| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Olive. Inhibition of calcium uptake by somatostatin in isolated rat islets of Langerhans. Endocrinology. vol 99. issue 3. 1976-10-29. PMID:782858. |
in the presence of a low concentration of calcium (0.2 mm), glucose caused a much greater increase in insulin secretion which was inhibited by addition of somatostatin, epinephrine or mannoheptulose. |
1976-10-29 |
2023-08-11 |
rat |
| E F Pfeiffer, S Raptis, R Ziegle. [Interaction between gastrointestinal hormones and endocrine regulation]. Zeitschrift fur Gastroenterologie. vol 14 Suppl. 1976-10-20. PMID:8883. |
since somatostatin inhibits insulin secretion and especially glucagon release as well as the exretory functions of the stomach and of the pancreas, the significance of this hormone possibly is that of a tissue hormone with inhibitory action on adjacent cells. |
1976-10-20 |
2023-08-11 |
human |
| E F Pfeiffer, S Raptis, R Ziegle. [Interaction between gastrointestinal hormones and endocrine regulation]. Zeitschrift fur Gastroenterologie. vol 14 Suppl. 1976-10-20. PMID:8883. |
the possible therapeutic significance of somatostatin administration to diabetics would lie in the saving of insulin. |
1976-10-20 |
2023-08-11 |
human |
| C Rufener, M Amherdt, D Baetens, N Yanaihara, L Orc. Immunofluorescent localization of secretin in pancreatic monolayer culture. Histochemistry. vol 47. issue 2. 1976-10-20. PMID:783098. |
the presence of cells containing secretin or a secretin-like peptide adds a new cell type to the three already characterized (insulin, glucagon and somatostatin containing cells) in monolayer culture. |
1976-10-20 |
2023-08-11 |
rat |
| A Lernmark, S J Chan, R Choy, A Nathans, R Carroll, H S Tager, A H Rubenstein, H H Swift, D F Steine. Biosynthesis of insulin and glucagon: a view of the current state of the art. Ciba Foundation symposium. vol 41. 1976-10-01. PMID:780079. |
foci of current attention discussed in this paper include (1) the possible existence of larger precursor forms than proinsulin, especially short-lived biosynthetic transients with extended nh2-termini analogous to the recently described immunoglobulin l chain and proparathyroid hormone precursors; (2) the large-scale production of insulin by chemical or genetic engineering approaches; (3) isolation of beta-cell plasma membranes; (4) regulatory mechanisms for the biosynthesis and secretion of insulin, the possible role of mrna modification in this process, and effects of somatostatin on insulin biosynthesis and secretion; (5) studies on the secretion, metabolism and clinical usefulness of the proinsulin c-peptide; (6) finally, the biosynthesis of glucagon and other peptide hormones and the general significance of precursor forms. |
1976-10-01 |
2023-08-11 |
Not clear |
| J E Gerich, M Lorenzi, D M Bier, E Tsalikian, V Schneider, J H Karam, P H Forsha. Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin. The Journal of clinical investigation. vol 57. issue 4. 1976-10-01. PMID:820717. |
when insulin was withdrawn, plasma glucose, beta-hydroxybutyrate, ffa, and glycerol all rose to higher levels (p less than 0.01) than those observed under similar conditions when somatostatin alone had been infused to suppress glucagon secretion. |
1976-10-01 |
2023-08-11 |
human |
| J E Gerich, M Lorenzi, D M Bier, E Tsalikian, V Schneider, J H Karam, P H Forsha. Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin. The Journal of clinical investigation. vol 57. issue 4. 1976-10-01. PMID:820717. |
after insulin was withdrawn, plasma beta-hydroxybutyrate, glycerol, and ffa all rose to higher levels (p less than 0.01) than those observed during infusion of somatostatin alone when growth hormone secretion was suppressed; no difference in plasma glucose, alanine, and glucagon levels was evident. |
1976-10-01 |
2023-08-11 |
human |
| G Copinschi, V Leclercq-Meyer, E Virasoro, M L'Hermite, L Vanhaelst, J Golstein, R Leclercq, F Féry, C Roby. Pituitary and extrapituitary effects of somatostatin in normal man. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 8. issue 3. 1976-09-25. PMID:181309. |
a decrease in plasma values of gh, prolactin, tsh, insulin and glucagon and in blood glucose was observed during somatostatin infusion, while ffa levels increased progressively. |
1976-09-25 |
2023-08-11 |
Not clear |
| P H Smith, S C Woods, D Port. Phentolamine blocks the somatostatin-mediated inhibition of insulin secretion. Endocrinology. vol 98. issue 4. 1976-09-01. PMID:776596. |
somatostatin inhibited both the basal and glucose-stimulated pancreaticoduodenal vein insulin output of dogs. |
1976-09-01 |
2023-08-11 |
Not clear |
