| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huihui Chen, Xuefang Liang, Xiaohong Gu, Qingfei Zeng, Zhigang Mao, Christopher J Martyniu. Environmentally relevant concentrations of sertraline disrupts behavior and the brain and liver transcriptome of juvenile yellow catfish (Tachysurus fulvidraco): Implications for the feeding and growth axis. Journal of hazardous materials. vol 409. 2021-05-31. PMID:33450510. |
transcript levels of neuropeptide y, somatostatin, growth hormone, and insulin growth factor 1 were reduced in the brain following ser exposure. |
2021-05-31 |
2023-08-13 |
Not clear |
| Arthur D Rigg. Making, Cloning, and the Expression of Human Insulin Genes in Bacteria: The Path to Humulin. Endocrine reviews. vol 42. issue 3. 2021-05-29. PMID:33340315. |
this question was answered in 1978 and in 1979 with the successful expression in e. coli of 2 mammalian hormones, first somatostatin and then human insulin. |
2021-05-29 |
2023-08-13 |
human |
| Huanjing Bi, Soujanya S Karanth, Kaiming Ye, Roland Stein, Sha Ji. Decellularized Tissue Matrix Enhances Self-Assembly of Islet Organoids from Pluripotent Stem Cell Differentiation. ACS biomaterials science & engineering. vol 6. issue 7. 2021-05-14. PMID:33463310. |
the exposure of ipscs to the dpecm during differentiation resulted in considerably elevated expression of key pancreatic transcription factors such as pdx-1, mafa, and nkx6.1 and the production of all major hormones, including insulin, glucagon, somatostatin, and pancreatic polypeptide from stem cell-derived organoids. |
2021-05-14 |
2023-08-13 |
human |
| Christiaan F Mooij, Carline E Tacke, Mirjam E van Albada, Winfried Barthlen, Hennie Bikker, Klaus Mohnike, Matthijs W N Oomen, A S Paul van Trotsenburg, Nitash Zwaveling-Soonawal. First report on the use of pasireotide in a case of severe congenital hyperinsulinism due to a homozygous ABCC8 mutation. Annals of pediatric endocrinology & metabolism. 2021-05-11. PMID:33971706. |
current treatment protocols include the first-generation somatostatin analogue octreotide while pasireotide, a second-generation somatostatin analogue, may be more effective in reducing insulin secretion. |
2021-05-11 |
2023-08-13 |
Not clear |
| Thomas Prudhomme, Karine Renaudin, Maria Letizia Lo Faro, Diego Cantarovich, Delphine Kervella, David Minault, Jérémy Hervouet, Stéphanie Le Bas-Bernardet, Georges Karam, Gilles Blancho, Julien Brancherea. Ex situ hypothermic perfusion of nonhuman primate pancreas: A feasibility study. Artificial organs. vol 44. issue 7. 2021-04-12. PMID:31995645. |
at 25 mm hg pp, focal congestion of islets appeared after 12-h. immunostaining for insulin, glucagon, and somatostatin was normal and similar in controls and perfused pancreas transplants even after 24-h. apoptosis index represented by cleaved caspase 3 activity, was less than 1% in perfusion and control groups, even after 24-h. hp of nonhuman primate pancreas is feasible and not deleterious as far as 24-h compared to scs. |
2021-04-12 |
2023-08-13 |
Not clear |
| Cornelius J Fernandez, Mayuri Agarwal, Biju Pottakkat, Nisha Nigil Haroon, Annu Susan George, Joseph M Pappacha. Gastroenteropancreatic neuroendocrine neoplasms: A clinical snapshot. World journal of gastrointestinal surgery. vol 13. issue 3. 2021-04-03. PMID:33796213. |
specific neuroendocrine biomarkers that are used in the diagnosis of functional nens include insulin, glucagon, vasoactive intestinal polypeptide, gastrin, somatostatin, adrenocorticotropin, growth hormone releasing hormone, parathyroid hormone-related peptide, serotonin, histamine, and 5-hydroxy indole acetic acid (5-hiaa). |
2021-04-03 |
2023-08-13 |
human |
