| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sedigheh Amiresmaili, Mohammad Khaksari, Nader Shahrokhi, Moslem Abolhassan. Evolution of TLR4 role in mediating the hepatoprotective effects of estradiol after traumatic brain injury in male rats. Biochemical pharmacology. vol 178. 2020-12-07. PMID:32445868. |
also, both classic [estrogen receptors alpha (erα) and beta (erβ)] and non-classic (g protein-coupled estrogen receptor gper) e2 receptors are involved in modulating the expression of tlr4. |
2020-12-07 |
2023-08-13 |
rat |
| Mohammad Borhan Al-Zghoul, Khaled Musa Mohammad Sale. Effects of thermal manipulation of eggs on the response of jejunal mucosae to posthatch chronic heat stress in broiler chickens. Poultry science. vol 99. issue 5. 2020-11-16. PMID:32359610. |
in this study, the aim was to investigate effects of chronic heat stress (chs) on the mrna levels of proinflammatory cytokines (interleukin [il]-6, il-8, il-1β, and tumor necrosis factor alpha [tnf-α]), toll-like receptors (tlr2 and tlr4), heat shock proteins (hsp70, heat shock transcription factor [hsf]-1, and hsf3) and antioxidant enzymes (catalase, glutathione peroxidase, nadph oxidase, and superoxide-dismutase) in the jejunal mucosae of broiler chickens subjected to thermal manipulation (tm) during embryogenesis. |
2020-11-16 |
2023-08-13 |
Not clear |
| Keisuke Tobita, Itsuki Watanabe, Masanori Sait. Specific vaginal lactobacilli suppress the inflammation induced by lipopolysaccharide stimulation through downregulation of toll-like receptor 4 expression in human embryonic intestinal epithelial cells. Bioscience of microbiota, food and health. vol 36. issue 1. 2020-09-30. PMID:28243550. |
exposure of int-407 cells to vlb attenuated both the lipopolysaccharide (lps)-induced stimulation of interleukin-8 and tumor necrosis factor alpha production and the lps-stimulated upregulation of tlr4 expression. |
2020-09-30 |
2023-08-13 |
human |
| Sebok Kumar Halder, Hayato Matsunaga, Hiroshi Ued. Experimental evidence for the involvement of F Journal of pharmacological sciences. vol 143. issue 2. 2020-09-15. PMID:32156464. |
experimental evidence for the involvement of f the inhibition of retinal ischemia-induced damage by post-ischemic prothymosin alpha (protα) was not affected in toll-like receptor 4 knockout (tlr4 |
2020-09-15 |
2023-08-13 |
Not clear |
| Patrick Coulombe, Grigorios N Paliouras, Ashley Clayton, Angela Hussainkhel, Megan Fuller, Vida Jovanovic, Shauna Dauphinee, Patricia Umlandt, Ping Xiang, Alistair H Kyle, Andrew I Minchinton, R Keith Humphries, Pamela A Hoodless, Jeremy D K Parker, Joanne L Wright, Aly Karsa. Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling. Cell reports. vol 27. issue 6. 2020-07-01. PMID:31067462. |
the sterile alpha motif (sam) and src homology 3 (sh3) domain containing protein 1 (sash1) acts as a scaffold in tlr4 signaling. |
2020-07-01 |
2023-08-13 |
Not clear |
| Xiaoyun Zhao, Jihong Feng, Li Zhang, Fang Zhao, Meifeng Li, Ying Du, Yuechuan Li, Qi Wu, Guanhua L. One functional variant in the 3'-untranslated region of TLR4 is associated with the elevated risk of ventilator-associated pneumonia in the patients with chronic obstructive pulmonary disease. Journal of cellular physiology. vol 234. issue 10. 2020-06-01. PMID:30972742. |
after stimulating by lps, a tlr4 ligand, the cc-genotyped cells expressed higher levels of il-8, il-6, and tumor necrosis factor alpha (tnf-α) on their surfaces than cells with the other genotypes. |
2020-06-01 |
2023-08-13 |
human |
| Ashwini Y Ramdasi, Vidya A Arankall. The expression patterns of immune response genes in the Peripheral Blood Mononuclear cells of pregnant women presenting with subclinical or clinical HEV infection are different and trimester-dependent: A whole transcriptome analysis. PloS one. vol 15. issue 2. 2020-04-24. PMID:32012176. |
the data suggests possible involvement of tlr4 and nod1 in pregnant patients and alpha defensins in all patient categories suggesting a role in protection. |
2020-04-24 |
2023-08-13 |
Not clear |
