| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J Koerker, C J Goodner, E W Chideckel, J W Ensinc. Adaptation to fasting in baboon. II. Regulation of lipolysis early and late in fasting. The American journal of physiology. vol 229. issue 2. 1975-12-05. PMID:1172376. |
the roles of insulin and glucagon were evaluated by a 2-h infusion of somatostatin after 18 and 65 h of fasting. |
1975-12-05 |
2023-08-11 |
Not clear |
| D Bryce, M Yeh, C Funderburk, H Todd, F Hertelend. Studies on growth hormone secretion. VII. Effects of somatostatin on plasma GH, insulin, and glucagon in sheep. Diabetes. vol 24. issue 9. 1975-12-04. PMID:169176. |
effects of somatostatin on plasma gh, insulin, and glucagon in sheep. |
1975-12-04 |
2023-08-11 |
Not clear |
| D Bryce, M Yeh, C Funderburk, H Todd, F Hertelend. Studies on growth hormone secretion. VII. Effects of somatostatin on plasma GH, insulin, and glucagon in sheep. Diabetes. vol 24. issue 9. 1975-12-04. PMID:169176. |
to determine whether synthetic somatostatin originally isolated from sheep hypothalamus can inhibit hormone secretion in the same species, we measured plasma levels of gh, insulin, glucagon, and glucose of normal sheep under a variety of experimental conditions in the presence and absence of somatostatin infusion. |
1975-12-04 |
2023-08-11 |
Not clear |
| D Bryce, M Yeh, C Funderburk, H Todd, F Hertelend. Studies on growth hormone secretion. VII. Effects of somatostatin on plasma GH, insulin, and glucagon in sheep. Diabetes. vol 24. issue 9. 1975-12-04. PMID:169176. |
similarly, somatostatin inhibited glucose, and glucagon provoked gh and insulin secretory responses without affecting glucose or ffa levels. |
1975-12-04 |
2023-08-11 |
Not clear |
| F R Ward, H Leblanc, S S Ye. The inhibitory effect of somatostatin on growth hormone, insulin and glucagon secretion in diabetes mellitus. The Journal of clinical endocrinology and metabolism. vol 41. issue 3. 1975-11-22. PMID:1159060. |
the inhibitory effect of somatostatin on growth hormone, insulin and glucagon secretion in diabetes mellitus. |
1975-11-22 |
2023-08-11 |
Not clear |
| F R Ward, H Leblanc, S S Ye. The inhibitory effect of somatostatin on growth hormone, insulin and glucagon secretion in diabetes mellitus. The Journal of clinical endocrinology and metabolism. vol 41. issue 3. 1975-11-22. PMID:1159060. |
the inhibitory effect of somatostatin on insulin, glucagon and growth hormone secretion was studied in 5 patients with diabetes mellitus. |
1975-11-22 |
2023-08-11 |
Not clear |
| F R Ward, H Leblanc, S S Ye. The inhibitory effect of somatostatin on growth hormone, insulin and glucagon secretion in diabetes mellitus. The Journal of clinical endocrinology and metabolism. vol 41. issue 3. 1975-11-22. PMID:1159060. |
in three maturity onset diabetics, somatostatin infusion abolished the insulin rise induced by breakfast and oral glucose, and in 2 of them, inhibited the basal insulin secretion by 50% seen during control studies. |
1975-11-22 |
2023-08-11 |
Not clear |
| F R Ward, H Leblanc, S S Ye. The inhibitory effect of somatostatin on growth hormone, insulin and glucagon secretion in diabetes mellitus. The Journal of clinical endocrinology and metabolism. vol 41. issue 3. 1975-11-22. PMID:1159060. |
following the somatostatin infusion, there was a prompt rebound increase in both insulin and glucagon levels with a relatively stable plasma glucose concentration. |
1975-11-22 |
2023-08-11 |
Not clear |
| S Shapiro, S Eto, N Fleischer, S G Bau. Regulation of in vitro insulin release from a transplantable Syrian hamster insulinoma. Endocrinology. vol 97. issue 2. 1975-11-20. PMID:169125. |
it would appear that inhibition of glucagon induced insulin release by somatostatin is not mediated by adenylate cyclase. |
1975-11-20 |
2023-08-11 |
Not clear |
| R Guillemin, M Fontain. [The historic role of insulin in the physiopathology of the metabolic complications from pancreatic diabetes. Therapeutic implications for somatostatin]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles. vol 280. issue 20. 1975-11-06. PMID:807423. |
possible ways in which somatostatin may influence the secretion of glucagon and insulin are discussed. |
1975-11-06 |
2023-08-11 |
Not clear |
| R Guillemin, M Fontain. [The historic role of insulin in the physiopathology of the metabolic complications from pancreatic diabetes. Therapeutic implications for somatostatin]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles. vol 280. issue 20. 1975-11-06. PMID:807423. |
