| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S D Garcia, C Jarrousse, G Rosseli. Biosynthesis of proinsulin and insulin in newborn rat pancreas. Interaction of glucose, cyclic AMP, somatostatin, and sulfonylureas on the (3H) leucine incorporation into immunoreactive insulin. The Journal of clinical investigation. vol 57. issue 1. 1976-03-24. PMID:173741. |
theophylline or dbcamp at 10 mm concentration did not reverse the somatostatin inhibitory effect on either insulin biosynthesis or release. |
1976-03-24 |
2023-08-11 |
human |
| S D Garcia, C Jarrousse, G Rosseli. Biosynthesis of proinsulin and insulin in newborn rat pancreas. Interaction of glucose, cyclic AMP, somatostatin, and sulfonylureas on the (3H) leucine incorporation into immunoreactive insulin. The Journal of clinical investigation. vol 57. issue 1. 1976-03-24. PMID:173741. |
high ca++ concentration in the incubation medium reversed the inhibitory effect of somatostatin on glucose-induced insulin biosynthesis as well as release. |
1976-03-24 |
2023-08-11 |
human |
| S D Garcia, C Jarrousse, G Rosseli. Biosynthesis of proinsulin and insulin in newborn rat pancreas. Interaction of glucose, cyclic AMP, somatostatin, and sulfonylureas on the (3H) leucine incorporation into immunoreactive insulin. The Journal of clinical investigation. vol 57. issue 1. 1976-03-24. PMID:173741. |
in both systems the inhibitory effect of somatostatin on insulin biosynthesis and release correlated well. |
1976-03-24 |
2023-08-11 |
human |
| S D Garcia, C Jarrousse, G Rosseli. Biosynthesis of proinsulin and insulin in newborn rat pancreas. Interaction of glucose, cyclic AMP, somatostatin, and sulfonylureas on the (3H) leucine incorporation into immunoreactive insulin. The Journal of clinical investigation. vol 57. issue 1. 1976-03-24. PMID:173741. |
these data suggest the following conclusions: (a) the role of the camp-phosphodiesterase system on insulin biosynthesis is likely to be greater in newborns than in adults; (b) the greater effectiveness of glucose and the camp system on insulin biosynthesis than on insulin release might possibly be related to the rapid accumulation of pancreatic iri which is observed in the perinatal period; (c) somatostatin, by direct interaction with the endocrine tissue, can inhibit glucose and camp-induced insulin biosynthesis as well as release; calcium reverses this inhibition; (d) sulfonylureas inhibit insulin biosynthesis in newborn rat pancreas an effect which has to be considered in the use of these agents in human disease. |
1976-03-24 |
2023-08-11 |
human |
| L Orci, R H Unge. Functional subdivision of islets of Langerhans and possible role of D cells. Lancet (London, England). vol 2. issue 7947. 1976-02-13. PMID:53729. |
in view of the inhibitory effect of somatostatin on both insulin and glucagon secretion, it is suggested that the arrangement of a, b and d cells is important to the normal and pathological functioning of the islet. |
1976-02-13 |
2023-08-11 |
Not clear |
| W T Norfleet, A S Pagliara, M W Haymond, F Matschinsk. Comparison of alpha- and beta-cell secretory responses in islets isolated with collagenase and in the isolated perfused pancreas of rats. Diabetes. vol 24. issue 11. 1976-01-17. PMID:171190. |
with the perfused pancreas, somatostatin caused 32 per cent inhibition of glucose-mediated insulin release and inhibited arginine-induced glucagon release by 72 per cent. |
1976-01-17 |
2023-08-11 |
rat |
| C Meissner, C Thum, W Beischer, G Winkler, K E Schröder, E F Pfeiffe. Antidiabetic action of somatostatin--assessed by the artificial pancreas. Diabetes. vol 24. issue 11. 1976-01-17. PMID:1102369. |
by means of a glucose-controlled insulin- and glucose-infusion system (gcigis) we examined the effect of somatostatin on insulin and glucose requirements following meals or oral glucose loads in juvenile diabetics. |
1976-01-17 |
2023-08-11 |
Not clear |
| C Meissner, C Thum, W Beischer, G Winkler, K E Schröder, E F Pfeiffe. Antidiabetic action of somatostatin--assessed by the artificial pancreas. Diabetes. vol 24. issue 11. 1976-01-17. PMID:1102369. |
in six of seven patients the insulin requirement with somatostatin was remarkably reduced to between 38 per cent and 79 per cent of that of otherwise identical control experiments. |
1976-01-17 |
2023-08-11 |
Not clear |
| C Meissner, C Thum, W Beischer, G Winkler, K E Schröder, E F Pfeiffe. Antidiabetic action of somatostatin--assessed by the artificial pancreas. Diabetes. vol 24. issue 11. 1976-01-17. PMID:1102369. |
it seems to us most likely that the well-known suppression of the secretion of growth hormone and glucagon, both insulin antagonists, is responsible for the antidiabetic action of somatostatin. |
1976-01-17 |
2023-08-11 |
Not clear |
