| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuki Takakura, Takayuki Suzuki, Naoto Hirai, Takuro Araki, Mai Ohishi, Hiromi Sato, Naoto Yamaguchi, Hiroyuki Takano, Noritaka Yamaguch. VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes. Biochemical and biophysical research communications. vol 669. 2023-06-01. PMID:37262950. |
we also found that vgll3 proteins are degraded by the proteasome, which causes switching of tead cofactors from vgll3 to yes-associated protein (yap) and transcriptional coactivator with a pdz-binding motif (taz). |
2023-06-01 |
2023-08-14 |
Not clear |
| Boting Ning, Andrew M Tilston-Lunel, Justice Simonetti, Julia Hicks-Berthet, Adeline Matschulat, Roxana Pfefferkorn, Avrum Spira, Matthew Edwards, Sarah Mazzilli, Marc E Lenburg, Jennifer E Beane, Xaralabos Varela. Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression. Journal of experimental & clinical cancer research : CR. vol 42. issue 1. 2023-05-07. PMID:37150829. |
evidence has suggested key roles for the hippo pathway effectors yap and taz and associated tead and tp63 transcription factor families in bronchial basal cell biology and lusc. |
2023-05-07 |
2023-08-14 |
Not clear |
| Jingyuan Wang, Haofeng Chen, Wulei Hou, Qingjian Han, Zuoyun Wan. Hippo Pathway in Schwann Cells and Regeneration of Peripheral Nervous System. Developmental neuroscience. 2023-04-20. PMID:37080186. |
its key transcriptional co-activators yap and taz regulate transcription factors such as tead family to direct gene expression. |
2023-04-20 |
2023-08-14 |
Not clear |
| Kota Noritsugu, Takehiro Suzuki, Kosuke Dodo, Kenji Ohgane, Yasue Ichikawa, Kota Koike, Satoshi Morita, Takashi Umehara, Kenji Ogawa, Mikiko Sodeoka, Naoshi Dohmae, Minoru Yoshida, Akihiro It. Lysine long-chain fatty acylation regulates the TEAD transcription factor. Cell reports. 2023-04-15. PMID:37060904. |
tead activity is primarily regulated by phosphorylation of its coactivators, yap and taz. |
2023-04-15 |
2023-08-14 |
Not clear |
| Kota Noritsugu, Takehiro Suzuki, Kosuke Dodo, Kenji Ohgane, Yasue Ichikawa, Kota Koike, Satoshi Morita, Takashi Umehara, Kenji Ogawa, Mikiko Sodeoka, Naoshi Dohmae, Minoru Yoshida, Akihiro It. Lysine long-chain fatty acylation regulates the TEAD transcription factor. Cell reports. 2023-04-15. PMID:37060904. |
lysine fatty acylation, like cysteine palmitoylation, contributes to the transcriptional activity of teads by enhancing the interaction with yap and taz, but it is more stable than cysteine acylation, suggesting that the lysine fatty-acylated tead acts as a "stable active form." |
2023-04-15 |
2023-08-14 |
Not clear |
| Wenchao Lu, Mengyang Fan, Wenzhi Ji, Jason Tse, Inchul You, Scott B Ficarro, Isidoro Tavares, Jianwei Che, Audrey Y Kim, Xijun Zhu, Andrew Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Stephen M Hinshaw, Behnam Nabet, Steven M Corsello, Nicholas Kwiatkowski, Jarrod A Marto, Tinghu Zhang, Nathanael S Gra. Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors. Journal of medicinal chemistry. 2023-03-22. PMID:36946421. |
transcriptional enhanced associate domain (tead) proteins together with their transcriptional coactivator yes-associated protein (yap) and transcriptional coactivator with the pdz-binding motif (taz) are important transcription factors and cofactors that regulate gene expression in the hippo pathway. |
2023-03-22 |
2023-08-14 |
Not clear |
| Feng Li, Vinny Negi, Ping Yang, Jeongkyung Lee, Ke Ma, Mousumi Moulik, Vijay K Yechoo. TEAD1 regulates cell proliferation through a pocket-independent transcription repression mechanism. Nucleic acids research. 2022-12-09. PMID:36484096. |
the existing paradigm is that tead co-activators, yap and taz, and co-repressor, vgll4, bind to the pocket region of tead1 to enable transcriptional activation or repressive function. |
