| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keith Garcia, Anne-Claude Gingras, Kieran F Harvey, Munir R Tana. TAZ/YAP fusion proteins: mechanistic insights and therapeutic opportunities. Trends in cancer. 2022-09-12. PMID:36096997. |
given that the n termini of taz or yap are fused to the c terminus of another transcriptional regulator, the resultant fusion proteins hyperactivate a tead transcription factor-based transcriptome. |
2022-09-12 |
2023-08-14 |
Not clear |
| Tetsuya Mizutani, Makoto Orisaka, Yumiko Miyazaki, Ririko Morichika, Miki Uesaka, Kaoru Miyamoto, Yoshio Yoshid. Inhibition of YAP/TAZ-TEAD activity induces cytotrophoblast differentiation into syncytiotrophoblast in human trophoblast. Molecular human reproduction. 2022-08-22. PMID:35993908. |
in the placenta, the expression of various genes is regulated by the hippo pathway through a transcription complex, yes-associated protein (yap)/transcriptional coactivator with pdz-binding motif (taz)-tea domain transcription factor (tead) (yap/taz-tead) activity. |
2022-08-22 |
2023-08-14 |
human |
| Chunle Zhao, Jun Gong, Yu Bai, Taoyuan Yin, Min Zhou, Shutao Pan, Yuhui Liu, Yang Gao, Zhenxiong Zhang, Yongkang Shi, Feng Zhu, Hang Zhang, Min Wang, Renyi Qi. A self-amplifying USP14-TAZ loop drives the progression and liver metastasis of pancreatic ductal adenocarcinoma. Cell death and differentiation. 2022-07-29. PMID:35906484. |
moreover, taz facilitated the transcription of usp14 by binding to the tea domain transcription factor (tead) 1/4 response element in the promoter of usp14. |
2022-07-29 |
2023-08-14 |
Not clear |
| Benjamin Zagiel, Patricia Melnyk, Philippe Cotell. Progress with YAP/TAZ-TEAD inhibitors: a patent review (2018-present). Expert opinion on therapeutic patents. 2022-06-29. PMID:35768160. |
overexpression of yes-associated protein (yap) or transcriptional coactivator with pdz-binding motif (taz) or tead has been demonstrated in cancers and yap is known to mediate resistance to cancer drugs. |
2022-06-29 |
2023-08-14 |
Not clear |
| Ji-Cheng Huang, Zhan-Peng Yue, Hai-Fan Yu, Zhan-Qing Yang, Yu-Si Wang, Bin Gu. TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NF-κB pathway. Molecular therapy. Nucleic acids. vol 28. 2022-05-04. PMID:35505966. |
after translocation into the nucleus, taz interacted with transcriptional enhanced associate domain (tead) and bound to the promoter of nuclear factor erythroid 2-related factor 2 (nrf2), whose blockage caused inability of taz to improve inflammation, implying that nrf2 is a direct target of taz. |
2022-05-04 |
2023-08-13 |
Not clear |
| Weifeng Tang, Min Li, Xiaoting Yangzhong, Xifeng Zhang, Anju Zu, Yunjiao Hou, Lin Li, Shibo Su. Hippo signaling pathway and respiratory diseases. Cell death discovery. vol 8. issue 1. 2022-04-21. PMID:35443749. |
hippo signaling pathway is mainly composed of mammalian ste20-like kinase 1/2 (mst1/2), large tumor suppressor 1/2 (lats1/2), ww domain of the sav family containing protein 1 (sav1), mob kinase activator 1 (mob1), yes-associated protein (yap) or transcriptional coactivator with pdz-binding motif (taz), and members of the tea domain (tead) family. |
2022-04-21 |
2023-08-13 |
Not clear |
| Kepeng Che, Ajaybabu V Pobbati, Caleb N Seavey, Yuriy Fedorov, Anton A Komar, Ashley Burtscher, Shuang Ma, Brian P Rubi. Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex. PloS one. vol 17. issue 4. 2022-04-13. PMID:35417479. |
we have previously shown that cell-based models that express the oncogenic taz-camta1 (tc) fusion protein display enhanced tead transcriptional activity because tc functions as an activated form of taz. |
2022-04-13 |
2023-08-13 |