the fact that it is possible to maintain normal blood glucose levels in pancreatectomised animals and in juvenile diabetics totally lacking in insulin, solely by the administration of somatostatin, is emphasised. |
1975-11-06 |
2023-08-11 |
Not clear |
| H Wagner, E Zierden, W H Haus. Effects of synthetic somatostatin on endotoxin-induced changes of growth hormone, cortisol and insulin in plasma, blood sugar and blood leukocytes in man. Klinische Wochenschrift. vol 53. issue 11. 1975-11-01. PMID:1152345. |
effects of synthetic somatostatin on endotoxin-induced changes of growth hormone, cortisol and insulin in plasma, blood sugar and blood leukocytes in man. |
1975-11-01 |
2023-08-11 |
Not clear |
| H Wagner, E Zierden, W H Haus. Effects of synthetic somatostatin on endotoxin-induced changes of growth hormone, cortisol and insulin in plasma, blood sugar and blood leukocytes in man. Klinische Wochenschrift. vol 53. issue 11. 1975-11-01. PMID:1152345. |
plasma levels of insulin and the blood sugar in man receiving endotoxin are firstly reduced in a significant manner and then increasing to normal values during somatostatin infusion. |
1975-11-01 |
2023-08-11 |
Not clear |
| I Valverde, R Dobbs, R H Unge. Heterogeneity of plasma glucagon immunoreactivity in normal, depancreatized, and alloxan-diabetic dogs. Metabolism: clinical and experimental. vol 24. issue 9. 1975-10-30. PMID:1152674. |
somatostatin or insulin infusion in depancreatized and alloxan-diabetic dogs resulted in disappearance of the 3500 molecular-weight fraction. |
1975-10-30 |
2023-08-11 |
Not clear |
| J Sieradzki, H Schatz, C Nierle, E F Pfeiffe. Somatostatin-induced inhibition of insulin secretion from isolated islets of rat pancreas in presence of glucagon. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 7. issue 4. 1975-10-21. PMID:168138. |
on the other hand, somatostatin exerted a significant inhibitory action on glucagon-potentiated insulin secretion (mean +/- sem, mu1/2 hrs/10 islets: glucose and glucagon: 1253 +/- 92; glucose, glucagon and somatostatin: 786 +/- 76). |
1975-10-21 |
2023-08-11 |
rat |
| J Sieradzki, H Schatz, C Nierle, E F Pfeiffe. Somatostatin-induced inhibition of insulin secretion from isolated islets of rat pancreas in presence of glucagon. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 7. issue 4. 1975-10-21. PMID:168138. |
the insulin output in th epresence of glucose, glucagon and somatostatin was also significantly smaller than in thepresence of glucose alone (1104 +/- 126) or of glucose and somatostatin (1061 +/- 122). |
1975-10-21 |
2023-08-11 |
rat |
| J Sieradzki, H Schatz, C Nierle, E F Pfeiffe. Somatostatin-induced inhibition of insulin secretion from isolated islets of rat pancreas in presence of glucagon. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 7. issue 4. 1975-10-21. PMID:168138. |
the failure of somatostatin to affect glucose-stimulated release of insulin from isolated islets contrasts its inhibitory action on insulin secretion as observed in the isolated perfused pancreas and in vivo. |
1975-10-21 |
2023-08-11 |
rat |
| J Sieradzki, H Schatz, C Nierle, E F Pfeiffe. Somatostatin-induced inhibition of insulin secretion from isolated islets of rat pancreas in presence of glucagon. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 7. issue 4. 1975-10-21. PMID:168138. |
however, somatostatin inhibited glucagon-potentiated insulin secretion in isolated islets which resulted in even lower insulin levels than obtained in the parallel experiments without glucagon. |
1975-10-21 |
2023-08-11 |
rat |
| S Efendic, V Grill, R Luf. Inhibition by somatostatin of glucose induced 3':5'-monophsophate (cyclic AMP) accumulation and insulin release in isolated pancreatic islets of the rat. FEBS letters. vol 55. issue 1. 1975-10-10. PMID:166881. |
inhibition by somatostatin of glucose induced 3':5'-monophsophate (cyclic amp) accumulation and insulin release in isolated pancreatic islets of the rat. |
1975-10-10 |
2023-08-11 |
rat |
| R T Curnow, R M Carey, A Taylor, A Johanson, F Mura. Somatostatin inhibition of insulin and gastrin hypersecretion in pancreatic islet-cell carcinoma. The New England journal of medicine. vol 292. issue 26. 1975-09-09. PMID:166308. |
somatostatin inhibition of insulin and gastrin hypersecretion in pancreatic islet-cell carcinoma. |
1975-09-09 |
2023-08-11 |
Not clear |