| N J Christensen, S E Christensen, A P Hansen, K Lundboe. The effect of somatostatin on plasma noradrenaline and plasma adrenaline concentrations during exercise and hypoglycemia. Metabolism: clinical and experimental. vol 24. issue 11. 1976-01-14. PMID:1186497. |
the effect of somatostatin, on the secretion of noradrenaline and adrenaline was studied in eight normal subjects during exercise and in insulin induced hypoglycemia. |
1976-01-14 |
2023-08-11 |
human |
| N J Christensen, S E Christensen, A P Hansen, K Lundboe. The effect of somatostatin on plasma noradrenaline and plasma adrenaline concentrations during exercise and hypoglycemia. Metabolism: clinical and experimental. vol 24. issue 11. 1976-01-14. PMID:1186497. |
the blood glucose concentration attained after insulin injection was lower during the infusion of somatostatin and evidence is presented which indicates that the higher adrenaline values during hypoglycemia were due to the lower blood glucose values attained. |
1976-01-14 |
2023-08-11 |
human |
| H Sakurai, R E Dobbs, R H Unge. The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus. Metabolism: clinical and experimental. vol 24. issue 11. 1976-01-14. PMID:1186499. |
the effect of glucagon suppression by somatostatin upon endogenous hyperglycemia was studied in three forms of experimental insulin deficiency in dogs: alloxan diabetes, total pancreatectomy, and diazoxide administration. |
1976-01-14 |
2023-08-11 |
Not clear |
| H Sakurai, R E Dobbs, R H Unge. The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus. Metabolism: clinical and experimental. vol 24. issue 11. 1976-01-14. PMID:1186499. |
however, when glucagon was suppressed after insulin withdrawal, glucose remained below 240 mg/dl, significantly less than the controls (p less than 0.005); when somatostatin was stopped, glucagon rose and glucose increased 88 +/- 19 mg/dl within an hour. |
1976-01-14 |
2023-08-11 |
Not clear |
| H Sakurai, R E Dobbs, R H Unge. The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus. Metabolism: clinical and experimental. vol 24. issue 11. 1976-01-14. PMID:1186499. |
glucagon suppression by somatostatin during diazoxide-induced blockade of insulin secretion in four normal dogs reduced hyperglycemia significantly but did not prevent it. |
1976-01-14 |
2023-08-11 |
Not clear |
| T Taminato, Y Seino, Y Goto, H Imur. Interaction of somatostatin and calcium in regulating insulin release from isolated pancreatic islets of rats. Biochemical and biophysical research communications. vol 66. issue 3. 1975-12-23. PMID:170939. |
interaction of somatostatin and calcium in regulating insulin release from isolated pancreatic islets of rats. |
1975-12-23 |
2023-08-11 |
rat |
| J E Gerich, M Lorenzi, J H Karam, V Schneider, P H Forsha. Abnormal pancreatic glucagon secretion and postprandial hyperglycemia in diabetes mellitus. JAMA. vol 234. issue 2. 1975-12-20. PMID:1242153. |
the combination of insulin and somatostatin caused a progressive fall in plasma glucose levels despite meal ingestion. |
1975-12-20 |
2023-08-11 |
human |
| J E Gerich, M Lorenzi, J H Karam, V Schneider, P H Forsha. Abnormal pancreatic glucagon secretion and postprandial hyperglycemia in diabetes mellitus. JAMA. vol 234. issue 2. 1975-12-20. PMID:1242153. |
somatostatin and insulin, administered subcutaneously in the same syringe, also abolished postprandial hyperglycemia. |
1975-12-20 |
2023-08-11 |
human |
| J E Gerich, M Lorenzi, J H Karam, V Schneider, P H Forsha. Abnormal pancreatic glucagon secretion and postprandial hyperglycemia in diabetes mellitus. JAMA. vol 234. issue 2. 1975-12-20. PMID:1242153. |
somatostatin, an inhibitor of glucagon secretion, may thus prove useful as an adjunct to insulin in the treatment of diabetes mellitus. |
1975-12-20 |
2023-08-11 |
human |
| D Le Roith, A I Vinik, S Epstein, P Baron, M N Olkenitzky, B L Pimston. Somatostatin and serum gastrin in normal subjects and in patients with pernicious anaemia, chronic liver and renal disease. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. vol 49. issue 39. 1975-12-18. PMID:1179234. |
arginine infusion caused an insignificant rise in serum gastrin which was unaffected by somatostatin, whereas insulin hypoglycaemia significantly stimulated gastrin release, which was inhibited by somatostatin. |
1975-12-18 |
2023-08-11 |
human |
| T Hökfelt, S Efendić, C Hellerström, O Johansson, R Luft, A Arimur. Cellular localization of somatostatin in endocrine-like cells and neurons of the rat with special references to the A1-cells of the pancreatic islets and to the hypothalamus. Acta endocrinologica. Supplementum. vol 200. 1975-12-12. PMID:52267. |
the occurrence of probable somatostatin containing cells in the pancreatic islets is of special interest in view of several recent studies demonstrating an inhibitory action of this peptide on glucagon and insulin secretion. |
1975-12-12 |
2023-08-11 |
rat |