| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Feng, H Yang, Y Zhang, H Wei, Z Zhu, B Zhu, M Yang, W Cao, L Wang, Z W. Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells. Oncogene. vol 36. issue 42. 2017-10-24. PMID:28604752. |
interaction of taz with the transcription factor tead was essential for taz activation of pd-l1 and induction of its expression. |
2017-10-24 |
2023-08-13 |
human |
| Floriane Gibault, Fabrice Bailly, Matthieu Corvaisier, Mathilde Coevoet, Guillemette Huet, Patricia Melnyk, Philippe Cotell. Molecular Features of the YAP Inhibitor Verteporfin: Synthesis of Hexasubstituted Dipyrrins as Potential Inhibitors of YAP/TAZ, the Downstream Effectors of the Hippo Pathway. ChemMedChem. vol 12. issue 12. 2017-09-29. PMID:28334506. |
together, our data suggest that, due to their chemical structures, porphyrin- and dipyrrin-related derivatives can directly target yap and/or taz proteins and inhibit tead transcriptional activity. |
2017-09-29 |
2023-08-13 |
human |
| Hung Yi Kristal Kaan, Adelene Y L Sim, Siew Kim Joyce Tan, Chandra Verma, Haiwei Son. Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches. PloS one. vol 12. issue 6. 2017-09-26. PMID:28570566. |
yap, taz (transcription co-activators) and tead (transcription factor) are the downstream transcriptional machinery and effectors of the pathway. |
2017-09-26 |
2023-08-13 |
Not clear |
| Luca Azzolin, Stefano Piccol. A TIAM Double Hit to Oppose YAP/TAZ. Cancer cell. vol 31. issue 5. 2017-09-20. PMID:28486099. |
uncover dual mechanisms of inhibiting yap/taz by tiam1 that oppose invasiveness of colorectal cancer cells: tiam1 interacts with taz in the cytoplasm to promote taz degradation by the destruction complex, whereas it antagonizes binding of taz/yap to tead in the nucleus. |
2017-09-20 |
2023-08-13 |
Not clear |
| Yoshinori Matsumoto, Jose La Rose, Melissa Lim, Hibret A Adissu, Napoleon Law, Xiaohong Mao, Feng Cong, Paula Mera, Gerard Karsenty, David Goltzman, Adele Changoor, Lucia Zhang, Megan Stajkowski, Marc D Grynpas, Carsten Bergmann, Robert Rottape. Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism. The Journal of clinical investigation. vol 127. issue 7. 2017-09-14. PMID:28581440. |
we show that fgf18 induces transcriptional coactivator with pdz-binding motif (taz) expression, which is required for osteoblast proliferation and differentiation through transcriptional enhancer associate domain (tead) and runt-related transcription factor 2 (runx2) transcription factors, respectively. |
2017-09-14 |
2023-08-13 |
mouse |
| Xiaobo Wang, Ze Zheng, Jorge Matias Caviglia, Kathleen E Corey, Tina M Herfel, Bishuang Cai, Ricard Masia, Raymond T Chung, Jay H Lefkowitch, Robert F Schwabe, Ira Taba. Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis. Cell metabolism. vol 24. issue 6. 2017-06-26. PMID:28068223. |
in vitro and in vivo mechanistic studies revealed that a key mechanism linking hepatocyte taz to nash fibrosis is taz/tea domain (tead)-mediated induction of indian hedgehog (ihh), a secretory factor that activates fibrogenic genes in hepatic stellate cells. |
2017-06-26 |
2023-08-13 |
human |
| Shunta Nagashima, Junichi Maruyama, Shodai Kawano, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hat. Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif. Cancer science. vol 107. issue 6. 2017-01-31. PMID:27009852. |
taz interacts with tea domain family members (tead), and upregulates genes implicated in epithelial-mesenchymal transition. |
2017-01-31 |
2023-08-13 |
human |
| Shunta Nagashima, Junichi Maruyama, Shodai Kawano, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hat. Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif. Cancer science. vol 107. issue 6. 2017-01-31. PMID:27009852. |
moreover, the compounds that weakened tead reporter activity did not necessarily decrease the unphosphorylated taz. |
2017-01-31 |
2023-08-13 |
human |
| Shunta Nagashima, Junichi Maruyama, Shodai Kawano, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hat. Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif. Cancer science. vol 107. issue 6. 2017-01-31. PMID:27009852. |
in this study, we focused on three compounds that decreased both tead reporter activity and unphosphorylated taz, and treated several human cancer cells with these compounds. |
2017-01-31 |
2023-08-13 |
human |
| Rajesh Kumar Gandhirajan, Manaswita Jain, Benedikt Walla, Marc Johnsen, Malte P Bartram, Minh Huynh Anh, Markus M Rinschen, Thomas Benzing, Bernhard Scherme. Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ). The Journal of biological chemistry. vol 291. issue 22. 2016-12-13. PMID:27048650. |
we further demonstrate that taz s-glutathionylation is critical for reactive oxygen species (ros)-mediated, taz-dependent tea domain transcription factor (tead) trans-activation. |
