| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Youngbum Cho, Jae-Yoon Kim, Namshin Ki. Comparative genomics and selection analysis of Yeonsan Ogye black chicken with whole-genome sequencing. Genomics. 2022-02-08. PMID:35134497. |
in particular, spp1 (secreted phosphoprotein 1), hsp90aa1 (heat shock protein 90 alpha family class a member 1), and p2rx4 (purinergic receptor p2x 4) could have considerable involvement in egg development and rnasel (ribonuclease l), brip1 (brca1 interacting protein c-terminal helicase 1), and tlr4 (toll-like receptor 4) are crucial for the determination of the innate immune response. |
2022-02-08 |
2023-08-13 |
chicken |
| Zhi-Peng Chen, Hai-Ping Huang, Xiao-Yan He, Bao-Zhen Wu, Yong Li. Early continuous blood purification affects TNF-α, IL-1β, and IL-6 in patients with severe acute pancreatitis via inhibiting TLR4 signaling pathway. The Kaohsiung journal of medical sciences. 2022-01-20. PMID:35049137. |
compared with group b, (1) the symptoms in group c improved more markedly; (2) protein contents of tlr4 and nuclear factor kappa b (nf-κb) in group c diminished more signally; (3) the abundances of tumor necrosis factor alpha (tnf-α), cytokine interleukin-1β (il-1β), and cytokine interleukin 6 (il-6) in group c decreased (p < 0.05); and (4) the abundance of tlr4 in group c was positively correlated with those of tnf-α, il-1β, and il-6 after treatment (all p < 0.001). |
2022-01-20 |
2023-08-13 |
Not clear |
| Tatsuro Egawa, Takeshi Ogawa, Takumi Yokokawa, Kohei Kido, Katsumasa Goto, Tatsuya Hayash. Methylglyoxal reduces molecular responsiveness to 4 weeks of endurance exercise in mouse plantaris muscle. Journal of applied physiology (Bethesda, Md. : 1985). 2022-01-13. PMID:35023763. |
mice in the voluntary exercise group were housed in a cage with a running wheel, while mice in the mg-treated groups received drinking water containing 1% mg. four weeks of voluntary exercise induced several molecular adaptations in the plantaris muscle, including increased expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (pgc1α), mitochondria complex proteins, toll-like receptor 4 (tlr4), 72-kda heat shock protein (hsp72), hexokinase ii, and glyoxalase 1; this also enhanced insulin-stimulated akt ser |
2022-01-13 |
2023-08-13 |
mouse |
| Chen Zhao, Yuwei Cao, Zhuo Zhang, Dechao Nie, Yanling L. Cinnamon and Eucalyptus Oils Suppress the Inflammation Induced by Lipopolysaccharide In Vivo. Molecules (Basel, Switzerland). vol 26. issue 23. 2021-12-10. PMID:34885991. |
the associated evaluation indicators include body weight gain, visceral edema coefficient, superoxide dismutase (sod), glutathione peroxidase (gsh-px), malondialdehyde (mda), nitrogen monoxide (no), interleukin-6 (il-6), interleukin-10 (il-10), tumor necrosis factor alpha (tnf-α), urea, crea, alt, tlr4, myd88, nf-κb, iκb-α, inos, and mn-sod. |
2021-12-10 |
2023-08-13 |
human |
| Yao Chen, Zhongshu Kuang, Wei Wei, Yanyan Hu, Sucheng Mu, Hailin Ding, Yi Han, Chaoyang Tong, Yilin Yang, Zhenju Son. Protective role of (5R)-5-hydroxytriptolide in lipopolysaccharide-induced acute lung injury by suppressing dendritic cell activation. International immunopharmacology. 2021-12-06. PMID:34865994. |
expression of toll-like receptor 4 (tlr4), phosphorylation of inhibitor kappa b alpha (iκbα) and nuclear translocation of nuclear factor kappa b (nf-κb) were explored by immunoblot. |
2021-12-06 |
2023-08-13 |
mouse |
| Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco E Bianchi, Hitoshi Okazaw. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology. Communications biology. vol 4. issue 1. 2021-11-11. PMID:34635772. |
extracellular high mobility group box 1 (hmgb1) protein, which is released from necrotic or hyper-activated neurons in ad, binds to toll-like receptor 4 (tlr4) of neighboring neurons, and activates protein kinase c alpha (pkcα) that executes ku70 phosphorylation at ser77/78. |
2021-11-11 |
2023-08-13 |
mouse |
| Xiao Sun, Yalei Cui, Yingying Su, Zimin Gao, Xinying Diao, Ju Li, Xiaoyan Zhu, Defeng Li, Zhentian Li, Chengzhang Wang, Yinghua Sh. Dietary Fiber Ameliorates Lipopolysaccharide-Induced Intestinal Barrier Function Damage in Piglets by Modulation of Intestinal Microbiome. mSystems. vol 6. issue 2. 2021-10-28. PMID:33824201. |
