| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W V Tamborlane, R S Sherwin, R Hendler, P Feli. Metabolic effects of somatostatin in maturity-onset diabetes. The New England journal of medicine. vol 297. issue 4. 1977-08-12. PMID:876274. |
furthermore, accentuation by somatostatin of hyperglycemia, hyperketonemia and hyperaminoacidemia in maturity-onset diabetes argues against its use in patients with residual insulin secretion. |
1977-08-12 |
2023-08-11 |
Not clear |
| S Efendić, P E Lins, R Luft, H Sievertsson, G Westin-Sjöda. Studies on the mechanism of somatostatin action on insulin release. V. Effect of somatostatin analogues on arginine induced release of insulin and glucagon from the perfused rat pancreas. Acta endocrinologica. vol 85. issue 3. 1977-07-29. PMID:194446. |
studies on the mechanism of somatostatin action on insulin release. |
1977-07-29 |
2023-08-11 |
rat |
| S Efendić, P E Lins, R Luft, H Sievertsson, G Westin-Sjöda. Studies on the mechanism of somatostatin action on insulin release. V. Effect of somatostatin analogues on arginine induced release of insulin and glucagon from the perfused rat pancreas. Acta endocrinologica. vol 85. issue 3. 1977-07-29. PMID:194446. |
v. effect of somatostatin analogues on arginine induced release of insulin and glucagon from the perfused rat pancreas. |
1977-07-29 |
2023-08-11 |
rat |
| S Efendić, P E Lins, R Luft, H Sievertsson, G Westin-Sjöda. Studies on the mechanism of somatostatin action on insulin release. V. Effect of somatostatin analogues on arginine induced release of insulin and glucagon from the perfused rat pancreas. Acta endocrinologica. vol 85. issue 3. 1977-07-29. PMID:194446. |
eighteen analogues of somatostatin have been used in order to elucidate the structure-activity relationship of the peptide on the release of insulin and glucagon from the isolated perfused rat pancreas. |
1977-07-29 |
2023-08-11 |
rat |
| B Willm. [Future prospect of diabetes therapy (author's transl)]. MMW, Munchener medizinische Wochenschrift. vol 119. issue 15. 1977-07-23. PMID:405569. |
somatostatin is available as a supplement to insulin therapy because it eliminates the growth hormone as possible source of diabetic vascular complications and it blocks the secretion of hormones with a contrainsular effect. |
1977-07-23 |
2023-08-11 |
Not clear |
| A Claro, V Grill, S Efendić, R Luf. Studies on the mechanisms of somatostatin action on insulin release. IV. effect of somatostatin on cyclic AMP levels and phosphodiesterase activity in isolated rat pancreatic islets. Acta endocrinologica. vol 85. issue 2. 1977-07-18. PMID:194442. |
studies on the mechanisms of somatostatin action on insulin release. |
1977-07-18 |
2023-08-11 |
rat |
| A Claro, V Grill, S Efendić, R Luf. Studies on the mechanisms of somatostatin action on insulin release. IV. effect of somatostatin on cyclic AMP levels and phosphodiesterase activity in isolated rat pancreatic islets. Acta endocrinologica. vol 85. issue 2. 1977-07-18. PMID:194442. |
the effects of somatostatin on insulin release and cyclic amp metabolism were studied in collagenase-isolated islets of langerhans from the rat. |
1977-07-18 |
2023-08-11 |
rat |
| A Claro, V Grill, S Efendić, R Luf. Studies on the mechanisms of somatostatin action on insulin release. IV. effect of somatostatin on cyclic AMP levels and phosphodiesterase activity in isolated rat pancreatic islets. Acta endocrinologica. vol 85. issue 2. 1977-07-18. PMID:194442. |
in dose-response studies, the inhibition by somatostatin of the effect of glucose on [3h]cyclic amp and insulin release could be overcome by a high concentration of the hexose (44.9 mm), suggesting competitive inhibition. |
1977-07-18 |
2023-08-11 |
rat |
| M Brown, J Rivier, W Val. Somatostatin: analogs with selected biological activities. Science (New York, N.Y.). vol 196. issue 4297. 1977-07-18. PMID:867045. |
[d-cys14]-somatostatin is the first analog of somatostatin found to be more potent in inhibiting glucagon and growth hormone secretion that it is in inhibiting insulin secretion. |
1977-07-18 |
2023-08-11 |
Not clear |
| M Brown, J Rivier, W Val. Somatostatin: analogs with selected biological activities. Science (New York, N.Y.). vol 196. issue 4297. 1977-07-18. PMID:867045. |
[d-trp8]-somatostatin is eight to ten times more potent than somatostatin in inhibiting insulin, glucagon, and growth hormone secretion. |
1977-07-18 |
2023-08-11 |
Not clear |
| H J Hirsch, S Loo, N Evans, J F Crigler, R M Filler, K H Gabba. Hypoglycemia of infancy and nesidioblastosis. Studies with somatostatin. The New England journal of medicine. vol 296. issue 23. 1977-06-30. PMID:193007. |