| Amin GhavamiNejad, Brian Lu, Melisa Samarikhalaj, Jackie Fule Liu, Sako Mirzaie, Sandra Pereira, Liwei Zhou, Adria Giacca, Xiao Yu W. Transdermal delivery of a somatostatin receptor type 2 antagonist using microneedle patch technology for hypoglycemia prevention. Drug delivery and translational research. 2021-03-08. PMID:33683625. |
in type 1 diabetes (t1d), on top of impaired pancreatic α-cells, excessive levels of somatostatin from δ-cells further inhibit glucagon secretion to counteract overdosed insulin. |
2021-03-08 |
2023-08-13 |
rat |
| Jakub Pobłocki, Anna Jasińska, Anhelli Syrenicz, Elżbieta Andrysiak-Mamos, Małgorzata Szczuk. The Neuroendocrine Neoplasms of the Digestive Tract: Diagnosis, Treatment and Nutrition. Nutrients. vol 12. issue 5. 2021-02-11. PMID:32429294. |
different nuclear medicine procedures can also be used, like somatostatin analogues scintigraphy (srs) and 68ga-dota-peptide pet/ct, as well as biochemical methods to determine the level of general neuroendocrine markers, such as chromogranin a (cga), 5-hydroxyindolacetic acid (5-hiaa), synaptopfysin and cell type-specific peptide hormones, and neurotransmitters like gastrin, insulin, serotonin, and histamine. |
2021-02-11 |
2023-08-13 |
Not clear |
| Matthew J Donohue, Robert T Filla, Daniel J Steyer, Wesley J Eaton, Michael G Rope. Rapid liquid chromatography-mass spectrometry quantitation of glucose-regulating hormones from human islets of Langerhans. Journal of chromatography. A. vol 1637. 2021-02-08. PMID:33360778. |
glucose homeostasis is maintained through the secretion of peptide hormones, such as insulin, somatostatin, and glucagon, from islets of langerhans, clusters of endocrine cells found in the pancreas. |
2021-02-08 |
2023-08-13 |
human |
| Matthew J Donohue, Robert T Filla, Daniel J Steyer, Wesley J Eaton, Michael G Rope. Rapid liquid chromatography-mass spectrometry quantitation of glucose-regulating hormones from human islets of Langerhans. Journal of chromatography. A. vol 1637. 2021-02-08. PMID:33360778. |
this report describes an lc-ms method using multiple reaction monitoring for quantitation of insulin, c-peptide, glucagon, and somatostatin secretion from human islet populations. |
2021-02-08 |
2023-08-13 |
human |
| Carlo Capella, Cristina Riva, Guido Rindi, Fausto Sessa, Luciana Usellini, Annamaria Chiaravalli, Luciano Carnevali, Enrico Solci. Histopathology, hormone products, and clinicopathological profile of endocrine tumors of the upper small intestine: A study of 44 cases. Endocrine pathology. vol 2. issue 2. 2021-01-10. PMID:32138393. |
in addition to the main cell type, 30 tumors showed one or more, usually minor, cell populations producing somatostatin, serotonin, cholecystokinin, pancreatic polypeptide, insulin, neurotensin, or the alpha chain of human chorionic gonadotropin. |
2021-01-10 |
2023-08-13 |
human |
| Simon J Raphael, N Wilson Rodger, Doug Geddes B . Colocalization of pancreatic polypeptide and insulin in secretory granules of a pancreatic endocrine neoplasm. Endocrine pathology. vol 3. issue 3. 2021-01-10. PMID:32138396. |
immunohistochem-istry and immunoelectron microscopy showed all the tumors to be plurihormonal, each containing three or more of the following: insulin, glucagon, somatostatin, pancreatic polypep-tide, gastrin, and serotonin. |
2021-01-10 |
2023-08-13 |
Not clear |
| Terry C Yin, Casey J Bauchle, Alix A J Rouault, Samuel B Stephens, Julien A Seba. The Insulinostatic Effect of Ghrelin Requires MRAP2 Expression in δ Cells. iScience. vol 23. issue 6. 2021-01-10. PMID:32535024. |
the mechanism through which this is accomplished is unclear, but recent studies suggest that ghrelin acts on δ cells to stimulate somatostatin release, which in turn inhibits insulin release from β cells. |
2021-01-10 |
2023-08-13 |
Not clear |