| Hossein Omidi-Ardali, Zahra Lorigooini, Amin Soltani, Shima Balali-Dehkordi, Hossein Amini-Khoe. Inflammatory responses bridge comorbid cardiac disorder in experimental model of IBD induced by DSS: protective effect of the trigonelline. Inflammopharmacology. vol 27. issue 6. 2020-04-21. PMID:30924005. |
heart, intestine and serum samples were taken for assessment of total antioxidant capacity, malondialdehyde (mda), gene expressions of inflammatory markers including tumor necrosis factor alpha (tnf-α), interleukin 1-beta (il/1β), toll- like receptor 4 (tlr4) as well as for evaluation of histopathological alterations. |
2020-04-21 |
2023-08-13 |
mouse |
| N Saat, A Risvanli, H Dogan, E Onalan, N Akpolat, I Seker, E Sahn. Effect of melatonin on torsion and reperfusion induced pathogenesis of rat uterus. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 94. issue 7. 2020-02-20. PMID:31070494. |
the mrna levels of rho-associated, coiled-coil containing protein kinases 1 (rock1), homeobox d10 (hox4 hoxd10), tlr4, nfκb1, caveolin 1 (cav1) heat shock protein 90 alpha (cytosolic), class b member 1 (hsp90ab1) and glyceraldehyde-3-phosphate dehydrogenase (gapdh) were determined using quantitative real-time polymerase chain reaction analysis (qrt-pcr). |
2020-02-20 |
2023-08-13 |
rat |
| Guozhen Yuan, Anbang Han, Jing Wu, Yingdong Lu, Dandan Zhang, Yuxiu Sun, Jian Zhang, Mingjing Zhao, Bingbing Zhang, Xiangning Cu. Bao Yuan decoction and Tao Hong Si Wu decoction improve lung structural remodeling in a rat model of myocardial infarction: Possible involvement of suppression of inflammation and fibrosis and regulation of the TGF-β1/Smad3 and NF-κB pathways. Bioscience trends. vol 12. issue 5. 2019-05-14. PMID:30473557. |
the levels of transforming growth factor-β1 (tgf-β1), type i collagen, phosphorylated-smad3 (p-smad3), tumor necrosis factor-α (tnf-α), toll-like receptor 4 (tlr4), active nuclear factor κb (nf-κb) and alpha smooth muscle actin (α-sma) were detected using western blotting. |
2019-05-14 |
2023-08-13 |
rat |
| Yi Yang, Chenyang Han, Li Guo, Qiaobin Gua. High expression of the HMGB1-TLR4 axis and its downstream signaling factors in patients with Parkinson's disease and the relationship of pathological staging. Brain and behavior. vol 8. issue 4. 2019-02-25. PMID:29670828. |
to detect the expression of high-mobility group box protein 1 (hmgb1) and toll-like receptor 4 (tlr4) and their downstream signaling factors-myeloid differentiation factor 88 (myd88), nuclear factor kappa b (nf-κb), and tumor necrosis factor alpha (tnf-α)-in the sera of patients with parkinson's disease (pd) in order to evaluate the relationship of the hmgb1-tlr4 axis with pd development and progression. |
2019-02-25 |
2023-08-13 |
Not clear |
| Aaron L Slusher, Tiffany M Zúñiga, Edmund O Aceved. Maximal Exercise Alters the Inflammatory Phenotype and Response of Mononuclear Cells. Medicine and science in sports and exercise. vol 50. issue 4. 2019-01-15. PMID:29112629. |
monocytes express the cd14 receptor that facilitates lipopolysaccharide (lps) ligation to toll-like receptor 4 (tlr4) to elicit production of interleukin (il)-6, il-10, and tumor necrosis factor alpha (tnf-α). |
2019-01-15 |
2023-08-13 |
Not clear |
| Shoichi Kageyama, Kojiro Nakamura, Takehiro Fujii, Bibo Ke, Rebecca A Sosa, Elaine F Reed, Nakul Datta, Ali Zarrinpar, Ronald W Busuttil, Jerzy W Kupiec-Weglinsk. Recombinant relaxin protects liver transplants from ischemia damage by hepatocyte glucocorticoid receptor: From bench-to-bedside. Hepatology (Baltimore, Md.). vol 68. issue 1. 2018-12-28. PMID:29350771. |
rhrlx-induced gr suppressed hepatocyte high-mobility group box 1 (hmgb1) translocation/release, accompanied by decreased toll-like receptor 4 (tlr4)/receptor for advanced glycation end products (rage), suppressed interleukin 1 beta (il1β), chemokine (c-c motif) ligand 2 (ccl2), c-x-c motif chemokine (cxcl)10, tumor necrosis factor alpha (tnfα), cxcl1, and cxcl2 levels, and attenuated neutrophil/macrophage accumulation in olt. |
2018-12-28 |
2023-08-13 |
human |