2022-12-09 |
2023-08-14 |
Not clear |
| Pasquale Sileo, Clémence Simonin, Patricia Melnyk, Marie-Christine Chartier-Harlin, Philippe Cotell. Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington's Disease and Other Neurodegenerative Disorders. Cells. vol 11. issue 22. 2022-11-26. PMID:36429058. |
when unphosphorylated, yap and taz translocate into the nucleus, where they mainly bind to the tead transcription factor family and activate genes related to cell proliferation and survival. |
2022-11-26 |
2023-08-14 |
Not clear |
| Youngchai Son, Jaeyeal Kim, Yongchan Kim, Sung-Gil Chi, Tackhoon Kim, Jinha Y. Discovery of dioxo-benzo[b]thiophene derivatives as potent YAP-TEAD interaction inhibitors for treating breast cancer. Bioorganic chemistry. vol 131. 2022-11-26. PMID:36434952. |
disruption of protein-protein interaction between transcriptional enhancer factor (tea)-domain (tead; a transcription factor) and its co-activator yes-associated protein (yap)/ transcriptional co-activator with pdz-binding motif (taz) is a potential therapeutic strategy against various types of solid tumors. |
2022-11-26 |
2023-08-14 |
Not clear |
| Liyam Laraba, Lily Hillson, Julio Grimm de Guibert, Amy Hewitt, Maisie R Jaques, Tracy T Tang, Leonard Post, Emanuela Ercolano, Ganesha Rai, Shyh Ming Yang, Daniel J Jagger, Waldemar Woznica, Philip Edwards, Aditya G Shivane, C Oliver Hanemann, David B Parkinso. Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma. Brain : a journal of neurology. 2022-09-23. PMID:36148553. |
using both genetic ablation of the hippo effectors yap and taz as well as novel tead palmitoylation inhibitors, we show that hippo signalling may be successfully targeted in vitro and in vivo to both block and, remarkably, regress schwannoma tumour growth. |
2022-09-23 |
2023-08-14 |
mouse |
| Keith Garcia, Anne-Claude Gingras, Kieran F Harvey, Munir R Tana. TAZ/YAP fusion proteins: mechanistic insights and therapeutic opportunities. Trends in cancer. 2022-09-12. PMID:36096997. |
given that the n termini of taz or yap are fused to the c terminus of another transcriptional regulator, the resultant fusion proteins hyperactivate a tead transcription factor-based transcriptome. |
2022-09-12 |
2023-08-14 |
Not clear |
| Tetsuya Mizutani, Makoto Orisaka, Yumiko Miyazaki, Ririko Morichika, Miki Uesaka, Kaoru Miyamoto, Yoshio Yoshid. Inhibition of YAP/TAZ-TEAD activity induces cytotrophoblast differentiation into syncytiotrophoblast in human trophoblast. Molecular human reproduction. 2022-08-22. PMID:35993908. |
in the placenta, the expression of various genes is regulated by the hippo pathway through a transcription complex, yes-associated protein (yap)/transcriptional coactivator with pdz-binding motif (taz)-tea domain transcription factor (tead) (yap/taz-tead) activity. |
2022-08-22 |
2023-08-14 |
human |
| Chunle Zhao, Jun Gong, Yu Bai, Taoyuan Yin, Min Zhou, Shutao Pan, Yuhui Liu, Yang Gao, Zhenxiong Zhang, Yongkang Shi, Feng Zhu, Hang Zhang, Min Wang, Renyi Qi. A self-amplifying USP14-TAZ loop drives the progression and liver metastasis of pancreatic ductal adenocarcinoma. Cell death and differentiation. 2022-07-29. PMID:35906484. |
moreover, taz facilitated the transcription of usp14 by binding to the tea domain transcription factor (tead) 1/4 response element in the promoter of usp14. |
2022-07-29 |
2023-08-14 |
Not clear |
| Benjamin Zagiel, Patricia Melnyk, Philippe Cotell. Progress with YAP/TAZ-TEAD inhibitors: a patent review (2018-present). Expert opinion on therapeutic patents. 2022-06-29. PMID:35768160. |
overexpression of yes-associated protein (yap) or transcriptional coactivator with pdz-binding motif (taz) or tead has been demonstrated in cancers and yap is known to mediate resistance to cancer drugs. |
2022-06-29 |
2023-08-14 |
Not clear |