Not clear |
| Angela Lauriola, Elisa Uliassi, Matteo Santucci, Maria Laura Bolognesi, Marco Mor, Laura Scalvini, Gian Marco Elisi, Gaia Gozzi, Lorenzo Tagliazucchi, Gaetano Marverti, Stefania Ferrari, Lorena Losi, Domenico D'Arca, Maria Paola Cost. Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library. Pharmaceutics. vol 14. issue 2. 2022-02-26. PMID:35214125. |
the transcriptional regulators yap (yes-associated protein) and taz (transcriptional co-activator with pdz-binding motif) are the major downstream effectors in the hippo pathway and are involved in cancer progression through modulation of the activity of tead (transcriptional enhanced associate domain) transcription factors. |
2022-02-26 |
2023-08-13 |
Not clear |
| Júlia Koch, Valério Marques Portela, Esdras Corrêa Dos Santos, Daniele Missio, Leonardo Guedes de Andrade, Zigomar da Silva, Bernardo Garziera Gasperin, Alfredo Quites Antoniazzi, Paulo Bayard Dias Gonçalves, Gustavo Zamberla. The Hippo pathway effectors YAP and TAZ interact with EGF-like signaling to regulate expansion-related events in bovine cumulus cells in vitro. Journal of assisted reproduction and genetics. 2022-01-29. PMID:35091965. |
to determine if the inhibition of the interaction between the hippo effector yap or its transcriptional co-activator taz with the tead family of transcription factors is critical for the cumulus expansion-related events induced by the egf network in cumulus-oocyte complexes (cocs). |
2022-01-29 |
2023-08-13 |
cattle |
| Yin Zhang, Ye-Ya Tan, Pei-Pei Chen, Hui Xu, Shu-Juan Xie, Shi-Jun Xu, Bin Li, Jun-Hao Li, Shun Liu, Jian-Hua Yang, Hui Zhou, Liang-Hu Q. Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development. Cell death & disease. vol 12. issue 12. 2021-12-15. PMID:34907157. |
mechanistically, we further demonstrated that mir-122 negatively regulates the outcomes of the hippo pathway transcription factor tead by directly targeting a number of hippo pathway regulators, including the coactivator taz and a key factor of the phosphatase complex ppp1cc, which contributes to the dephosphorylation of yap, another coactivator downstream of the hippo pathway. |
2021-12-15 |
2023-08-13 |
mouse |
| Soma Tripathi, Tetsuaki Miyake, Jonathan Kelebeev, John C McDermot. TAZ exhibits phase separation properties and interacts with Smad7 and β-catenin to repress skeletal myogenesis. Journal of cell science. 2021-12-03. PMID:34859820. |
ectopic taz, while potently active on a tead reporter (hip-hop), repressed myogenin and myod enhancer regions and myogenin protein level. |
2021-12-03 |
2023-08-13 |
drosophila_melanogaster |
| Nicholas Van Sciver, Makoto Ohashi, Nicholas P Pauly, Jillian A Bristol, Scott E Nelson, Eric C Johannsen, Shannon C Kenne. Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells. PLoS pathogens. vol 17. issue 8. 2021-11-30. PMID:34339458. |
we demonstrate that depletion of either yap or taz inhibits the ability of phorbol ester (tpa) treatment, cellular differentiation or the ebv brlf1 immediate-early (ie) protein to induce lytic ebv reactivation in oral keratinocytes, and show that over-expression of constitutively active forms of yap and taz reactivate lytic ebv infection in conjunction with tead family members. |
2021-11-30 |
2023-08-13 |
human |
| Nicholas Van Sciver, Makoto Ohashi, Nicholas P Pauly, Jillian A Bristol, Scott E Nelson, Eric C Johannsen, Shannon C Kenne. Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells. PLoS pathogens. vol 17. issue 8. 2021-11-30. PMID:34339458. |
furthermore, we demonstrate that yap, taz, and tead family members are expressed at much higher levels in epithelial cell lines in comparison to b-cell lines, and find that ebv infection of oral keratinocytes increases the level of activated (dephosphorylated) yap and taz. |
