| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R H Unger, L Orc. Possible roles of the pancreatic D-cell in the normal and diabetic states. Diabetes. vol 26. issue 3. 1977-04-28. PMID:320077. |
glucagon stimulates both insulin and somatostatin release, while insulin and somatostatin both inhibit glucagon release, providing the basis for a feedback relationship through which a-cell secretion may be restrained. |
1977-04-28 |
2023-08-11 |
Not clear |
| R H Unger, L Orc. Possible roles of the pancreatic D-cell in the normal and diabetic states. Diabetes. vol 26. issue 3. 1977-04-28. PMID:320077. |
in addition, glucagon-mediated insulin secretion may be estrained by glucagon-stimulated somatostatin release. |
1977-04-28 |
2023-08-11 |
Not clear |
| M A Griffey, H H Conaway, D L Harshfield, J E Whitne. Effect of somatostatin on insulin secretion induced by ionophore A23187. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 154. issue 2. 1977-04-25. PMID:320600. |
effect of somatostatin on insulin secretion induced by ionophore a23187. |
1977-04-25 |
2023-08-11 |
Not clear |
| S E Olsson, A Anderson, B Petersson, C Hellerströ. Effects of somatostatin on the biosynthesis and release of insulin from isolated pancreatic islets. Diabete & metabolisme. vol 2. issue 4. 1977-04-25. PMID:797594. |
effects of somatostatin on the biosynthesis and release of insulin from isolated pancreatic islets. |
1977-04-25 |
2023-08-11 |
mouse |
| S E Olsson, A Anderson, B Petersson, C Hellerströ. Effects of somatostatin on the biosynthesis and release of insulin from isolated pancreatic islets. Diabete & metabolisme. vol 2. issue 4. 1977-04-25. PMID:797594. |
the glucose-stimulated insulin release of pancreatic islets isolated either from normal mice or from mice with the obese-hyperglycemic syndrome (genotype ob/ob) was inhibited by somatostatin in the concentration range 10(-2) - 10(-4) mm. |
1977-04-25 |
2023-08-11 |
mouse |
| S E Olsson, A Anderson, B Petersson, C Hellerströ. Effects of somatostatin on the biosynthesis and release of insulin from isolated pancreatic islets. Diabete & metabolisme. vol 2. issue 4. 1977-04-25. PMID:797594. |
islets prepared from the obese-hyperglycemic mice appeared most sensitive and there was a strong inhibitory action on the insulin release irrespective of whether the islets were exposed to somatostatin directly after isolation or after five days in tissue culture. |
1977-04-25 |
2023-08-11 |
mouse |
| S E Olsson, A Anderson, B Petersson, C Hellerströ. Effects of somatostatin on the biosynthesis and release of insulin from isolated pancreatic islets. Diabete & metabolisme. vol 2. issue 4. 1977-04-25. PMID:797594. |
there was, however, no effect of somatostatin on the glucose-stimulated insulin biosynthesis of the mouse islets. |
1977-04-25 |
2023-08-11 |
mouse |
| S E Olsson, A Anderson, B Petersson, C Hellerströ. Effects of somatostatin on the biosynthesis and release of insulin from isolated pancreatic islets. Diabete & metabolisme. vol 2. issue 4. 1977-04-25. PMID:797594. |
it is concluded that somatostatin does not affect the insulin biosynthesis of isolated islets at concentrations which inhibit insulin release. |
1977-04-25 |
2023-08-11 |
mouse |
| H J Hah. [Regulation of pancreatic glucagon secretion]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete. vol 31. issue 20. 1977-04-15. PMID:798428. |
in addition to this the hormones insulin and somatostatin formed by the islets of langerhans of the pancreas seem to be of importance for the local reactivity of the a-cells of the endocrine pancreas. |
1977-04-15 |
2023-08-11 |
Not clear |
| H J Hahn, H D Gottschlin. Somatostatin-induced inhibition of insulin secretion by isolated pancreatic rat islets prepared by micro-dissection or collagenase digestion. Diabete & metabolisme. vol 2. issue 3. 1977-03-31. PMID:188697. |
the effect of somatostatin on insulin secretion in response to a variety of stimuli was investigated in micro-dissected as well as collagenase isolated pancreatic rat islets. |
1977-03-31 |
2023-08-11 |
rat |
| H J Hahn, H D Gottschlin. Somatostatin-induced inhibition of insulin secretion by isolated pancreatic rat islets prepared by micro-dissection or collagenase digestion. Diabete & metabolisme. vol 2. issue 3. 1977-03-31. PMID:188697. |
somatostatin inhibited insulin secretion in both islet preparations in the presence of different initiators, but failed to affect the hormone output induced by theophylline, 1-methyl-3-isobutylxanthin (ibmx) or p-chloromercuriphenylsulfonic acid (cmbs). |
