| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shu Li, Xing Li, Yong-Bin Yang, Su-Fang W. YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells. Apoptosis : an international journal on programmed cell death. 2024-03-30. PMID:38553612. |
next, the expression levels of yap, taz and tead in cervical tissues and cells were observed by immunohistochemistry, qrt-pcr and western blot. |
2024-03-30 |
2024-04-01 |
human |
| Shu Li, Xing Li, Yong-Bin Yang, Su-Fang W. YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells. Apoptosis : an international journal on programmed cell death. 2024-03-30. PMID:38553612. |
subsequently, the stemness characteristics, glycolysis level and malignant transformation of cells in each group were observed by sphere-formation assay, commercial kit, mtt, transwell, scratch experiment, xenotransplantation and western blot.the expression of yap, taz and tead increased significantly in cervical cancer tissue and cell line at the stage of cin2/3 and scc. |
2024-03-30 |
2024-04-01 |
human |
| Shubhashree Parimita, Amitava Das, Sanjoy Samant. VGLL1 stabilization of cytoplasmic TAZ promotes EGFR expression and maintains tumor initiating cells in breast cancer independent of TEAD. Cellular signalling. 2024-02-28. PMID:38417636. |
vgll1 stabilization of cytoplasmic taz promotes egfr expression and maintains tumor initiating cells in breast cancer independent of tead. |
2024-02-28 |
2024-03-02 |
Not clear |
| Abraham Behrmann, Dalian Zhong, Li Li, Shangkui Xie, Megan Mead, Parastoo Sabaeifard, Mohammad Goodarzi, Andrew Lemoff, Julia Kozlitina, Dwight A Towle. Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz(Wwtr1) Activation in Male LDLR-/- Mice. Endocrinology. 2023-12-20. PMID:38123514. |
wnt16 stimulated taz binding to acta2 chromatin and h3k4me3 methylation.. tead cognates in the acta2 promoter conveyed transcriptional responses to wnt16 and taz. |
2023-12-20 |
2023-12-23 |
mouse |
| Yang Zhao, Marisela Sheldon, Yutong Sun, Li M. New Insights into YAP/TAZ-TEAD-Mediated Gene Regulation and Biological Processes in Cancer. Cancers. vol 15. issue 23. 2023-12-09. PMID:38067201. |
key mammalian hippo pathway kinases, including mst1/2 and lats1/2, inhibit cellular growth by inactivating the tead coactivators, yap, and taz. |
2023-12-09 |
2023-12-17 |
Not clear |
| Tao Liu, Jiaojiao Zhou, Yanmin Chen, Jia Fang, Song Liu, Costa Frangou, Hai Wang, Jianmin Zhan. Genome-Wide Characterization of TAZ Binding Sites in Mammary Epithelial Cells. Cancers. vol 15. issue 19. 2023-10-14. PMID:37835407. |
taz bound to enhancer regions following a switch in potential tead and fosl2 transcription factor motifs. |
2023-10-14 |
2023-10-15 |
Not clear |
| Adelya Gabdulkhakova, Yekaterina Krutsenko, Junjie Zhu, Silvia Liu, Minakshi Poddar, Sucha Singh, Xiaochao Ma, Kari Nejak-Bowen, Satdarshan P S Monga, Laura M Molin. Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury. Hepatology communications. vol 7. issue 9. 2023-08-09. PMID:37556373. |
taz, a paralog of yap, was significantly upregulated in yapko hepatocytes and interacted with tea domain family member (tead) transcription factors, suggesting possible compensatory activity. |
2023-08-09 |
2023-08-16 |
Not clear |
| Cornelis J Boogerd, Ilaria Perini, Eirini Kyriakopoulou, Su Ji Han, Phit La, Britt van der Swaan, Jari B Berkhout, Danielle Versteeg, Jantine Monshouwer-Kloots, Eva van Rooi. Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation. Nature communications. vol 14. issue 1. 2023-08-05. PMID:37543677. |
