| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Gordin, L Eriksson, A K Blom, M R Taskinen, F Fyhrquis. Lack of behavioural effects following intraventricular infusion of somatostatin in the conscious goat. Pharmacology, biochemistry, and behavior. vol 9. issue 2. 1979-01-24. PMID:714974. |
iv infusion of 100 to 600 microgram and icv infusion of 600 microgram of somatostatin caused a difinite reduction in the secretion of insulin and growth hormone, but had no effect on the concentration of blood glucose. |
1979-01-24 |
2023-08-11 |
rat |
| G Herbai, S Westman-Naeser, L Carlsson, K Nilsso. Prolonged serum insulin decreasing effects of two synthetic somatostatin analogues studied in vivo by a new animal method. Preliminary communication. Upsala journal of medical sciences. vol 83. issue 3. 1979-01-15. PMID:715946. |
prolonged serum insulin decreasing effects of two synthetic somatostatin analogues studied in vivo by a new animal method. |
1979-01-15 |
2023-08-11 |
mouse |
| G Herbai, S Westman-Naeser, L Carlsson, K Nilsso. Prolonged serum insulin decreasing effects of two synthetic somatostatin analogues studied in vivo by a new animal method. Preliminary communication. Upsala journal of medical sciences. vol 83. issue 3. 1979-01-15. PMID:715946. |
two newly synthesized analogues of somatostatin, d-alanine-somatostatin and des-alanine-des glycine-des-amino-somatostatin produced a more prolonged and greater decrease in the serum insulin values of ob-ob mice than did somatostatin. |
1979-01-15 |
2023-08-11 |
mouse |
| R C McEvoy, O D Hegr. Syngeneic transplantation of fetal rat pancreas. II. Effect of insulin treatment on the growth and differentiation of pancreatic implants fifteen days after transplantation. Diabetes. vol 27. issue 10. 1978-12-20. PMID:359389. |
using the morphometric technique of linear scanning, the insulin, glucagon, and somatostatin immunocytochemically positive, cell masses of the fetal pancreatic implants were quantitated. |
1978-12-20 |
2023-08-11 |
rat |
| P L Werner, J P Palme. Immunoreactive glucagon responses to oral glucose, insulin infusion and deprivation, and somatostatin in pancreatectomized man. Diabetes. vol 27. issue 10. 1978-12-20. PMID:700256. |
immunoreactive glucagon responses to oral glucose, insulin infusion and deprivation, and somatostatin in pancreatectomized man. |
1978-12-20 |
2023-08-11 |
human |
| S E Christensen, A P Hansen, K Lundbae. Somatostatin in maturity-onset diabetes. Diabetes. vol 27. issue 10. 1978-12-20. PMID:700257. |
somatostatin induced the same changes in the parameters of both groups of diabetic patients: a rise in plasma ffa, which gradually disappeared after some hours of infusion, a suppression of plasma glucagon and insulin, and an augmentation of plasma glucose both postprandially and during the night. |
1978-12-20 |
2023-08-11 |
Not clear |
| S E Christensen, A P Hansen, K Lundbae. Somatostatin in maturity-onset diabetes. Diabetes. vol 27. issue 10. 1978-12-20. PMID:700257. |
the results indicate that a preparation with a pattern of hormone suppression like that of somatostatin will not be useful in the control of maturity-onset diabetes, because it suppresses insulin and elevates the blood glucose concentration. |
1978-12-20 |
2023-08-11 |
Not clear |
| L J Klaff, A I Vinik, M Berelowitz, W P Jackso. Circulating antibodies in diabetics treated with conventional and purified insulins. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. vol 54. issue 4. 1978-12-02. PMID:694712. |
conventional insulins contain impurities which are immunogenic; these include pancreatic polypeptide (pp), glucagon and somatostatin and intermediates of insulin synthesis co-extracted during purification. |
1978-12-02 |
2023-08-11 |
Not clear |
| A D Cherrington, W W Lacy, J L Chiasso. Effect of glucagon on glucose production during insulin deficiency in the dog. The Journal of clinical investigation. vol 62. issue 3. 1978-11-29. PMID:690190. |
a selective deficiency of insulin or a combined deficiency of both pancreatic hormones was created by infusing somatostatin alone or in combination with an intraportal replacement infusion of glucagon. |
1978-11-29 |
2023-08-11 |
dog |
| P Thor, R Król, S J Konturek, D H Coy, A V Schall. Effect of somatostatin on myoelectrical activity of small bowel. The American journal of physiology. vol 235. issue 3. 1978-11-29. PMID:696818. |
