| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Kadowaki, T Taminato, T Chiba, K Mori, H Abe, Y Goto, Y Seino, S Matsukura, M Nozawa, T Fujit. Somatostatin release from isolated perfused rat pancreas. Possible role of endogenous somatostatin on insulin release. Diabetes. vol 28. issue 6. 1979-08-16. PMID:446917. |
in order to elucidate the role of endogenous somatostatin in the control of insulin and glucagon secretion, glucagon- or insulin-induced somatostatin release from the isolated perfused rat pancreas was studied. |
1979-08-16 |
2023-08-11 |
rat |
| S Kadowaki, T Taminato, T Chiba, K Mori, H Abe, Y Goto, Y Seino, S Matsukura, M Nozawa, T Fujit. Somatostatin release from isolated perfused rat pancreas. Possible role of endogenous somatostatin on insulin release. Diabetes. vol 28. issue 6. 1979-08-16. PMID:446917. |
the addition of insulin (10(-7) m and 10(-6) m) had no significant effect on somatostatin and glucagon release. |
1979-08-16 |
2023-08-11 |
rat |
| S Kadowaki, T Taminato, T Chiba, K Mori, H Abe, Y Goto, Y Seino, S Matsukura, M Nozawa, T Fujit. Somatostatin release from isolated perfused rat pancreas. Possible role of endogenous somatostatin on insulin release. Diabetes. vol 28. issue 6. 1979-08-16. PMID:446917. |
these results raise the possibility that endogenous somatostatin and glucagon together regulate insulin secretion, suggesting a close interrelationship between insulin, glucagon, and somatostatin secretion within the islet. |
1979-08-16 |
2023-08-11 |
rat |
| D Giugliano, R Torella, S Sgambat. A comparative study of metabolic and hormonal responses to somatostatin and propranolol in man. Acta diabetologica latina. vol 16. issue 1. 1979-08-16. PMID:452822. |
the aim of this study was to compare the metabolic and hormonal effects of somatostatin to those of propranolol, a beta-adrenergic blocking agent known to reduce basal insulin secretion. |
1979-08-16 |
2023-08-11 |
human |
| D Giugliano, R Torella, S Sgambat. A comparative study of metabolic and hormonal responses to somatostatin and propranolol in man. Acta diabetologica latina. vol 16. issue 1. 1979-08-16. PMID:452822. |
somatostatin resulted in a significant decrease of basal insulin (p less than 0.05) and glucagon (p less than 0.01) and raised plasma ffa levels from a mean basal value of 417 +/- 24 mueq/1 (x +/- sem) to 600 +/- 46 mueq/1 at 60 min (p less than 0.01). |
1979-08-16 |
2023-08-11 |
human |
| C Bordi, R Togni, D Baetens, M Ravazzola, F Malaisse-Lagae, L Orc. Human islet cell tumor storing pancreatic polypeptide: a light and electron microscopic study. The Journal of clinical endocrinology and metabolism. vol 46. issue 2. 1979-07-28. PMID:374422. |
negative results were obtained with antisera directed against insulin, pancreatic glucagon, somatostatin, gli, vip, secretin, and gastrin. |
1979-07-28 |
2023-08-11 |
human |
| E Ipp, J Rivier, R E Dobbs, M Brown, W Vale, R H Unge. Somatostatin analogs inhibit somatostatin release. Endocrinology. vol 104. issue 5. 1979-07-28. PMID:436775. |
to determine if, like insulin, somatostatin inhibits its own secretion from the pancreas, nonimmunoreactive analogs of somatostatin were perfused in an isolated dog pancreaticoduodenal preparation using a nonrecirculating system. |
1979-07-28 |
2023-08-11 |
dog |
| E Ipp, J Rivier, R E Dobbs, M Brown, W Vale, R H Unge. Somatostatin analogs inhibit somatostatin release. Endocrinology. vol 104. issue 5. 1979-07-28. PMID:436775. |
at a concentration of 1 ng/ml, des asn5-[d-trp8]somatostatin significantly inhibited sli as well as insulin and glucagon release. |
1979-07-28 |
2023-08-11 |
dog |
| E Ipp, J Rivier, R E Dobbs, M Brown, W Vale, R H Unge. Somatostatin analogs inhibit somatostatin release. Endocrinology. vol 104. issue 5. 1979-07-28. PMID:436775. |
perfusion of glucagon at a concentration of 10 ng/ml failed to overcome the blockade of sli and insulin release caused by 50 ng/ml des asn5-[d-trp8]somatostatin. |
1979-07-28 |
2023-08-11 |
dog |
| J Gerich, K Greene, M Hara, R Rizza, G Patto. Radioimmunoassay of somatostatin and its application in the study of pancreatic somatostatin secretion in vitro. The Journal of laboratory and clinical medicine. vol 93. issue 6. 1979-07-28. PMID:438602. |
both arginine and glucose, known modulators of insulin and glucagon secretion, were found to stimulate somatostatin release. |
1979-07-28 |
2023-08-11 |
rat |
| M Ito. Immunoreactive somatostatin in the hypothalamus and other regions of the rat brain: effects of insulin, glucose, alpha- or beta-blocker and L-dopa. Endocrinologia japonica. vol 26. issue 1. 1979-07-25. PMID:35344. |
