| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Grill, U Adamson, E Ceras. Immediate and time-dependent effects of glucose on insulin release from rat pancreatic tissue. Evidence for different mechanisms of action. The Journal of clinical investigation. vol 61. issue 4. 1978-08-14. PMID:207721. |
omission of ca(++) as well as the inclusion of somatostatin or mannoheptulose during the first pulse abolished insulin secretion during this time period; however, only the inclusion of mannoheptulose deleted the potentiation of the second pulse. |
1978-08-14 |
2023-08-11 |
rat |
| W V Tamborlane, R S Sherwin, R Hendler, P Feli. Biphasic effect of somatostatin on oral glucose tolerance in maturity-onset diabetes. Metabolism: clinical and experimental. vol 27. issue 7. 1978-08-14. PMID:661568. |
somatostatin inhibited glucose-stimulated insulin release and reduced plasma glucagon by 50%--65%. |
1978-08-14 |
2023-08-11 |
Not clear |
| P H Smith, M Chen, S C Woods, J W Ensinck, D Port. Inhibition of insulin and glucagon secretion by somatostatin: are there indirect effects? Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 157. issue 4. 1978-07-26. PMID:349571. |
inhibition of insulin and glucagon secretion by somatostatin: are there indirect effects? |
1978-07-26 |
2023-08-11 |
Not clear |
| J C Basabe, D P Udrisar, C F Knopf, N Aparici. The influence of pentoxyfylline [1-(5-oxohexyl-) 3,7-dimethylxanthine] (BL 191) on the insulin secretion induced by glibenclamide and by arginine/glucose in the perfused pancreas. Acta diabetologica latina. vol 14. issue 5-6. 1978-07-26. PMID:418615. |
the results obtained show that: 1) bl 191 (5 mm) is capable of stimulating insulin secretion, even in the presence of another stimulator; 2) bl 191 increases both phases of the secretion produced by constant arginine 20 mm/glucose 5 mm perfusion; 3) bl 191 significantly increases and turns biphasic the monophasic insulin secretion pattern produced by 1 microgram/ml glibenclamide; 4) the effects mentioned in points 2) and 3) are inhibited if the phosphodiesterase activator imidazole (300 mg/100 ml) is present in the perfusion medium; 5) the phosphodiesterase inhibitor theophylline has the same effects as bl 191, except for its inability to stimulate insulin release in the absence of another stimulator; 6) somatostatin (100 ng/ml) significantly inhibits insulin secretion produced by arginine/glucose or glibenclamide, as well as by arginine, glucose plus theophylline or bl 191, and by glibenclamide plus theophylline or bl 191, in both cases the inhibitory effect of somatostatin is reduced by the presence of bl 191 or theophylline. |
1978-07-26 |
2023-08-11 |
rat |
| A A Barros D'sa, S R Bloom, J H Baro. Inhibition by somatostatin (growth-hormone release-inhibiting hormone, GH-RIH) of gastric acid and pepsin and G-cell release of gastrin. Gut. vol 19. issue 4. 1978-07-24. PMID:348581. |
somatostatin inhibited gastric acid response to four gastric stimulants--insulin, food, histamine, and pentagastrin. |
1978-07-24 |
2023-08-11 |
Not clear |
| A A Barros D'sa, S R Bloom, J H Baro. Inhibition by somatostatin (growth-hormone release-inhibiting hormone, GH-RIH) of gastric acid and pepsin and G-cell release of gastrin. Gut. vol 19. issue 4. 1978-07-24. PMID:348581. |
somatostatin inhibited the gastrin response to insulin and food. |
1978-07-24 |
2023-08-11 |
Not clear |
| A S Luyckx, P J Lefebvr. Effect of somatostatin in the Syrian hamster bearing a transplantable islet-cell tumor. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 10. issue 2. 1978-07-15. PMID:206496. |
these results indicate that somatostatin does not reduce the hyperglucagonemia due to the transplantable islet-cell tumor but nevertheless decreases blood glucose and plasma insulin. |
1978-07-15 |
2023-08-11 |
Not clear |
| W B Rhoten, P H Smit. Localization of four polypeptide hormones in the saurian pancreas. The American journal of anatomy. vol 151. issue 4. 1978-06-12. PMID:347917. |
glucagon, insulin, somatostatin, and pancreatic polypeptide have been localized in the anolian pancreas using peroxidase-antiperoxidase immunocytochemistry. |
1978-06-12 |
2023-08-11 |
Not clear |
| S E Christensen, A P Hansen, J Weeke, K Lundbae. 24-hour studies of the effects of somatostatin on the levels of plasma growth hormone, glucagon, and glucose in normal subjects and juvenile diabetics. Diabetes. vol 27. issue 3. 1978-06-12. PMID:640235. |
in the normals, somatostatin suppressed plasma growth hormone, glucagon, and insulin but increased plasma glucose. |
1978-06-12 |
2023-08-11 |
human |
| S E Christensen, A P Hansen, J Weeke, K Lundbae. 24-hour studies of the effects of somatostatin on the levels of plasma growth hormone, glucagon, and glucose in normal subjects and juvenile diabetics. Diabetes. vol 27. issue 3. 1978-06-12. PMID:640235. |
the elevated plasma glucose levels in normals must be due to the suppressive effects of somatostatin on insulin secretion. |
