| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D G Johnson, J W Ensinck, D Koerker, J Palmer, C J Goodne. Inhibition of glucagon and insulin secretion by somatostatin in the rat pancreas perfused in situ. Endocrinology. vol 96. issue 2. 1975-05-06. PMID:1089535. |
perfusion of growth hormone inhibitory factor (somatostatin) into rat pancreas inhibited secretion of glucagon and insulin into medium containing 5.5 mm glucose. |
1975-05-06 |
2023-08-11 |
rat |
| D G Johnson, J W Ensinck, D Koerker, J Palmer, C J Goodne. Inhibition of glucagon and insulin secretion by somatostatin in the rat pancreas perfused in situ. Endocrinology. vol 96. issue 2. 1975-05-06. PMID:1089535. |
the acute phase of insulin secretion in response to arginine was attenuated by somatostatin, and subsequent secretion was decreased to control levels. |
1975-05-06 |
2023-08-11 |
rat |
| D G Johnson, J W Ensinck, D Koerker, J Palmer, C J Goodne. Inhibition of glucagon and insulin secretion by somatostatin in the rat pancreas perfused in situ. Endocrinology. vol 96. issue 2. 1975-05-06. PMID:1089535. |
pretreatment for 5 min with somatostatin blocked even acute-phase insulin secretion in response to arginine. |
1975-05-06 |
2023-08-11 |
rat |
| D G Johnson, J W Ensinck, D Koerker, J Palmer, C J Goodne. Inhibition of glucagon and insulin secretion by somatostatin in the rat pancreas perfused in situ. Endocrinology. vol 96. issue 2. 1975-05-06. PMID:1089535. |
somatostatin did not affect basal or glucose-stimulated secretion of insulin from rat pancreatic islets isolated by the collagenase technique. |
1975-05-06 |
2023-08-11 |
rat |
| D G Johnson, J W Ensinck, D Koerker, J Palmer, C J Goodne. Inhibition of glucagon and insulin secretion by somatostatin in the rat pancreas perfused in situ. Endocrinology. vol 96. issue 2. 1975-05-06. PMID:1089535. |
arginine-stimulated secretion of insulin was enhanced by somatostatin in isolated islets. |
1975-05-06 |
2023-08-11 |
rat |
| D G Johnson, J W Ensinck, D Koerker, J Palmer, C J Goodne. Inhibition of glucagon and insulin secretion by somatostatin in the rat pancreas perfused in situ. Endocrinology. vol 96. issue 2. 1975-05-06. PMID:1089535. |
these results demonstrate a direct effect of somatostatin on the pancreas to inhibit secretion of glucagon and insulin. |
1975-05-06 |
2023-08-11 |
rat |
| D G Johnson, J W Ensinck, D Koerker, J Palmer, C J Goodne. Inhibition of glucagon and insulin secretion by somatostatin in the rat pancreas perfused in situ. Endocrinology. vol 96. issue 2. 1975-05-06. PMID:1089535. |
the failure of somatostatin to inhibit insulin secretion in pancreatic islets may be due to alterations in the beta cells produced by the isolation procedure. |
1975-05-06 |
2023-08-11 |
rat |
| D G Johnson, J W Ensinck, D Koerker, J Palmer, C J Goodne. Inhibition of glucagon and insulin secretion by somatostatin in the rat pancreas perfused in situ. Endocrinology. vol 96. issue 2. 1975-05-06. PMID:1089535. |
it is also possible that the effect of somatostatin on insulin secretion may be mediated indirectly. |
1975-05-06 |
2023-08-11 |
rat |
| H Sakurai, R Dobbs, R H Unge. Somatostatin-induced changes in insulin and glucagon secretion in normal and diabetic dogs. The Journal of clinical investigation. vol 54. issue 6. 1975-02-27. PMID:4436439. |
6.7 mug per min of somatostatin significantly lowered pancreatoduodenal vein glucagon and insulin within 2.5 min and profoundly suppressed their secretion throughout the infusion. |
1975-02-27 |
2023-08-11 |
Not clear |