df improved intestinal morphology and barrier function, inhibited the expression of inflammatory signal pathways (toll-like receptor 2 [tlr2], tlr4, and nf-κb) and proinflammatory cytokines (interleukin 1β [il-1β], il-6, and tumor necrosis factor alpha [tnf-α]), and upregulated the expression of barrier-related genes (encoding claudin-1, occludin, and zo-1). |
2021-10-28 |
2023-08-13 |
Not clear |
| A M Kabel, H H Arab, M A Abd Elmaabou. Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis. Human & experimental toxicology. vol 40. issue 10. 2021-10-25. PMID:33840231. |
the survival rate, liver function tests, tissue antioxidant enzymes, malondialdehyde (mda), nuclear factor (erythroid derived 2)-like 2 (nrf2), transforming growth factor beta 1 (tgf-β1), interleukin 1 alpha (il-1α), and toll-like receptor 4 (tlr4) were measured. |
2021-10-25 |
2023-08-13 |
rat |
| Bo Pang, Ling Qiao, Shaoxin Wang, Xin Guo, Yun Xie, Liping Ha. MiR-214-3p plays a protective role in diabetic neuropathic rats by regulating Nav1.3 and TLR4. Cell biology international. vol 45. issue 11. 2021-10-15. PMID:34296787. |
in addition, sodium channel protein type 3 subunit alpha isoform 1 (nav1.3) and tlr4 were identified as targets of mir-214-3p via dual-luciferase reporter assay. |
2021-10-15 |
2023-08-13 |
rat |
| Minli Sun, Xiaodan Han, Di Zhou, Jing Zhong, Lixin Liu, Yirui Wang, Jiahui Ni, Xiaoyan Shen, Chao Liang, Hao Fan. BIG1 mediates sepsis-induced lung injury by modulating lipid raft-dependent macrophage inflammatory responses. Acta biochimica et biophysica Sinica. vol 53. issue 8. 2021-08-04. PMID:34153089. |
in vitro studies revealed that big1 deficiency reduces the upregulation and secretion of tumor necrosis factor alpha (tnf-α), interleukin-6 (il-6), and il-1β and inhibits the activation of the toll-like receptor 4 (tlr4)/myeloid differentiation primary response 88-dependent nuclear factor kappa-b signaling pathway induced by the lipopolysaccharide (lps) treatment. |
2021-08-04 |
2023-08-13 |
mouse |
| Alireza Karimollah, Anahid Hemmatpur, Taha Vahi. Revisiting bupropion anti-inflammatory action: involvement of the TLR2/TLR4 and JAK2/STAT3. Inflammopharmacology. vol 29. issue 4. 2021-07-23. PMID:34218389. |
pro-/anti-inflammatory cytokines [tumor necrosis factor alpha (tnfα), interleukin-1β (il-1β), il-17, and il-10] were assessed at both transcriptional and translational levels as well as the involvement of jak2 /stat3, tlr2, and tlr4 signaling in this process. |
2021-07-23 |
2023-08-13 |
human |
| Shang-Lang Huang, Ting-Chang Chang, Chuck C K Chao, Nian-Kang Su. TLR4/IL-6/IRF1 signaling regulates androgen receptor expression: A potential therapeutic target to overcome taxol resistance in ovarian cancer. Biochemical pharmacology. vol 186. 2021-06-30. PMID:33556340. |
in addition, tlr4 knockdown inhibits gp130 and il-6 receptor alpha (il6rα) activities, indicating that tlr4 plays a critical role in il-6 signaling. |
2021-06-30 |
2023-08-13 |
Not clear |
| Olivera Djuric, Marina Andjelkovic, Misa Vreca, Anita Skakic, Sonja Pavlovic, Ivana Novakovic, Bojan Jovanovic, Vesna Skodric-Trifunovic, Ljiljana Markovic-Deni. Genetic variants in TNFA, LTA, TLR2 and TLR4 genes and risk of sepsis in patients with severe trauma: nested case-control study in a level-1 trauma centre in SERBIA. Injury. vol 52. issue 3. 2021-06-17. PMID:33436266. |
we aimed to evaluate the association between 8 different snvs within tumor necrosis factor alpha (tnfa), lymphotoxin alpha (lta) and toll-like receptor (tlr2 and tlr4) genes and the risk of posttraumatic sepsis. |
2021-06-17 |
2023-08-13 |
Not clear |
| Virgínia Juliani Gomes, Priscila Rezeck Nunes, Mariana Letícia Matias, Vanessa Rocha Ribeiro, Amanda Carreira Devides, Camila Ferreira Bannwart-Castro, Graziela Gorete Romagnoli, José Carlos Peraçoli, Maria Terezinha Serrão Peraçoli, Mariana Romao-Veig. Silibinin induces in vitro M2-like phenotype polarization in monocytes from preeclamptic women. International immunopharmacology. vol 89. issue Pt A. 2021-06-03. PMID:33045562. |