1978-06-12 |
2023-08-11 |
human |
| R H Unger, R E Dobbs, L Orc. Insulin, glucagon, and somatostatin secretion in the regulation of metabolism. Annual review of physiology. vol 40. 1978-05-17. PMID:205166. |
insulin, glucagon, and somatostatin secretion in the regulation of metabolism. |
1978-05-17 |
2023-08-11 |
Not clear |
| V L Cascio, G Galvanini, S Adami, S Cinti, I Bianchi, L Cominacini, L A Scur. Failure of somatostatin to diagnose organic hyperinsulinism. Clinical endocrinology. vol 8. issue 1. 1978-04-26. PMID:627095. |
tolbutamide induced insulin release was completely inhibited by somatostatin as in normal subjects. |
1978-04-26 |
2023-08-11 |
human |
| V L Cascio, G Galvanini, S Adami, S Cinti, I Bianchi, L Cominacini, L A Scur. Failure of somatostatin to diagnose organic hyperinsulinism. Clinical endocrinology. vol 8. issue 1. 1978-04-26. PMID:627095. |
these results suggest that the inhibition test with somatostatin does not seem to be a better or safer way of diagnosing insulin producing tumours. |
1978-04-26 |
2023-08-11 |
human |
| b' J C Dunbar, M F Walsh, P P Fo\\xc3\\xa. The serum glucose response to glucagon suppression with somatostatin, insulin or antiglucagon serum in depancreatized rats. Diabetologia. vol 14. issue 1. 1978-04-26. PMID:627333.' |
the serum glucose response to glucagon suppression with somatostatin, insulin or antiglucagon serum in depancreatized rats. |
1978-04-26 |
2023-08-11 |
rat |
| R A DeFronzo, R S Sherwin, M Dillingham, R Hendler, W V Tamborlane, P Feli. Influence of basal insulin and glucagon secretion on potassium and sodium metabolism. Studies with somatostatin in normal dogs and in normal and diabetic human beings. The Journal of clinical investigation. vol 61. issue 2. 1978-03-29. PMID:621284. |
to examine the role of basal insulin and glucagon secretion in potassium and sodium homeostasis, somatostatin, a potent inhibitor of insulin and glucagon secretion, was infused for 5 h into healthy human subjects, maturity-onset diabetes, juvenile-onset diabetics, and normal dogs. |
1978-03-29 |
2023-08-11 |
human |
| R A DeFronzo, R S Sherwin, M Dillingham, R Hendler, W V Tamborlane, P Feli. Influence of basal insulin and glucagon secretion on potassium and sodium metabolism. Studies with somatostatin in normal dogs and in normal and diabetic human beings. The Journal of clinical investigation. vol 61. issue 2. 1978-03-29. PMID:621284. |
a similar rise in serum potassium was observed in normal conscious dogs given somatostatin and was reversed by insulin replacement. |
1978-03-29 |
2023-08-11 |
human |
| R A DeFronzo, R S Sherwin, M Dillingham, R Hendler, W V Tamborlane, P Feli. Influence of basal insulin and glucagon secretion on potassium and sodium metabolism. Studies with somatostatin in normal dogs and in normal and diabetic human beings. The Journal of clinical investigation. vol 61. issue 2. 1978-03-29. PMID:621284. |
in dogs given intravenous potassium chloride in doses (0.375 meq/kg per h) which do not alter basal insulin levels, the rise in serum potassium (0.6 meq/liter in controls) increased 100% when somatostatin was administered together with the kcl infusion. |
1978-03-29 |
2023-08-11 |
human |
| R A DeFronzo, R S Sherwin, M Dillingham, R Hendler, W V Tamborlane, P Feli. Influence of basal insulin and glucagon secretion on potassium and sodium metabolism. Studies with somatostatin in normal dogs and in normal and diabetic human beings. The Journal of clinical investigation. vol 61. issue 2. 1978-03-29. PMID:621284. |
addition of replacement doses of insulin to the somatostatin infusion resulted in increments in serum potassium which were comparable to infusion of kcl alone. |
1978-03-29 |
2023-08-11 |
human |
| R A DeFronzo, R S Sherwin, M Dillingham, R Hendler, W V Tamborlane, P Feli. Influence of basal insulin and glucagon secretion on potassium and sodium metabolism. Studies with somatostatin in normal dogs and in normal and diabetic human beings. The Journal of clinical investigation. vol 61. issue 2. 1978-03-29. PMID:621284. |
it is concluded that (a) potassium homeostasis is influenced by basal insulin levels in the absence of which serum potassium concentration rises and potassium tolerance declines; (b) this effect of insulin is mediated via extrarenal mechanisms of potassium disposal; (c) somatostatin has a biphasic effect on urinary sodium secretion, the mechanism of which remains to be established. |
1978-03-29 |
2023-08-11 |
human |
| K Murakami, H Taniguchi, M Hasegawa, T Kobayashi, Y Watanab. [The physiological role of somatostatin in insulin release--enhanced insulin release from rat islets pre-treated with anti-somatostatin serum (author's transl)]. Nihon Naibunpi Gakkai zasshi. vol 53. issue 10. 1978-02-18. PMID:338377. |
[the physiological role of somatostatin in insulin release--enhanced insulin release from rat islets pre-treated with anti-somatostatin serum (author's transl)]. |
1978-02-18 |
2023-08-11 |
rat |