| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soujanya S Karanth, Shuofei Sun, Huanjing Bi, Kaiming Ye, Sha Ji. Angiopoietins stimulate pancreatic islet development from stem cells. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34193893. |
moreover, ang2 augmented the expression of all islet hormones, including insulin, glucagon, somatostatin, and pancreatic polypeptide; and β cell transcription factors, including nkx6.1, mafa, ucn3, and pdx1. |
2021-11-08 |
2023-08-13 |
Not clear |
| b' Betina Biagetti, Anna Aulinas, Anna Casteras, Santiago P\\xc3\\xa9rez-Hoyos, Rafael Sim\\xc3\\xb. HOMA-IR in acromegaly: a systematic review and meta-analysis. Pituitary. vol 24. issue 2. 2021-11-04. PMID:33085039.' |
this review is aimed at examining whether the homeostatic model assessment of insulin resistance (homa-ir) is higher in caucasian, adult, treatment-naïve patients with acromegaly (acro) than in the reference population independently of diabetes presence and to evaluate the impact of treatment [surgery and somatostatin analogues (ssas)] on its assessment. |
2021-11-04 |
2023-08-13 |
Not clear |
| Kiyoshi Chinen, Naoaki Sakata, Gumpei Yoshimatsu, Masafumi Nakamura, Shohta Kodam. Therapeutic effects of acylated ghrelin-specific receptor GHS-R1a antagonist in islet transplantation. Scientific reports. vol 11. issue 1. 2021-11-02. PMID:34711885. |
dls treatment promoted insulin production and suppressed somatostatin production, suggesting that cancelation of the binding between ghrelin and ghs-r1a on β or δ cells improved insulin expression. |
2021-11-02 |
2023-08-13 |
mouse |
| A N Bradbery, J A Coverdale, C J Hartz, A A Millican, M S Goehring, K K Fikes, E Picking, C J Hammer, K A Dunlap, R C Cardoso, T A Wickersham, J L Leatherwood, M C Satterfiel. Effect of maternal overnutrition on predisposition to insulin resistance in the foal: Maternal parameters and foal pancreas histoarchitecture. Animal reproduction science. vol 227. 2021-11-01. PMID:33636430. |
immunofluoresent analysis of insulin, glucagon, and somatostatin indicate no difference in intensity of staining (p> 0.10). |
2021-11-01 |
2023-08-13 |
Not clear |
| Rosa Lynn Schmitz, Julia Weissbach, Jan Kleilein, Jessica Bell, Stefan Hüttelmaier, Fabrice Viol, Till Clauditz, Patricia Grabowski, Helmut Laumen, Jonas Rosendahl, Patrick Michl, Jörg Schrader, Sebastian Kru. Targeting HDACs in Pancreatic Neuroendocrine Tumor Models. Cells. vol 10. issue 6. 2021-11-01. PMID:34204116. |
hdac inhibition stimulated redifferentiation of human primary pannet cells by increasing mrna-expression of somatostatin receptors (sstrs) and insulin production. |
2021-11-01 |
2023-08-13 |
mouse |
| Karla F Leavens, Chia-Min Liao, Alyssa L Gagne, Siddharth Kishore, Fabian L Cardenas-Diaz, Deborah L French, Paul Gadu. Generation of a double insulin and somatostatin reporter line, SCSe001-A-3, for the advancement of stem cell-derived pancreatic islets. Stem cell research. vol 50. 2021-10-27. PMID:33316598. |
generation of a double insulin and somatostatin reporter line, scse001-a-3, for the advancement of stem cell-derived pancreatic islets. |
2021-10-27 |
2023-08-13 |
human |
| Marine L Croze, Marcus F Flisher, Arthur Guillaume, Caroline Tremblay, Glyn M Noguchi, Sabrina Granziera, Kevin Vivot, Vincent C Castillo, Scott A Campbell, Julien Ghislain, Mark O Huising, Vincent Poitou. Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice. Molecular metabolism. vol 45. 2021-10-25. PMID:33484949. |
free fatty acid receptor 4 (ffar4/gpr120) is a g protein-coupled receptor whose activation in islets of langerhans promotes insulin and glucagon secretion and inhibits somatostatin secretion. |
2021-10-25 |
2023-08-13 |
mouse |
| Marine L Croze, Marcus F Flisher, Arthur Guillaume, Caroline Tremblay, Glyn M Noguchi, Sabrina Granziera, Kevin Vivot, Vincent C Castillo, Scott A Campbell, Julien Ghislain, Mark O Huising, Vincent Poitou. Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice. Molecular metabolism. vol 45. 2021-10-25. PMID:33484949. |
as gpr120 mrna is enriched in somatostatin-secreting δ cells, we hypothesized that gpr120 activation stimulates insulin and glucagon secretion via inhibition of somatostatin release. |
2021-10-25 |
2023-08-13 |
mouse |
| Xue W Ng, Yong H Chung, David W Pisto. Intercellular Communication in the Islet of Langerhans in Health and Disease. Comprehensive Physiology. vol 11. issue 3. 2021-10-25. PMID:34190340. |
blood glucose homeostasis requires proper function of pancreatic islets, which secrete insulin, glucagon, and somatostatin from the β-, α-, and δ-cells, respectively. |
2021-10-25 |
2023-08-13 |
Not clear |
| Berit Svendsen, Jens J Hols. Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets. Diabetologia. vol 64. issue 1. 2021-08-19. PMID:33043402. |
paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets. |
2021-08-19 |
2023-08-13 |
mouse |
| Berit Svendsen, Jens J Hols. Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets. Diabetologia. vol 64. issue 1. 2021-08-19. PMID:33043402. |
