| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heng Zhang, Chen-Ying Liu, Zheng-Yu Zha, Bin Zhao, Jun Yao, Shimin Zhao, Yue Xiong, Qun-Ying Lei, Kun-Liang Gua. Correction: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. The Journal of biological chemistry. vol 294. issue 15. 2021-03-14. PMID:30979850. |
correction: tead transcription factors mediate the function of taz in cell growth and epithelial-mesenchymal transition. |
2021-03-14 |
2023-08-13 |
Not clear |
| Heinrich Kovar, Lisa Bierbaumer, Branka Radic-Sarika. The YAP/TAZ Pathway in Osteogenesis and Bone Sarcoma Pathogenesis. Cells. vol 9. issue 4. 2021-02-19. PMID:32326412. |
efforts to clinically translate the wealth of available knowledge of the pathway for cancer diagnostic and therapeutic purposes focus mainly on yap and taz expression and their role as transcriptional co-activators of tead transcription factors but rarely consider the expression and activity of pathway modulatory components and other transcriptional partners of yap and taz. |
2021-02-19 |
2023-08-13 |
Not clear |
| Zihan Xiu, Jiao Liu, Xin Wu, Xiangyong Li, Sanzhong Li, Xiaofeng Wu, Xiaohua Lv, Hua Ye, Xudong Tan. Cytochalasin H isolated from mangrove-derived endophytic fungus inhibits epithelial-mesenchymal transition and cancer stemness Journal of Cancer. vol 12. issue 4. 2021-01-15. PMID:33442415. |
additionally, cyh significantly down-regulated yap and taz expression and up-regulated last1/2 and mst1/2 expression, and cyh inhibited the interaction between yap and tead. |
2021-01-15 |
2023-08-13 |
Not clear |
| Fedir Bokhovchuk, Yannick Mesrouze, Clara Delaunay, Typhaine Martin, Frédéric Villard, Marco Meyerhofer, Patrizia Fontana, Catherine Zimmermann, Dirk Erdmann, Pascal Furet, Clemens Scheufler, Tobias Schmelzle, Patrick Chèn. Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors. Protein science : a publication of the Protein Society. vol 29. issue 2. 2020-12-21. PMID:31697419. |
the most distal elements of this pathway, the tead transcription factors, are regulated by several proteins, such as yap (yes-associated protein), taz (transcriptional co-activator with pdz-binding motif) and vgll1-4 (vestigial-like members 1-4). |
2020-12-21 |
2023-08-13 |
Not clear |
| Gian Marco Elisi, Matteo Santucci, Domenico D'Arca, Angela Lauriola, Gaetano Marverti, Lorena Losi, Laura Scalvini, Maria Laura Bolognesi, Marco Mor, Maria Paola Cost. Repurposing of Drugs Targeting YAP-TEAD Functions. Cancers. vol 10. issue 9. 2020-09-30. PMID:30223434. |
several drugs in clinical practice have been reported for modulating the major hippo pathway's terminal effectors, namely yap (yes1-associated protein), taz (transcriptional co-activator with pdz-binding motif) and tead (transcriptional enhanced associate domains), which are directly involved in the regulation of cell growth and tissue homeostasis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jason W Lui, Sixia Xiao, Kelsey Ogomori, Jon E Hammarstedt, Elizabeth C Little, Deborah Lan. The Efficiency of Verteporfin as a Therapeutic Option in Pre-Clinical Models of Melanoma. Journal of Cancer. vol 10. issue 1. 2020-09-30. PMID:30662519. |
yap and taz act as drivers of melanoma through its interaction with the tead family of transcription factors. |
2020-09-30 |
2023-08-13 |
mouse |
| Kazem Nouri, Taha Azad, Min Ling, Helena J Janse van Rensburg, Alexander Pipchuk, He Shen, Yawei Hao, Jianmin Zhang, Xiaolong Yan. Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive Cancers. vol 11. issue 10. 2020-09-28. PMID:31635084. |
given this, some have suggested that disrupting the interaction of the hippo core component yap and its paralog taz with transcriptional factor tead may be an effective strategy for cancer therapy. |