| Ji-Cheng Huang, Zhan-Peng Yue, Hai-Fan Yu, Zhan-Qing Yang, Yu-Si Wang, Bin Gu. TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NF-κB pathway. Molecular therapy. Nucleic acids. vol 28. 2022-05-04. PMID:35505966. |
after translocation into the nucleus, taz interacted with transcriptional enhanced associate domain (tead) and bound to the promoter of nuclear factor erythroid 2-related factor 2 (nrf2), whose blockage caused inability of taz to improve inflammation, implying that nrf2 is a direct target of taz. |
2022-05-04 |
2023-08-13 |
Not clear |
| Weifeng Tang, Min Li, Xiaoting Yangzhong, Xifeng Zhang, Anju Zu, Yunjiao Hou, Lin Li, Shibo Su. Hippo signaling pathway and respiratory diseases. Cell death discovery. vol 8. issue 1. 2022-04-21. PMID:35443749. |
hippo signaling pathway is mainly composed of mammalian ste20-like kinase 1/2 (mst1/2), large tumor suppressor 1/2 (lats1/2), ww domain of the sav family containing protein 1 (sav1), mob kinase activator 1 (mob1), yes-associated protein (yap) or transcriptional coactivator with pdz-binding motif (taz), and members of the tea domain (tead) family. |
2022-04-21 |
2023-08-13 |
Not clear |
| Kepeng Che, Ajaybabu V Pobbati, Caleb N Seavey, Yuriy Fedorov, Anton A Komar, Ashley Burtscher, Shuang Ma, Brian P Rubi. Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex. PloS one. vol 17. issue 4. 2022-04-13. PMID:35417479. |
we have previously shown that cell-based models that express the oncogenic taz-camta1 (tc) fusion protein display enhanced tead transcriptional activity because tc functions as an activated form of taz. |
2022-04-13 |
2023-08-13 |
Not clear |
| Angela Lauriola, Elisa Uliassi, Matteo Santucci, Maria Laura Bolognesi, Marco Mor, Laura Scalvini, Gian Marco Elisi, Gaia Gozzi, Lorenzo Tagliazucchi, Gaetano Marverti, Stefania Ferrari, Lorena Losi, Domenico D'Arca, Maria Paola Cost. Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library. Pharmaceutics. vol 14. issue 2. 2022-02-26. PMID:35214125. |
the transcriptional regulators yap (yes-associated protein) and taz (transcriptional co-activator with pdz-binding motif) are the major downstream effectors in the hippo pathway and are involved in cancer progression through modulation of the activity of tead (transcriptional enhanced associate domain) transcription factors. |
2022-02-26 |
2023-08-13 |
Not clear |
| Júlia Koch, Valério Marques Portela, Esdras Corrêa Dos Santos, Daniele Missio, Leonardo Guedes de Andrade, Zigomar da Silva, Bernardo Garziera Gasperin, Alfredo Quites Antoniazzi, Paulo Bayard Dias Gonçalves, Gustavo Zamberla. The Hippo pathway effectors YAP and TAZ interact with EGF-like signaling to regulate expansion-related events in bovine cumulus cells in vitro. Journal of assisted reproduction and genetics. 2022-01-29. PMID:35091965. |
to determine if the inhibition of the interaction between the hippo effector yap or its transcriptional co-activator taz with the tead family of transcription factors is critical for the cumulus expansion-related events induced by the egf network in cumulus-oocyte complexes (cocs). |
2022-01-29 |
2023-08-13 |
cattle |
| Yin Zhang, Ye-Ya Tan, Pei-Pei Chen, Hui Xu, Shu-Juan Xie, Shi-Jun Xu, Bin Li, Jun-Hao Li, Shun Liu, Jian-Hua Yang, Hui Zhou, Liang-Hu Q. Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development. Cell death & disease. vol 12. issue 12. 2021-12-15. PMID:34907157. |
mechanistically, we further demonstrated that mir-122 negatively regulates the outcomes of the hippo pathway transcription factor tead by directly targeting a number of hippo pathway regulators, including the coactivator taz and a key factor of the phosphatase complex ppp1cc, which contributes to the dephosphorylation of yap, another coactivator downstream of the hippo pathway. |
2021-12-15 |
2023-08-13 |
mouse |