| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Tang, Yu Du, Jun Wan. TAZ-hTrap: A Rationally Designed, Disulfide-Stapled Tead Helical Hairpin Trap to Selectively Capture Hippo Signaling Taz With Potent Antigynecological Tumor Activity. Journal of molecular recognition : JMR. 2024-12-03. PMID:39626959. |
taz-htrap: a rationally designed, disulfide-stapled tead helical hairpin trap to selectively capture hippo signaling taz with potent antigynecological tumor activity. |
2024-12-03 |
2024-12-06 |
human |
| Bin Tang, Yu Du, Jun Wan. TAZ-hTrap: A Rationally Designed, Disulfide-Stapled Tead Helical Hairpin Trap to Selectively Capture Hippo Signaling Taz With Potent Antigynecological Tumor Activity. Journal of molecular recognition : JMR. 2024-12-03. PMID:39626959. |
the transcriptional coactivator with pdz-binding motif (taz) binds to and then activates tead through forming a three-helix bundle (thb) at their complex interface. |
2024-12-03 |
2024-12-06 |
human |
| Bin Tang, Yu Du, Jun Wan. TAZ-hTrap: A Rationally Designed, Disulfide-Stapled Tead Helical Hairpin Trap to Selectively Capture Hippo Signaling Taz With Potent Antigynecological Tumor Activity. Journal of molecular recognition : JMR. 2024-12-03. PMID:39626959. |
the thb is defined by a double-helical hairpin from tead and a single α-helix from taz, serving as the key interaction hotspot between tead and taz. |
2024-12-03 |
2024-12-06 |
human |
| Florine Toulotte, Mathilde Coevoet, Maxime Liberelle, Fabrice Bailly, Benjamin Zagiel, Muriel Gelin, Frédéric Allemand, Patrick Fourquet, Patricia Melnyk, Jean-François Guichou, Philippe Cotell. Towards the design of ligands of the internal pocket TEADs C-terminal domain. European journal of medicinal chemistry. vol 282. 2024-11-21. PMID:39571457. |
phosphorylation of the transcription co-activator yap (yes associated protein) and taz (transcriptional coactivator with pdz-binding motif) regulates their nuclear import and therefore their interaction with tead (transcriptional enhanced associated domain). |
2024-11-21 |
2024-11-24 |
Not clear |
| Alexandra Pelenyi, Cooper Atterton, Justin Jones, Laura Currey, Majd Al-Khalily, Lucinda Wright, Nyoman D Kurniawan, Stefan Thor, Michael Pipe. Expression of the Hippo pathway effector, TEAD1, within the developing murine forebrain. Gene expression patterns : GEP. 2024-11-18. PMID:39557142. |
when the hippo pathway is 'off', however, yap and taz can enter the nucleus, where they interact with the transcription factors of the tea domain (tead) family to regulate transcriptional activity. |
2024-11-18 |
2024-11-22 |
mouse |
| Briana Branch, Yao Yuan, Mariastella Cascone, Francesco Raimondi, Ramiro Iglesias-Bartolom. An improved TEAD dominant-negative protein inhibitor to study Hippo YAP1/TAZ-dependent transcription. bioRxiv : the preprint server for biology. 2024-11-06. PMID:39502361. |
hippo signaling is one of the top pathways altered in human cancer, and intensive focus has been devoted to developing therapies targeting hippo-dependent transcription mediated by yap1 and taz interaction with tead proteins. |
2024-11-06 |
2024-11-08 |
human |
| Briana Branch, Yao Yuan, Mariastella Cascone, Francesco Raimondi, Ramiro Iglesias-Bartolom. An improved TEAD dominant-negative protein inhibitor to study Hippo YAP1/TAZ-dependent transcription. bioRxiv : the preprint server for biology. 2024-11-06. PMID:39502361. |
teadi specifically blocks the nuclear interactions of tead with yap1 and taz, enabling precise dissection of hippo tead-dependent and independent effects on cell fate. |
