| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhongyue Yang, Catherine P Kirschke, Liping Huan. Lack of maternal exposure to somatostatin leads to diet-induced insulin and leptin resistance in mouse male offspring. Journal of molecular endocrinology. 2025-03-11. PMID:40066865. |
lack of maternal exposure to somatostatin leads to diet-induced insulin and leptin resistance in mouse male offspring. |
2025-03-11 |
2025-03-14 |
mouse |
| Zhongyue Yang, Catherine P Kirschke, Liping Huan. Lack of maternal exposure to somatostatin leads to diet-induced insulin and leptin resistance in mouse male offspring. Journal of molecular endocrinology. 2025-03-11. PMID:40066865. |
these results demonstrate that a lack of fetal somatostatin exposure impairs the islet development in offspring and increases risk of obesity, insulin resistance, and leptin resistance later in life. |
2025-03-11 |
2025-03-14 |
mouse |
| Joshua J Davis, James Thornham, Michael G Rope. Online LC-MS/MS Analysis for Profiling Peptide Hormone Secretion Dynamics from Islets of Langerhans. Analytical chemistry. 2025-02-11. PMID:39931908. |
online detection of insulin, c-peptide, glucagon, and somatostatin levels was performed using a triple quadrupole mass spectrometer. |
2025-02-11 |
2025-02-13 |
human |
| Yuliya Krivova, Alexandra Proshchina, Dmitry Otlyga, Anastasia Kharlamova, Sergey Savelie. Detection of Insulin in Insulin-Deficient Islets of Patients with Type 1 Diabetes. Life (Basel, Switzerland). vol 15. issue 1. 2025-01-25. PMID:39860066. |
pancreatic autopsies from two children with recent-onset t1d, two adults with longstanding t1d, and three control subjects were examined using double immunofluorescent labeling with antibodies to insulin, glucagon and somatostatin. |
2025-01-25 |
2025-01-28 |
human |
| Yuki Taki, Takashi Kono, Tatsuma Matsuda, Ryunosuke Kozu, Masanori Fujimoto, Ikki Sakuma, Naoko Hashimoto, Kentaro Horiguchi, Yoshinori Higuchi, Tomoaki Tanak. Short- and long-term glycemic effects of pasireotide in patients with acromegaly: a comprehensive case study with review of literature. Endocrine journal. 2025-01-22. PMID:39842795. |
however, it induces hyperglycemia by inhibiting insulin secretion via somatostatin receptor 5 (sstr5). |
2025-01-22 |
2025-01-25 |
Not clear |
| Mingyu Yang, Kousik Mandal, Moa Södergren, Özge Dumral, Lena Winroth, Anders Tenghol. Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes. Acta physiologica (Oxford, England). vol 241. issue 2. 2025-01-13. PMID:39803760. |
somatostatin from pancreatic δ-cells is a paracrine regulator of insulin and glucagon secretion, but the release kinetics and whether secretion is altered in diabetes is unclear. |
2025-01-13 |
2025-01-16 |
Not clear |
| Jiwon Hahm, Dawn Kumar, Juan Andres Fernandez Andrade, Edith Arany, David J Hil. Bi-Hormonal Endocrine Cell Presence Within the Islets of Langerhans of the Human Pancreas Throughout Life. Cells. vol 14. issue 1. 2025-01-10. PMID:39791735. |
immunofluorescence microscopy was performed for insulin, glucagon, and somatostatin presence on paraffin-embedded sections of pancreata from 20 donors without diabetes aged between 11 days and 79 years of age. |
2025-01-10 |
2025-01-13 |
human |
| Zhongyue Yang, Catherine P Kirschke, Yimeng Cai, Liping Huan. A double knockout for zinc transporter 8 and somatostatin in mice reveals their distinct roles in regulation of insulin secretion and obesity. Genes & nutrition. vol 19. issue 1. 2024-11-20. PMID:39567934. |
a double knockout for zinc transporter 8 and somatostatin in mice reveals their distinct roles in regulation of insulin secretion and obesity. |
2024-11-20 |
2024-11-23 |
mouse |
| Xue Wen Ng, Michael R DiGruccio, Chen Kong, Jeongmin Lee, David W Pisto. Role of Complexin 2 in the regulation of hormone secretion from the islet of Langerhans. bioRxiv : the preprint server for biology. 2024-11-18. PMID:39554053. |
regulated secretion of insulin from β-cells, glucagon from α-cells, and somatostatin from δ-cells is necessary for the maintenance of glucose homeostasis. |
2024-11-18 |
2024-11-22 |
Not clear |
| Peter A Sojk. Glucose Homeostasis and Derangement in Birds. The veterinary clinics of North America. Exotic animal practice. 2024-10-16. PMID:39414473. |
glucagon and somatostatin appear to play a greater role than insulin in glucose homeostasis in birds. |
2024-10-16 |
2024-10-19 |
Not clear |
| Peiheng Zhang, Ying Gao, Honghua Wu, Jian Zhang, Junqing Zhan. [Fulminant type 1 diabetes mellitus with acute pancreatitis: A case report and literature review]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. vol 56. issue 5. 2024-10-14. PMID:39397476. |
after the treatment of fasting, fluid replacement, anti-infection, somatostatin, anticoagulation and intravenous insulin sequential subcutaneous insulin pump, the patient gained the alleviation of pancreatitis, restoration of oral intake, and relatively stable blood glucose levels. |