2020-09-28 |
2023-08-13 |
Not clear |
| Patricia García, Lorena Rosa, Sergio Vargas, Helga Weber, Jaime A Espinoza, Felipe Suárez, Isabel Romero-Calvo, Nicole Elgueta, Vanessa Rivera, Bruno Nervi, Javiera Obreque, Pamela Leal, Eduardo Viñuela, Gloria Aguayo, Sabrina Muñiz, Alfredo Sagredo, Juan C Roa, Carolina Bizam. Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer. Cancers. vol 12. issue 4. 2020-09-28. PMID:32218280. |
this study aimed to evaluate the expression of the major hippo pathway components mammalian ste20-like protein kinase 1 (mst1), yap1 and transcriptional coactivator with pdz-binding motif (taz) and examined the effects of verteporfin (vp), a small molecular inhibitor of yap1-tea domain transcription factor (tead) protein interaction, in metastatic gbc cell lines and patient-derived organoids (pdos). |
2020-09-28 |
2023-08-13 |
Not clear |
| Jing Zhang, Osamu Yamada, Shinya Kida, Shinya Murase, Toshio Hattori, Yoshiteru Oshima, Haruhisa Kikuch. Downregulation of PD-L1 via amide analogues of brefelamide: Alternatives to antibody-based cancer immunotherapy. Experimental and therapeutic medicine. vol 19. issue 4. 2020-09-28. PMID:32256803. |
tpfs compound-mediated pd-l1 inhibition was partially abolished by the disruption of the putative transcriptional co-activator with pdz (taz)/tea domain (tead)-binding motif in the pd-l1 promoter. |
2020-09-28 |
2023-08-13 |
mouse |
| Wei Zhao, Li-Wen Li, Rui-Feng Tian, Qiu-Feng Dong, Peng-Qi Li, Zhi-Feng Yan, Xin Yang, Jun-Li Huo, Zhou Fei, Hai-Ning Zhe. Truncated TEAD-binding protein of TAZ inhibits glioma survival through the induction of apoptosis and repression of epithelial-mesenchymal transition. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-17. PMID:31209945. |
transcriptional coactivator with pdz-binding motif (taz), a hippo pathway downstream effector, promotes tumor progression by serving as a transcriptional coactivator with tead. |
2020-09-17 |
2023-08-13 |
Not clear |
| Anwesha Dey, Xaralabos Varelas, Kun-Liang Gua. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nature reviews. Drug discovery. vol 19. issue 7. 2020-09-01. PMID:32555376. |
many of these roles are mediated by the transcriptional effectors yap and taz, which direct gene expression via control of the tead family of transcription factors. |
2020-09-01 |
2023-08-13 |
Not clear |
| Wei Zhou, Yiping Li, Jinhua Song, Chenglong L. Fluorescence polarization assay for the identification and evaluation of inhibitors at YAP-TEAD protein-protein interface 3. Analytical biochemistry. vol 586. 2020-08-10. PMID:31479631. |
inhibition of the pathway promotes the translocation of the major hippo pathway effectors, the yes-associated protein (yap) and its paralog taz, to the nucleus, where they interact with the transcription factor family transcriptional enhancer associate domain (tead), thus coactivating the expression of downstream genes, leading to cell transformation, tissue overgrowth, and tumor development. |
2020-08-10 |
2023-08-13 |
Not clear |
| Rui-Juan Niu, Qing-Chuan Zheng, Hong-Xing Zhan. Molecular dynamics simulations study of influence of Tyr422Ala mutation on transcriptional enhancer activation domain 4 (TEAD4) and transcription co-activators complexes. Journal of theoretical biology. vol 472. 2020-07-16. PMID:30978352. |
the transcription co-activators yes-associated protein (yap) and its paralog transcription co-activators with pdz-binding motif (taz), binding to tead to promote transcription of genes in cell proliferation and anti-apoptosis, are key effectors of the hippo pathway. |
2020-07-16 |
2023-08-13 |
