| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Shanzer, I Ricardo-Lax, R Keshet, N Reuven, Y Shau. The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner. Oncogene. vol 34. issue 32. 2015-11-23. PMID:25362852. |
the hippo tumor suppressor pathway activates the kinase lats, which phosphorylates taz, leading to its nuclear exclusion and blunting tead coactivation. |
2015-11-23 |
2023-08-13 |
Not clear |
| Ivette Valencia-Sama, Yulei Zhao, Dulcie Lai, Helena J Janse van Rensburg, Yawei Hao, Xiaolong Yan. Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor. The Journal of biological chemistry. vol 290. issue 27. 2015-10-26. PMID:25995450. |
hippo component taz functions as a co-repressor and negatively regulates Δnp63 transcription through tea domain (tead) transcription factor. |
2015-10-26 |
2023-08-13 |
human |
| Ivette Valencia-Sama, Yulei Zhao, Dulcie Lai, Helena J Janse van Rensburg, Yawei Hao, Xiaolong Yan. Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor. The Journal of biological chemistry. vol 290. issue 27. 2015-10-26. PMID:25995450. |
taz regulates these biological functions by up-regulating downstream cellular genes through transactivation of transcription factors such as tead and ttf1. |
2015-10-26 |
2023-08-13 |
human |
| Ivette Valencia-Sama, Yulei Zhao, Dulcie Lai, Helena J Janse van Rensburg, Yawei Hao, Xiaolong Yan. Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor. The Journal of biological chemistry. vol 290. issue 27. 2015-10-26. PMID:25995450. |
by using human breast and lung epithelial cells, we have further characterized Δnp63, a p53 gene family member, and shown that taz suppresses Δnp63 mrna, protein expression, and promoter activity through interaction with the transcription factor tead. |
2015-10-26 |
2023-08-13 |
human |
| Ivette Valencia-Sama, Yulei Zhao, Dulcie Lai, Helena J Janse van Rensburg, Yawei Hao, Xiaolong Yan. Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor. The Journal of biological chemistry. vol 290. issue 27. 2015-10-26. PMID:25995450. |
we also show that tead can inhibit Δnp63 promoter activity and that taz can directly interact with Δnp63 promoter-containing tead binding sites. |
2015-10-26 |
2023-08-13 |
human |
| Juliet Rashidian, Erwan Le Scolan, Xiaodan Ji, Qingwei Zhu, Melinda M Mulvihill, Daniel Nomura, Kunxin Lu. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Science signaling. vol 8. issue 363. 2015-10-05. PMID:25670202. |
finally, we showed that ski repressed the transcriptional activity of taz by binding to the taz partner tead and recruiting the transcriptional co-repressor ncor1 to the tead-taz complex. |
2015-10-05 |
2023-08-13 |
human |
| Ying-Wei Li, He Shen, Costa Frangou, Nuo Yang, Jin Guo, Bo Xu, Wiam Bshara, Lori Shepherd, Qianqian Zhu, Jianmin Wang, Qiang Hu, Song Liu, Carl D Morrison, Peiqing Sun, Jianmin Zhan. Characterization of TAZ domains important for the induction of breast cancer stem cell properties and tumorigenesis. Cell cycle (Georgetown, Tex.). vol 14. issue 1. 2015-09-21. PMID:25602524. |
we further showed in non-transformed human mammary basal epithelial cells that expression of constitutively active taz confers cancer stem cell (csc) traits that are dependent on the taz and tead interacting domains. |
2015-09-21 |
2023-08-13 |
human |
| Matteo Santucci, Tatiana Vignudelli, Stefania Ferrari, Marco Mor, Laura Scalvini, Maria Laura Bolognesi, Elisa Uliassi, Maria Paola Cost. The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment. Journal of medicinal chemistry. vol 58. issue 12. 2015-09-14. PMID:25719868. |
yes associated protein (yap) and transcriptional co-activator with pdz-binding motif (taz) are its targets and terminal effectors: inhibition of the pathway promotes yap/taz translocation to the nucleus, where they interact with transcriptional enhancer associate domain (tead) transcription factors and coactivate the expression of target genes, promoting cell proliferation. |
2015-09-14 |
2023-08-13 |
Not clear |
| Joel B Miesfeld, Brian A Lin. Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway. Mechanisms of development. vol 133. 2015-06-22. PMID:24560909. |
when the transcriptional co-activators, yap and taz were restricted from interacting with dna-binding tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline resulting in strong cardia bifida. |
2015-06-22 |
2023-08-12 |
drosophila_melanogaster |
| Maren Diepenbruck, Lorenz Waldmeier, Robert Ivanek, Philipp Berninger, Phil Arnold, Erik van Nimwegen, Gerhard Christofor. Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition. Journal of cell science. vol 127. issue Pt 7. 2015-04-09. PMID:24554433. |
tead transcription factors and their transcriptional co-activators yap and taz have been previously implicated in promoting an emt; however, their direct transcriptional target genes and their functional role during emt have remained elusive. |
2015-04-09 |
2023-08-12 |
Not clear |
