| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maren Diepenbruck, Lorenz Waldmeier, Robert Ivanek, Philipp Berninger, Phil Arnold, Erik van Nimwegen, Gerhard Christofor. Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition. Journal of cell science. vol 127. issue Pt 7. 2015-04-09. PMID:24554433. |
tead transcription factors and their transcriptional co-activators yap and taz have been previously implicated in promoting an emt; however, their direct transcriptional target genes and their functional role during emt have remained elusive. |
2015-04-09 |
2023-08-12 |
Not clear |
| Maren Diepenbruck, Lorenz Waldmeier, Robert Ivanek, Philipp Berninger, Phil Arnold, Erik van Nimwegen, Gerhard Christofor. Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition. Journal of cell science. vol 127. issue Pt 7. 2015-04-09. PMID:24554433. |
the results demonstrate that tead transcription factors are crucial regulators of the cellular distribution of yap and taz, and together they control the expression of genes critical for emt and metastasis. |
2015-04-09 |
2023-08-12 |
Not clear |
| Henning Wackerhage, Dominic P Del Re, Robert N Judson, Marius Sudol, Junichi Sadoshim. The Hippo signal transduction network in skeletal and cardiac muscle. Science signaling. vol 7. issue 337. 2015-03-30. PMID:25097035. |
these two research areas were joined by the finding that the hippo pathway regulates the activity of tead transcription factors mainly through phosphorylation of the transcriptional coactivators yap and taz, which bind to and activate teads. |
2015-03-30 |
2023-08-13 |
Not clear |
| Yannick Mesrouze, Jean Christophe Hau, Dirk Erdmann, Catherine Zimmermann, Patrizia Fontana, Tobias Schmelzle, Patrick Chèn. The surprising features of the TEAD4-Vgll1 protein-protein interaction. Chembiochem : a European journal of chemical biology. vol 15. issue 4. 2014-11-04. PMID:24504694. |
having studied the interaction between vgll1-derived peptides and human tead4, we show that, although it lacks a key secondary structure element required for tight binding by two other tead cofactors (yap and taz), vgll1-derived peptides bind to tead with nanomolar affinity. |
2014-11-04 |
2023-08-12 |
mouse |
| Jean Christophe Hau, Dirk Erdmann, Yannick Mesrouze, Pascal Furet, Patrizia Fontana, Catherine Zimmermann, Tobias Schmelzle, Francesco Hofmann, Patrick Chèn. The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences. Chembiochem : a European journal of chemical biology. vol 14. issue 10. 2014-05-07. PMID:23780915. |
in this pathway, the yap and taz transcriptional cofactors play a key role in stimulating gene transcription through their interaction with the tead transcriptional factors. |
2014-05-07 |
2023-08-12 |
human |
| Jean Christophe Hau, Dirk Erdmann, Yannick Mesrouze, Pascal Furet, Patrizia Fontana, Catherine Zimmermann, Tobias Schmelzle, Francesco Hofmann, Patrick Chèn. The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences. Chembiochem : a European journal of chemical biology. vol 14. issue 10. 2014-05-07. PMID:23780915. |
our study of yap and taz peptides in biochemical and biophysical assays shows that both proteins have essentially the same affinity for tead. |
2014-05-07 |
2023-08-12 |
human |
| Jean Christophe Hau, Dirk Erdmann, Yannick Mesrouze, Pascal Furet, Patrizia Fontana, Catherine Zimmermann, Tobias Schmelzle, Francesco Hofmann, Patrick Chèn. The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences. Chembiochem : a European journal of chemical biology. vol 14. issue 10. 2014-05-07. PMID:23780915. |
this convergent optimization of the yap/taz tead binding site suggests that the similarity in the affinities of binding of yap to tead and of taz to tead is important for hippo pathway functionality. |
2014-05-07 |
2023-08-12 |
human |
| Yang An, Qianqian Kang, Yaofeng Zhao, Xiaoxiang Hu, Ning L. Lats2 modulates adipocyte proliferation and differentiation via hippo signaling. PloS one. vol 8. issue 8. 2014-04-08. PMID:23977200. |
upon activation, lats2 phosphorylates yap and taz, leading to their retention in the cytoplasm, preventing them from activating the transcription factor tead in the nucleus. |
2014-04-08 |
2023-08-12 |
drosophila_melanogaster |
| Wanjin Hon. Angiomotin'g YAP into the nucleus for cell proliferation and cancer development. Science signaling. vol 6. issue 291. 2014-03-25. PMID:24003252. |
nuclear translocation of the transcription factors yes-associated protein (yap) and transcriptional coactivator with pdz-binding motif (taz) and their subsequent interaction with tea domain (tead) transcriptional factors program pro-proliferative and antiapoptotic transcription. |
2014-03-25 |
2023-08-12 |
Not clear |
| Dulcie Lai, Xiaolong Yan. BMP4 is a novel transcriptional target and mediator of mammary cell migration downstream of the Hippo pathway component TAZ. Cellular signalling. vol 25. issue 8. 2013-12-30. PMID:23673366. |
