| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keisuke Nakatani, Tomohiko Maehama, Miki Nishio, Junji Otani, Keiko Yamaguchi, Miki Fukumoto, Hiroki Hikasa, Shinji Hagiwara, Hiroshi Nishina, Tak Wah Mak, Teruki Honma, Yasumitsu Kondoh, Hiroyuki Osada, Minoru Yoshida, Akira Suzuk. Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation. Cancer science. vol 112. issue 10. 2021-10-13. PMID:34289205. |
yes-associated protein 1 (yap1) and its paralogue pdz-binding motif (taz) play pivotal roles in cell proliferation, migration, and invasion, and abnormal activation of these tead transcriptional coactivators is found in diverse cancers in humans and mice. |
2021-10-13 |
2023-08-13 |
mouse |
| Yao Yuan, Natalia Salinas Parra, Qianming Chen, Ramiro Iglesias-Bartolom. Oncogenic Hedgehog-Smoothened Signaling Depends on YAP1‒TAZ/TEAD Transcription to Restrain Differentiation in Basal Cell Carcinoma. The Journal of investigative dermatology. 2021-10-01. PMID:34293352. |
in this study, we utilize tead inhibitor, an inhibitor of the binding of yap1 and taz with their main transcriptional target tead in a mouse model of basal cell carcinoma, to unveil the consequences of yap1/taz transcriptional blockage in cancer cells. |
2021-10-01 |
2023-08-13 |
mouse |
| Laura Currey, Stefan Thor, Michael Pipe. TEAD family transcription factors in development and disease. Development (Cambridge, England). vol 148. issue 12. 2021-08-02. PMID:34128986. |
hippo pathway activity is mediated by the transcriptional co-factors yes-associated protein (yap) and transcriptional co-activator with pdz-binding motif (taz), which interact with tea domain (tead) proteins to regulate gene expression. |
2021-08-02 |
2023-08-13 |
Not clear |
| Laura Currey, Stefan Thor, Michael Pipe. TEAD family transcription factors in development and disease. Development (Cambridge, England). vol 148. issue 12. 2021-08-02. PMID:34128986. |
although the roles of yap and taz have been intensively studied, the roles played by tead proteins are less well understood. |
2021-08-02 |
2023-08-13 |
Not clear |
| Yue Yu, Xingli Su, Qiaohong Qin, Ying Hou, Xin Zhang, Hongmei Zhang, Min Jia, Yulong Che. Yes-associated protein and transcriptional coactivator with PDZ-binding motif as new targets in cardiovascular diseases. Pharmacological research. vol 159. 2021-07-06. PMID:32553712. |
as transcriptional co-activators, yes-associated protein (yap) and transcriptional coactivator with pdz-binding motif (taz) can regulate cell proliferation, migration, differentiation, and apoptosis by interacting with the transcription factors [e.g., transcriptional enhancer associate domain (tead) family members]. |
2021-07-06 |
2023-08-13 |
Not clear |
| Garam Kim, Poshan Yugal Bhattarai, Sung-Chul Lim, Jin-Young Kim, Hong Seok Cho. PIN1 facilitates ubiquitin-mediated degradation of serine/threonine kinase 3 and promotes melanoma development via TAZ activation. Cancer letters. vol 499. 2021-05-20. PMID:33253791. |
furthermore, pin1 plays a critical role in the nuclear translocation of taz, which forms a complex with tead to increase ctgf expression. |
2021-05-20 |
2023-08-13 |
human |
| Jeffrey K Holden, James J Crawford, Cameron L Noland, Stephen Schmidt, Jason R Zbieg, Jennifer A Lacap, Richard Zang, Gregory M Miller, Yue Zhang, Paul Beroza, Rohit Reja, Wendy Lee, Jeffrey Y K Tom, Rina Fong, Micah Steffek, Saundra Clausen, Thjis J Hagenbeek, Taishan Hu, Zheng Zhou, Hong C Shen, Christian N Cunningha. Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling. Cell reports. vol 31. issue 12. 2021-04-28. PMID:32579935. |
the transcriptional enhanced associate domain (tead) family of transcription factors serves as the receptors for the downstream effectors of the hippo pathway, yap and taz, to upregulate the expression of multiple genes involved in cellular proliferation and survival. |
