas promotes the SDF-1α/CXCR4 axis-induced NSC migration via the PI3K/Akt/FOXO3a, ERK/MAPK, and NF-κB signaling pathways. Neuroscience letters. vol 616. 2016-08-04. PMID:26827717. |
these effects are accompanied by the up-regulation of nestin, n-cadherin, tlr4, tnf-α, cyclin d1, egfr, alpha 6 integrin, mmp-2, mmp-9, and inos, including sdf-1α and cxcr4 themselves. |
2016-08-04 |
2023-08-13 |
Not clear |
| Darin J Knapp, Kathryn M Harper, Buddy A Whitman, Zachary Zimomra, George R Brees. Stress and Withdrawal from Chronic Ethanol Induce Selective Changes in Neuroimmune mRNAs in Differing Brain Sites. Brain sciences. vol 6. issue 3. 2016-07-30. PMID:27472367. |
restraint stress alone elevated chemokine (c-c motif) ligand 2 (ccl2), interleukin-1-beta (il-1β), tumor necrosis factor alpha (tnfα) and toll-like receptor 4 (tlr4) mrnas in the cerebral cortex within 4 h with a return to a control level by 24 h. these increases were not accompanied by an increase in corresponding proteins. |
2016-07-30 |
2023-08-13 |
rat |
| Nikos E Papaioannou, Ioannis F Voutsas, Pinelopi Samara, Ourania E Tsitsiloni. A flow cytometric approach for studying alterations in the cytoplasmic concentration of calcium ions in immune cells following stimulation with thymic peptides. Cellular immunology. vol 302. 2016-07-28. PMID:26790897. |
we tried to detect such changes, in intracellular signaling pathways downstream tlr4 in immune cells, following stimulation with prothymosin alpha (protα) and its decapeptide protα(100-109). |
2016-07-28 |
2023-08-13 |
human |
| Huiqi Wang, Yuanzhuo Chen, Wenjie Li, Congye Li, Xiangyu Zhang, Hu Peng, Chengjin Ga. Ligustrazine effect on lipopolysaccharide-induced pulmonary damage in rats. Burns : journal of the International Society for Burn Injuries. vol 41. issue 6. 2016-06-20. PMID:26088147. |
blood gas analysis, hematoxylin-eosin staining dye extravasation and diffuse alveolar damage (dad) score, the wet/dry lung tissue (w/d) ratios, the expression of cd31+ vascular endothelial microparticles (emps), tumor necrosis factor alpha (tnf-α) levels, and the protein expression of rho-associated coiled-coil-forming protein kinase (rock) ii and toll-like receptor 4 (tlr4) were analyzed. |
2016-06-20 |
2023-08-13 |
rat |
| Xue-mei Mo, Han-xiao Su. The Anti-inflammatory Effect of the CXCR4 Antagonist-N15P Peptide and Its Modulation on Inflammation-Associated Mediators in LPS-Induced PBMC. Inflammation. vol 38. issue 3. 2016-02-23. PMID:25676435. |
in this study, we evaluated the anti-inflammatory effects of n15p polypeptide by the lps-induced peripheral blood mononuclear cell (pbmc) model and measured the level of inflammatory factors (tumor necrosis factor alpha (tnf-α), il-6, il-8, nuclear factor kappab (nf-κb), cyclooxygenase-2 (cox-2), toll-like receptor 4 (tlr4), myd88, phosphoinositide 3-kinase (pi3k), and akt). |
2016-02-23 |
2023-08-13 |
Not clear |
| Yu-Li Lin, Yu-Chen Hu, Cheng-Chao Liang, Shih-Yeh Lin, Yu-Chih Liang, Hui-Ping Yuan, Bor-Luen Chian. Enterovirus-71 virus-like particles induce the activation and maturation of human monocyte-derived dendritic cells through TLR4 signaling. PloS one. vol 9. issue 10. 2016-01-01. PMID:25360749. |
our study findings clarified the important role for tlr4 signaling in dcs in response to ev71 vlps and showed that ev71 vlps induced inhibitor of kappab alpha (iκbα) degradation and nuclear factor of kappab (nf-κb) activation. |
2016-01-01 |
2023-08-13 |
human |
