| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Arimura, H Sato, A Dupont, N Nishi, A V Schall. Somatostatin: abundance of immunoreactive hormone in rat stomach and pancreas. Science (New York, N.Y.). vol 189. issue 4207. 1976-05-25. PMID:56779. |
growth hormone release-inhibiting hormone (somatostatin), a hypothalamic peptide that inhibits the release of growth hormone and also the secretion of insulin glucagon, and gastrin, was found in the rat stomach and pancreas in a concentration similar to that in the hypothalamus, as measured by radioimmunoassay. |
1976-05-25 |
2023-08-11 |
rat |
| F Van Kerse. Inhibition by somatostatin of tolbutamide-induced insulin secretion in a patient with an insulinoma. The Netherlands journal of medicine. vol 19. issue 1. 1976-04-30. PMID:175307. |
inhibition by somatostatin of tolbutamide-induced insulin secretion in a patient with an insulinoma. |
1976-04-30 |
2023-08-11 |
Not clear |
| M Gottsmann, R Landgraf, W Londong, K Werde. [Influence of somatastatin on oral glucose tolerance in autonomous hypersecretion of growth hormone, prolactin or insulin (author's transl)]. Klinische Wochenschrift. vol 53. issue 24. 1976-04-29. PMID:175208. |
the ogtts were pathologic due to the hgh- and hprl-induced insulin antagonism; they could not be normalized or improved by somatostatin. |
1976-04-29 |
2023-08-11 |
Not clear |
| M Gottsmann, R Landgraf, W Londong, K Werde. [Influence of somatastatin on oral glucose tolerance in autonomous hypersecretion of growth hormone, prolactin or insulin (author's transl)]. Klinische Wochenschrift. vol 53. issue 24. 1976-04-29. PMID:175208. |
only the peak of the blood sugar curve was shifted from one to two and a half hours after glucose administration; insulin and hgh levels were regularly suppressed after somatostatin whereas hprl remained unchanged in most instances. |
1976-04-29 |
2023-08-11 |
Not clear |
| M Gottsmann, R Landgraf, W Londong, K Werde. [Influence of somatastatin on oral glucose tolerance in autonomous hypersecretion of growth hormone, prolactin or insulin (author's transl)]. Klinische Wochenschrift. vol 53. issue 24. 1976-04-29. PMID:175208. |
these findings show that the pathologic glucose tolerance due to insulin antagonism could not be improved by somatostatin in contrast to the deteriorated glucose tolerance in insulinopenic states. |
1976-04-29 |
2023-08-11 |
Not clear |
| S Efendić, P E Lins, G Sigurdsson, B Ivemark, P O Granberg, R Luf. Effect of somatostatin on basal and glucose induced insulin release in five patients with hyperinsulinaemia. Acta endocrinologica. vol 81. issue 3. 1976-04-29. PMID:946344. |
effect of somatostatin on basal and glucose induced insulin release in five patients with hyperinsulinaemia. |
1976-04-29 |
2023-08-11 |
human |
| S Efendić, P E Lins, G Sigurdsson, B Ivemark, P O Granberg, R Luf. Effect of somatostatin on basal and glucose induced insulin release in five patients with hyperinsulinaemia. Acta endocrinologica. vol 81. issue 3. 1976-04-29. PMID:946344. |
somatostatin in a dose of 490 mug over 90 min inhibited basal insulin release in one subject with hyperplasia of the pancreatic islets and in two with benign insulin secreting adenomas. |
1976-04-29 |
2023-08-11 |
human |
| S Efendić, P E Lins, G Sigurdsson, B Ivemark, P O Granberg, R Luf. Effect of somatostatin on basal and glucose induced insulin release in five patients with hyperinsulinaemia. Acta endocrinologica. vol 81. issue 3. 1976-04-29. PMID:946344. |
in the patient with islet hyperplasia and in one of the adenoma patients, who had an exaggerated insulin response to glucose (maximal response 10-30 times the basal insulin value), somatostatin also suppressed glucose induced insulin release. |
1976-04-29 |
2023-08-11 |
human |
| S Efendić, P E Lins, G Sigurdsson, B Ivemark, P O Granberg, R Luf. Effect of somatostatin on basal and glucose induced insulin release in five patients with hyperinsulinaemia. Acta endocrinologica. vol 81. issue 3. 1976-04-29. PMID:946344. |
our data suggest a beneficial therapeutic effect of somatostatin in patients with spontaneous hyperinsulinism with a pronounced insulin response to glucose. |
1976-04-29 |
2023-08-11 |
human |