furthermore, we show that arid1a directly binds and inhibits the proliferation-promoting transcriptional coactivators yap and taz, indicating arid1a sequesters yap/taz from their dna-binding partner tead. |
2023-08-05 |
2023-08-14 |
human |
| Chan-I Chung, Junjiao Yang, Xiaokun Sh. Chemogenetic Minitool for Dissecting the Roles of Protein Phase Separation. ACS central science. vol 9. issue 7. 2023-07-31. PMID:37521779. |
to address this question, we have designed a chemogenetic tool, dubbed spark-on, which manipulates the ps of yap and taz without a biological stimulus, forming condensates that are transcriptionally active, containing the dna-binding partner tead, genomic dna, transcriptional machinery, and nascent rna. |
2023-07-31 |
2023-08-14 |
Not clear |
| Kuang Tan, Qiaolin Yang, Yineng Han, Ziyao Zhuang, Yi Zhao, KunYao Guo, Anqi Tan, Yunfei Zheng, Weiran L. Elastic modulus of hydrogel regulates osteogenic differentiation via liquid-liquid phase separation of YAP. Journal of biomedical materials research. Part A. 2023-07-26. PMID:37494632. |
in contrast, the expression of yap, taz and tead was increased in the hbmscs in the low-elastic-modulus gelma. |
2023-07-26 |
2023-08-14 |
rat |
| Yuki Takakura, Takayuki Suzuki, Naoto Hirai, Takuro Araki, Mai Ohishi, Hiromi Sato, Naoto Yamaguchi, Hiroyuki Takano, Noritaka Yamaguch. VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes. Biochemical and biophysical research communications. vol 669. 2023-06-01. PMID:37262950. |
we also found that vgll3 proteins are degraded by the proteasome, which causes switching of tead cofactors from vgll3 to yes-associated protein (yap) and transcriptional coactivator with a pdz-binding motif (taz). |
2023-06-01 |
2023-08-14 |
Not clear |
| Boting Ning, Andrew M Tilston-Lunel, Justice Simonetti, Julia Hicks-Berthet, Adeline Matschulat, Roxana Pfefferkorn, Avrum Spira, Matthew Edwards, Sarah Mazzilli, Marc E Lenburg, Jennifer E Beane, Xaralabos Varela. Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression. Journal of experimental & clinical cancer research : CR. vol 42. issue 1. 2023-05-07. PMID:37150829. |
evidence has suggested key roles for the hippo pathway effectors yap and taz and associated tead and tp63 transcription factor families in bronchial basal cell biology and lusc. |
2023-05-07 |
2023-08-14 |
Not clear |
| Jingyuan Wang, Haofeng Chen, Wulei Hou, Qingjian Han, Zuoyun Wan. Hippo Pathway in Schwann Cells and Regeneration of Peripheral Nervous System. Developmental neuroscience. 2023-04-20. PMID:37080186. |
its key transcriptional co-activators yap and taz regulate transcription factors such as tead family to direct gene expression. |
2023-04-20 |
2023-08-14 |
Not clear |
| Kota Noritsugu, Takehiro Suzuki, Kosuke Dodo, Kenji Ohgane, Yasue Ichikawa, Kota Koike, Satoshi Morita, Takashi Umehara, Kenji Ogawa, Mikiko Sodeoka, Naoshi Dohmae, Minoru Yoshida, Akihiro It. Lysine long-chain fatty acylation regulates the TEAD transcription factor. Cell reports. 2023-04-15. PMID:37060904. |
tead activity is primarily regulated by phosphorylation of its coactivators, yap and taz. |
2023-04-15 |
2023-08-14 |
Not clear |
| Kota Noritsugu, Takehiro Suzuki, Kosuke Dodo, Kenji Ohgane, Yasue Ichikawa, Kota Koike, Satoshi Morita, Takashi Umehara, Kenji Ogawa, Mikiko Sodeoka, Naoshi Dohmae, Minoru Yoshida, Akihiro It. Lysine long-chain fatty acylation regulates the TEAD transcription factor. Cell reports. 2023-04-15. PMID:37060904. |