| Hongli Chen, Xiaotong Sun, Xiaomei Yang, Yonghao Hou, Xiaoqian Yu, Yang Wang, Jianbo Wu, Dejie Liu, Huanliang Wang, Jingui Yu, Wenbo Y. Dexmedetomidine reduces ventilator-induced lung injury (VILI) by inhibiting Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signaling pathway. Bosnian journal of basic medical sciences. vol 18. issue 2. 2018-11-27. PMID:29510084. |
pathological changes, lung wet/dry (w/d) weight ratio, lung myeloperoxidase (mpo) activity, levels of inflammatory cytokines (i.e., interleukin [il]-1β, tumor necrosis factor alpha [tnf-α], and il-6) in the bronchoalveolar lavage fluid (balf) and lung tissues, expression of toll-like receptor 4 (tlr4) and nuclear factor (nf)-κb, and activation of nf-κb in lung tissues were measured. |
2018-11-27 |
2023-08-13 |
rat |
| Sajid Ur Rahman, Yu Li, Yingying Huang, Lei Zhu, Shibin Feng, Jinjie Wu, Xichun Wan. Treatment of inflammatory bowel disease via green tea polyphenols: possible application and protective approaches. Inflammopharmacology. vol 26. issue 2. 2018-09-05. PMID:29532213. |
green tea polyphenols (gtps) play significant roles in down regulating signaling pathways because gtps exert effective antioxidant properties and regulate toll-like receptor 4 (tlr4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (tnf-α) production by blocking transcription nuclear factor-kappa b (nf-kb) activation and upstream of mediated i kappa b kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (cox-2). |
2018-09-05 |
2023-08-13 |
Not clear |
| Hyunbin D Huh, Eun A Ra, Taeyun A Lee, Sujin Kang, Areum Park, Eunhye Lee, Junhee L Choi, Eunji Jang, Ji Eun Lee, Sungwook Lee, Boyoun Par. STRAP Acts as a Scaffolding Protein in Controlling the TLR2/4 Signaling Pathway. Scientific reports. vol 6. 2018-07-03. PMID:27934954. |
consequently, the depletion of strap severely impairs interleukin-6 (il-6), tumor necrosis factor alpha (tnf-α), and il-1β production, whereas its overexpression causes a significant increase in the secretion of these pro-inflammatory cytokines by tlr2 or tlr4 agonist-stimulated macrophages. |
2018-07-03 |
2023-08-13 |
Not clear |
| Li Liu, Jena J Steinl. Loss of TLR4 in mouse Müller cells inhibits both MyD88-dependent and -independent signaling. PloS one. vol 12. issue 12. 2018-02-07. PMID:29287085. |
we performed western blotting and elisa analyses to determine whether loss of tlr4 affected myeloid differentiation primary response protein (myd88)-dependent or -independent signaling, leading to reduced levels of tumor necrosis factor alpha (tnfα) and interleukin 1 beta (il1β) in whole retinal lysates from the tlr4 floxed and tlr4-pdgfrα-cre mice. |
2018-02-07 |
2023-08-13 |
mouse |
| Stefan Vordenbäumen, Thorsten Saenger, Achim Braukmann, Tamara Tahan, Ellen Bleck, Joachim Jose, Matthias Schneide. Human casein alpha s1 induces proinflammatory cytokine expression in monocytic cells by TLR4 signaling. Molecular nutrition & food research. vol 60. issue 5. 2017-12-05. PMID:26909866. |
human casein alpha s1 induces proinflammatory cytokine expression in monocytic cells by tlr4 signaling. |
2017-12-05 |
2023-08-13 |
human |
| Sakika Yanai, Daisuke Tokuhara, Daisuke Tachibana, Mika Saito, Yuko Sakashita, Haruo Shintaku, Masayasu Koyam. Diabetic pregnancy activates the innate immune response through TLR5 or TLR1/2 on neonatal monocyte. Journal of reproductive immunology. vol 117. 2017-12-04. PMID:27351455. |
after monocytes were cultured with lipopolysaccharide (tlr4 ligand), flagellin (tlr5 ligand), pam3csk4 (tlr1/tlr2 ligand), zymosan (tlr2/tlr6 ligand), or macrophage-activating lipopeptide (tlr2/tlr6 ligand) for 12h, the cytokine levels (interleukin [il]-8, il-6, il-1β, il-10, tumor necrosis factor alpha and il-12) in the culture supernatants were measured. |
2017-12-04 |
2023-08-13 |
Not clear |
| Derek W Edwardson, Justin Boudreau, Jonathan Mapletoft, Carita Lanner, A Thomas Kovala, Amadeo M Parissent. Inflammatory cytokine production in tumor cells upon chemotherapy drug exposure or upon selection for drug resistance. PloS one. vol 12. issue 9. 2017-10-12. PMID:28915246. |
tumor necrosis factor alpha (tnf-α) has been shown to be released by tumor cells in response to docetaxel, and lipopolysaccharides (lps), the latter through activation of toll-like receptor 4 (tlr4). |
2017-10-12 |
2023-08-13 |
Not clear |