| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Botha, A I Vinik, P T Child, W P Jackso. Inhibition of exaggerated gastrointestinal glucagon responses in chronic pancreatitis by somatostatin. The Journal of clinical endocrinology and metabolism. vol 45. issue 6. 1978-02-18. PMID:591621. |
intravenous administration of 200 microgram of somatostatin, followed by infusion of 200 microgram over 2 1/2 h, abolished the gli and insulin responses, but did not change glucose tolerance. |
1978-02-18 |
2023-08-11 |
human |
| J L Botha, A I Vinik, P T Child, W P Jackso. Inhibition of exaggerated gastrointestinal glucagon responses in chronic pancreatitis by somatostatin. The Journal of clinical endocrinology and metabolism. vol 45. issue 6. 1978-02-18. PMID:591621. |
this contrasts with the relatively minor effects of somatostatin on gli responses in control subjects where the clear deterioration in glucose tolerance may relate to inhibition of insulin release. |
1978-02-18 |
2023-08-11 |
human |
| V Sako, H Schatz, V Maier, E F Pfeiffe. Insulin release from collagenase-isolated islets of rat pancreas in the presence of cyclic AMP and somatostatin. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 9. issue 5. 1978-01-27. PMID:200535. |
insulin release from collagenase-isolated islets of rat pancreas in the presence of cyclic amp and somatostatin. |
1978-01-27 |
2023-08-11 |
rat |
| V Sako, H Schatz, V Maier, E F Pfeiffe. Insulin release from collagenase-isolated islets of rat pancreas in the presence of cyclic AMP and somatostatin. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 9. issue 5. 1978-01-27. PMID:200535. |
in order to study the role of cyclic amp in the inhibition by somatostatin of glucose-induced insulin release, the effect of somatostatin on the potentiation by dibutyryl-cyclic amp (db-camp) of insulin release from isolated pancreatic islets of rats was examined. |
1978-01-27 |
2023-08-11 |
rat |
| V Sako, H Schatz, V Maier, E F Pfeiffe. Insulin release from collagenase-isolated islets of rat pancreas in the presence of cyclic AMP and somatostatin. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 9. issue 5. 1978-01-27. PMID:200535. |
glucose-induced insulin release was reduced by somatostatin in concentrations of 1 microgram/ml. |
1978-01-27 |
2023-08-11 |
rat |
| V Sako, H Schatz, V Maier, E F Pfeiffe. Insulin release from collagenase-isolated islets of rat pancreas in the presence of cyclic AMP and somatostatin. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 9. issue 5. 1978-01-27. PMID:200535. |
somatostatin in a concentration of 100 ng/ml significantly abolished the potentiation by db-camp of insulin release (p less than 0;01), in spite of exerting no inhibition of glucose-induced insulin release. |
1978-01-27 |
2023-08-11 |
rat |
| V Sako, H Schatz, V Maier, E F Pfeiffe. Insulin release from collagenase-isolated islets of rat pancreas in the presence of cyclic AMP and somatostatin. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 9. issue 5. 1978-01-27. PMID:200535. |
however, in the presence of theophylline 5 mm, somatostatin 100 ng/ml did not show that inhibitory effect on the potentiated insulin release. |
1978-01-27 |
2023-08-11 |
rat |
| R S Sherwin, W Tamborlane, R Hendler, L Saccá, R A DeFronzo, P Feli. Influence of glucagon replacement on the hyperglycemic and hyperketonemic response to prolonged somatostatin infusion in normal man. The Journal of clinical endocrinology and metabolism. vol 45. issue 5. 1978-01-27. PMID:925134. |
the addition of glucagon to somatostatin resulted in a 30-40% rise in plasma glucagon, whereas plasma insulin declined by 40-50% in both treatment groups. |
1978-01-27 |
2023-08-11 |
human |
| Y Harano, S Ohgaku, H Hidaka, K Haneda, R Kikkawa, Y Shigeta, H Ab. Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity. The Journal of clinical endocrinology and metabolism. vol 45. issue 5. 1978-01-27. PMID:925138. |
glucose, insulin and somatostatin infusion for the determination of insulin sensitivity. |
1978-01-27 |
2023-08-11 |
human |
| Y Harano, S Ohgaku, H Hidaka, K Haneda, R Kikkawa, Y Shigeta, H Ab. Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity. The Journal of clinical endocrinology and metabolism. vol 45. issue 5. 1978-01-27. PMID:925138. |