intravenous infusions of somatostatin were administered in various doses (0.6--5.0 microgram/kg.h) while spike activity and slow waves were recorded under fasting conditions, after a meat meal, or during intravenous infusion of gastrin, caerulein, or insulin. |
1978-11-29 |
2023-08-11 |
Not clear |
| S R Bloom, A V Edward. Certain pharmacological characteristics of the release of pancreatic glucagon in response to stimulation of the splanchnic nerves. The Journal of physiology. vol 280. 1978-11-22. PMID:690873. |
in addition, the effects of insulin, atropine and somatostatin on the glucagon response to splanchnic nerve stimulation have been assessed in adrenalectomized dogs. |
1978-11-22 |
2023-08-11 |
Not clear |
| J E Geric. Somatostatin and the endocrine pancreas. Current topics in molecular endocrinology. vol 3. 1978-11-18. PMID:211005. |
the presence of somatostatin within the pancreatic d cells raises the possibility that it may function as a local regulator of insulin and glucagon release. |
1978-11-18 |
2023-08-11 |
Not clear |
| S Bab. [Physiological significance of endogenous somatostatin in insulin and glucagon secretion]. Horumon to rinsho. Clinical endocrinology. vol 26. issue 6. 1978-11-18. PMID:688664. |
[physiological significance of endogenous somatostatin in insulin and glucagon secretion]. |
1978-11-18 |
2023-08-11 |
Not clear |
| S Efendic, P E Lins, R Luf. Somatostatin and insulin secretion. Metabolism: clinical and experimental. vol 27. issue 9 Suppl 1. 1978-10-25. PMID:210356. |
somatostatin and insulin secretion. |
1978-10-25 |
2023-08-11 |
Not clear |
| H J Hahn, H D Gottschling, P Woltansk. Effect of somatostatin on insulin secretion and cAMP content of isolated pancreatic rat islets. Metabolism: clinical and experimental. vol 27. issue 9 Suppl 1. 1978-10-25. PMID:210357. |
effect of somatostatin on insulin secretion and camp content of isolated pancreatic rat islets. |
1978-10-25 |
2023-08-11 |
rat |
| B J Li. Effects of somatostatin on insulin biosynthesis, glucose oxidation, and cyclic guanosine monophosphate level. Metabolism: clinical and experimental. vol 27. issue 9 Suppl 1. 1978-10-25. PMID:210358. |
effects of somatostatin on insulin biosynthesis, glucose oxidation, and cyclic guanosine monophosphate level. |
1978-10-25 |
2023-08-11 |
Not clear |
| P Raskin, R H Unge. Glucagon and diabetes. The Medical clinics of North America. vol 62. issue 4. 1978-10-25. PMID:355737. |
we have considered the evidence, first, that the presence of glucagon is essential in the pathogenesis of the full syndrome that results from complete insulin deficiency; second, that in the diabetic in whom insulin levels are relatively fixed, a rise in glucagon concentration contributes to endogenous hyperglycemia; and, third, that conventional methods of treatment of diabetes do not fully correct either the abnormal glucagon levels or the hyperglycemia, but when insulin therapy is supplemented with somatostatin, an agent which suppresses both glucagon and growth hormone, both hyperglycemia and hyperglucagonemia are corrected. |
1978-10-25 |
2023-08-11 |
Not clear |
| P Schauder, C McIntosh, U Panten, J Arends, R Arnold, H Frerichs, W Creutzfeld. Dynamics of somatostatin and insulin release from isolated rat pancreatic islets: evidence for intraislet interactions between B cells and D cells. Metabolism: clinical and experimental. vol 27. issue 9 Suppl 1. 1978-10-25. PMID:355781. |
dynamics of somatostatin and insulin release from isolated rat pancreatic islets: evidence for intraislet interactions between b cells and d cells. |
1978-10-25 |
2023-08-11 |
rat |
| C B Wollheim, B Blondel, M Kikuchi, G W Shar. Inhibition of insulin release by somatostatin: no evidence for interaction with calcium. Metabolism: clinical and experimental. vol 27. issue 9 Suppl 1. 1978-10-25. PMID:355783. |
inhibition of insulin release by somatostatin: no evidence for interaction with calcium. |
1978-10-25 |
2023-08-11 |
Not clear |
| E L Lie. Effect of somatostatin and a glucagon-specific analog on glucose homeostasis during arginine infusion. Metabolism: clinical and experimental. vol 27. issue 9. 1978-10-25. PMID:682972. |
the glucose response to arginine infusion in normal rats was studied during insulin and glucagon deficiency (somatostatin infusion, 1 mg/kg/hr) or selective glucagon deficiency ([d-cys14]-somatostain infusion, 1 mg/kg/hr). |
1978-10-25 |
2023-08-11 |
rat |