| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas G Hill, David J Hil. The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612880. |
this is mediated partly through circulatory feedback of the major secreted hormones, insulin and glucagon, but also by autocrine and paracrine actions within the islet by a range of other secreted products, including somatostatin, urocortin 3, serotonin, glucagon-like peptide-1, acetylcholine, and ghrelin. |
2024-04-13 |
2024-04-15 |
Not clear |
| Glyn M Noguchi, Vincent C Castillo, Cynthia J Donaldson, Marcus R Flisher, Ariana T Momen, Alan Saghatelian, Mark O Huisin. Urocortin3 contributes to paracrine inhibition of islet alpha cells in mice. The Journal of endocrinology. 2024-04-09. PMID:38593829. |
additionally, urocortin3 (ucn3) is a hormone that is co-released from beta cells with insulin and acts locally to potentiate somatostatin secretion from delta cells. |
2024-04-09 |
2024-04-12 |
mouse |
| Maria Salomon Estebanez, Chris Worth, Indraneel Banerje. Congenital Hyperinsulinism - Notes for the General Pediatrician. Indian pediatrics. 2024-04-08. PMID:38584412. |
specific medical therapies with diazoxide and/or somatostatin receptor analogues may be commenced after the finding of detectable insulin at hypoglycemia, a biochemical characteristic of chi. |
2024-04-08 |
2024-04-10 |
Not clear |
| Alison Murray, Sonia Priscila Rodas Marquez, Mansa Krishnamurthy, Oscar Lopez-Nunez, Juan P Gurria, Andrew T Trout, Susan Almazan, Krishnamallika Mutyala, Amy Shah, Jonathan Howel. Multifocal Insulinoma as the Unique Presenting Feature of MEN1 in an Adolescent. Hormone research in paediatrics. 2024-03-05. PMID:38442699. |
while the primary lesion stained for insulin and somatostatin by immunofluorescence (if), consistent with his clinical presentation, the additional tumors expressed glucagon, somatostatin, pancreatic polypeptide, and chromogranin a but were negative for insulin. |
2024-03-05 |
2024-03-08 |
Not clear |
| Ali H Shilleh, Katrina Viloria, Johannes Broichhagen, Jonathan E Campbell, David J Hodso. GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells. Peptides. 2024-02-15. PMID:38360354. |
glucagon-like peptide 1 receptor (glp1r) and glucose-dependent insulinotropic polypeptide receptor (gipr) are transmembrane receptors involved in insulin, glucagon and somatostatin secretion from the pancreatic islet. |
2024-02-15 |
2024-02-18 |
Not clear |
| Katie C Coate, Christopher J Ramnanan, Marta Smith, Jason J Winnick, Guillaume Kraft, Jose Irimia-Dominguez, Ben Farmer, E Patrick Donahue, Peter J Roach, Alan D Cherrington, Dale S Edgerto. Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog. American journal of physiology. Endocrinology and metabolism. 2024-02-07. PMID:38324258. |
glucagon was either infused into the hepato-portal vein at a 6-fold basal rate in the presence of somatostatin and basal insulin, or it was maintained at a basal level in control studies. |
2024-02-07 |
2024-02-09 |
dog |
| Emily G Hoffman, Ninoschka C D'Souza, Richard T Liggins, Michael C Riddel. Pharmacologic inhibition of somatostatin receptor 2 to restore glucagon counterregulation in diabetes. Frontiers in pharmacology. vol 14. 2024-02-01. PMID:38298268. |
glucose homeostasis is primarily maintained by pancreatic hormones, insulin and glucagon, with an emerging role for a third islet hormone, somatostatin, in regulating insulin and glucagon responses. |
2024-02-01 |
2024-02-03 |
Not clear |
| Emily G Hoffman, Ninoschka C D'Souza, Richard T Liggins, Michael C Riddel. Pharmacologic inhibition of somatostatin receptor 2 to restore glucagon counterregulation in diabetes. Frontiers in pharmacology. vol 14. 2024-02-01. PMID:38298268. |
under healthy conditions, somatostatin secreted from pancreatic islet δ-cells inhibits both insulin and glucagon release through somatostatin receptor- induced camp-mediated downregulation and paracrine inhibition of β- and α-cells, respectively. |
2024-02-01 |
2024-02-03 |
Not clear |
| Weiguan Du, Haining Wang, Ye Liu, Tianpei Hon. Recurrent hypoglycemia induced by clopidogrel: A case report and mini review. Journal of diabetes investigation. 2023-12-08. PMID:38063248. |
severe cases had been treated with drugs that reduce pancreatic insulin secretion (such as somatostatin and diazoxide), immunosuppressants (glucocorticoids, azathioprine and rituximab) and even immunoadsorption to remove the insulin autoantibody from the body. |
2023-12-08 |
2023-12-17 |
Not clear |
| Katie C Coate, Christopher J Ramnanan, Marta Smith, Jason J Winnick, Guillaume Kraft, Jose M Irimia, Ben Farmer, Patrick Donahue, Peter J Roach, Alan D Cherrington, Dale S Edgerto. Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog. bioRxiv : the preprint server for biology. 2023-10-09. PMID:37808670. |