taz induces bmp4 transcription through the tead family of transcription factors, which mediate bmp4 promoter activation through binding to tead response element 1 (tre1). |
2013-12-30 |
2023-08-12 |
Not clear |
| Ajaybabu V Pobbati, Siew Wee Chan, Ian Lee, Haiwei Song, Wanjin Hon. Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes. Structure (London, England : 1993). vol 20. issue 7. 2012-11-02. PMID:22632831. |
remarkably, vgll1 interacts with tead in a manner similar to the transcription coactivators, as well as oncogenes yap and taz, despite having a varied primary sequence. |
2012-11-02 |
2023-08-12 |
drosophila_melanogaster |
| Krishna P L Bhat, Katrina L Salazar, Veerakumar Balasubramaniyan, Khalida Wani, Lindsey Heathcock, Faith Hollingsworth, Johanna D James, Joy Gumin, Kristin L Diefes, Se Hoon Kim, Alice Turski, Yasaman Azodi, Yuhui Yang, Tiffany Doucette, Howard Colman, Erik P Sulman, Frederick F Lang, Ganesh Rao, Sjef Copray, Brian D Vaillant, Kenneth D Aldap. The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes & development. vol 25. issue 24. 2012-02-02. PMID:22190458. |
the coexpression of taz, but not a mutated form of taz that lacks tead binding, with platelet-derived growth factor-b (pdgf-b) resulted in high-grade tumors with mes features in a murine model of glioma. |
2012-02-02 |
2023-08-12 |
Not clear |
| Krishna P L Bhat, Katrina L Salazar, Veerakumar Balasubramaniyan, Khalida Wani, Lindsey Heathcock, Faith Hollingsworth, Johanna D James, Joy Gumin, Kristin L Diefes, Se Hoon Kim, Alice Turski, Yasaman Azodi, Yuhui Yang, Tiffany Doucette, Howard Colman, Erik P Sulman, Frederick F Lang, Ganesh Rao, Sjef Copray, Brian D Vaillant, Kenneth D Aldap. The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes & development. vol 25. issue 24. 2012-02-02. PMID:22190458. |
our studies uncover a direct role for taz and tead in driving the mes differentiation of malignant glioma. |
2012-02-02 |
2023-08-12 |
Not clear |
| Sandra Habbig, Malte P Bartram, Roman U Müller, Ricarda Schwarz, Nikolaos Andriopoulos, Shuhua Chen, Josef G Sägmüller, Martin Hoehne, Volker Burst, Max C Liebau, H Christian Reinhardt, Thomas Benzing, Bernhard Scherme. NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway. The Journal of cell biology. vol 193. issue 4. 2011-07-21. PMID:21555462. |
moreover, nphp4 induced release from 14-3-3 binding and nuclear translocation of yap and taz, promoting tea domain (tead)/taz/yap-dependent transcriptional activity. |
2011-07-21 |
2023-08-12 |
drosophila_melanogaster |
| Dulcie Lai, King Ching Ho, Yawei Hao, Xiaolong Yan. Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer research. vol 71. issue 7. 2011-07-11. PMID:21349946. |
interaction of taz with the tead family of transcription factors was essential for taz to activate the cyr61/ctgf promoters and to induce taxol resistance. |
2011-07-11 |
2023-08-12 |
human |
| Siew Wee Chan, Chun Jye Lim, Li Shen Loo, Yaan Fun Chong, Caixia Huang, Wanjin Hon. TEADs mediate nuclear retention of TAZ to promote oncogenic transformation. The Journal of biological chemistry. vol 284. issue 21. 2009-07-07. PMID:19324876. |
in this study, we show that taz interacts with tead transcriptional factors. |
2009-07-07 |
2023-08-12 |
Not clear |
| Heng Zhang, Chen-Ying Liu, Zheng-Yu Zha, Bin Zhao, Jun Yao, Shimin Zhao, Yue Xiong, Qun-Ying Lei, Kun-Liang Gua. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. The Journal of biological chemistry. vol 284. issue 20. 2009-06-30. PMID:19324877. |
tead transcription factors mediate the function of taz in cell growth and epithelial-mesenchymal transition. |
2009-06-30 |
2023-08-12 |
human |
| Heng Zhang, Chen-Ying Liu, Zheng-Yu Zha, Bin Zhao, Jun Yao, Shimin Zhao, Yue Xiong, Qun-Ying Lei, Kun-Liang Gua. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. The Journal of biological chemistry. vol 284. issue 20. 2009-06-30. PMID:19324877. |
we demonstrate here that tead is a key downstream transcription factor mediating the function of taz. |
2009-06-30 |
2023-08-12 |
human |
| Heng Zhang, Chen-Ying Liu, Zheng-Yu Zha, Bin Zhao, Jun Yao, Shimin Zhao, Yue Xiong, Qun-Ying Lei, Kun-Liang Gua. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. The Journal of biological chemistry. vol 284. issue 20. 2009-06-30. PMID:19324877. |
disruption of tead-taz binding or silencing of tead expression blocked the function of taz to promote cell proliferation and to induce epithelial-mesenchymal transition, demonstrating tead as a key downstream effector of taz. |
2009-06-30 |
2023-08-12 |
human |
| Heng Zhang, Chen-Ying Liu, Zheng-Yu Zha, Bin Zhao, Jun Yao, Shimin Zhao, Yue Xiong, Qun-Ying Lei, Kun-Liang Gua. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. The Journal of biological chemistry. vol 284. issue 20. 2009-06-30. PMID:19324877. |
we also identified ctgf, a gene that regulates cell adhesion, proliferation, and migration, as a direct target of taz and tead. |
2009-06-30 |
2023-08-12 |
human |