2024-11-06 |
2024-11-08 |
human |
| Briana Branch, Yao Yuan, Mariastella Cascone, Francesco Raimondi, Ramiro Iglesias-Bartolom. An improved TEAD dominant-negative protein inhibitor to study Hippo YAP1/TAZ-dependent transcription. bioRxiv : the preprint server for biology. 2024-11-06. PMID:39502361. |
additionally, we find that tbds derived from vgll4 and yap1 are insufficient to block taz-induced tead activity, revealing crucial differences in yap1 and taz displacement mechanisms by dominant-negative tbds. |
2024-11-06 |
2024-11-08 |
human |
| Briana Branch, Yao Yuan, Mariastella Cascone, Francesco Raimondi, Ramiro Iglesias-Bartolom. An improved TEAD dominant-negative protein inhibitor to study Hippo YAP1/TAZ-dependent transcription. bioRxiv : the preprint server for biology. 2024-11-06. PMID:39502361. |
structural differences in yap1 and taz tbds were also identified, which may contribute to the distinct binding of these proteins to tead. |
2024-11-06 |
2024-11-08 |
human |
| Anwen Shao, Joseph L Kissil, Chen-Ming Fa. The L27 domain of MPP7 enhances TAZ-YY1 cooperation to renew muscle stem cells. EMBO reports. 2024-11-04. PMID:39496834. |
we show that mpp7 and amot join taz and yy1 to regulate a selected number of common genes that harbor tead and yy1 binding sites. |
2024-11-04 |
2024-11-07 |
Not clear |
| Kostas A Papavassiliou, Amalia A Sofianidi, Fotios G Spiliopoulos, Vassiliki A Gogou, Antonios N Gargalionis, Athanasios G Papavassilio. YAP/TAZ Signaling in the Pathobiology of Pulmonary Fibrosis. Cells. vol 13. issue 18. 2024-09-27. PMID:39329703. |
yap and taz, components of the hippo pathway, play significant roles in cell proliferation, differentiation, and fibrosis by modulating gene expression through interactions with tea domain (tead) transcription factors. |
2024-09-27 |
2024-09-29 |
Not clear |
| Ioanna Akrida, Maria Makrygianni, Sofia Nikou, Francesk Mulita, Vasiliki Bravou, Helen Papadak. Hippo pathway effectors YAP, TAZ and TEAD are associated with EMT master regulators ZEB, Snail and with aggressive phenotype in phyllodes breast tumors. Pathology, research and practice. vol 262. 2024-08-17. PMID:39153238. |
hippo pathway effectors yap, taz and tead are associated with emt master regulators zeb, snail and with aggressive phenotype in phyllodes breast tumors. |
2024-08-17 |
2024-08-20 |
Not clear |
| Jie Gao, Caihong Pi, Junmei Pan, Wei Zho. Research progress of Hippo pathway effector molecules in rheumatic immune system diseases. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2024-06-20. PMID:38899353. |
effector molecules,such as yes-associated protein (yap), transcriptional coactivator with pdz-binding motif (taz), transcriptional enhanced associate domain transcriptional factor (tead), monopolar spindle-one binder (mob1), large tumor suppressor (lats), can stimulate fibroblast-like synovial cell migration and invasion in rheumatoid arthritis, regulate osteoarthritis disease progression, promote pathological new bone formation in ankylosing spondylitis, sustain submandibular gland development while delaying sjogren's syndrome progression, mediate alpha-smooth muscle actin in systemic sclerosis, and refine the regulation of target genes associated with pulmonary fibrosis. |
2024-06-20 |
2024-06-22 |
Not clear |
| Jongwan Kim, Haiyan Jin, Jinhyuk Kim, Seon Yeon Cho, Sungho Moon, Jianmin Wang, Jiashun Mao, Kyoung Tai N. Leveraging the Fragment Molecular Orbital and MM-GBSA Methods in Virtual Screening for the Discovery of Novel Non-Covalent Inhibitors Targeting the TEAD Lipid Binding Pocket. International journal of molecular sciences. vol 25. issue 10. 2024-05-25. PMID:38791396. |