| H Sakurai, R Dobbs, R H Unge. Somatostatin-induced changes in insulin and glucagon secretion in normal and diabetic dogs. The Journal of clinical investigation. vol 54. issue 6. 1975-02-27. PMID:4436439. |
it is concluded that in normal dogs pharmacologic doses of somatostatin virtually abolish insulin and glucagon secretion in the basal state and during hyperaminoacidemia. |
1975-02-27 |
2023-08-11 |
Not clear |
| J E Gerich, M Lorenzi, V Schneider, P H Forsha. Effect of somatostatin on plasma glucose and insulin responses to glucagon and tolbutamide in man. The Journal of clinical endocrinology and metabolism. vol 39. issue 6. 1975-02-18. PMID:4430704. |
effect of somatostatin on plasma glucose and insulin responses to glucagon and tolbutamide in man. |
1975-02-18 |
2023-08-11 |
Not clear |
| D L Curry, L L Bennet. Reversal of somatostatin inhibition of insulin secretion by calcium. Biochemical and biophysical research communications. vol 60. issue 3. 1975-01-25. PMID:4611421. |
reversal of somatostatin inhibition of insulin secretion by calcium. |
1975-01-25 |
2023-08-11 |
Not clear |
| M Peracchi, E Reschini, L Cantalamessa, G Giustina, F Cavagnini, M Pinto, P Bulgheron. Effect of somatostatin on blood glucose, plasma growth hormone, insulin, and free fatty acids in normal subjects and acromegalic patients. Metabolism: clinical and experimental. vol 23. issue 11. 1975-01-14. PMID:4418535. |
effect of somatostatin on blood glucose, plasma growth hormone, insulin, and free fatty acids in normal subjects and acromegalic patients. |
1975-01-14 |
2023-08-11 |
human |
| S Efendic, R Luft, V Gril. Effect of somatostatin on glucose induced insulin release in isolated perfused rat pancreas and isolated rat pancreatic islets. FEBS letters. vol 42. issue 2. 1974-11-18. PMID:4368634. |
effect of somatostatin on glucose induced insulin release in isolated perfused rat pancreas and isolated rat pancreatic islets. |
1974-11-18 |
2023-08-11 |
rat |
| D L Curry, L L Bennett, C H L. Direct inhibition of insulin secretion by synthetic somatostatin. Biochemical and biophysical research communications. vol 58. issue 3. 1974-08-21. PMID:4599685. |
direct inhibition of insulin secretion by synthetic somatostatin. |
1974-08-21 |
2023-08-11 |
Not clear |
| G W DeVane, T M Siler, S S Ye. Acute suppression of insulin and glucose levels by synthetic somatostatin in normal human subjects. The Journal of clinical endocrinology and metabolism. vol 38. issue 5. 1974-06-19. PMID:4823929. |
acute suppression of insulin and glucose levels by synthetic somatostatin in normal human subjects. |
1974-06-19 |
2023-08-11 |
human |
| D J Koerker, W Ruch, E Chideckel, J Palmer, C J Goodner, J Ensinck, C C Gal. Somatostatin: hypothalamic inhibitor of the endocrine pancreas. Science (New York, N.Y.). vol 184. issue 4135. 1974-05-31. PMID:4594711. |
somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion in fasted cats and rats. |
1974-05-31 |
2023-08-11 |
rat |
| S S Yen, T M Siler, G W DeVan. Effect of somatostatin in patients with acromegaly: suppression of growth hormone, prolactin, insulin and glucose levels. The New England journal of medicine. vol 290. issue 17. 1974-05-17. PMID:4593614. |
effect of somatostatin in patients with acromegaly: suppression of growth hormone, prolactin, insulin and glucose levels. |
1974-05-17 |
2023-08-11 |
Not clear |
| K G Alberti, N J Christensen, S E Christensen, A P Hansen, J Iversen, K Lundbaek, K Seyer-Hansen, H Orsko. Inhibition of insulin secretion by somatostatin. Lancet (London, England). vol 2. issue 7841. 1974-01-16. PMID:4127645. |
inhibition of insulin secretion by somatostatin. |
1974-01-16 |
2023-08-11 |
Not clear |