| P H Smith, S C Woods, D Port. Phentolamine blocks the somatostatin-mediated inhibition of insulin secretion. Endocrinology. vol 98. issue 4. 1976-09-01. PMID:776596. |
it is proposed that alpha-adrenergic mechanisms play a role in the inhibition of insulin secretion by somatostatin. |
1976-09-01 |
2023-08-11 |
Not clear |
| b' E Carmina, P Lanzara, A Jann\\xc3\\xa. [Changes in blood sugar, and insulin levels induced by somatostatin in normal, diabetic and acromegalic subjects]. Minerva medica. vol 67. issue 18. 1976-09-01. PMID:934480.' |
[changes in blood sugar, and insulin levels induced by somatostatin in normal, diabetic and acromegalic subjects]. |
1976-09-01 |
2023-08-11 |
human |
| b' E Carmina, P Lanzara, A Jann\\xc3\\xa. [Changes in blood sugar, and insulin levels induced by somatostatin in normal, diabetic and acromegalic subjects]. Minerva medica. vol 67. issue 18. 1976-09-01. PMID:934480.' |
the effect of somatostatin on plasma sugar and insulin levels was determined in 8 normal, 7 diabetic and 5 acromegalic subjects. |
1976-09-01 |
2023-08-11 |
human |
| A Tiengo, D Fedele, E Marchiori, R Nosadini, M Mugge. Suppression and stimulation mechanisms controlling glucagon secretion in a case of islet-cell tumor producing glucagon, insulin, and gastrin. Diabetes. vol 25. issue 5. 1976-08-02. PMID:5326. |
glucagon, insulin, and gastrin levels were suppressed by somatostatin while calcium infusion caused a paradoxical increase. |
1976-08-02 |
2023-08-11 |
Not clear |
| L A Scuro, V Lo Cascio, S Adami, G Galvanini, I Bianchi, L Cominacini, A Corgnat. Somatostatin inhibition of insulin secretion in insulin-producing tumors. Metabolism: clinical and experimental. vol 25. issue 6. 1976-08-02. PMID:178978. |
somatostatin inhibition of insulin secretion in insulin-producing tumors. |
1976-08-02 |
2023-08-11 |
Not clear |
| S E Christensen, J Nerup, A P Hansen, K Lundbae. Effects of somatostatin on basal levels of plasma growth hormone and insulin in acromegalics: dose-response studies and attempted total growth hormone suppression. The Journal of clinical endocrinology and metabolism. vol 42. issue 5. 1976-08-02. PMID:773950. |
effects of somatostatin on basal levels of plasma growth hormone and insulin in acromegalics: dose-response studies and attempted total growth hormone suppression. |
1976-08-02 |
2023-08-11 |
Not clear |
| S E Christensen, J Nerup, A P Hansen, K Lundbae. Effects of somatostatin on basal levels of plasma growth hormone and insulin in acromegalics: dose-response studies and attempted total growth hormone suppression. The Journal of clinical endocrinology and metabolism. vol 42. issue 5. 1976-08-02. PMID:773950. |
a significant dose-response relationship could be demonstrated between somatostatin and the suppressions of plasma growth hormone and insulin. |
1976-08-02 |
2023-08-11 |
Not clear |
| D Porte, S C Woods, M Chen, P H Smith, J W Ensinc. Central factors in the control of insulin and glucagon secretion. Pharmacology, biochemistry, and behavior. vol 3. issue 1 Suppl. 1976-08-02. PMID:775499. |
somatostatin has been shown to inhibit pancreatic glucagon and insulin secretion when infused into the pancreatic artery of intact dogs in vivo in the absence of a change of systemic glucose concentration. |
1976-08-02 |
2023-08-11 |
Not clear |
| D Porte, S C Woods, M Chen, P H Smith, J W Ensinc. Central factors in the control of insulin and glucagon secretion. Pharmacology, biochemistry, and behavior. vol 3. issue 1 Suppl. 1976-08-02. PMID:775499. |
although less inhibition is observed when the same amount of hormone is infused intraportally, the potency of somatostatin when given directly into the liver suggests extrapancreatic effects as well as direct pancreatic effects on insulin and glucagon secretion. |
1976-08-02 |
2023-08-11 |
Not clear |
| H Schatz, E F Pfeiffe. [The endocrine pancreas. From the isolated islet to the "artificial pancreas" (author's transl)]. MMW, Munchener medizinische Wochenschrift. vol 118. issue 16. 1976-08-02. PMID:818514. |
while the clinical application of somatostatin in diabetes mellitus seems problematic at present, the use of a glucose-controlled system of insulin infusion ("artificial pancreas") makes possible a metabolic state approaching the healthy condition. |
1976-08-02 |
2023-08-11 |
Not clear |
| S Efendić, R Luft, H Sievertsso. Relative effects of somatostatin and two somatostatin analogues on the release of insulin, glucagon and growth hormone. FEBS letters. vol 58. issue 1. 1976-08-02. PMID:1225595. |
relative effects of somatostatin and two somatostatin analogues on the release of insulin, glucagon and growth hormone. |
1976-08-02 |
2023-08-11 |
Not clear |