glucose, insulin and somatostatin infusion over 2 hours effectively suppressed endogenous secretion of insulin, glucagon and growth hormones. |
1978-01-27 |
2023-08-11 |
human |
| J C Basabe, J C Cresto, N Aparici. Studies on the mode of action of somatostatin on insulin secretion. Endocrinology. vol 101. issue 5. 1977-12-29. PMID:199419. |
studies on the mode of action of somatostatin on insulin secretion. |
1977-12-29 |
2023-08-11 |
rat |
| J C Basabe, J C Cresto, N Aparici. Studies on the mode of action of somatostatin on insulin secretion. Endocrinology. vol 101. issue 5. 1977-12-29. PMID:199419. |
the effect of somatostatin on insulin release by incubated slices of rat pancreas was studied. |
1977-12-29 |
2023-08-11 |
rat |
| J C Basabe, J C Cresto, N Aparici. Studies on the mode of action of somatostatin on insulin secretion. Endocrinology. vol 101. issue 5. 1977-12-29. PMID:199419. |
somatostatin inhibited insulin release induced by arginine/glucose (a/g), glucagon, glibenclamide, pentoxifyllin, 3',5'-adenosine monophosphate (camp), phentolamine, and kcl. |
1977-12-29 |
2023-08-11 |
rat |
| J C Basabe, J C Cresto, N Aparici. Studies on the mode of action of somatostatin on insulin secretion. Endocrinology. vol 101. issue 5. 1977-12-29. PMID:199419. |
these results suggest that the inhibitory effect of somatostatin on insulin secretion could result from calcium translocation in pancreatic beta cells. |
1977-12-29 |
2023-08-11 |
rat |
| Y Sakamoto, Y Ide, N Minami, N Tajima, H Yamad. [Effects of somatostatin on pancreatic isolated islets and peripheral tissues of rats]. Nihon Naibunpi Gakkai zasshi. vol 53. issue 7. 1977-12-29. PMID:334584. |
this study was performed in order to evaluate the effects of somatostatin on insulin releasing mechanisms and on glucose uptake in peripheral tissues using isolated pancreatic islets, isolated rat diaphragms and epididymal fat pads. |
1977-12-29 |
2023-08-11 |
rat |
| Y Sakamoto, Y Ide, N Minami, N Tajima, H Yamad. [Effects of somatostatin on pancreatic isolated islets and peripheral tissues of rats]. Nihon Naibunpi Gakkai zasshi. vol 53. issue 7. 1977-12-29. PMID:334584. |
insulin release by various concentrations of glucose were examined, and it was found that 100 ng/ml of somatostatin significantly inhibited insulin release at the glucose concentration of 200 mg/dl. |
1977-12-29 |
2023-08-11 |
rat |
| Y Sakamoto, Y Ide, N Minami, N Tajima, H Yamad. [Effects of somatostatin on pancreatic isolated islets and peripheral tissues of rats]. Nihon Naibunpi Gakkai zasshi. vol 53. issue 7. 1977-12-29. PMID:334584. |
somatostatin also significantly inhibted insulin release by the administration of 5microgram/ml of glucagon with 200 mg/dl of glucose concentration and 20 mm of orginine with 200mg/dl of glucose concentrations. |
1977-12-29 |
2023-08-11 |
rat |
| Y Sakamoto, Y Ide, N Minami, N Tajima, H Yamad. [Effects of somatostatin on pancreatic isolated islets and peripheral tissues of rats]. Nihon Naibunpi Gakkai zasshi. vol 53. issue 7. 1977-12-29. PMID:334584. |
but at the glucose concentration of 50mg/dl, no significant inhibition of somatostatin on insulin release was observed even when various concentrations of glucagon or arginine were added. |
1977-12-29 |
2023-08-11 |
rat |
| Y Sakamoto, Y Ide, N Minami, N Tajima, H Yamad. [Effects of somatostatin on pancreatic isolated islets and peripheral tissues of rats]. Nihon Naibunpi Gakkai zasshi. vol 53. issue 7. 1977-12-29. PMID:334584. |
the results indicated that somatostatin directly inhibited insulin release from rat pancreatic islets but had no effect on glucose uptake in peripheral tissues. |
1977-12-29 |
2023-08-11 |
rat |
| Y Sakamoto, Y Ide, N Minami, N Tajima, H Yamad. [Effects of somatostatin on pancreatic isolated islets and peripheral tissues of rats]. Nihon Naibunpi Gakkai zasshi. vol 53. issue 7. 1977-12-29. PMID:334584. |
the inhibitory effect of somatostatin on insulin release may act through the common mechanism of both glucose and other substances in leading to insulin release. |
1977-12-29 |
2023-08-11 |
rat |