2024-10-14 |
2024-10-16 |
Not clear |
| Neetu Prince, Jagadish Ramasamy, Soosai Manickam Amirtham, Elanchezhian Rajendran, Puurnima Man. Isolated bovine pancreatic islets as an alternate in vitro model for diabetes research. The Indian journal of medical research. vol 159. issue 5. 2024-10-09. PMID:39382423. |
fluorescent and diaminobenzidine (dab) staining with insulin, glucagon and somatostatin revealed the arrangement of the cells in each islet. |
2024-10-09 |
2024-10-11 |
cattle |
| Sandeep Sasidharan, Sabu John, Isha Puri, Muhammad Azhar, Mary Mallappalli. Octreotide Causing Hyperkalemia: A Case Report and Review of the Literature. Cureus. vol 16. issue 8. 2024-09-30. PMID:39347364. |
octreotide, a synthetic analog of somatostatin, is widely utilized for its inhibitory effects on various hormones, including growth hormone, insulin, and glucagon. |
2024-09-30 |
2024-10-02 |
Not clear |
| Ifrah I Ali, Crystal D'Souza, Saeed Tariq, Ernest A Adeghat. Adropin Is Expressed in Pancreatic Islet Cells and Reduces Glucagon Release in Diabetes Mellitus. International journal of molecular sciences. vol 25. issue 18. 2024-09-28. PMID:39337311. |
serum levels of insulin, glucagon pancreatic polypeptide (pp), and somatostatin were measured using a luminex |
2024-09-28 |
2024-10-01 |
rat |
| Nirun Hewawasam, Debalina Sakar, Olivia Bolton, Blerinda Delishaj, Maha Almutairi, Aileen King, Ayse S Dereli, Chloe Despontin, Patrick Gilon, Sue Reeves, Michael Patterson, Astrid Christine Hauge-Evan. The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner. The Journal of endocrinology. 2024-09-18. PMID:39292603. |
leap2 enhanced insulin secretion in islets from males (p<0.01) but not females (p<0.2), whilst ag-stimulated somatostatin release was significantly reversed by leap2 in males (p<0.001) but not females (p<0.2). |
2024-09-18 |
2024-09-21 |
mouse |
| Nirun Hewawasam, Debalina Sakar, Olivia Bolton, Blerinda Delishaj, Maha Almutairi, Aileen King, Ayse S Dereli, Chloe Despontin, Patrick Gilon, Sue Reeves, Michael Patterson, Astrid Christine Hauge-Evan. The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner. The Journal of endocrinology. 2024-09-18. PMID:39292603. |
our findings show that ag and leap2 regulate insulin and somatostatin release in an opposing and sex-dependent manner, which in males can be modulated by e2. |
2024-09-18 |
2024-09-21 |
mouse |
| Sara Heebøll, Gregers Wegener, Henning Grønbæk, Søren Nielse. Comparable glucagon-stimulated amino acid suppression in individuals with and without hepatic steatosis or steatohepatitis. American journal of physiology. Endocrinology and metabolism. 2024-09-18. PMID:39291967. |
we performed a somatostatin clamp with infusions of insulin and low-dose followed by high-dose glucagon. |
2024-09-18 |
2024-09-20 |
human |
| Gal Lenz, Lynn Miao, Ayelet Lenz, Jacob Mares, Janine Quijano, Heather N Zook, Hirotake Komatsu, Pablo Garcia, Kevin Ferreri, Hsun Teresa Ku, Fouad Kandee. Characterization of Human Pancreatic Islet Cells using a Single-Cell Western Blot Platform. Pancreas. 2024-09-11. PMID:39259841. |
in this study, we aimed to test the suitability of scwestern to detect protein markers for beta (insulin), alpha (glucagon), and delta (somatostatin) cells, the three major endocrine cell types in islets. |
2024-09-11 |
2024-09-14 |
human |
| Ho Yan Yeung, Iris Bea L Ramiro, Daniel B Andersen, Thomas Lund Koch, Alexander Hamilton, Walden E Bjørn-Yoshimoto, Samuel Espino, Sergey Y Vakhrushev, Kasper B Pedersen, Noortje de Haan, Agnes L Hipgrave Ederveen, Baldomero M Olivera, Jakob G Knudsen, Hans Bräuner-Osborne, Katrine T Schjoldager, Jens Juul Holst, Helena Safavi-Hemam. Fish-hunting cone snail disrupts prey's glucose homeostasis with weaponized mimetics of somatostatin and insulin. Nature communications. vol 15. issue 1. 2024-08-20. PMID:39164229. |
fish-hunting cone snail disrupts prey's glucose homeostasis with weaponized mimetics of somatostatin and insulin. |
2024-08-20 |
2024-08-23 |
Not clear |
| Elisa Moser, Ayako Ura, Loreen Vogel, Katja Steiger, Carolin Mogler, Matthias Evert, Bruno Märkl, Klemens Scheidhauer, Marc Martignoni, Helmut Friess, Alexander von Werder, Ilaria Marinoni, Aurel Perren, Günter Klöppel, Atsuko Kasajim. ARX, PDX1, ISL1 and CDX2 expression distinguishes five subgroups of PanNETs with correlations to histology, hormone expression and outcome. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2024-08-15. PMID:39147030. |
185 pannets (non-functioning 165, functioning 20) resected between 1996 and 2023 were classified into five subgroups (a1, a2, b, c, d) by cluster analysis based on arx, pdx1, isl1 and cdx2 expression and correlated with trabecular vs. solid histology, expression of insulin, glucagon, pp, somatostatin, serotonin, gastrin, calcitonin, acth, daxx/atrx, men1 and alt status by fish, and disease-free survival (dfs). |
2024-08-15 |
2024-08-18 |
Not clear |