1977-03-31 |
2023-08-11 |
rat |
| L Orci, D Baetens, M Ravazzola, Y Stefan, F Malaisse-Laga. [Pancreatic polypeptide islets and glucagon islets : distinct topographic distribution in rat pancreas]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles. vol 283. issue 10. 1977-03-31. PMID:827358. |
the immunocytochemical technique for the cellular localization of hormones allows a precise identification of islet cell types responsible for the production of insulin, glucagon, somatostatin and pancreatic polypeptide. |
1977-03-31 |
2023-08-11 |
rat |
| C Meyers, A Arimura, A Gordin, R Fernandez-Durango, D H Coy, A V Schally, J Drouin, L Ferland, M Beaulieu, F Labri. Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release. Biochemical and biophysical research communications. vol 74. issue 2. 1977-03-31. PMID:836315. |
somatostatin analogs which inhibit glucagon and growth hormone more than insulin release. |
1977-03-31 |
2023-08-11 |
Not clear |
| R S Sherwin, R Hendler, R DeFronzo, J Wahren, P Feli. Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin. Proceedings of the National Academy of Sciences of the United States of America. vol 74. issue 1. 1977-03-21. PMID:264686. |
glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin. |
1977-03-21 |
2023-08-11 |
human |
| R S Sherwin, R Hendler, R DeFronzo, J Wahren, P Feli. Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin. Proceedings of the National Academy of Sciences of the United States of America. vol 74. issue 1. 1977-03-21. PMID:264686. |
infusion of exogenous insulin so as to restore plasma insulin to preinfusion values or cessation of the somatostatin infusion with restoration of endogenous insulin secretion resulted in a prompt reduction of plasma glucose to baseline values. |
1977-03-21 |
2023-08-11 |
human |
| R S Sherwin, R Hendler, R DeFronzo, J Wahren, P Feli. Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin. Proceedings of the National Academy of Sciences of the United States of America. vol 74. issue 1. 1977-03-21. PMID:264686. |
we conclude that somatostatin caused only transient hypoglycemia in normal subjects and that hyperglycemia eventually developes as a consequence of insulin deficiency. |
1977-03-21 |
2023-08-11 |
human |
| J Wahren, S Efendić, R Luft, L Hagenfeldt, O Björkman, P Feli. Influence of somatostatin on splanchnic glucose metabolism in postabsorptive and 60-hour fasted humans. The Journal of clinical investigation. vol 59. issue 2. 1977-03-15. PMID:833277. |
it is concluded that (a) somatostatin-induced hypoglucagonemia results in inhibition of splanchnic glucose output in glycogen-depleted, 60-h fasted subjects as well as in postabsorptive subjects, indicating an effect of glucagon on hepatic gluconeogenesis as well as glycogenolysis; (b) the glucagonsensitive step(s) in gluconeogenesis affected by somatostatin involves primarily intra-hepatic disposal rather than net hepatic uptake of glucose precursors; (c) splanchnic uptake of fatty acids and ketone output are increased in the face of combined insulin and glucagon deficiency; and (d) diminished splanchnic blood flow may contribute to some of the effects of somatostatin on splanchnic metabolism. |
1977-03-15 |
2023-08-11 |
human |
| J E Liljenquist, G L Mueller, A D Cherrington, U Keller, Chiasson J-L, J M Perry, W W Lacy, D Rabinowit. Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man. The Journal of clinical investigation. vol 59. issue 2. 1977-03-15. PMID:833282. |
in contrast, when somatostatin alone was administered to normal men, resulting in combined insulin and glucagon deficiency (euglycemia again maintained), nsgp fell markedly but only transiently, reaching its nadir at 15 min. |
1977-03-15 |
2023-08-11 |
Not clear |
| P M Dubois, C Paulin, J A Chayviall. Identification of gastrin-secreting cells and cholecystokinin-secreting cells in the gastrointestinal tract of the human fetus and adult man. Cell and tissue research. vol 175. issue 3. 1977-02-16. PMID:793724. |
the specificity of immunocytological reactions was ascertained by studying the inhibition of the reaction by gastrin, c.c.k., secretin, somatostatin, glucagon, insulin, serotonin, histamin, caerulein and octapeptide of c.c.k. |
1977-02-16 |
2023-08-11 |
human |
| P Felig, J Wahren, R Sherwin, R Hendle. Insulin, glucagon, and somatostatin in normal physiology and diabetes mellitus. Diabetes. vol 25. issue 12. 1977-01-29. PMID:992227. |
insulin, glucagon, and somatostatin in normal physiology and diabetes mellitus. |
1977-01-29 |
2023-08-11 |
human |