2021-04-28 |
2023-08-13 |
mouse |
| Qi Li, Yang Sun, Gopala K Jarugumilli, Shun Liu, Kyvan Dang, Jennifer L Cotton, Jordi Xiol, Pui Yee Chan, Michael DeRan, Lifang Ma, Rui Li, Lihua J Zhu, Joyce H Li, Andrew B Leiter, Y Tony Ip, Fernando D Camargo, Xuelian Luo, Randy L Johnson, Xu Wu, Junhao Ma. Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. Cell stem cell. vol 26. issue 5. 2021-04-27. PMID:32259481. |
combining this chemical tool with genetic and proteomics approaches, we show that intestinal wnt inhibition by lats deletion is yes-associated protein (yap)/transcriptional activator with pdz-binding domain (taz) dependent but tead independent. |
2021-04-27 |
2023-08-13 |
human |
| Ajaybabu V Pobbati, Wanjin Hon. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. vol 10. issue 8. 2021-04-07. PMID:32206112. |
the transcriptional co-regulators yap and taz pair primarily with the tead family of transcription factors to elicit a gene expression signature that plays a prominent role in cancer development, progression and metastasis. |
2021-04-07 |
2023-08-13 |
Not clear |
| Ayumi Kaneda, Toshihiro Seike, Tomohiro Danjo, Takahiro Nakajima, Nobumasa Otsubo, Daisuke Yamaguchi, Yoshiro Tsuji, Kaori Hamaguchi, Mai Yasunaga, Yoichi Nishiya, Michihiko Suzuki, Jun-Ichi Saito, Rie Yatsunami, Satoshi Nakamura, Yoshitaka Sekido, Kiyotoshi Mor. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma. American journal of cancer research. vol 10. issue 12. 2021-03-27. PMID:33415007. |
in the hippo pathway, transcriptional enhanced associate domain (tead) which is a transcription factor is activated by forming a complex with yes-associated protein 1 (yap1) or transcriptional coactivator with pdz-binding motif (taz, also called wwtr1). |
2021-03-27 |
2023-08-13 |
Not clear |
| Heng Zhang, Chen-Ying Liu, Zheng-Yu Zha, Bin Zhao, Jun Yao, Shimin Zhao, Yue Xiong, Qun-Ying Lei, Kun-Liang Gua. Correction: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. The Journal of biological chemistry. vol 294. issue 15. 2021-03-14. PMID:30979850. |
correction: tead transcription factors mediate the function of taz in cell growth and epithelial-mesenchymal transition. |
2021-03-14 |
2023-08-13 |
Not clear |
| Heinrich Kovar, Lisa Bierbaumer, Branka Radic-Sarika. The YAP/TAZ Pathway in Osteogenesis and Bone Sarcoma Pathogenesis. Cells. vol 9. issue 4. 2021-02-19. PMID:32326412. |
efforts to clinically translate the wealth of available knowledge of the pathway for cancer diagnostic and therapeutic purposes focus mainly on yap and taz expression and their role as transcriptional co-activators of tead transcription factors but rarely consider the expression and activity of pathway modulatory components and other transcriptional partners of yap and taz. |
2021-02-19 |
2023-08-13 |
Not clear |
| Zihan Xiu, Jiao Liu, Xin Wu, Xiangyong Li, Sanzhong Li, Xiaofeng Wu, Xiaohua Lv, Hua Ye, Xudong Tan. Cytochalasin H isolated from mangrove-derived endophytic fungus inhibits epithelial-mesenchymal transition and cancer stemness Journal of Cancer. vol 12. issue 4. 2021-01-15. PMID:33442415. |
additionally, cyh significantly down-regulated yap and taz expression and up-regulated last1/2 and mst1/2 expression, and cyh inhibited the interaction between yap and tead. |
2021-01-15 |
2023-08-13 |
Not clear |
| Fedir Bokhovchuk, Yannick Mesrouze, Clara Delaunay, Typhaine Martin, Frédéric Villard, Marco Meyerhofer, Patrizia Fontana, Catherine Zimmermann, Dirk Erdmann, Pascal Furet, Clemens Scheufler, Tobias Schmelzle, Patrick Chèn. Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors. Protein science : a publication of the Protein Society. vol 29. issue 2. 2020-12-21. PMID:31697419. |
