| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiu To Yeung, Angelica Guerrero-Castilla, Mercedes Cano, Mario F Muñoz, Antonio Ayala, Sandro Argüelle. Dysregulation of the Hippo pathway signaling in aging and cancer. Pharmacological research. vol 143. 2020-03-03. PMID:30910741. |
however, its deregulation can induce tumors throughout the body by regulating cell proliferation, disrupting cell polarity, releasing yap and taz from the scribble complexes and facilitating survival gene expression via activation of tead transcription factors. |
2020-03-03 |
2023-08-13 |
human |
| Nerea Borreguero-Muñoz, Georgina C Fletcher, Mario Aguilar-Aragon, Ahmed Elbediwy, Zoé I Vincent-Mistiaen, Barry J Thompso. The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth. PLoS biology. vol 17. issue 10. 2020-02-27. PMID:31613895. |
the hippo signalling pathway restricts cell proliferation in animal tissues by inhibiting yes-associated protein (yap or yap1) and transcriptional activator with a pdz domain (taz or ww-domain-containing transcriptional activator [wwtr1]), coactivators of the scalloped (sd or tead) dna-binding transcription factor. |
2020-02-27 |
2023-08-13 |
drosophila_melanogaster |
| Giulia Gobbi, Benedetta Donati, Italo Faria Do Valle, Francesca Reggiani, Federica Torricelli, Daniel Remondini, Gastone Castellani, Davide Carlo Ambrosetti, Alessia Ciarrocchi, Valentina Sancis. The Hippo pathway modulates resistance to BET proteins inhibitors in lung cancer cells. Oncogene. vol 38. issue 42. 2020-02-26. PMID:31406246. |
we also showed that taz, yap, and their partner tead are direct targets of brd4 and that treatment with beti downregulates their expression. |
2020-02-26 |
2023-08-13 |
Not clear |
| Reza Ebrahimighaei, Madeleine C McNeill, Sarah A Smith, Jason P Wray, Kerrie L Ford, Andrew C Newby, Mark Bon. Elevated cyclic-AMP represses expression of exchange protein activated by cAMP (EPAC1) by inhibiting YAP-TEAD activity and HDAC-mediated histone deacetylation. Biochimica et biophysica acta. Molecular cell research. vol 1866. issue 10. 2020-01-16. PMID:31255721. |
inhibition of tead activity using sirna-silencing of its co-factors yap and taz, expression of dominant-negative tead or treatment with yap-tead inhibitors, significantly inhibited epac1 expression. |
2020-01-16 |
2023-08-13 |
Not clear |
| Matthew L Fisher, Daniel Grun, Gautam Adhikary, Wen Xu, Richard L Ecker. Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells. Oncotarget. vol 8. issue 66. 2019-11-20. PMID:29299145. |
we demonstrate that yap1, taz and tead (tea domain transcription factor) levels are elevated in braf inhibitor resistant mcs cells and enhance cell survival, spheroid formation, matrigel invasion and tumor formation. |
2019-11-20 |
2023-08-13 |
Not clear |
| Matthew L Fisher, Daniel Grun, Gautam Adhikary, Wen Xu, Richard L Ecker. Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells. Oncotarget. vol 8. issue 66. 2019-11-20. PMID:29299145. |
moreover, increased yap1, taz and tead are associated with sustained erk1/2 activity that is not suppressed by braf inhibitor. |
2019-11-20 |
2023-08-13 |
Not clear |
| Matteo Astone, Jason Kuan Han Lai, Sirio Dupont, Didier Y R Stainier, Francesco Argenton, Andrea Vettor. Zebrafish mutants and TEAD reporters reveal essential functions for Yap and Taz in posterior cardinal vein development. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:29976931. |
zebrafish mutants and tead reporters reveal essential functions for yap and taz in posterior cardinal vein development. |
2019-10-28 |
2023-08-13 |
human |
| Helena J Janse van Rensburg, Dulcie Lai, Taha Azad, Yawei Hao, Xiaolong Yan. TAZ enhances mammary cell proliferation in 3D culture through transcriptional regulation of IRS1. Cellular signalling. vol 52. 2019-10-22. PMID:30138697. |
mechanistically, taz interacts with the irs1 promoter through the tead family of transcription factors and enhances its activity. |
2019-10-22 |
2023-08-13 |
Not clear |
| Samuel A Manning, Lucas G Dent, Shu Kondo, Ziqing W Zhao, Nicolas Plachta, Kieran F Harve. Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo. Current biology : CB. vol 28. issue 10. 2019-10-15. PMID:29754899. |
the central downstream pathway protein in drosophila is the transcriptional co-activator yorkie (yap and taz in humans), which regulates gene expression with the scalloped/tea domain family member (tead) transcription factors [1-8]. |
2019-10-15 |
2023-08-13 |
drosophila_melanogaster |
| Ja Hyun Koo, Kun-Liang Gua. Interplay between YAP/TAZ and Metabolism. Cell metabolism. vol 28. issue 2. 2019-09-30. PMID:30089241. |
under favorable conditions, yap and taz are active to promote cell growth through a transcriptional program mediated by the tead family transcription factors. |
2019-09-30 |
2023-08-13 |
Not clear |
| Ameer L Elaimy, Santosh Guru, Cheng Chang, Jianhong Ou, John J Amante, Lihua Julie Zhu, Hira Lal Goel, Arthur M Mercuri. VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin. Science signaling. vol 11. issue 528. 2019-09-16. PMID:29717062. |