immunoreactive somatostatin in the hypothalamus and other regions of the rat brain: effects of insulin, glucose, alpha- or beta-blocker and l-dopa. |
1979-07-25 |
2023-08-11 |
rat |
| I Lundquist, F Sundler, B Ahrén, J Alumets, R Håkanso. Somatostatin, pancreatic polypeptide, substance P, and neurotensin: cellular distribution and effects on stimulated insulin secretion in the mouse. Endocrinology. vol 104. issue 3. 1979-07-25. PMID:374060. |
somatostatin, pancreatic polypeptide, substance p, and neurotensin: cellular distribution and effects on stimulated insulin secretion in the mouse. |
1979-07-25 |
2023-08-11 |
mouse |
| R L Gingerich, S L Aronoff, D M Kipnis, P E Lac. Insulin and glucagon secretion from rat islets maintained in a tissue culture-perifusion system. Diabetes. vol 28. issue 4. 1979-07-16. PMID:374172. |
freshly isolated islets are relatively insensitive to somatostatin, requiring 100 ng/ml to suppress partially the glucose-induced insulin secretion. |
1979-07-16 |
2023-08-11 |
rat |
| D Rabin, G L Mueller, W W Lacy, J E Liljenquis. Splanchnic metabolism of alanine in intact man. Effects of somatostatin and somatostatin plus insulin. Diabetes. vol 28. issue 5. 1979-07-16. PMID:437378. |
effects of somatostatin and somatostatin plus insulin. |
1979-07-16 |
2023-08-11 |
Not clear |
| D Rabin, G L Mueller, W W Lacy, J E Liljenquis. Splanchnic metabolism of alanine in intact man. Effects of somatostatin and somatostatin plus insulin. Diabetes. vol 28. issue 5. 1979-07-16. PMID:437378. |
we examined splanchnic metabolism of alanine in 15 normal males under three sets of conditions: infusion of saline (control studies); infusion of somatostatin (srif) (bihormonal deficiency of insulin and glucagon); and infusion of somatostatin plus insulin (selective glucagon deficiency). |
1979-07-16 |
2023-08-11 |
Not clear |
| E Samols, G C Wei. Adrenergic modulation of pancreatic A, B, and D cells alpha-Adrenergic suppression and beta-adrenergic stimulation of somatostatin secretion, alpha-adrenergic stimulation of glucagon secretion in the perfused dog pancreas. The Journal of clinical investigation. vol 63. issue 2. 1979-06-29. PMID:34627. |
a dose range of beta-receptor blockade was tested, and putative alpha-adrenergic effects were confirmed by combined alpha- and beta-adrenergic receptor blockade.beta-adrenergic agonism (2 ng/ml isoproterenol) induced a mean integrated increase of 79+/-20% in somatostatin secretion, whereas glucagon and insulin secretion were increased by 185+/-45 and 495+/-146%, respectively. |
1979-06-29 |
2023-08-11 |
dog |
| G Robinson, I Dawso. A formalin fixative for immunochemical and ultrastructural studies on gastrointestinal endocrine cells. Journal of clinical pathology. vol 32. issue 1. 1979-06-29. PMID:372249. |
using indirect immunofluorescence, indirect immunoperoxidase, and unlabelled antibody enzyme techniques, gastrin, pancreatic glucagon, insulin, and somatostatin were localised in sections of both wax- and resin-embedded tissues that had been fixed in a buffered formalin solution. |
1979-06-29 |
2023-08-11 |
Not clear |
| V Schusdziarra, D Rouiller, A Arimura, R H Unge. Antisomatostatin serum increases levels of hormones from the pituitary and gut, but not from the pancreas. Endocrinology. vol 103. issue 5. 1979-06-29. PMID:748027. |
these findings suggest that endogenous somatostatin influences the secretion of growth hormone and gli via a pathway readily accessible to intravenously injected antibodies, probably via the circulation, whereas any influence that somatostatin may have upon the secretion of insulin and glucagon must take place via a pathway inaccessible to intravenously administered antisomatostatin serum, i.e. |
1979-06-29 |
2023-08-11 |
Not clear |
| H Taniguchi, M Hasegawa, T Kobayashi, Y Watanabe, K Murakami, M Seki, A Tsutou, M Utsumi, H Makimura, M Sakoda, S Bab. Enhancement of leucine-induced insulin secretion by somatostatin antiserum pretreatment. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 11. issue 1. 1979-06-26. PMID:372079. |
enhancement of leucine-induced insulin secretion by somatostatin antiserum pretreatment. |
1979-06-26 |
2023-08-11 |
rat |
| H Taniguchi, M Hasegawa, T Kobayashi, Y Watanabe, K Murakami, M Seki, A Tsutou, M Utsumi, H Makimura, M Sakoda, S Bab. Enhancement of leucine-induced insulin secretion by somatostatin antiserum pretreatment. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 11. issue 1. 1979-06-26. PMID:372079. |
insulin secretion induced by leucine and leucine plus glucose from rat pancreatic islets was enhanced by prior treatment with somatostatin antiserum as compared with normal rabbit serum in vitro. |
1979-06-26 |
2023-08-11 |
rat |