| M Brown, J Rivier, W Val. Biological activity of somatostatin and somatostatin analogs on inhibtion of arginine-induced insulin and glucagon release in the rat. Endocrinology. vol 98. issue 2. 1976-04-23. PMID:813991. |
biological activity of somatostatin and somatostatin analogs on inhibtion of arginine-induced insulin and glucagon release in the rat. |
1976-04-23 |
2023-08-11 |
rat |
| M Brown, J Rivier, W Val. Biological activity of somatostatin and somatostatin analogs on inhibtion of arginine-induced insulin and glucagon release in the rat. Endocrinology. vol 98. issue 2. 1976-04-23. PMID:813991. |
somatostatin and dihydrosomatostatin (h2somatostatin) are equipotent in inhibiting insulin and glucagon release induced by arginine in the rat. |
1976-04-23 |
2023-08-11 |
rat |
| M Brown, J Rivier, W Val. Biological activity of somatostatin and somatostatin analogs on inhibtion of arginine-induced insulin and glucagon release in the rat. Endocrinology. vol 98. issue 2. 1976-04-23. PMID:813991. |
[d-trp8]-somatostatin is 6-8 times as potent as somatostatin in inhibiting insulin and glucagon release induced by arginine. |
1976-04-23 |
2023-08-11 |
rat |
| M Peracchi, E Reschini, L Cantalamessa, A Catania, G Giustin. Inhibitory effect of somatostatin on dibutyryl cyclic AMP-induced insulin and growth hormone release in human subjects. Metabolism: clinical and experimental. vol 25. issue 3. 1976-04-19. PMID:175241. |
inhibitory effect of somatostatin on dibutyryl cyclic amp-induced insulin and growth hormone release in human subjects. |
1976-04-19 |
2023-08-11 |
human |
| M Peracchi, E Reschini, L Cantalamessa, A Catania, G Giustin. Inhibitory effect of somatostatin on dibutyryl cyclic AMP-induced insulin and growth hormone release in human subjects. Metabolism: clinical and experimental. vol 25. issue 3. 1976-04-19. PMID:175241. |
the effect of somatostatin on the responses of blood glucose, plasma immunoreactive insulin (iri), growth hormone (gh), and free fatty acids (ffa) to the injection of dibutyryl cyclic amp (dbc) was studied in six normal volunteers. |
1976-04-19 |
2023-08-11 |
human |
| R B Lockhart-Ewart, C Mok, J M Marti. Neuroendocrine control of insulin secretion. Diabetes. vol 25. issue 2. 1976-04-19. PMID:814025. |
the effects of thyrotropin-releasing hormone, luteinizing hormone-releasing hormone, substance p, somatostatin, and a partially purified hypothalamic extract on insulin secretion were tested both in vitro and in vivo. |
1976-04-19 |
2023-08-11 |
Not clear |
| R B Lockhart-Ewart, C Mok, J M Marti. Neuroendocrine control of insulin secretion. Diabetes. vol 25. issue 2. 1976-04-19. PMID:814025. |
only somatostatin and the hypothalamic extract affected insulin secretion. |
1976-04-19 |
2023-08-11 |
Not clear |
| R B Lockhart-Ewart, C Mok, J M Marti. Neuroendocrine control of insulin secretion. Diabetes. vol 25. issue 2. 1976-04-19. PMID:814025. |
in vitro, somatostatin decreased glucose-stimulated insulin secretion by isolated islets and in vivo significantly reduced the rate of insulin output into the portal vein. |
1976-04-19 |
2023-08-11 |
Not clear |
| P Mattes, S Raptis, T Heil, H Rasche, R Schec. Extended somatostatin treatment of a patient with bleeding ulcer. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 7. issue 6. 1976-04-19. PMID:1213658. |
gastric secretion as well as gastrin, insulin and growth hormone levels were significantly inhibited by somatostatin. |
1976-04-19 |
2023-08-11 |
human |
| N Altszuler, B Gottlieb, J Hampshir. Interaction of somatostatin, glucagon, and insulin on hepatic glucose output in the normal dog. Diabetes. vol 25. issue 2. 1976-04-19. PMID:1248672. |
interaction of somatostatin, glucagon, and insulin on hepatic glucose output in the normal dog. |
1976-04-19 |
2023-08-11 |
dog |
| K Lundbaek, A P Hansen, H Orskov, S E Christensen, J Iversen, K Seyer-Hansen, K G Alberti, R Whitefoo. Failure of somatostatin to correct manifest diabetic ketoacidosis. Lancet (London, England). vol 1. issue 7953. 1976-04-10. PMID:55530. |
in three patients 2 to 3 h somatostatin infusions were twice superimposed upon a continuous 9-5 h insulin infusion (1 unit/h). |
1976-04-10 |
2023-08-11 |
Not clear |