the results showed that the in vitro treatment of monocytes from preeclamptic women with sb downregulated the endogenous activation of nf-κb and the expression of surface receptors tlr4 and cd64, and reduced the synthesis of the pro-inflammatory cytokines interleukin 1 (il-1β), il-6, il-8, il-12p70, il-23, and tumour necrosis factor alpha (tnf-α) compared with cultures not treated with sb. |
2021-06-03 |
2023-08-13 |
Not clear |
| Maiju Rinne, Kert Mätlik, Tiina Ahonen, Fabio Vedovi, Giovanni Zappia, Vânia M Moreira, Jari Yli-Kauhaluoma, Sakari Leino, Outi Salminen, Eija Kalso, Mikko Airavaara, Henri Xhaar. Mitoxantrone, pixantrone and mitoxantrone (2-hydroxyethyl)piperazine are toll-like receptor 4 antagonists, inhibit NF-κB activation, and decrease TNF-alpha secretion in primary microglia. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 154. 2021-05-26. PMID:32730846. |
mitoxantrone was shown to bind directly to the tlr4, and pixantrone and mitoxantrone (2-hydroxyethyl)piperazine were shown to inhibit the production of proinflammatory cytokines such as tumor necrosis factor alpha (tnfα) in primary microglia. |
2021-05-26 |
2023-08-13 |
Not clear |
| Huizong Su, Qian Wang, Yue Li, Jingyi Jin, Bo Tan, Dongming Yan, Bin Zou, Guochao Song, Fengyi Weng, Furong Qi. Effect of Different Ratios of Yinchen and Gancao Decoction on ANIT-Treated Cholestatic Liver Injury in Mice and Its Potential Underlying Mechanism. Frontiers in pharmacology. vol 12. 2021-05-04. PMID:33935705. |
moreover, the expression levels of toll-like receptor 4 (tlr4), interleukin-1β (il-1β), il-6, tumor necrosis factor alpha (tnf-α), c-c ligand 2 (ccl2), and c-x-c ligand 2 (cxcl2) in the liver were significantly reduced. |
2021-05-04 |
2023-08-13 |
mouse |
| Xiaokun Han, Xi Chen, Shuilian Chen, Qian Luo, Xuan Liu, Anqi He, Shengyu He, Jin Qiu, Pei Chen, Yihui Wu, Jiejie Zhuang, Meng Yang, Chuangran Wu, Nandan Wu, Ying Yang, Jian Ge, Jing Zhuang, Keming Y. Tetramethylpyrazine attenuates endotoxin-induced retinal inflammation by inhibiting microglial activation via the TLR4/NF-κB signalling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-03-01. PMID:32460188. |
moreover, toll like receptor 4 (tlr4), phosphorylation of inhibitor of nf-κb alpha (p-iκb-α) and the translocation of nuclear factor kappa b p65 (nf-κb p65) were significantly downregulated in retinal microglial cells with tmp pretreatment, which indicated that tmp might suppress lps-induced retinal microglial activation through tlr4/nf-κb signalling pathway. |
2021-03-01 |
2023-08-13 |
Not clear |
| Reina Sasaki, Tatsuo Kanda, Mariko Fujisawa, Naoki Matsumoto, Ryota Masuzaki, Masahiro Ogawa, Shunichi Matsuoka, Kazumichi Kuroda, Mitsuhiko Moriyam. Different Mechanisms of Action of Regorafenib and Lenvatinib on Toll-Like Receptor-Signaling Pathways in Human Hepatoma Cell Lines. International journal of molecular sciences. vol 21. issue 9. 2021-02-16. PMID:32397371. |
in response to lenvatinib, four and 16 genes were upregulated in huh7 and hepg2 cells, respectively, and two genes (interleukin 1 alpha and tlr4) were upregulated in both cells. |
2021-02-16 |
2023-08-13 |
human |
| Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Keyue Liu, Kiyoshi Teshigawara, Hideo Takahashi, Masahiro Nishibori, Shuji Mor. Differential contribution of possible pattern-recognition receptors to advanced glycation end product-induced cellular responses in macrophage-like RAW264.7 cells. Biotechnology and applied biochemistry. vol 67. issue 2. 2021-02-02. PMID:31654427. |
in the ko clone lacking tlr4 and tlr2, age-stimulated tumor necrosis factor alpha (tnf-α) expression and phosphorylation of iκbα, p38, and extracellular signal-regulated kinase (erk) were significantly attenuated, suggesting that age-mediated responses are largely dependent on tlrs. |
2021-02-02 |
2023-08-13 |
Not clear |
| Shefeng Zhang, Li Xu, Ruifeng Liang, Chenhua Yang, Peiren Wan. Baicalin suppresses renal fibrosis through microRNA-124/TLR4/NF-κB axis in streptozotocin-induced diabetic nephropathy mice and high glucose-treated human proximal tubule epithelial cells. Journal of physiology and biochemistry. vol 76. issue 3. 2021-02-01. PMID:32500512. |
protein levels of coliv, fn, nf-κb inhibitor alpha (iκbα), phosphorylated iκbα (p-iκbα), p65, phosphorylated p65 (p-p65), and toll-like receptor 4 (tlr4) were measured by western blot assay. |
2021-02-01 |
2023-08-13 |
mouse |