the most distal elements of this pathway, the tead transcription factors, are regulated by several proteins, such as yap (yes-associated protein), taz (transcriptional co-activator with pdz-binding motif) and vgll1-4 (vestigial-like members 1-4). |
2020-12-21 |
2023-08-13 |
Not clear |
| Gian Marco Elisi, Matteo Santucci, Domenico D'Arca, Angela Lauriola, Gaetano Marverti, Lorena Losi, Laura Scalvini, Maria Laura Bolognesi, Marco Mor, Maria Paola Cost. Repurposing of Drugs Targeting YAP-TEAD Functions. Cancers. vol 10. issue 9. 2020-09-30. PMID:30223434. |
several drugs in clinical practice have been reported for modulating the major hippo pathway's terminal effectors, namely yap (yes1-associated protein), taz (transcriptional co-activator with pdz-binding motif) and tead (transcriptional enhanced associate domains), which are directly involved in the regulation of cell growth and tissue homeostasis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jason W Lui, Sixia Xiao, Kelsey Ogomori, Jon E Hammarstedt, Elizabeth C Little, Deborah Lan. The Efficiency of Verteporfin as a Therapeutic Option in Pre-Clinical Models of Melanoma. Journal of Cancer. vol 10. issue 1. 2020-09-30. PMID:30662519. |
yap and taz act as drivers of melanoma through its interaction with the tead family of transcription factors. |
2020-09-30 |
2023-08-13 |
mouse |
| Kazem Nouri, Taha Azad, Min Ling, Helena J Janse van Rensburg, Alexander Pipchuk, He Shen, Yawei Hao, Jianmin Zhang, Xiaolong Yan. Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive Cancers. vol 11. issue 10. 2020-09-28. PMID:31635084. |
given this, some have suggested that disrupting the interaction of the hippo core component yap and its paralog taz with transcriptional factor tead may be an effective strategy for cancer therapy. |
2020-09-28 |
2023-08-13 |
Not clear |
| Patricia García, Lorena Rosa, Sergio Vargas, Helga Weber, Jaime A Espinoza, Felipe Suárez, Isabel Romero-Calvo, Nicole Elgueta, Vanessa Rivera, Bruno Nervi, Javiera Obreque, Pamela Leal, Eduardo Viñuela, Gloria Aguayo, Sabrina Muñiz, Alfredo Sagredo, Juan C Roa, Carolina Bizam. Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer. Cancers. vol 12. issue 4. 2020-09-28. PMID:32218280. |
this study aimed to evaluate the expression of the major hippo pathway components mammalian ste20-like protein kinase 1 (mst1), yap1 and transcriptional coactivator with pdz-binding motif (taz) and examined the effects of verteporfin (vp), a small molecular inhibitor of yap1-tea domain transcription factor (tead) protein interaction, in metastatic gbc cell lines and patient-derived organoids (pdos). |
2020-09-28 |
2023-08-13 |
Not clear |
| Jing Zhang, Osamu Yamada, Shinya Kida, Shinya Murase, Toshio Hattori, Yoshiteru Oshima, Haruhisa Kikuch. Downregulation of PD-L1 via amide analogues of brefelamide: Alternatives to antibody-based cancer immunotherapy. Experimental and therapeutic medicine. vol 19. issue 4. 2020-09-28. PMID:32256803. |
tpfs compound-mediated pd-l1 inhibition was partially abolished by the disruption of the putative transcriptional co-activator with pdz (taz)/tea domain (tead)-binding motif in the pd-l1 promoter. |
2020-09-28 |
2023-08-13 |
mouse |
| Wei Zhao, Li-Wen Li, Rui-Feng Tian, Qiu-Feng Dong, Peng-Qi Li, Zhi-Feng Yan, Xin Yang, Jun-Li Huo, Zhou Fei, Hai-Ning Zhe. Truncated TEAD-binding protein of TAZ inhibits glioma survival through the induction of apoptosis and repression of epithelial-mesenchymal transition. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-17. PMID:31209945. |
transcriptional coactivator with pdz-binding motif (taz), a hippo pathway downstream effector, promotes tumor progression by serving as a transcriptional coactivator with tead. |
2020-09-17 |
2023-08-13 |
Not clear |