the transcriptional enhanced associate domain (tead) family of transcription factors acts as a receptor for downstream effectors, namely yes-associated protein (yap) and transcriptional co-activator with pdz-binding motif (taz), which binds to various transcription factors and is essential for stimulated gene transcription. |
2024-05-25 |
2024-05-27 |
Not clear |
| Susu Guo, Xiaodi Hu, Jennifer L Cotton, Lifang Ma, Qi Li, Jiangtao Cui, Yongjie Wang, Ritesh P Thakare, Zhipeng Tao, Y Tony Ip, Xu Wu, Jiayi Wang, Junhao Ma. VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent transcription and tumorigenesis by engaging p300. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746415. |
studies on hippo pathway regulation of tumorigenesis largely center on yap and taz, the transcriptional co-regulators of tead. |
2024-05-15 |
2024-05-27 |
Not clear |
| Kira R Mills, Jyoti Misra, Hedieh Torabifar. Allosteric Modulation of the YAP/TAZ-TEAD Interaction by Palmitoylation and Small-Molecule Inhibitors. The journal of physical chemistry. B. 2024-04-12. PMID:38606592. |
because yap and taz exert their oncogenic effects by binding with tead, it is critical to understand this key interaction to develop cancer therapeutics. |
2024-04-12 |
2024-04-14 |
Not clear |
| Kira R Mills, Jyoti Misra, Hedieh Torabifar. Allosteric Modulation of the YAP/TAZ-TEAD Interaction by Palmitoylation and Small-Molecule Inhibitors. The journal of physical chemistry. B. 2024-04-12. PMID:38606592. |
utilizing molecular dynamics simulations, our investigation not only provides detailed atomistic insight into the yap/taz-tead dynamics but also unveils that the inhibitor studied influences the binding of yap and taz to tead in distinct manners. |
2024-04-12 |
2024-04-14 |
Not clear |
| Oisun Jung, Min-Jeong Baek, Colin Wooldrik, Keith R Johnson, Kurt W Fisher, Jinchao Lou, Tanei J Ricks, Tianmu Wen, Michael D Best, Vincent L Cryns, Richard A Anderson, Suyong Cho. Nuclear phosphoinositide signaling promotes YAP/TAZ-TEAD transcriptional activity in breast cancer. The EMBO journal. 2024-04-02. PMID:38565949. |
the hippo pathway effectors yes-associated protein 1 (yap) and its homolog taz are transcriptional coactivators that control gene expression by binding to tea domain (tead) family transcription factors. |
2024-04-02 |
2024-04-05 |
Not clear |
| Hironori Otsuki, Takeshi Uemori, Yohei Inai, Yui Suzuki, Tetsuro Araki, Ken-Ichiro Nan-Ya, Kouichi Yoshinar. Reversible and monitorable nephrotoxicity in rats by the novel potent transcriptional enhanced associate domain (TEAD) inhibitor, K-975. The Journal of toxicological sciences. vol 49. issue 4. 2024-03-31. PMID:38556354. |
transcriptional enhanced associate domain (tead), a transcription activator of the hippo pathway, forms the complex with a transcriptional coactivator yes-associated protein (yap) or a transcriptional coactivator pdz-binding motif (taz). |
2024-03-31 |
2024-04-03 |
mouse |
| Shu Li, Xing Li, Yong-Bin Yang, Su-Fang W. YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells. Apoptosis : an international journal on programmed cell death. 2024-03-30. PMID:38553612. |
a number of studies have confirmed that yes-associated protein (yap)/transcriptional co-activator with pdz-binding motif (taz)-transcriptional enhanced associate domain (tead) activity is the driver of cancer development. |
2024-03-30 |
2024-04-01 |
human |