glucagon was either infused into the hepato-portal vein at a 6-fold basal rate in the presence of somatostatin and basal insulin, or it was maintained at a basal level in control studies. |
2023-10-09 |
2023-10-15 |
dog |
| Anne Mones, Sheila Criswel. Immunohistochemical evaluation of hormones secreted by pancreatic endocrine tumors. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023-10-03. PMID:37787578. |
islet cell components include alpha, beta, pp, delta and epsilon cells, which secrete glucagon, insulin, pancreatic polypeptide, somatostatin and ghrelin, respectively. |
2023-10-03 |
2023-10-07 |
Not clear |
| Anne Mones, Sheila Criswel. Immunohistochemical evaluation of hormones secreted by pancreatic endocrine tumors. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023-10-03. PMID:37787578. |
glucagon was the most frequently secreted hormone (83%) in pets followed by insulin, ghrelin, pancreatic polypeptide and somatostatin. |
2023-10-03 |
2023-10-07 |
Not clear |
| Samantha E Adamson, Zipeng A Li, Jing W Hughe. Beta cell primary cilia mediate somatostatin responsiveness via SSTR3. Islets. vol 15. issue 1. 2023-09-03. PMID:37660302. |
somatostatin is a paracrine modulator of insulin secretion and beta cell function with pleotropic effects on glucose homeostasis. |
2023-09-03 |
2023-09-07 |
mouse |
| Samantha E Adamson, Zipeng A Li, Jing W Hughe. Beta cell primary cilia mediate somatostatin responsiveness via SSTR3. Islets. vol 15. issue 1. 2023-09-03. PMID:37660302. |
we show that sstr3, a ciliary gpcr, mediates somatostatin suppression of insulin secretion in mouse islets. |
2023-09-03 |
2023-09-07 |
mouse |
| Chrisanthi Zouli, Eleana Zisimopoulou, Alexandra Chrisoulido. Biomarkers in neuroendocrine neoplasms. Hellenic journal of nuclear medicine. vol 26 Suppl. 2023-09-02. PMID:37658563. |
functional nens can be divided into carcinoid tumors, with serotonin overproduction, and functional gep nen's (mostly located in pancreas) that may secrete insulin, vip, gastrin, glucagon or somatostatin. |
2023-09-02 |
2023-09-07 |
Not clear |
| Antwi-Boasiako Oteng, Liu Li. GPCR-mediated effects of fatty acids and bile acids on glucose homeostasis. Frontiers in endocrinology. vol 14. 2023-07-24. PMID:37484954. |
activation of these gpcrs affects the release of incretin hormones by enteroendocrine cells and/or the secretion of insulin, glucagon, and somatostatin by pancreatic islets, all of which regulate systemic glucose homeostasis. |
2023-07-24 |
2023-08-14 |
Not clear |
| Joshua J Davis, Matthew J Donohue, Emmanuel O Ogunkunle, Wesley J Eaton, Daniel J Steyer, Michael G Rope. Simultaneous monitoring of multiple hormones from human islets of Langerhans using solid-phase extraction-mass spectrometry. Analytical and bioanalytical chemistry. 2023-07-13. PMID:37442843. |
in this report, response surface methodology was used to identify a set of optimal solid-phase extraction (spe) conditions for the islet-secreted peptides, insulin, c-peptide, glucagon, and somatostatin. |
2023-07-13 |
2023-08-14 |
human |
| Gerardo J Félix-Martínez, J Rafael Godínez-Fernánde. A primer on modelling pancreatic islets: from models of coupled β-cells to multicellular islet models. Islets. vol 15. issue 1. 2023-07-07. PMID:37415423. |
pancreatic islets are mini-organs composed of hundreds or thousands of ɑ, β and δ-cells, which, respectively, secrete glucagon, insulin and somatostatin, key hormones for the regulation of blood glucose. |
2023-07-07 |
2023-08-14 |
Not clear |
| Christine A Juliana, Jinghua Chai, Pablo Arroyo, Elizabeth Rico-Bautista, Stephen F Betz, Diva D De Leó. A selective nonpeptide somatostatin receptor 5 (SST5) agonist effectively decreases insulin secretion in hyperinsulinism. The Journal of biological chemistry. 2023-05-13. PMID:37178920. |
a selective nonpeptide somatostatin receptor 5 (sst5) agonist effectively decreases insulin secretion in hyperinsulinism. |
2023-05-13 |
2023-08-14 |
Not clear |
| Yusuke Tanaka, Kenichi Watanabe, Yasuhiro Morita, Yoshiyasu Kobayash. Multiple endocrine neoplasia in a sheep: insulinoma, adrenocortical carcinoma with myxoid differentiation, and thyroid C-cell carcinoma. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2023-05-06. PMID:37148257. |
these proliferating cells, which had abundant eosinophilic-to-amphophilic cytoplasm and hyperchromatic nuclei, were immunopositive for insulin and negative for glucagon and somatostatin; the lesion was diagnosed as an insulinoma. |
2023-05-06 |
2023-08-14 |
Not clear |