| Linbao Zhang, Wei Sun, Haigang Chen, Zhe Zhang, Wengui Ca. Transcriptomic Changes in Liver of Juvenile Cynoglossus semilaevis following Perfluorooctane Sulfonate Exposure. Environmental toxicology and chemistry. vol 39. issue 3. 2020-11-04. PMID:31726483. |
exposure to pfos also altered the gene expression levels of hormones (inhibin, insulin, somatostatin, and glucagon), which could lead to severe metabolic and endocrine dysfunction. |
2020-11-04 |
2023-08-13 |
zebrafish |
| Leire Méndez-Giménez, Silvia Ezquerro, Inês V da Silva, Graça Soveral, Gema Frühbeck, Amaia Rodrígue. Pancreatic Aquaporin-7: A Novel Target for Anti-diabetic Drugs? Frontiers in chemistry. vol 6. 2020-10-01. PMID:29675407. |
the endocrine pancreas (10% of the total pancreatic cells) is composed by the islets of langerhans, which are distributed in α, β, δ, ε, and pancreatic polypeptide (pp) cells that secrete glucagon, insulin, somatostatin, ghrelin and pp, respectively. |
2020-10-01 |
2023-08-13 |
mouse |
| Tao Wang, Andreas Riegger, Markus Lamla, Sebastian Wiese, Patrick Oeckl, Markus Otto, Yuzhou Wu, Stephan Fischer, Holger Barth, Seah Ling Kuan, Tanja Wei. Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides. Chemical science. vol 7. issue 5. 2020-10-01. PMID:29997815. |
the site-selective functionalization of (a) the peptide hormone somatostatin, (b) the interchain disulfide of bovine insulin and (c) functionalization of the proteins gfp and lysozyme with allyl sulfones proceeds in aqueous solution. |
2020-10-01 |
2023-08-13 |
cattle |
| Maged S Abdel-Kader, Gamal A Soliman, Rehab F Abdel-Rahman, Abdulaziz S Saeedan, Reham M Abd-Elsalam, Hanan A Ogal. Effect of olive leaves extract on the antidiabetic effect of glyburide for possible herb-drug interaction. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 27. issue 8. 2020-10-01. PMID:31885478. |
moreover, glb plus ole-500 combination had the greatest effect on restoration of the insulin content of beta (β) cells and reduction of the glucagon and somatostatin of alpha (α) and delta (δ) endocrine cells in the pancreatic islets among the different treatment. |
2020-10-01 |
2023-08-13 |
rat |
| Megan Cory, Abu Saleh Md Moin, Antoinette Moran, Robert A Rizza, Peter C Butler, Sangeeta Dhawan, Alexandra E Butle. An Increase in Chromogranin A-Positive, Hormone-Negative Endocrine Cells in Pancreas in Cystic Fibrosis. Journal of the Endocrine Society. vol 2. issue 9. 2020-09-30. PMID:30202828. |
pancreas sections were stained for chromogranin a, insulin, and a cocktail of glucagon, somatostatin, pancreatic polypeptide, and ghrelin and evaluated for the frequency of cphn cells. |
2020-09-30 |
2023-08-13 |
human |
| Pengxun Han, Yao Wang, Hongyue Zhan, Wenci Weng, Xuewen Yu, Na Ge, Wenjing Wang, Gaofeng Song, Tiegang Yi, Shunmin Li, Mumin Shao, Huili Su. Artemether ameliorates type 2 diabetic kidney disease by increasing mitochondrial pyruvate carrier content in db/db mice. American journal of translational research. vol 11. issue 3. 2020-09-30. PMID:30972169. |
in addition, it increased serum insulin level and restored the normal ratio of insulin, glucagon, and somatostatin levels in islets. |
2020-09-30 |
2023-08-13 |
mouse |
| Ludovic Galas, Magalie Bénard, Alexis Lebon, Yutaro Komuro, Damien Schapman, Hubert Vaudry, David Vaudry, Hitoshi Komur. Postnatal Migration of Cerebellar Interneurons. Brain sciences. vol 7. issue 6. 2020-09-29. PMID:28587295. |
in addition, cortical-layer specific regulatory factors such as neuropeptides (pituitary adenylate cyclase-activating polypeptide (pacap), somatostatin) or proteins (tissue-type plasminogen activator (tpa), insulin growth factor-1 (igf-1)) have been shown to inhibit or stimulate the migratory process of interneurons. |
2020-09-29 |
2023-08-13 |
Not clear |