mouse |
| Yao Yuan, Jeannie Park, Amber Feng, Parirokh Awasthi, Zhiyong Wang, Qianming Chen, Ramiro Iglesias-Bartolom. YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity. Nature communications. vol 11. issue 1. 2020-07-15. PMID:32193376. |
here we introduce teadi, a genetically encoded inhibitor of the interaction of yap1 and taz with tead, as a tool to characterize the transcriptional networks and biological effects regulated by tead transcription factors. |
2020-07-15 |
2023-08-13 |
mouse |
| Bailey V Fearing, Liufang Jing, Marcos N Barcellona, Savannah Est Witte, Jacob M Buchowski, Lukas P Zebala, Michael P Kelly, Scott Luhmann, Munish C Gupta, Amit Pathak, Lori A Setto. Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 12. 2020-06-26. PMID:31638828. |
upon preservation of a rounded shape, human np cells similarly showed cytosolic retention of transcriptional coactivator yes-associated protein (yap) and its paralogue pdz-binding motif (taz) with associated decline in activation of its transcription factor tea domain family member-binding domain (tead). |
2020-06-26 |
2023-08-13 |
human |
| Shigeki Sekine, Tohru Kiyono, Eijitsu Ryo, Reiko Ogawa, Susumu Wakai, Hitoshi Ichikawa, Koyu Suzuki, Satoru Arai, Koji Tsuta, Mitsuaki Ishida, Yuko Sasajima, Naoki Goshima, Naoya Yamazaki, Taisuke Mor. Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma. The Journal of clinical investigation. vol 129. issue 9. 2020-06-23. PMID:31145701. |
yap1 and wwtr1, also known as yap and taz, respectively, encode paralogous transcriptional activators of tead, which are negatively regulated by the hippo signaling pathway. |
2020-06-23 |
2023-08-13 |
Not clear |
| Julie Giraud, Silvia Molina-Castro, Lornella Seeneevassen, Elodie Sifré, Julien Izotte, Camille Tiffon, Cathy Staedel, Hélène Boeuf, Solène Fernandez, Philippe Barthelemy, Francis Megraud, Philippe Lehours, Pierre Dubus, Christine Varo. Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells. International journal of cancer. vol 146. issue 8. 2020-05-18. PMID:31489619. |
yap1 and taz oncoproteins (y/t) interact with tea domain family member 1 (tead) transcription factors to promote cell survival and proliferation in multiple tissues. |
2020-05-18 |
2023-08-13 |
mouse |
| Fedir Bokhovchuk, Yannick Mesrouze, Aude Izaac, Marco Meyerhofer, Catherine Zimmermann, Patrizia Fontana, Tobias Schmelzle, Dirk Erdmann, Pascal Furet, Joerg Kallen, Patrick Chèn. Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy. The FEBS journal. vol 286. issue 12. 2020-05-15. PMID:30903741. |
tead transcriptional activity is regulated via interactions with the yap, taz and vgll proteins. |
2020-05-15 |
2023-08-13 |
human |
| Ajaybabu V Pobbati, Tom Mejuch, Sayan Chakraborty, Hacer Karatas, Sakshibeedu R Bharath, Stéphanie M Guéret, Pierre-Alexis Goy, Gernot Hahne, Axel Pahl, Sonja Sievers, Ernesto Guccione, Haiwei Song, Herbert Waldmann, Wanjin Hon. Identification of Quinolinols as Activators of TEAD-Dependent Transcription. ACS chemical biology. vol 14. issue 12. 2020-05-13. PMID:31742995. |
yap and taz pair with the tead (tea domain) family of transcription factors to initiate transcription. |
2020-05-13 |
2023-08-13 |
Not clear |
| Eugene Lee, Ji-Yun Ko, Juyoung Kim, Jeong-Won Park, Songhee Lee, Gun-Il I. Osteogenesis and angiogenesis are simultaneously enhanced in BMP2-/VEGF-transfected adipose stem cells through activation of the YAP/TAZ signaling pathway. Biomaterials science. vol 7. issue 11. 2020-03-30. PMID:31435635. |
taz, tead, and ankrd1 were overexpressed in bmp2-/vegf-transfected ascs, possibly proposing the mechanism of enhanced bone regeneration and angiogenesis. |
2020-03-30 |
2023-08-13 |
rat |