in a complex with the transcription factor tead, taz then bound and repressed the promoter of the gene encoding the rac gtpase-activating protein (rac gap) β2-chimaerin. |
2019-09-16 |
2023-08-13 |
Not clear |
| Nathan R Zemke, Dawei Gou, Arnold J Ber. Dedifferentiation by adenovirus E1A due to inactivation of Hippo pathway effectors YAP and TAZ. Genes & development. vol 33. issue 13-14. 2019-09-12. PMID:31171701. |
most of the increase in h3k27/18ac was in enhancers near tead transcription factors bound by hippo signaling-regulated coactivators yap and taz. |
2019-09-12 |
2023-08-13 |
human |
| Wanlei Yang, Weiqi Han, An Qin, Ziyi Wang, Jiake Xu, Yu Qia. The emerging role of Hippo signaling pathway in regulating osteoclast formation. Journal of cellular physiology. vol 233. issue 6. 2019-04-09. PMID:29219182. |
upon activation, mst and last, transcriptional co-activators yap and taz bind to the members of the tea domain (tead) family transcription factors, and influence osteoclast differentiation via regulating the expression of downstream target genes such as connective tissue growth factor (ctgf/ccn2) and cysteine-rich protein 61 (cyr61/ccn1). |
2019-04-09 |
2023-08-13 |
Not clear |
| Hung Yi Kristal Kaan, Siew Wee Chan, Siew Kim Joyce Tan, Fusheng Guo, Chun Jye Lim, Wanjin Hong, Haiwei Son. Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex. Scientific reports. vol 7. issue 1. 2018-12-11. PMID:28515457. |
the pathway has three components: the upstream regulatory factors, the kinase core, and the downstream transcriptional machinery, which consists of yap, taz (transcription co-activators) and tead (transcription factor). |
2018-12-11 |
2023-08-13 |
Not clear |
| Kaiqian Que, Yuanhe Tong, Ganbo Que, Li Li, Hongcheng Lin, Shuai Huang, Ruoyu Wang, Langlang Tan. Downregulation of miR-874-3p promotes chemotherapeutic resistance in colorectal cancer via inactivation of the Hippo signaling pathway. Oncology reports. vol 38. issue 6. 2018-07-20. PMID:29039607. |
furthermore, our results demonstrated that mir-874-3p directly inhibited the expression of transcriptional co-activators yap and taz of the hippo signaling pathway, resulting in the inactivation of the tead transcription. |
2018-07-20 |
2023-08-13 |
Not clear |
| Deanna N Edwards, Verra M Ngwa, Shan Wang, Eileen Shiuan, Dana M Brantley-Sieders, Laura C Kim, Albert B Reynolds, Jin Che. The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ. Science signaling. vol 10. issue 508. 2018-07-20. PMID:29208682. |
we found that the receptor tyrosine kinase epha2 activated the tead family transcriptional coactivators yap and taz (yap/taz), likely in a ligand-independent manner, to promote glutamine metabolism in cells and mouse models of her2-positive breast cancer. |
2018-07-20 |
2023-08-13 |
mouse |
| Stanley Artap, Lauren J Manderfield, Cheryl L Smith, Andrey Poleshko, Haig Aghajanian, Kelvin See, Li Li, Rajan Jain, Jonathan A Epstei. Endocardial Hippo signaling regulates myocardial growth and cardiogenesis. Developmental biology. vol 440. issue 1. 2018-06-22. PMID:29727635. |
this pathway impacts upon two partially redundant transcription cofactors, yap and taz, that interact with other factors, including members of the tead family, to affect expression of downstream genes. |
2018-06-22 |
2023-08-13 |
Not clear |
| Congshan Sun, Vanessa De Mello, Abdalla Mohamed, Huascar P Ortuste Quiroga, Amaya Garcia-Munoz, Abdullah Al Bloshi, Annie M Tremblay, Alexander von Kriegsheim, Elaina Collie-Duguid, Neil Vargesson, David Matallanas, Henning Wackerhage, Peter S Zammi. Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function. Stem cells (Dayton, Ohio). vol 35. issue 8. 2018-04-16. PMID:28589555. |
hippo pathway downstream effectors yap and taz play key roles in cell proliferation and regeneration, regulating gene expression especially via tead transcription factors. |
2018-04-16 |
2023-08-13 |
human |
| Jihang Yu, Adel Alharbi, Hongchao Shan, Yawei Hao, Brooke Snetsinger, Michael J Rauh, Xiaolong Yan. TAZ induces lung cancer stem cell properties and tumorigenesis by up-regulating ALDH1A1. Oncotarget. vol 8. issue 24. 2018-04-09. PMID:28415606. |
further rna-seq and qrt-pcr analysis identified aldh1a1, a well-established csc marker, as critical taz downstream target and showed that taz induces aldh1a1 transcription by activating its promoter activity through interaction with the transcription factor tead. |
2018-04-09 |
2023-08-13 |
mouse |
| Brendan M Gabriel, D Lee Hamilton, Annie M Tremblay, Henning Wackerhag. The Hippo signal transduction network for exercise physiologists. Journal of applied physiology (Bethesda, Md. : 1985). vol 120. issue 10. 2017-12-14. PMID:26940657. |
the ubiquitous transcriptional coactivators yap (gene symbol yap1) and taz (gene symbol wwtr1) regulate gene expression mainly by coactivating the tead transcription factors. |
2017-12-14 |
2023-08-13 |
Not clear |