lysine fatty acylation, like cysteine palmitoylation, contributes to the transcriptional activity of teads by enhancing the interaction with yap and taz, but it is more stable than cysteine acylation, suggesting that the lysine fatty-acylated tead acts as a "stable active form." |
2023-04-15 |
2023-08-14 |
Not clear |
| Wenchao Lu, Mengyang Fan, Wenzhi Ji, Jason Tse, Inchul You, Scott B Ficarro, Isidoro Tavares, Jianwei Che, Audrey Y Kim, Xijun Zhu, Andrew Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Stephen M Hinshaw, Behnam Nabet, Steven M Corsello, Nicholas Kwiatkowski, Jarrod A Marto, Tinghu Zhang, Nathanael S Gra. Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors. Journal of medicinal chemistry. 2023-03-22. PMID:36946421. |
transcriptional enhanced associate domain (tead) proteins together with their transcriptional coactivator yes-associated protein (yap) and transcriptional coactivator with the pdz-binding motif (taz) are important transcription factors and cofactors that regulate gene expression in the hippo pathway. |
2023-03-22 |
2023-08-14 |
Not clear |
| Feng Li, Vinny Negi, Ping Yang, Jeongkyung Lee, Ke Ma, Mousumi Moulik, Vijay K Yechoo. TEAD1 regulates cell proliferation through a pocket-independent transcription repression mechanism. Nucleic acids research. 2022-12-09. PMID:36484096. |
the existing paradigm is that tead co-activators, yap and taz, and co-repressor, vgll4, bind to the pocket region of tead1 to enable transcriptional activation or repressive function. |
2022-12-09 |
2023-08-14 |
Not clear |
| Pasquale Sileo, Clémence Simonin, Patricia Melnyk, Marie-Christine Chartier-Harlin, Philippe Cotell. Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington's Disease and Other Neurodegenerative Disorders. Cells. vol 11. issue 22. 2022-11-26. PMID:36429058. |
when unphosphorylated, yap and taz translocate into the nucleus, where they mainly bind to the tead transcription factor family and activate genes related to cell proliferation and survival. |
2022-11-26 |
2023-08-14 |
Not clear |
| Youngchai Son, Jaeyeal Kim, Yongchan Kim, Sung-Gil Chi, Tackhoon Kim, Jinha Y. Discovery of dioxo-benzo[b]thiophene derivatives as potent YAP-TEAD interaction inhibitors for treating breast cancer. Bioorganic chemistry. vol 131. 2022-11-26. PMID:36434952. |
disruption of protein-protein interaction between transcriptional enhancer factor (tea)-domain (tead; a transcription factor) and its co-activator yes-associated protein (yap)/ transcriptional co-activator with pdz-binding motif (taz) is a potential therapeutic strategy against various types of solid tumors. |
2022-11-26 |
2023-08-14 |
Not clear |
| Liyam Laraba, Lily Hillson, Julio Grimm de Guibert, Amy Hewitt, Maisie R Jaques, Tracy T Tang, Leonard Post, Emanuela Ercolano, Ganesha Rai, Shyh Ming Yang, Daniel J Jagger, Waldemar Woznica, Philip Edwards, Aditya G Shivane, C Oliver Hanemann, David B Parkinso. Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma. Brain : a journal of neurology. 2022-09-23. PMID:36148553. |
using both genetic ablation of the hippo effectors yap and taz as well as novel tead palmitoylation inhibitors, we show that hippo signalling may be successfully targeted in vitro and in vivo to both block and, remarkably, regress schwannoma tumour growth. |
2022-09-23 |
2023-08-14 |
mouse |