| D T Babiker, S M Bakhiet, M M Mukhta. Leishmania donovani influenced cytokines and Toll-like receptors expression among Sudanese visceral leishmaniasis patients. Parasite immunology. vol 37. issue 8. 2015-12-15. PMID:25982946. |
the production of interleukin 10 (il-10), tumour necrosis factor alpha (tnf) and interferon gamma (ifng) cytokines was measured, and the expression of toll-like receptors (tlr2, tlr4 and tlr9) was done in the blood samples and also in the thp1 cell line. |
2015-12-15 |
2023-08-13 |
human |
| Yoshiteru Kagawa, Yuki Yasumoto, Kazem Sharifi, Majid Ebrahimi, Ariful Islam, Hirofumi Miyazaki, Yui Yamamoto, Tomoo Sawada, Hiroko Kishi, Sei Kobayashi, Motoko Maekawa, Takeo Yoshikawa, Eiichi Takaki, Akira Nakai, Hiroshi Kogo, Toyoshi Fujimoto, Yuji Owad. Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-1. Glia. vol 63. issue 5. 2015-12-07. PMID:25601031. |
in fabp7-knockout (ko) astrocytes, the ligand-dependent accumulation of toll-like receptor 4 (tlr4) and glial cell-line-derived neurotrophic factor receptor alpha 1 into lipid raft was decreased, and the activation of mitogen-activated protein kinases and nuclear factor-κb was impaired after lipopolysaccharide (lps) stimulation when compared with wild-type astrocytes. |
2015-12-07 |
2023-08-13 |
Not clear |
| W Shen, A Chang, J Wang, W Zhou, R Gao, J Li, Y Xu, X Luo, R Xiang, N Luo, D G Stupac. TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer. Oncogenesis. vol 4. 2015-10-27. PMID:26501855. |
tifa-mediated oligomerization and poly-ubiquitinylation of traf6 mediates signaling downstream of the tumor necrosis factor alpha receptor 1 (tnfar-i) and interleukin-1/toll-like receptor 4 (tlr4) pathways. |
2015-10-27 |
2023-08-13 |
mouse |
| Durbadal Ojha, Hemanta Mukherjee, Supriya Mondal, Aditya Jena, Ved Prakash Dwivedi, Keshab C Mondal, Bharti Malhotra, Amalesh Samanta, Debprasad Chattopadhya. Anti-inflammatory activity of Odina wodier Roxb, an Indian folk remedy, through inhibition of toll-like receptor 4 signaling pathway. PloS one. vol 9. issue 8. 2015-05-22. PMID:25153081. |
further, we determine the toll-like receptor 4 (tlr4), myeloid differentiation primary response gene 88 (myd88), c-jun n-terminal kinases (jnk), nuclear factor kappa-b cells (nf-κb), and nf-kb inhibitor alpha (ik-bα) by protein and mrna expression, and western blot analysis in drug treated lps-induced murine macrophage model. |
2015-05-22 |
2023-08-13 |
mouse |
| Peng Wang, Si-Wei You, Yin-Jie Yang, Xiao-Yan Wei, Ya-Zhou Wang, Xin Wang, Ding-Jun Hao, Fang Kuang, Li-Xin Shan. Systemic injection of low-dose lipopolysaccharide fails to break down the blood-brain barrier or activate the TLR4-MyD88 pathway in neonatal rat brain. International journal of molecular sciences. vol 15. issue 6. 2015-01-29. PMID:24905408. |
meanwhile, tlr4, adaptin myeloid differentiation factor 88 (myd88), nuclear transcription factor kappa-b (nf-κb) p50 and tumor necrosis factor alpha (tnfα) in the neonatal rat brain were determined by quantitative real-time polymerase chain reaction (pcr) and western blot. |
2015-01-29 |
2023-08-13 |
rat |
| Danielle J Glynn, Mark R Hutchinson, Wendy V Ingma. Toll-like receptor 4 regulates lipopolysaccharide-induced inflammation and lactation insufficiency in a mouse model of mastitis. Biology of reproduction. vol 90. issue 5. 2015-01-21. PMID:24671877. |
tlr4 null mutation resulted in an altered immune-signaling fingerprint following induction of mastitis, with attenuated serum cytokines, including cxcl1, ccl2, interleukin 1 beta, and tumor necrosis factor alpha compared to wild-type mice. |
2015-01-21 |
2023-08-12 |
mouse |