the beta cells were exquisitely sensitive to infusions of synthetic cyclic somatostatin, with a dose-dependent rise in blood glucose and concomitant suppression of serum insulin levels. |
1977-06-30 |
2023-08-11 |
Not clear |
| R Assan, C Heuclin, J R Girard, A Basdevant, J Predine, J M Husso. Hormonal and metabolic effects of somatostatin in diabetic patients submitted to an i.v. arginine infusion. Diabete & metabolisme. vol 3. issue 1. 1977-06-30. PMID:870353. |
substrate responses to arginine were also modified by somatostatin: alanine disappearance was impaired, this effect being dose-related; plasma ffa and 3-hydroxybutyrate concentrations showed a significant increase rather than decrease, consistent with somatostatin suppression of residual insulin secretion. |
1977-06-30 |
2023-08-11 |
human |
| C Capella, E Solcia, B Frigerio, R Buffa, L Usellini, P Fontan. The endocrine cells of the pancreas and related tumours. Ultrastructural study and classification. Virchows Archiv. A, Pathological anatomy and histology. vol 373. issue 4. 1977-06-22. PMID:193245. |
up to seven endocrine cell types have been identified ultrastructurally in the pancreas, including glucagon a cells, insulin b cells, somatostatin d cells, pancreatic peptide f cells and 5-hydroxytryptamine ec cells. |
1977-06-22 |
2023-08-11 |
Not clear |
| J E Geric. Somatostatin. Its possible role in carbohydrate homeostasis and the treatment of diabetes mellitus. Archives of internal medicine. vol 137. issue 5. 1977-06-22. PMID:324423. |
studies using synthetic somatostatin have provided evidence that glucagon is a physiologically important hormone that exacerbates the consequences of insulin deficiency in human diabetes mellitus. |
1977-06-22 |
2023-08-11 |
human |
| J E Geric. Somatostatin. Its possible role in carbohydrate homeostasis and the treatment of diabetes mellitus. Archives of internal medicine. vol 137. issue 5. 1977-06-22. PMID:324423. |
the ability of somatostatin to diminish both fasting and post-prandial hyperglycemia and to forestall the development of ketoacidosis after withdrawal of insulin in insulin-dependent diabetics suggests a potential therapeutic use of this agent in diabetes. |
1977-06-22 |
2023-08-11 |
human |
| P Schauder, C McIntosh, J Arends, R Arnold, H Frerichs, W Creutzfeld. Somatostatin and insulin release from isolated rat pancreatic islets in response to D-glucose, l-leucine, alpha-ketoisocaproic acid or D-glyceraldehyde: evidence for a regulatory role of adenosine-3' ,5'-cyclic monophosphate. Biochemical and biophysical research communications. vol 75. issue 3. 1977-06-11. PMID:193496. |
somatostatin and insulin release from isolated rat pancreatic islets in response to d-glucose, l-leucine, alpha-ketoisocaproic acid or d-glyceraldehyde: evidence for a regulatory role of adenosine-3' ,5'-cyclic monophosphate. |
1977-06-11 |
2023-08-11 |
rat |
| M Ukai, I Inoue, T Itats. Effect of somatostatin on neurotensin-induced glucagon release and hyperglycemia. Endocrinology. vol 100. issue 5. 1977-05-27. PMID:849724. |
infusion of somatostatin along with neurotensin suppressed glucagon and insulin responses to neurotensin and prevented the rise in blood glucose levels. |
1977-05-27 |
2023-08-11 |
Not clear |
| J Marco, J A Hedo, M L Villaneuv. Inhibition of intestinal glucagon-like immunoreactivity (GLI) secretion by somatostatin in man. The Journal of clinical endocrinology and metabolism. vol 44. issue 4. 1977-05-27. PMID:849979. |
the well-known suppressor effect of somatostatin on glucagon and insulin secretion was also detected. |
1977-05-27 |
2023-08-11 |
human |
| J Marco, J A Hedo, M L Villaneuv. Inhibition of intestinal glucagon-like immunoreactivity (GLI) secretion by somatostatin in man. The Journal of clinical endocrinology and metabolism. vol 44. issue 4. 1977-05-27. PMID:849979. |
finally, during somatostatin infusion the initial elevation of blood sugar after oral glucose, in the absence of insulin response, appeared considerably delayed. |
1977-05-27 |
2023-08-11 |
human |
| R H Unger, L Orc. Possible roles of the pancreatic D-cell in the normal and diabetic states. Diabetes. vol 26. issue 3. 1977-04-28. PMID:320077. |
the a-, d-, and b-cells--the islet cells that contain, respectively, immunoreactive glucagon, somatostatin, and insulin--are distributed within a specialized heterocellular region of the islets of langerhans as if to permit heterologous contacts between all three cell types. |
1977-04-28 |
2023-08-11 |
Not clear |