| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Davis, N R Lazaru. An in vitro system for studying insulin release: effects of glucose and glucose-6-phosphate. The Journal of physiology. vol 271. issue 1. 1977-12-29. PMID:335048. |
adrenaline and somatostatin did not inhibit glucose-mediated insulin release. |
1977-12-29 |
2023-08-11 |
rabbit |
| A Gordin, C Meyers, A Arimura, D H Coy, A V Schall. An in vivo model for testing inhibition of arginine-induced insulin and glucagon release by somatostatin analogs. Acta endocrinologica. vol 86. issue 4. 1977-12-29. PMID:335762. |
an in vivo model for testing inhibition of arginine-induced insulin and glucagon release by somatostatin analogs. |
1977-12-29 |
2023-08-11 |
rat |
| A Gordin, C Meyers, A Arimura, D H Coy, A V Schall. An in vivo model for testing inhibition of arginine-induced insulin and glucagon release by somatostatin analogs. Acta endocrinologica. vol 86. issue 4. 1977-12-29. PMID:335762. |
an animal model for testing the in vivo potency of somatostatin analogs in inhibiting the release of insulin and glucagon is described. |
1977-12-29 |
2023-08-11 |
rat |
| A Gordin, C Meyers, A Arimura, D H Coy, A V Schall. An in vivo model for testing inhibition of arginine-induced insulin and glucagon release by somatostatin analogs. Acta endocrinologica. vol 86. issue 4. 1977-12-29. PMID:335762. |
concomitant infusion of graded doses of somatostatin (2.5, 10, 40 and 160 microgram/100 g bw) for 30 min inhibited both insulin and glucagon release in a dose-dependent manner, enabling us to test somatostatin analogs for insulin and glucagon-suppressive activity in a semi-quantitative manner. |
1977-12-29 |
2023-08-11 |
rat |
| C S Pace, M Murphy, S Conant, P E Lac. Somatostatin inhibition of glucose-induced electrical activity in cultured rat islet cells. The American journal of physiology. vol 233. issue 5. 1977-12-29. PMID:335898. |
electrophysiological studies of rat islet cells in monolayer culture were undertaken to determine the role of transmembranous ionic fluxes in the inhibitory action of somatostatin on insulin release. |
1977-12-29 |
2023-08-11 |
rat |
| S Vethamany-Globus, M Globus, J A Hartford, I Fraser, D Webe. Hormone control in regeneration: effects of somatostatin on appendage regeneration, blood glucose and liver glycogen in Diemictylus viridescens. Journal of embryology and experimental morphology. vol 40. 1977-12-29. PMID:915418. |
in the present communication, synthetic somatostatin, a hypothalamic factor which has a known inhibitory effect on the release of growth hormone, thyroid-stimulating hormone, prolactin, insulin and glucagon in man and other mammals, was found to have an inhibitory effect on limb and tail regeneration in adult diemictylus viridescens, when the newts were treated with a daily dose of 3-5 or 15 microgram/animal for a period of 34 days post-amputation. |
1977-12-29 |
2023-08-11 |
Not clear |
| F Hertelendy, D Calabria, H Todd, B Raa. Somatostatin inhibits urinary cyclic AMP excretion in diabetic rats. Endocrinology. vol 101. issue 4. 1977-11-30. PMID:198195. |
while somatostatin tended to increase cyclic gmp excretion, insulin had an opposite effect in diabetic but not in normal rats. |
1977-11-30 |
2023-08-11 |
rat |
| C B Wollheim, M Kikuchi, A E Renold, G W Shar. Somatostatin- and epinephrine-induced modifications of 45Ca++ fluxes and insulin release in rat pancreatic islets maintained in tissue culture. The Journal of clinical investigation. vol 60. issue 5. 1977-11-30. PMID:332717. |
the effects of somatostatin and epinephrine have been studied with regard to glucose-induced insulin release and (45)ca(++) uptake by rat pancreatic islets after 2 days in tissue culture and with regard to (45)ca(++) efflux from islets loaded with the radio-isotope during the 2 days of culture. |
1977-11-30 |
2023-08-11 |
rat |
| C B Wollheim, M Kikuchi, A E Renold, G W Shar. Somatostatin- and epinephrine-induced modifications of 45Ca++ fluxes and insulin release in rat pancreatic islets maintained in tissue culture. The Journal of clinical investigation. vol 60. issue 5. 1977-11-30. PMID:332717. |
somatostatin inhibited the stimulation of insulin release by glucose in a concentration-related manner (1-1,000 ng/ml) but was without effect on the glucose-induced stimulation of (45)ca(++) uptake. |
1977-11-30 |
2023-08-11 |
rat |
| C B Wollheim, M Kikuchi, A E Renold, G W Shar. Somatostatin- and epinephrine-induced modifications of 45Ca++ fluxes and insulin release in rat pancreatic islets maintained in tissue culture. The Journal of clinical investigation. vol 60. issue 5. 1977-11-30. PMID:332717. |