| Maren Diepenbruck, Lorenz Waldmeier, Robert Ivanek, Philipp Berninger, Phil Arnold, Erik van Nimwegen, Gerhard Christofor. Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition. Journal of cell science. vol 127. issue Pt 7. 2015-04-09. PMID:24554433. |
the results demonstrate that tead transcription factors are crucial regulators of the cellular distribution of yap and taz, and together they control the expression of genes critical for emt and metastasis. |
2015-04-09 |
2023-08-12 |
Not clear |
| Henning Wackerhage, Dominic P Del Re, Robert N Judson, Marius Sudol, Junichi Sadoshim. The Hippo signal transduction network in skeletal and cardiac muscle. Science signaling. vol 7. issue 337. 2015-03-30. PMID:25097035. |
these two research areas were joined by the finding that the hippo pathway regulates the activity of tead transcription factors mainly through phosphorylation of the transcriptional coactivators yap and taz, which bind to and activate teads. |
2015-03-30 |
2023-08-13 |
Not clear |
| Yannick Mesrouze, Jean Christophe Hau, Dirk Erdmann, Catherine Zimmermann, Patrizia Fontana, Tobias Schmelzle, Patrick Chèn. The surprising features of the TEAD4-Vgll1 protein-protein interaction. Chembiochem : a European journal of chemical biology. vol 15. issue 4. 2014-11-04. PMID:24504694. |
having studied the interaction between vgll1-derived peptides and human tead4, we show that, although it lacks a key secondary structure element required for tight binding by two other tead cofactors (yap and taz), vgll1-derived peptides bind to tead with nanomolar affinity. |
2014-11-04 |
2023-08-12 |
mouse |
| Jean Christophe Hau, Dirk Erdmann, Yannick Mesrouze, Pascal Furet, Patrizia Fontana, Catherine Zimmermann, Tobias Schmelzle, Francesco Hofmann, Patrick Chèn. The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences. Chembiochem : a European journal of chemical biology. vol 14. issue 10. 2014-05-07. PMID:23780915. |
in this pathway, the yap and taz transcriptional cofactors play a key role in stimulating gene transcription through their interaction with the tead transcriptional factors. |
2014-05-07 |
2023-08-12 |
human |
| Jean Christophe Hau, Dirk Erdmann, Yannick Mesrouze, Pascal Furet, Patrizia Fontana, Catherine Zimmermann, Tobias Schmelzle, Francesco Hofmann, Patrick Chèn. The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences. Chembiochem : a European journal of chemical biology. vol 14. issue 10. 2014-05-07. PMID:23780915. |
our study of yap and taz peptides in biochemical and biophysical assays shows that both proteins have essentially the same affinity for tead. |
2014-05-07 |
2023-08-12 |
human |
| Jean Christophe Hau, Dirk Erdmann, Yannick Mesrouze, Pascal Furet, Patrizia Fontana, Catherine Zimmermann, Tobias Schmelzle, Francesco Hofmann, Patrick Chèn. The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences. Chembiochem : a European journal of chemical biology. vol 14. issue 10. 2014-05-07. PMID:23780915. |
this convergent optimization of the yap/taz tead binding site suggests that the similarity in the affinities of binding of yap to tead and of taz to tead is important for hippo pathway functionality. |
2014-05-07 |
2023-08-12 |
human |
| Yang An, Qianqian Kang, Yaofeng Zhao, Xiaoxiang Hu, Ning L. Lats2 modulates adipocyte proliferation and differentiation via hippo signaling. PloS one. vol 8. issue 8. 2014-04-08. PMID:23977200. |
upon activation, lats2 phosphorylates yap and taz, leading to their retention in the cytoplasm, preventing them from activating the transcription factor tead in the nucleus. |
2014-04-08 |
2023-08-12 |
drosophila_melanogaster |
| Wanjin Hon. Angiomotin'g YAP into the nucleus for cell proliferation and cancer development. Science signaling. vol 6. issue 291. 2014-03-25. PMID:24003252. |
nuclear translocation of the transcription factors yes-associated protein (yap) and transcriptional coactivator with pdz-binding motif (taz) and their subsequent interaction with tea domain (tead) transcriptional factors program pro-proliferative and antiapoptotic transcription. |
2014-03-25 |
2023-08-12 |
Not clear |
| Dulcie Lai, Xiaolong Yan. BMP4 is a novel transcriptional target and mediator of mammary cell migration downstream of the Hippo pathway component TAZ. Cellular signalling. vol 25. issue 8. 2013-12-30. PMID:23673366. |
taz induces bmp4 transcription through the tead family of transcription factors, which mediate bmp4 promoter activation through binding to tead response element 1 (tre1). |
2013-12-30 |
2023-08-12 |
Not clear |
| Ajaybabu V Pobbati, Siew Wee Chan, Ian Lee, Haiwei Song, Wanjin Hon. Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes. Structure (London, England : 1993). vol 20. issue 7. 2012-11-02. PMID:22632831. |
remarkably, vgll1 interacts with tead in a manner similar to the transcription coactivators, as well as oncogenes yap and taz, despite having a varied primary sequence. |
2012-11-02 |
2023-08-12 |
drosophila_melanogaster |