2021-11-30 |
2023-08-13 |
human |
| Leslie Olmedo-Nieva, J Omar Muñoz-Bello, Joaquín Manzo-Merino, Marcela Lizan. New insights in Hippo signalling alteration in human papillomavirus-related cancers. Cellular signalling. vol 76. 2021-11-29. PMID:33148514. |
it has been demonstrated that e6 proteins promote the increase of the hippo elements yap, taz and tead, at protein level, as well as their transcriptional targets. |
2021-11-29 |
2023-08-13 |
human |
| Manon Sturbaut, Fabrice Bailly, Mathilde Coevoet, Pasquale Sileo, Martine Pugniere, Maxime Liberelle, Romain Magnez, Xavier Thuru, Marie-Christine Chartier-Harlin, Patricia Melnyk, Muriel Gelin, Frédéric Allemand, Jean-François Guichou, Philippe Cotell. Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors. European journal of medicinal chemistry. vol 226. 2021-11-22. PMID:34509860. |
it controls the phosphorylation of the transcription co-activator yap (yes associated protein) and taz (transcriptional coactivator with pdz-binding motif) in order to control their nuclear import and their interaction with tead (transcriptional enhanced associated domain). |
2021-11-22 |
2023-08-13 |
Not clear |
| Valeria Canu, Sara Donzelli, Andrea Sacconi, Federica Lo Sardo, Claudio Pulito, Noa Bossel, Anna Di Benedetto, Paola Muti, Claudio Botti, Eytan Domany, Silvio Bicciato, Sabrina Strano, Yosef Yarden, Giovanni Blandin. Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation. Cell death and differentiation. vol 28. issue 5. 2021-11-17. PMID:33230261. |
reassuringly, the depletion of yap, taz, and tead strongly reduced spag5 expression and diminished its oncogenic effects. |
2021-11-17 |
2023-08-13 |
Not clear |
| Valeria Canu, Sara Donzelli, Andrea Sacconi, Federica Lo Sardo, Claudio Pulito, Noa Bossel, Anna Di Benedetto, Paola Muti, Claudio Botti, Eytan Domany, Silvio Bicciato, Sabrina Strano, Yosef Yarden, Giovanni Blandin. Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation. Cell death and differentiation. vol 28. issue 5. 2021-11-17. PMID:33230261. |
yap, taz coactivators, and tead transcription factors are key components of the hippo signaling pathway involved in tumor initiation, progression, and metastasis. |
2021-11-17 |
2023-08-13 |
Not clear |
| Yiju Wei, Huacheng Luo, Patricia P Yee, Lijun Zhang, Zhijun Liu, Haiyan Zheng, Lei Zhang, Benjamin Anderson, Miaolu Tang, Suming Huang, Wei L. Paraspeckle Protein NONO Promotes TAZ Phase Separation in the Nucleus to Drive the Oncogenic Transcriptional Program. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2021-10-30. PMID:34716691. |
their interaction shows temporal regulation parallel to the interaction between taz and tead as well as to the expression of taz target genes. |
2021-10-30 |
2023-08-13 |
mouse |
| Yiju Wei, Huacheng Luo, Patricia P Yee, Lijun Zhang, Zhijun Liu, Haiyan Zheng, Lei Zhang, Benjamin Anderson, Miaolu Tang, Suming Huang, Wei L. Paraspeckle Protein NONO Promotes TAZ Phase Separation in the Nucleus to Drive the Oncogenic Transcriptional Program. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2021-10-30. PMID:34716691. |
accordingly, nono depletion reduces taz interactions with tead, rpb1, and enhancers. |
2021-10-30 |
2023-08-13 |
mouse |
| Lizhi He, Henry Pratt, Mingshi Gao, Fengxiang Wei, Zhiping Weng, Kevin Struh. YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation. eLife. vol 10. 2021-10-18. PMID:34463254. |
the yap and taz paralogs are transcriptional co-activators recruited to target sites by tead proteins. |
2021-10-18 |
2023-08-13 |
Not clear |