similarly, under perifusion conditions, both phases of insulin release were inhibited by somatostatin while no effect was observed on the pattern of (45)ca(++) efflux after glucose.epinephrine, in contrast to somatostatin, caused a concentration-dependent inhibition of the stimulation of both insulin release and (45)ca(++) uptake by glucose. |
1977-11-30 |
2023-08-11 |
rat |
| C B Wollheim, M Kikuchi, A E Renold, G W Shar. Somatostatin- and epinephrine-induced modifications of 45Ca++ fluxes and insulin release in rat pancreatic islets maintained in tissue culture. The Journal of clinical investigation. vol 60. issue 5. 1977-11-30. PMID:332717. |
somatostatin inhibits insulin release without any detectable effect upon the handling of calcium by the islets. |
1977-11-30 |
2023-08-11 |
rat |
| N Altszuler, E Moraru, J Hampshir. On the mechanism of diazoxide-induced hyperglycemia. Diabetes. vol 26. issue 10. 1977-11-30. PMID:908462. |
infusion of somatostatin along with insulin prevented the effects of diazoxide on plasma glucose and glucose production. |
1977-11-30 |
2023-08-11 |
Not clear |
| J E Gerich, T A Schultz, S B Lewis, J H Kara. Clinical evaluation of somatostatin as a potential ajunct to insulin in the management of diabetes mellitus. Diabetologia. vol 13. issue 5. 1977-11-30. PMID:908478. |
clinical evaluation of somatostatin as a potential ajunct to insulin in the management of diabetes mellitus. |
1977-11-30 |
2023-08-11 |
Not clear |
| J E Gerich, T A Schultz, S B Lewis, J H Kara. Clinical evaluation of somatostatin as a potential ajunct to insulin in the management of diabetes mellitus. Diabetologia. vol 13. issue 5. 1977-11-30. PMID:908478. |
to determine whether somatostatin, an inhibitor of glucagon and growth hormone secretion, might be useful as an adjunct to insulin the management of diabetic hyperglycaemia, seven insulin-requiring diabetic men were given somatostatin (100 microgram/h, iv) continuously for 3 days after their diabetes had been treated intensively by diet and insulin on a metabolic ward. |
1977-11-30 |
2023-08-11 |
Not clear |
| J E Gerich, T A Schultz, S B Lewis, J H Kara. Clinical evaluation of somatostatin as a potential ajunct to insulin in the management of diabetes mellitus. Diabetologia. vol 13. issue 5. 1977-11-30. PMID:908478. |
during infusion of somatostatin and despite reduction in average insulin dose exceeding 50%, there was improvement in diabetic control as assessed by postprandial hyperglycaemia, 24-h glycosuria and the average daily serum glucose level and its fluctuation; when somatostatin was discontinued, but insulin doses held constant, diabetic control rapidly worsened. |
1977-11-30 |
2023-08-11 |
Not clear |
| J E Gerich, T A Schultz, S B Lewis, J H Kara. Clinical evaluation of somatostatin as a potential ajunct to insulin in the management of diabetes mellitus. Diabetologia. vol 13. issue 5. 1977-11-30. PMID:908478. |
these results indicate that somatostatin plus insulin can be a more effective regimen than insulin alone in controlling diabetic hyperglycaemia. |
1977-11-30 |
2023-08-11 |
Not clear |
| J E Gerich, T A Schultz, S B Lewis, J H Kara. Clinical evaluation of somatostatin as a potential ajunct to insulin in the management of diabetes mellitus. Diabetologia. vol 13. issue 5. 1977-11-30. PMID:908478. |
a longer acting and more selective somatostatin preparation may prove useful as an adjunct to insulin in the management of diabetes. |
1977-11-30 |
2023-08-11 |
Not clear |
| E Ipp, R E Dobbs, V Harris, A Arimura, W Vale, R H Unge. The effects of gastrin, gastric inhibitory polypeptide, secretin, and the octapeptide of cholecystokinin upon immunoreactive somatostatin release by the perfused canine pancreas. The Journal of clinical investigation. vol 60. issue 5. 1977-11-30. PMID:908761. |
with all four polypeptides the pattern of the somatostatin response resembled that of insulin. |
1977-11-30 |
2023-08-11 |
dog |
| E Ipp, R E Dobbs, V Harris, A Arimura, W Vale, R H Unge. The effects of gastrin, gastric inhibitory polypeptide, secretin, and the octapeptide of cholecystokinin upon immunoreactive somatostatin release by the perfused canine pancreas. The Journal of clinical investigation. vol 60. issue 5. 1977-11-30. PMID:908761. |
it appears that pancreatic somatostatin release is stimulated by gastrointestinal hormones that influence the secretion of insulin and glucagon. |
1977-11-30 |
2023-08-11 |
dog |
| N Faure, J H Dussault, A Nadeau, F Szots, H Guyda, F Labri. Effect of somatostatin on thyrotropin, prolactin, growth hormone and insulin responses to thyrotropin releasing hormone and arginine in healthy, hypothyroid and acromegalic subjects. Canadian Medical Association journal. vol 117. issue 5. 1977-11-25. PMID:409475. |
effect of somatostatin on thyrotropin, prolactin, growth hormone and insulin responses to thyrotropin releasing hormone and arginine in healthy, hypothyroid and acromegalic subjects. |
1977-11-25 |
2023-08-11 |
human |