the endocrine pancreas comprises the islets of langerhans, primarily consisting of beta cells, alpha cells and delta cells responsible for secretion of insulin, glucagon and somatostatin, respectively. |
2021-08-19 |
2023-08-13 |
mouse |
| Berit Svendsen, Jens J Hols. Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets. Diabetologia. vol 64. issue 1. 2021-08-19. PMID:33043402. |
glucagon has been demonstrated to importantly regulate insulin secretion, while somatostatin powerfully inhibits both insulin and glucagon secretion. |
2021-08-19 |
2023-08-13 |
mouse |
| Berit Svendsen, Jens J Hols. Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets. Diabetologia. vol 64. issue 1. 2021-08-19. PMID:33043402. |
in this study we investigated how secretion of somatostatin is regulated by paracrine signalling from glucagon and insulin. |
2021-08-19 |
2023-08-13 |
mouse |
| Fatma Kaya-Dagistanli, Melek Oztur. Transdifferentiation of both intra- and extra-islet cells into beta cells in nicotinamide treated neonatal diabetic rats: An in situ hybridization and double immunohistochemical study. Acta histochemica. vol 122. issue 7. 2021-08-05. PMID:33066834. |
the pancreatic tissue sections were immunostained with insulin, glucagon, somatostatin, pdx1, notch1 and active caspase-3 antibodies, and double immunostained with insulin/pcna, insulin/glucagon and insulin/somatostatin antibodies. |
2021-08-05 |
2023-08-13 |
rat |
| Marta Perez-Frances, Léon van Gurp, Maria Valentina Abate, Valentina Cigliola, Kenichiro Furuyama, Eva Bru-Tari, Daniel Oropeza, Taïna Carreaux, Yoshio Fujitani, Fabrizio Thorel, Pedro L Herrer. Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production. Nature communications. vol 12. issue 1. 2021-08-03. PMID:34294685. |
within islets, glucagon and somatostatin, released respectively from α- and δ-cells, modulate the secretion of insulin by β-cells. |
2021-08-03 |
2023-08-13 |
mouse |
| S Mozel, S Szymańczyk, M Krzysiak, I Puzio, A Zacharko-Siembida, M B Arciszewsk. Immunohistochemical study on the expression of biologically active substances in the endocrine pancreas of the European bison. Polish journal of veterinary sciences. vol 23. issue 3. 2021-07-16. PMID:33006860. |
therefore, the present immunohistochemical investigation was conducted in a wild species, the european bison, using antibodies against glucagon-like peptide-1 (glp1), glucagon, insulin and somatostatin. |
2021-07-16 |
2023-08-13 |
Not clear |
| Hongjun Deng, Fengying Yang, Xiaoyi Ma, Ying Wang, Qi Chen, Li Yua. Long-Term Liraglutide Administration Induces Pancreas Neogenesis in Adult T2DM Mice. Cell transplantation. vol 29. 2021-06-25. PMID:32584149. |
the primitive bud was characterized by scattered single monohormonal cells expressing insulin, glp-1, somatostatin, or pancreatic polypeptide, and four-hormonal cells, but no acinar cells and ductal epithelial cells. |
2021-06-25 |
2023-08-13 |
mouse |
| Ian J Jackson, Muraly Puttabyatappa, Miranda Anderson, Meha Muralidharan, Almudena Veiga-Lopez, Brigid Gregg, Sean Limesand, Vasantha Padmanabha. Developmental programming: Prenatal testosterone excess disrupts pancreatic islet developmental trajectory in female sheep. Molecular and cellular endocrinology. vol 518. 2021-06-25. PMID:32726642. |
the morphological and functional changes in pancreatic islet were assessed through detection of 1) islet hormones (insulin, glucagon) and apoptotic beta cells at fetal day 90 and 2) islet hormones (insulin, glucagon and somatostatin), and pancreatic lipid and collagen accumulation in adults. |
2021-06-25 |
2023-08-13 |
Not clear |
| Ian J Jackson, Muraly Puttabyatappa, Miranda Anderson, Meha Muralidharan, Almudena Veiga-Lopez, Brigid Gregg, Sean Limesand, Vasantha Padmanabha. Developmental programming: Prenatal testosterone excess disrupts pancreatic islet developmental trajectory in female sheep. Molecular and cellular endocrinology. vol 518. 2021-06-25. PMID:32726642. |
adult prenatal t-treated female sheep manifested 1) significant increase in beta cell size and a tendency for increase in insulin and somatostatin stained area and proportion of beta cells in the islet; and 2) significant increase in pancreatic islet collagen and a tendency towards increased lipid accumulation. |
2021-06-25 |
2023-08-13 |
Not clear |
| Simone Esposito, Domitilla Vanni, Sergio Menta, Laura Orsatti, Edith Monteagud. Comparison of different protein precipitation and solid-phase extraction protocols for the study of the catabolism of peptide drugs by LC-HRMS. Journal of peptide science : an official publication of the European Peptide Society. vol 26. issue 9. 2021-06-04. PMID:32633064. |
to this purpose, four model peptides representative of different classes (somatostatin, glp-2, human insulin and liraglutide) were digested with trypsin and chymotrypsin to simulate proteolytic catabolism. |
2021-06-04 |
2023-08-13 |
human |