2016-12-13 |
2023-08-13 |
mouse |
| Tomomi E Kimura, Aparna Duggirala, Madeleine C Smith, Stephen White, Graciela B Sala-Newby, Andrew C Newby, Mark Bon. The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP. Journal of molecular and cellular cardiology. vol 90. 2016-10-11. PMID:26625714. |
here we investigated the role of components of the growth-regulatory hippo pathway, specifically the transcription factor tead and its co-factors yap and taz in vsmc. |
2016-10-11 |
2023-08-13 |
Not clear |
| PuiYee Chan, Xiao Han, Baohui Zheng, Michael DeRan, Jianzhong Yu, Gopala K Jarugumilli, Hua Deng, Duojia Pan, Xuelian Luo, Xu W. Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway. Nature chemical biology. vol 12. issue 4. 2016-08-08. PMID:26900866. |
tea domain (tead) transcription factors bind to the coactivators yap and taz and regulate the transcriptional output of the hippo pathway, playing critical roles in organ size control and tumorigenesis. |
2016-08-08 |
2023-08-13 |
human |
| PuiYee Chan, Xiao Han, Baohui Zheng, Michael DeRan, Jianzhong Yu, Gopala K Jarugumilli, Hua Deng, Duojia Pan, Xuelian Luo, Xu W. Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway. Nature chemical biology. vol 12. issue 4. 2016-08-08. PMID:26900866. |
strikingly, palmitoylation did not alter tead's localization, but it was required for tead's binding to yap and taz and was dispensable for its binding to the vgll4 tumor suppressor. |
2016-08-08 |
2023-08-13 |
human |
| Jun Wang, Yang Xiao, Chih-Wei Hsu, Idaliz M Martinez-Traverso, Min Zhang, Yan Bai, Mamoru Ishii, Robert E Maxson, Eric N Olson, Mary E Dickinson, Joshua D Wythe, James F Marti. Yap and Taz play a crucial role in neural crest-derived craniofacial development. Development (Cambridge, England). vol 143. issue 3. 2016-07-11. PMID:26718006. |
analysis of foxc1 regulatory regions revealed a conserved recognition element for the yap and taz dna binding co-factor tead. |
2016-07-11 |
2023-08-13 |
mouse |
| Rui Gong, Fa-Xing Y. Targeting the Hippo Pathway for Anti-cancer Therapies. Current medicinal chemistry. vol 22. issue 35. 2016-06-29. PMID:26429069. |
yap and taz, two major effectors of the hippo pathway, function as transcriptional co-activators and promote target gene expression mainly through interaction with tead family transcription factors. |
2016-06-29 |
2023-08-13 |
Not clear |
| Kun Zhang, Hai-Xia Qi, Zhi-Mei Hu, Ya-Nan Chang, Zhe-Min Shi, Xiao-Hui Han, Ya-Wei Han, Rui-Xue Zhang, Zhen Zhang, Ting Chen, Wei Hon. YAP and TAZ Take Center Stage in Cancer. Biochemistry. vol 54. issue 43. 2016-04-18. PMID:26465056. |
in the hippo pathway, mst1/2 and lats1/2 regulate downstream transcription coactivators yap and taz, which mainly interact with tead family transcription factors to promote tissue proliferation, self-renewal of normal and cancer stem cells, migration, and carcinogenesis. |
2016-04-18 |
2023-08-13 |
drosophila_melanogaster |
| Megan L Finch-Edmondson, Robyn P Strauss, Adam M Passman, Marius Sudol, George C Yeoh, Bernard A Callu. TAZ Protein Accumulation Is Negatively Regulated by YAP Abundance in Mammalian Cells. The Journal of biological chemistry. vol 290. issue 46. 2016-03-07. PMID:26432639. |
structure/function analyses suggest that yap-induced taz degradation is a consequence of yap-targeted gene transcription involving tead factors. |
2016-03-07 |
2023-08-13 |
mouse |
| Guosheng Tan, Xinping Cao, Qiangsheng Dai, Bing Zhang, Jianwen Huang, Shiqiu Xiong, Yong yu Zhang, Wei Chen, Jianyong Yang, Heping L. A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ. Oncotarget. vol 6. issue 11. 2016-02-11. PMID:25895125. |
here, we report a microrna, mir-129-5p, directly represses yap and taz expression, leading to the inactivation of tea domain (tead) transcription, and the downregulation of hippo downstream genes, connective tissue growth factor (ctgf) and cyclin a. |
2016-02-11 |
2023-08-13 |
human |
| Liwen Guo, Lisong Ten. YAP/TAZ for cancer therapy: opportunities and challenges (review). International journal of oncology. vol 46. issue 4. 2015-12-07. PMID:25652178. |
conversely, when the hippo pathway is deactivated, yap and taz will translocate into nucleus and promote transcription of downstream genes by forming complexes with transcription factors, such as transcriptional enhancer factors (tef; also referred to as tead), runt-domain transcription factors (runx) and others. |
2015-12-07 |
2023-08-13 |
human |
| M Shanzer, I Ricardo-Lax, R Keshet, N Reuven, Y Shau. The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner. Oncogene. vol 34. issue 32. 2015-11-23. PMID:25362852. |
taz is a pro-oncogenic transcription coactivator of the tead transcription factors. |
2015-11-23 |
2023-08-13 |
Not clear |